Serum protein apolipoprotein c ii. Medical search. Frequent questions

It circulates as a component of lipoprotein particles and as a lipid-free serum protein (6). (rndsystems.com)
Circulating levels of ApoH are postively correlated with triglyceride-rich lipoprotein (VLDL) components in type II diabetes (9). (rndsystems.com)
Low-density lipoprotein receptor-related protein 5 gene polymorphisms and genetic susceptibility to abdominal aortic aneurysm. (cdc.gov)
Serum amyloid A (SAA), an acute phase reactant, is a high-density lipoprotein-associated lipoprotein. (biomedcentral.com)
Apolipoprotein B binds to specific receptors on cell membranes and is involved in removal of LDL and very low density lipoprotein (VLDL) cholesterol from circulation. (thermofisher.com)
Low-density lipoprotein (LDL) is the carrier protein for cholesterol in the blood. (thermofisher.com)
Apolipoprotein B is mostly synthesized in the liver, and is a major apolipoprotein of very low density, intermediate density and low density lipoproteins (LDL) as well as being a major component of lipoprotein (a). (thermofisher.com)
CXCL16, which was originally described as a scavenger receptor for phosphatidylserine and oxidized low-density lipoprotein (SR-PSOX), is one of the few scavenger receptors that has two distinct forms: membrane-bound and soluble. (medsci.org)
Serum lipids profiles, including total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), triglyceride (TG), apolipoprotein A-Ⅰ (apoA-Ⅰ), apolipoprotein B (apoB) and clinicopathologic data were analyzed. (researchsquare.com)
15] found that oxidized low-density lipoprotein (ox-LDL) in serum was higher in ovarian cancer patients than in control subjects, but total cholesterol (TC) and high-density lipoprotein (HDL) showed no such association. (researchsquare.com)
Associations were not systematically stronger when comparing traditional lipids (total cholesterol, low-density lipoprotein or high-density lipoprotein) to apolipoproteins. (nih.gov)
The high-fat diet produced different effects on the serum lipids and lipoprotein levels of the athletes. (meatrition.com)
It has been shown that elevated select 15 000 people aged 3 to 69 years serum levels of low-density lipoprotein from district 13 in the east of Tehran for the (LDL) cholesterol, total cholesterol and study. (who.int)

Apolipoprotein B (apo B) in human plasma is a major protein of low density lipoproteins (LDL) with a molecular mass of approximately 260-500 kDa. (thermofisher.com)
Main lipid and protein components of high-density lipoproteins. (encyclopedia.pub)
Circulating lipoproteins and their protein constituents, apolipoproteins, are risk factors for chronic kidney disease (CKD). (nih.gov)

Apolipoprotein E (APOE) genotype-associated disease risks: a phenome-wide, registry-based, case-control study utilising the UK Biobank. (cdc.gov)
After injection of PVT1 -silencing lentiviruses, AAA was induced in Apolipoprotein E-deficient (ApoE −/− ) male mice by angiotensin II (Ang II) infusion for four weeks. (molcells.org)
Only 10% of amyloidosis deposits consist of components such as glycosaminoglycans (GAGs), apolipoprotein-E (apoE), and serum amyloid P-component (SAP), while nearly 90% of the deposits consist of amyloid fibrils that are formed by the aggregation of misfolded proteins. (medscape.com)

Atherosclerosis, which is believed to be the common pathophysiological basis of cardiovascular disease, is caused by inflammation, oxidative stress, and impaired lipid metabolism [ 2 , 3 ] . (medsci.org)
We examined the effects of high-carbohydrate and high-fat diets on the serum lipid levels of distance runners. (meatrition.com)
Tehran Lipid and Glucose Study was initi- disease (CVD) since the mid-1970s, this ated in 1998 to determine the risk factors of is still the primary cause of morbidity and arteriosclerosis among the urban population mortality in many countries [ 1,2 ]. (who.int)

Atherosclerosis 2010 Apr 209 (2): 487-91. (cdc.gov)
Apolipoprotein B is a ligand for the LDL receptor and elevated levels are associated with premature atherosclerosis. (thermofisher.com)

PVDF membrane was probed with 0.25 µg/mL of Sheep Anti-Mouse/Rat Apolipoprotein H/ApoH Antigen Affinity-purified Polyclonal Antibody (Catalog # AF6575) followed by HRP-conjugated Anti-Sheep IgG Secondary Antibody (Catalog # HAF016 ). (rndsystems.com)
PVDF membrane was probed with 1 µg/mL of Goat Anti-Mouse Serum Amyloid A1/A2 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF2948) followed by HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # HAF017 ). (rndsystems.com)
Goat Anti-Mouse Serum Amyloid A1/A2 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF2948) was biotinylated and incubated with the protein captured on the plate. (rndsystems.com)

