• Increased preoperative serum neopterin concentrations are associated with a poor prognosis in patients with breast carcinoma. (edu.pl)
  • Measurement of neopterin concentrations in body fluids like blood serum, cerebrospinal fluid or urine provides information about activation of cellular immune activation in humans under the control of T helper cells type 1. (wikipedia.org)
  • High neopterin production is associated with increased production of reactive oxygen species, neopterin concentrations also allow to estimate the extent of oxidative stress elicited by the immune system. (wikipedia.org)
  • Neopterin concentrations usually correlate with the extent and activity of the disease, and are also useful to monitor during therapy in these patients. (wikipedia.org)
  • Elevated neopterin concentrations are among the best predictors of adverse outcome in patients with HIV infection, in cardiovascular disease and in various types of cancer. (wikipedia.org)
  • Blood concentrations of neopterin and biopterin in subjects with depression: A systematic review and meta-analysis. (wikipedia.org)
  • Of possible significance, elevated concentrations of interleukin-6 (IL-6) and neopterin in saliva and serum of patients with the erosive-atrophic form of oral lichen planus suggest they may be involved in the etiology of this disease variation. (medscape.com)
  • During the intervention period, geometric mean (GSD) of serum vitamin B12 concentrations increased from 304 (1.40) to 359 (1.42) pmol/L in the fish protein group ( P vs. controls = 0.004) and mean (SD) serum selenium increased from 1.18 (0.22) to 1.30 (0.20) μmol/L ( P vs. controls = 0.002). (springer.com)
  • Including a salmon fish protein supplement in the daily diet for 8 weeks, increases serum vitamin B12 and selenium concentrations. (springer.com)
  • A nested case-control study was conducted within the European Prospective Investigation into Cancer and Nutrition cohort using data on plasma concentrations of total neopterin (T-N, sum of neopterin and 7,8-dihydroneopterin) in 830 incident CRC case patients (561 colon and 269 rectal) matched within risk sets to 830 control participants. (escholarship.org)
  • A prospective study of the immune system activation biomarker neopterin and colorectal cancer risk. (escholarship.org)
  • Neopterin may be relevant for colorectal cancer (CRC) development, as a biomarker of cellular immune activity exerting pleiotropic effects on cellular ageing, oxidative stress, and inflammation. (escholarship.org)
  • Neopterin levels can be used as an early prognostic biomarker for COVID-19 on admission. (wustl.edu)
  • Neopterin production, tryptophan degradation, and mental depression-What is the link? (wikipedia.org)
  • Neopterin has been extensively used as a clinical marker of immune activation during inflammation in a wide range of conditions and stresses. (mdpi.com)
  • 1] Fuchs D, Weiss G, Wachter H. Neopterin, biochemistry and clinical use as a marker for cellular immune reactions. (edu.pl)
  • Neopterin as marker for activation of cellular immunity: immunologic basis and clinical application. (edu.pl)
  • Neopterin as a marker for activated cell-mediated immunity: application in HIV infection. (edu.pl)
  • Neopterin serves as a marker of cellular immune system activation. (wikipedia.org)
  • Neopterin as a marker for immune system activation. (wikipedia.org)
  • Neopterin, a prognostic marker in human malignancies. (wikipedia.org)
  • On the contrary, the increase in mean serum levels of the macrophage marker neo-pterin was significantly higher in patients treated with IL-2 alone than in those treated with IL-2 plus MLT. (karger.com)
  • The CSF concentration of the cellular immune activation marker neopterin and the cytokines IL-6 and IL-10 were increased over control and post-treatment levels in all patients, with maximal levels observed in late-stage (meningoencephalitic) individuals. (elsevierpure.com)
  • PhD thesis Serum neopterin as an immunological marker of disease activity in inflammatory diseases. (voetzorgplus.com)
  • The sensitivity and specificity of serum neopterin for the cut-off value of 90 nmol / L to identify severe COVID-19 cases were 100 % and 76 %, respectively. (wustl.edu)