Compared to routinely used ELISAs, multiple reaction monitoring (MRM)-based mass spectrometry allows multiplexing and detection of proteins for which antibodies are not available. (uni-ulm.de)
In an immunochemical reaction, Apolipoprotein B in the human serum sample form immune complexes with specific antibodies. (cdc.gov)
The Eagle Biosciences Anti-beta 2 GP-I ELISA Assay Kit is used for the quantitative determination of IgG or IgM antibodies to ß2 glycoprotein-I (beta2 GP-I) in human serum or plasma for the diagnosis of anti-phospholipid antibody syndrome (APAS). (eaglebio.com)
The Anti-Beta 2 GP1 ELISA is an enzyme immunoassay for the quantitative determination of IgG or IgM antibodies to ß2 glycoprotein-I in human serum or plasma. (eaglebio.com)
Unlike phospholipid antibodies which occur in some patients having infectious disease, phospholipid antibodies of autoimmune disease patients seem to recognize the relevant phospholipids in association with a plasma protein cofactor. (eaglebio.com)
Most autoimmune anti-phospholipid antibodies require the serum cofactor b2GPI for optimal binding. (diapharma.com)
Diluted serum samples, calibrator sera, and controls are incubated in cardiolipin coated microwells, allowing aCL antibodies present in the samples to react with the immobilized antigen. (diapharma.com)
After their removal of unbound serum proteins by washing, antibodies specific for human IgG, IgM, or IgA labeled with HRP are added forming complexes with the CL bound antibodies. (diapharma.com)
Color develops in the wells at an intensity proportional to the serum concentration of aCL antibodies. (diapharma.com)
In the case of growth hormone, antibodies with binding capacities lower than 2 mg/mL have not been associated with growth attenuation. (meltonsouthdrivingschool.com.au)

Western blot shows lysates of rat liver tissue and mouse serum. (rndsystems.com)
Mice were sacrificed and the following parameters were analyzed: whole blood gene expression, blood and bronchoalveolar lavage (BAL) differentials, serum protein profiling by immunoplex and proteomics, and gene expression analysis in the lung and extrapulmonary tissues including aorta, heart and liver. (cdc.gov)
This was followed by an acute phase response including CRP, SAA-1, SAP and haptoglobin as shown by elevated serum protein levels and liver gene expression. (cdc.gov)
At 28d, serum acute phase proteins with immune function including complement C3, apolipoprotein A-I and A-II, alpha2-marcoglobulin, serotransferrin and liver carboxylesterase N were increased. (cdc.gov)
In 1946, it was proposed that circulating colloids, including serum albumin, may affect the synthesis and/or secretion of albumin in the liver. (jci.org)
liver transplantation is potentially curative in patients with fibrinogen A alpha-chain FRA and, possibly, in some patients with apolipoprotein AI amyloidosis. (medscape.com)
C-reactive protein (CRP) is an acute-phase protein of the pentraxin family produced in the liver in response to inflammatory signals, particularly interleukin-6, which is synergistically enhanced by IL-1β. (nature.com)
Serum apolipoprotein A1 and haptoglobin, in patients with suspected drug-induced liver injury (DILI) as biomarkers of recovery. (scilifelab.se)
C-reactive protein is produced by the liver. (ultalabtests.com)
The liver and gut synthesize apolipoprotein (Apo) A-I which become discoid nascent HDL after interaction with the ATP-binding cassette transporter A-1 (ABCA-1). (encyclopedia.pub)
This review will focus on the contribution of high-throughput genomic and proteomic approaches to the study of fibrogenesis and fibrosis progression, concentrating on the most prevalent human chronic liver diseases and findings from animal models in liver tissue, isolated liver cells, cell lines and serum. (biomedcentral.com)
TUDCA is often used to help minimize damage to the liver, whilst Clomid can be taken during and after a cycle, to prevent gynecomastia and help restore testosterone production 2 x 200mg per day. (meltonsouthdrivingschool.com.au)
The RNA-seq analysis revealed remarkable differences in the expression profiles between the two tissues, allowing the identification of liver- and testis-specific transcripts which may play a fundamental role in important biological processes carried out by these two organs. (biomedcentral.com)

In addition to the fibrillar amyloid protein, the deposits also contain serum amyloid P component and glycosaminoglycans. (msdmanuals.com)

This antibody functions as an ELISA detection antibody when paired with Rat Anti-Mouse Serum Amyloid A1/A2 Monoclonal Antibody (Catalog # MAB2948 ). (rndsystems.com)
Mouse Serum Amyloid A1/A2 ELISA Standard Curve. (rndsystems.com)
MIA1609 targets Apolipoprotein B in ELISA, IP and RIA applications and shows reactivity with Human samples. (thermofisher.com)
The Anti-beta 2 GP-I ELISA is for research use only and not for diagnostic procedures. (eaglebio.com)

In hypothyroid patients, LDL-cholesterol and apo B concentrations decrease significantly after L-T, replacement treatment (from 4.49 ± 2.51 to 2.76 + 0.70 mmol/ L, P = 0.036 and from 89.4 ± 16.1 to 78.3 ± 13.3 mg/dL, P = 0.05, respectively), whereas no significant change was observed in the total cholesterol, HDL-C, LpA-I, LpA-I:A-II and apo A-I concentrations. (lokmanhekim.edu.tr)
14] reported that women with a higher serum cholesterol level had an increased risk of ovarian cancer. (researchsquare.com)
The proteins produced from these genes work together to remove cholesterol and phospholipids from cells. (medlineplus.gov)
The ABCA1 gene provides instructions for making a protein that removes cholesterol and phospholipids from cells by moving them across the cell membrane. (medlineplus.gov)
HDL apolipoproteins and ABCA1: partners in the removal of excess cellular cholesterol. (medlineplus.gov)
The reason dietary stearic acid is considered benign is based on its failure to elevate plasma cholesterol concentrations (1, 2). (blogspot.com)
Subjects with hyperhomocysteinaemia had significantly elevated total cholesterol, LDL cholesterol, apolipoprotein A and apolipoprotein B and lower vitamin B levels compared with subjects with 12 normohomocysteinaemia. (who.int)
Hcy levels correlated with total cholesterol ( r = 0.09), apolipoprotein A ( r = 0.012), and B ( r = 0.013) levels and total/HDL cholesterol ratio ( r = -0.085). (who.int)

Elevated triglycerides are determined based upon serum laboratory values being greater than 149 mg/dL. (medscape.com)
Very high levels of triglycerides are defined by serum levels of 500 mg/dL or greater and can be concerning for development of pancreatitis . (medscape.com)

The effect of serum lipids on ovarian cancer is controversial. (researchsquare.com)
No consistent differences became apparent between traditional lipids and apolipoproteins. (nih.gov)

The conditions that underlie amyloid deposition may be either acquired or hereditary, and at least 20 different proteins can form amyloid fibrils in vivo. (medscape.com)
[ 4 ] In humans, about 23 different unrelated proteins are known to form amyloid fibrils in vivo. (medscape.com)

Haptoglobin-related protein is a protein that in humans is encoded by the HPR gene. (wikipedia.org)
We aimed to evaluate the possible prognostic value of ActiTest and FibroTest proteins apoliprotein-A1, haptoglobin and alpha-2-macroglobulin, in patients with DILI. (scilifelab.se)
Repeated apolipoprotein-A1 and haptoglobin remained significantly higher in the DILI cases that recovered (n = 65) versus those that did not (n = 16), at inclusion, at 4-8 weeks and at 8-12 weeks. (scilifelab.se)
We identified that apolipoprotein-A1 and haptoglobin had significant predictive values for the prediction of recovery at 12 weeks in DILI, enabling the construction of a new prognostic panel, the DILI-ActiTest, which needs to be independently validated. (scilifelab.se)
Proteomic research of porcine serum show that some protein, such as for example haptoglobin, annexin IV, apolipoprotein A-I, and fetuin, are biomarkers of welfare in these pets (4). (researchensemble.com)

Detects mouse and rat Apolipoprotein H/ApoH in Western blots and detects recombinant mouse Apolipoprotein H/ApoH in direct ELISAs. (rndsystems.com)
Detects mouse Serum Amyloid A1/SAA1 and mouse Serum Amyloid A2/SAA2 in direct ELISAs and Western blots. (rndsystems.com)
MIA1609 detects Apolipoprotein B which has a predicted molecular weight of approximately 502 kDa. (thermofisher.com)