  • OBJECTIVES: In this study, it was aimed to determine the prognostic value of the neopterin for the prediction of severe disease in patients with COVID-19. (wustl.edu)
  • Neopterin, Inflammation, and Oxidative Stress: What Could We Be Missing? (mdpi.com)
  • Serum neopterin levels in relation to mild and severe COVID-19. (wikipedia.org)
  • CONCLUSIONS: Serum neopterin levels on hospitalization were significantly higher in severe COVID-19 disease than mild COVID-19 patients. (wustl.edu)
  • The value of urinary neopterin as an immunological parameter in patients with malignant tumors of the genitourinary tract. (edu.pl)
  • Shanab A, El-Desouky M, Kholoussi N, El-Kamah G, Fahmi A. Evaluation of neopterin as a prognostic factor in patients with beta-thalassemia, in comparison with cytokines and immunoglobulins. (saripediatri.org)
  • The aim of this study was to evaluate serum neopterin levels if it is viable predictor for prognosis in breast carcinoma patients. (edu.pl)
  • The aim of the study was to evaluate the levels of these serum biomarkers and their association with well-established prognostic factors in CMNs. (scielo.br)
  • Shao Y, Sun X, He Y, Liu C, Liu H. Elevated levels of serum tumor markers CEA and CA15-3 are prognostic parameters for different molecular subtypes of breast cancer. (scielo.br)
  • These associations implied that participants with extremely low or high levels of serum lipids would be expected to show poorer cognitive performance. (researchsquare.com)
  • Neopterin may be a useful diagnostic adjunct in the noninvasive assessment of CBD. (cdc.gov)
  • Serum neopterin for early assessment of severity of severe acute respiratory syndrome. (wikipedia.org)
  • This triggered our interest in exploring how serum lipids relate to cognitive function in different subgroups. (researchsquare.com)
  • Multivariable linear regression analyses examined serum lipids level as predictors of sex- and age-specific measure of cognitive function in different BMI levels, which were adjusted for nationality, BMI, systolic blood pressure (SBP), diastolic blood pressure (DBP), smoking status, alcohol consumption and education level. (researchsquare.com)
  • Results: Cognitive function score have different concentration curves in serum lipids quartile levels in different BMI categories. (researchsquare.com)
  • Conclusion: The associations of serum lipids with cognitive function were related with BMI levels and differed between gender and age groups. (researchsquare.com)
  • Previous studies speculated that associations of serum lipids with cognitive performance are inversely U-shaped or J-shaped ( 6 ). (researchsquare.com)
  • The possible pathophysiological mechanisms of high serum lipids with the risk of cognitive decline is that high level of cholesterol can contribute to an overproduction and accumulation of β-amyloid in the brain ( 7 ). (researchsquare.com)
  • Serum TC was negatively associated with cognitive function score in overweight (β±SE: -2.55±1.26, P=0.043) mid-life adults, and serum HDL-C was positively associated with cognitive function score in overweight (β±SE: 2.15±0.94, P=0.022) and obese (β±SE: 5.33±2.07, P=0.011) older adults. (researchsquare.com)
  • Neopterin in diagnosis of human immunodeficiency virus infection in infants. (ucsf.edu)
  • However, the analysis of neopterin alone neglects the cellular reactions that generate it in response to interferon-γ. (mdpi.com)
  • Akgul EO, Aydin I, Cayci T, Kurt YG, Aydin F, Agilli M. The indicator of cellular immune response in body fluids: neopterin. (saripediatri.org)
  • Neopterin is a useful indicator of the activation state of the cellular immune system, and an elevated level predicts prognosis in different types of tumors. (edu.pl)
  • Darlix A, Lamy PJ, Lopez-Crapez E, Braccini AL, Firmin N, Romieu G, Thezenas S, Jacot W. Serum HER2 extra-cellular domain, S100ß and CA 15-3 levels are independent prognostic factors in metastatic breast cancer patients. (scielo.br)