PCR results confirmed the trypanosomes positive for the T. b. rhodesiense -specific serum resistance-associated gene ( 1 ). (cdc.gov)
Early effects of pulmonary CNT exposure include a rapid but transient increase in inflammatory blood gene expression (IL-1beta, CXCL2) and serum cytokines (IL-6, IL-5, CCL11). (cdc.gov)
The transcription rate of the albumin gene was higher in NAR than in normal rats and was dramatically reduced by raising serum albumin to 1.6 g/dl. (jci.org)
Intravenous infusion of albumin into normal rats also decreased transcriptional activity of the albumin gene by 50-60%, and this decrease correlated with changes in serum colloid osmotic pressure after albumin infusion. (jci.org)
Inhibition of albumin gene transcription was also observed upon intravenous infusion of other protein or nonprotein macromolecules, such as gamma-globulin and dextran. (jci.org)
Feedback regulation of albumin gene expression by serum colloids may serve as a specific homeostatic mechanism to maintain the steady-state level of total protein in the circulation. (jci.org)
The intestinal and the hepatic forms of Apolipoprotein B are encoded by a single gene from a single, very long mRNA. (thermofisher.com)
There is a rare hereditary form of beta-2-microglobulin amyloidosis due to a mutation to the relevant gene. (msdmanuals.com)
The movement of these substances across the membrane is enhanced by another protein called apolipoprotein A-I (apoA-I), which is produced by the APOA1 gene. (medlineplus.gov)
Given the high genomic affinity between the two coelacanth species, the here described de novo transcriptome assembly can be considered a valuable support tool for the improvement of gene prediction within the genome of L. chalumnae and a valuable resource for investigation of many aspects of tetrapod evolution. (biomedcentral.com)

A specific band was detected for Serum Amyloid A1/A2 at approximately 14 kDa (as indicated) using 50 µg/mL of (Catalog # AF2948) followed by 1:50 dilution of HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # HAF109 ). (rndsystems.com)
Recombinant Mouse Serum Amyloid A1/A2 protein was serially diluted 2-fold and captured by Rat Anti-Mouse Serum Amyloid A1/A2 Monoclonal Antibody (Catalog # MAB2948 ) coated on a Clear Polystyrene Microplate (Catalog # DY990 ). (rndsystems.com)
The following product was used in this experiment: Apolipoprotein B Monoclonal Antibody (F2C9) from Thermo Fisher Scientific, catalog # MIA1609, RRID AB_11152638. (thermofisher.com)
What is the role of Beta 2 Glycoprotein 1 (B2GP1) in anti-phospholipid antibody binding? (diapharma.com)

Detection of Mouse Serum Amyloid A1/A2 by Western Blot. (rndsystems.com)
Western blot shows mouse serum and mouse plasma. (rndsystems.com)
Western blot shows recombinant mouse Serum Amyloid A1 and recombinant mouse Serum Amyloid A2. (rndsystems.com)
Detection of Mouse Serum Amyloid A1/A2 by Simple Western TM . (rndsystems.com)
Simple Western lane view shows mouse serum, loaded at a 1:100 dilution. (rndsystems.com)
After Ang II infusion, mouse serum levels of pro-inflammatory cytokines were analysed, and aortic tissues were isolated for histological, RNA, and protein analysis. (molcells.org)

Detection of Rat and Mouse Apolipoprotein H/ApoH by Western Blot. (rndsystems.com)
Western blot analysis of pooled samples of NAF from healthy volunteers versus NAF from women with breast cancer confirmed the overexpression of vitamin D-binding protein in tumor-bearing breasts. (biomedcentral.com)

2 However, the CRP concentration rises quickly up to 1000 mg l −1 in the first few days following an acute-phase stimulus and decreases back to baseline with a half-life of 19 h when the stimulus has ceased. (nature.com)
In fractions 1-4 from newborn CF piglets an additional cluster containing acute phase proteins was observed, suggesting an early inflammatory response in CF piglets. (biomedcentral.com)

A specific band was detected for Apolipoprotein H/ApoH at approximately 50-60 kDa (as indicated). (rndsystems.com)
A specific band was detected for Serum Amyloid A1/A2 at approximately 12 kDa (as indicated). (rndsystems.com)

Bovine Apolipoprotein-H polypeptide is purified from fetal calf serum (FCS) by proprietary protein-chemical techniques, having an Mw of approximately 70kDa. (assaygenie.com)
Opinions differ as to whether those breast cancers supplemented by 10% fetal bovine serum, penicillin, and streptomycin. (lu.se)

Following an incubation period of 60 min at room temperature (RT), unbound serum components are removed by a wash step. (eaglebio.com)

Significantly different abundances were observed for five adipokines (adipsin, adiponectin, chemerin, leptin, vaspin) and four apolipoproteins (apo-B100/-C2/-C4/-D) between the body mass index (BMI) groups. (uni-ulm.de)
Further analysis showed that protein expression of CXCL16, CXCR6, disintegrin and metalloproteinase-10 (ADAM10) in the radial arteries of the inflamed group was significantly increased. (medsci.org)
Additionally, Ang II treatment significantly increased PVT1 expression, both in cultured mouse VSMCs and in AAA murine abdominal aortic tissues. (molcells.org)
While apolipoprotein B showed no consistent associations, a higher apolipoprotein B/A1 ratio was significantly associated with lower eGFR in both studies. (nih.gov)
Recent study demonstrates, that serum Clusterin level increases significantly in diabetic type II patients and in patients with developing coronary heart disease, or myocardial infarction. (biovendor.com)

2004) and subsequently to report on selective Aβ dependent alterations in synaptic proteins and neurotransmitter receptors, including surface glutamate receptors and PSD-95 (Almeida et al. (lu.se)

Apolipoprotein H (APOH) attaches to numerous kinds of negatively charged substances for instance phospholipids, and dextran sulfate. (assaygenie.com)

Apolipoprotein H (ApoH), also known as beta 2‑Glycoprotein I/ beta 2-GPI, is a variably glycosylated member of the complement control superfamily of proteins with a molecular weight of aproximately 50 kDa (1, 2). (rndsystems.com)

17 As serum CRP concentration reflects the magnitude of inflammation, it has also become a routine laboratory parameter in daily clinical practice for diagnosis and monitoring of autoimmune inflammatory disorders such as rheumatoid arthritis. (nature.com)
The intensity of the scattered light is proportional to the concentration of Apolipoprotein B in the sample. (cdc.gov)
Les chantillons provenant des animaux qui prsentaient la plus grande augmentation de concentration de cortisol salivaire ont t regroups et analyss sur gels en 2-dimensions. (researchensemble.com)
Additionally, we investigated whether the basal serum testosterone concentration influences the performance in countermovement jump CMJ, 30 s all out cycle sprint, and one arm isometric elbow flexion. (meltonsouthdrivingschool.com.au)

Here, we observed that HDL isolated from healthy individuals inhibited the production of inflammatory cytokines by peripheral monocytes stimulated with a Toll-like receptor 2 agonist. (lww.com)
Furthermore, knockdown of PVT1 reversed Ang II-induced AAA-associated alterations in mice, as evidenced by attenuation of aortic diameter dilation, marked adventitial thickening, loss of elastin in the aorta, enhanced aortic cell apoptosis, elevated MMP-2 and MMP-9, reduced TIMP-1, and increased pro-inflammatory cytokines. (molcells.org)
In conclusion, our findings demonstrate that knockdown of lncRNA PVT1 suppresses VSMC apoptosis, ECM disruption, and serum pro-inflammatory cytokines in a murine Ang II-induced AAA model. (molcells.org)

These proteins were identified as odorant-binding protein and fragments of albumin. (researchensemble.com)

Amyloidosis is a disorder of protein folding in which normally soluble proteins undergo a conformational change and are deposited in the extracellular space in an abnormal fibrillar form. (medscape.com)
Amyloid fibrils are made of normally soluble misfolded proteins that aggregate into oligomers and then insoluble fibrils. (msdmanuals.com)

Changes on proteomic and metabolomic profile in serum of mice induced by chronic exposure to tramadol. (iasp-pain.org)
Proteomic analysis revealed 31 differential expressed serum proteins (9 increased and 22 decreased) in tramadol-treated mice (oral, 50 mg/kg, 5 weeks) as compared with the control ones. (iasp-pain.org)
Moreover, integrated proteomic and metabolomic revealed that the protein digestion and absorption is the common enrichment KEGG pathway. (iasp-pain.org)
A previous study in sera from patients with esophageal squamous cell carcinoma (ESCC) that used mass spectrometry and proteomic technologies found that SAA was upregulated and could be used to differentiate patients from healthy individuals [ 18 ]. (biomedcentral.com)
We used mass-spectrometry based proteomic analysis of unstimulated and carbachol stimulated newborn wild-type (WT) and cystic fibrosis transmembrane conductance regulator (CFTR) null (CF) piglet airways to study proteins in the airway surface liquid and mucus, to investigate if levels of MUC5AC and MUC5B were affected by carbachol stimulation and whether the proteins clustered according to function. (biomedcentral.com)
We used a previously validated multiplexed 10-min, targeted proteomic assay to assess 54 candidate cerebrospinal fluid (CSF) biomarkers in two independent cohorts comprising individuals with neurodegenerative dementias and healthy controls. (lu.se)