  • While the high level of neopterin observed in the late-stage patient CSF is indicative of widespread cellular activation, the increased levels of IL-6 and IL-10 suggest that counter-inflammatory cellular responses may be important in the regulation of neuropathogenesis in late-stage human African trypanosomiasis. (elsevierpure.com)
  • The identification of putative prognostic factors in canine mammary neoplasms (CMNs) has been focused on tissue-specific biomarkers, but the serum biomarkers, including cancer antigen 15-3 (CA 15-3), c-reactive protein (CRP), and lactate dehydrogenase (LDH) have been demonstrated to display clinical application in cases of CMNs. (scielo.br)
  • Severe and mild COVID-19 cases were compared in terms of clinical and laboratory findings as well as serum neopterin levels on hospital admission. (wustl.edu)
  • that causes a clinical syndrome of intellectual disability with cognitive and behavioral abnormalities caused by elevated serum phenylalanine. (msdmanuals.com)
  • 7] Murr C, Bergant A, Widschwndter M, Heim K, Schrocksnadel H, Fuchs D. Neopterin is an independent prognostic variable in females with breast cancer. (edu.pl)
  • Inflammatory markers neopterin and soluble intercellular adhesion molecule (sICAM-1) appeared to be clinically useful for isolated assessments of disease activity. (who.int)
  • Neopterin produced by macrophages on stimulation with interferon-gamma, which is an important cytokine in the anti-viral immune response, hence it can be used to predict the severity of disease in COVID-19 cases. (wustl.edu)
  • The levels of CA 15-3, CRP and LDH were significantly higher in the serum of female dogs with CMNs compared to the healthy ones. (scielo.br)
  • After adjustment for confounding factors, serum TG was positively associated with cognitive function score in underweight (β±SE: 2.06±0.88, P=0.023) and obese (β±SE: 1.44±0.71, P=0.045) male group, and serum HDL-C was positively associated with cognitive function score in overweight (β±SE: 1.89±0.92, P=0.041) and obese (β±SE: 5.04±1.62, P=0.002) female group. (researchsquare.com)
  • Neopterin belongs to the chemical group known as pteridines. (wikipedia.org)
  • Analysis of CSF/serum concentration quotients indicated that IL-10 and neopterin were derived from central nervous system synthesis in at least 25% of the patients. (elsevierpure.com)
  • To assess the prognostic utility of neopterin between the severe and mild COVID-19 groups, a receiver-operating characteristic (ROC) curve was generated, and the area under the curve (AUC) was calculated. (wustl.edu)
  • Two reviews concluded that high serum cholesterol associates with cognitive function and the association is strongly age-dependent ( 10 , 11 ). (researchsquare.com)
  • And a possible explanation for low serum lipid levels with the risk of cognitive decline is the nutritional status of participants. (researchsquare.com)
  • However the associations between serum or plasma triglyceride (TG) and cognitive function were complicated and associated with body mass index (BMI) and gender (Table 1). (researchsquare.com)
  • So far, the association between prediagnostic neopterin and colon and rectal cancer risk has not been evaluated in human populations. (escholarship.org)
  • The role of neopterin in atherogenesis and cardiovascular risk stratification. (wikipedia.org)
  • Elevated maternal serum @a-fetoprotein levels: What is the risk of fetalancuploidy? (ntnu.edu.tw)
  • Increased neopterin production is found in, but not limited to, the following diseases: Viral infections including human immunodeficiency virus (HIV), hepatitis B and hepatitis C, SARS-CoV-1, SARS-CoV-2. (wikipedia.org)
  • Female dogs with CMNs were found to exhibit highest serum levels of CA 15-3, CRP, and LDH. (scielo.br)
  • Serum neopterin was investigated in 56 breast carcinoma patients, 16 patients with benign breast lesions and 16 healthy women as controls. (edu.pl)
  • Kadar neopterin serum berkorelasi dengan kadar feritin serum, FS tidak dapat digunakan untuk memprediksi status imun pada penyandang talasemia-β mayor anak. (saripediatri.org)
  • There was no difference between the groups in serum levels of the other micronutrients measured. (springer.com)