The analyst should use the special sampling weights in this file to analyze Apolipoprotein B (ApoB). (cdc.gov)
Normal plasma apolipoprotein B levels are around 800mg/L. Apolipoprotein B occurs in plasma as two main isoforms, apoB-48 and apoB-100. (thermofisher.com)
The shorter apoB-48 protein is produced after RNA editing of the apoB-100 transcript at residue 2180 (CAA->UAA), resulting in the creation of a stop codon, and early translation termination. (thermofisher.com)

Adipokines and apolipoproteins are key regulators and potential biomarkers in obesity and associated diseases and their quantitative assessment is crucial for functional analyses to understand disease mechanisms. (uni-ulm.de)
Further studies will be necessary to confirm the value of using these proteins as salivary biomarkers of stress in pigs. (researchensemble.com)
Biomarkers of tension are AZD7762 sought in bloodstream or serum commonly. (researchensemble.com)
A 2-dimensional gel electrophoresis (2-DE) map of porcine saliva has recently been published (14) and used to identify biomarkers of disease in growing pigs under field conditions (15). (researchensemble.com)
The results indicate that several of the proteins included in the panel may serve as synaptic biomarkers for AD. (lu.se)

Polymorphisms that slightly vary native peptides or inflammatory processes set the stage for abnormal protein folding and amyloid fibril deposition. (medscape.com)

Thus, we established an MRM method to quantify 9 adipokines and 10 apolipoproteins in human serum. (uni-ulm.de)
We sought to determine whether ICAT technology could quantify and identify differential expression of tumor-specific proteins in nipple aspirate fluid (NAF) from the tumor-bearing and contralateral disease-free breasts of patients with unilateral early-stage breast cancer. (biomedcentral.com)
ICAT tandem MS was able to identify and quantify differences in specific protein expression between NAF samples from tumor-bearing and disease-free breasts. (biomedcentral.com)

Of note, the effects of Ang II in facilitating cell apoptosis, increasing matrix metalloproteinase (MMP)-2 and MMP-9, reducing tissue inhibitor of MMP (TIMP)-1, and promoting switching from the contractile to synthetic phenotype in cultured VSMCs were enhanced by overexpression of PVT1 but attenuated by knockdown of PVT1 . (molcells.org)
Advanced glycation is a major pathway for the posttranslational modification of plasma and tissue proteins. (iospress.com)

Using sliver nanoparticles modified with ß-cyclodextrin and α-iron oxide (ß-CD/α-Fe2O3@AgNPs) as surface-enhanced Raman spectroscopy (SERS) substrate, two sensitive methods for detecting apramycin and kanamycin were established. (bvsalud.org)

Amyloidosis is any of a group of disparate conditions characterized by extracellular deposition of insoluble fibrils composed of misaggregated proteins. (msdmanuals.com)
Moreover, it was proposed that Clusterin functions as an extracellular chaperon that stabilizes stressed proteins in a folding-competent state, and that the protein is involved in programmed cell death. (biovendor.com)

Furthermore, other proteins, such as for example serum amyloid A, paraoxonase AZD7762 1, and platelet-activating element acetylhydrolase, may become markers of the oxidative tension response in pigs, as continues to be postulated in additional pet varieties (5). (researchensemble.com)

The MIA1609 immunogen is purified human serum LDL. (thermofisher.com)

Autoaggregation through the beta domains initiates fibril formation (4), providing a template for ongoing deposition of precursor proteins and for the development of the stable, mainly beta-sheet, core structure of the fibril (5). (medscape.com)
Localized forms of amyloidosis appear to be caused by local production and deposition of an amyloidogenic protein (most often immunoglobulin light chains) within the affected organ rather than by deposition of circulating proteins. (msdmanuals.com)
These proteins either arise from proteins expressed by cells at the deposition site (localized), or they precipitate systemically after production at a local site (systemic). (medscape.com)

ß2 GP-I, a serum protein with a molecular weight of 50 kDa affects platelet aggregation and coagulation. (eaglebio.com)

Proteins enriched in HDL from patients with ESRD (ESRD-HDL) included surfactant protein B (SP-B), apolipoprotein C-II, serum amyloid A (SAA), and α-1-microglobulin/bikunin precursor. (lww.com)
The drawing depicts a generic amyloid fibril precursor protein (1) in equilibrium with a partially unfolded, molten, globulelike form of the protein (2) and its completely denatured state (3). (medscape.com)
The amyloidogenic precursor proteins in patients with familial renal amyloidosis are thought to be less stable than their wild-type counterparts, causing them to populate intermediate, molten, globulelike states more readily. (medscape.com)
Alpha2HS-glycoprotein [Heavy:Light (H:L) ratio 0.63] was underexpressed in NAF from tumor-bearing breasts, while lipophilin B (H:L ratio 1.42), beta-globin (H:L ratio 1.98), hemopexin (H:L ratio 1.73), and vitamin D-binding protein precursor (H:L ratio 1.82) were overexpressed. (biomedcentral.com)

To investigate this difference, we used shotgun proteomics to identify 49 HDL-associated proteins in a uremia-specific pattern. (lww.com)
To address which proteins are collected on the bundled strands and which are not, we compared proteins easily washed off the tracheobronchial surface with the protein composition of Alcian blue stained mucus using mass spectrometry-based proteomics. (biomedcentral.com)
Compared with DNA analysis (genomics) and RNA analysis (expression profiling), the examination of protein expression (proteomics) may be more relevant to tumor physiology as protein stability and activity are largely what determine cellular phenotype and function [ 8 ]. (biomedcentral.com)
Targeted proteomics is an attractive means of quantifying novel proteins in cerebrospinal and other fluids, and has potential to help overcome this bottleneck in biomarker development. (lu.se)

[ 2 ] Research has shown that almost all patients with familial renal amyloidoses (FRA) are heterozygous for mutations in the genes for lysozyme, apolipoprotein AI, apolipoprotein AII, or fibrinogen A alpha-chain and that the amyloid fibrils in this condition are derived from the respective variant proteins. (medscape.com)
For practical purposes, depending on the enzyme activity and the presence of mutations in the G6Pase and T genes, respectively, GSD type I may be subdivided into 2 major forms. (medscape.com)
Total RNA from tumors the expression of thousands of genes (3) to address complex questions was isolated using two successive rounds of Trizol. (lu.se)

The cerebrospinal fluid (CSF) had 4 leukocytes/μL and normal levels of protein and glucose, and no trypanosomes were detected after double centrifugation. (cdc.gov)
The initiating reaction is the nonenzymatic addition of sugars such as glucose to the primary amino groups of proteins, i.e., mainly to lysine residues. (iospress.com)
[ 2 ] In 1978, Narisawa et al proposed that a transport defect of glucose-6-phosphate (G6P) into the microsomal compartment may be present in some patients with GSD type I. (medscape.com)
Applying this technique to AD we demonstrate differences in proteins involved in glucose metabolism and neuroinflammation that collectively have potential clinical diagnostic utility. (lu.se)

Macrophage stimulating protein (MSP) was discovered as a serum protein that promoted mouse macrophage motility ( 13 ), and was later purified to homogeneity from human plasma ( 14 ). (spandidos-publications.com)
Forty-three ESRD patients were divided into the control group (n=17) and the inflamed group (n=26) based on plasma C-reactive protein (CRP) levels. (medsci.org)
Oxidizability of human plasma measured in the presence of Cu(II) was found to correlate with the oxidizability of LDL measured in the common Cu(II)‐based LDL oxidation assay. (iospress.com)
The protein is constitutively secreted by a number of cell types including epithelial and neuronal cells and is a major protein in physiological fluids including plasma, milk, urine, cerebrospinal fluid and semen. (biovendor.com)

Standard is recombinant protein based. (biovendor.com)

In patients with systemic lupus erythematosus (SLE), reduced serum Clusterin levels correlated inversely with disease activity. (biovendor.com)

The associations between apolipoprotein A1, apolipoprotein B and their ratio with glomerular filtration rate estimated from the new CKD Epidemiology Collaboration (CKD-EPI) equation (eGFR) are not well studied in the general population. (nih.gov)

Statistical analyses showed that 2 proteins had significant differences in expression before and after the induction of stress. (researchensemble.com)
Prospective analyses related baseline apolipoprotein levels to subsequent CKD incidence over 10 years using the ARIC Carotid MRI follow-up cohort (n=1659). (nih.gov)
Meta-analyses of the individual participant data from the two prospective cohort studies were performed. (biomedcentral.com)

The limits of detection (LODs) (S/N = 3) were 3.42 and 0.31 nmol/L. The two SERS methods were effectively applied to detect apramycin and kanamycin in beef samples and commercial injection. (bvsalud.org)

In summary, this multiplexed assay facilitated the investigation of relationships between adipokines or apolipoproteins and phenotypes or clinical parameters in large cohorts, which may contribute to disease prediction approaches in the future. (uni-ulm.de)

In direct ELISAs, approximately 40% cross-reactivity with recombinant human Apolipoprotein H/ApoH is observed. (rndsystems.com)
Additionally, we applied our MRM assay to serum samples from normal weight children and human adipocyte cell culture supernatants to proof the feasibility for large cohort studies and distinct biological matrices. (uni-ulm.de)
The structure of serum resistance-associated protein and its implications for human African trypanosomiasis. (ox.ac.uk)
Only two trypanosome subspecies are able to cause human African trypanosomiasis. (ox.ac.uk)
To establish an infection in human blood, they must overcome the innate immune system by resisting the toxic effects of trypanolytic factor 1 and trypanolytic factor 2 (refs. (ox.ac.uk)
One of the two human-infective subspecies, Trypanosoma brucei rhodesiense, differs from non-infective trypanosomes solely by the presence of the serum resistance-associated protein, which binds directly to ApoL1 and blocks its pore-forming capacity3-5. (ox.ac.uk)
Patient serum is diluted with sample diluent and incubated in microwells coated with human b2GPI. (diapharma.com)
Quality Controls are human serum based. (biovendor.com)

Introduction/Background To further extend and improve the utility of two FDA-cleared multivariate index assays for preoperative malignancy risk assessment of adnexal masses, we developed a third generation multivariate index assay MIA3G that stratifies patients with an adnexal mass into three risk groups. (bmj.com)
Isotope-coded affinity tag (ICAT) tandem mass spectrometry (MS) allows for qualitative and quantitative analysis of paired protein samples. (biomedcentral.com)

Familial renal amyloidosis (FRA) is a group of hereditary disorders in which misfolded proteins-amyloid-accumulate in the kidneys, causing proteinuria and/or hypertension followed by progressive kidney failure. (medscape.com)
A number of normal (wild-type) and mutant proteins are susceptible to such misfolding and aggregation (amyloidogenic proteins), thus accounting for the wide variety of causes and types of amyloidosis. (msdmanuals.com)
For amyloidosis to develop, in addition to production of amyloidogenic proteins, there is probably also a failure of the normal clearance mechanisms for such misfolded proteins. (msdmanuals.com)
In systemic amyloidosis, circulating amyloidogenic proteins form deposits in a variety of organs. (msdmanuals.com)
Amyloidosis caused by aggregation of beta-2-microglobulin can occur in patients on long-term hemodialysis, but the incidence has declined with use of modern high-flow dialysis membranes. (msdmanuals.com)

b2GPI, also called apolipoprotein H, is an antiphospholipid protein cofactor with natural anticoagulant properties and an affinity for negatively-charged phospholipids. (diapharma.com)

Anatomy2

Organisms2

Diseases3

Chemicals and Drugs39

Analytical, Diagnostic and Therapeutic Techniques and Equipment5

Phenomena and Processes2

Information Science1

Lipoprotein13

Lipoproteins3

APOE3

Lipid3

Atherosclerosis2

Antigen Affinity-purified Polyclonal Antibody3

Antibodies10

Liver13

Amyloid P compone1

ELISA4

Cholesterol8

Triglycerides2

LIPIDS2

Form amyloid fibrils in vivo2

Haptoglobin5

Detects3

Gene10

Antibody4

Mouse serum6

Western Blot2

Acute2

Specific band was detected2

Fetal2

Unbound serum1

Significantly5

Synaptic proteins1

Charged substances1

Complement1

Concentration4

Cytokines3

Albumin1

Normally soluble2

Proteomic6

ApoB3

Biomarkers5

Peptides1

Quantify3

Tissue2

Nanoparticles1

Extracellular2

Paraoxonase1

Immunogen1

Deposition3

Molecular weight1

Precursor4

Proteomics4

Genes3

Glucose4

Plasma4

Recombinant Protein1

Levels correlated1

Ratio1

Analyses3

Detection1

Phenotypes1

Human8

Mass2

Amyloidosis5

Cofactor1