• The aim of our systematic review was to assess the effects of selenium supplementation on Hashimoto's thyroiditis. (karger.com)
  • These preliminary studies show the positive effects of selenium supplementation on inflammatory activity in autoimmune thyroid conditions, but the long-term effects of supplementation on thyroid health are still unknown. (chriskresser.com)
  • To the best of our knowledge, the effects of selenium supplementation on clinical outcomes had not been previously tested in PPCM. (biomedcentral.com)
  • Selenium supplementation in people with Hashimoto's thyroiditis might reduce antibody levels and result in a decreased dosage of levothyroxine (LT 4 ) and may provide other beneficial effects (e.g. on mood and health-related quality of life). (karger.com)
  • In conclusion, the results of these four studies, assessed at unclear to high risk of bias, show that evidence to support or refute the efficacy of selenium supplementation in people with Hashimoto's thyroiditis is incomplete and not reliable to help inform clinical decision making. (karger.com)
  • Selenomethionine and sodium selenite are the two most common oral forms of selenium supplementation that are available in variable dosages (100 and 200 μg/day) [ 6,7 ]. (karger.com)
  • The purpose of this study was to evaluate the effect of the supplementation of two selenium sources at different doses. (scielo.br)
  • The data was analyzed with repeated measures in time in a mixed model with type of selenium supplementation, periods of evaluation (one period of two weeks + five periods of four weeks) and their interactions as fixed effects, and animal and the worker that collected the ejaculates as random effects. (scielo.br)
  • Results showed no difference in selenium supplementation with the sources and doses used. (scielo.br)
  • I summarized several studies, which found that selenium supplementation reduced inflammation and damage to thyroid tissue, lowered thyroid antibody levels in the blood, and improved the conversion of T4 to T3. (chriskresser.com)
  • And we know that selenium is an essential component of the enzymes that convert T4 to T3, but whether supplementation will increase serum T3 levels is unclear. (chriskresser.com)
  • While it seems that selenium supplementation would be an obvious solution to poor thyroid function, long-term consumption of high doses of selenium can lead to complications such as gastrointestinal upsets, hair loss, white blotchy nails, garlic breath odor, fatigue, irritability, and mild nerve damage. (chriskresser.com)
  • 2 ) It was a large clinical trial (with over 35,000 participants) that examined the relationship between baseline selenium status, supplementation with selenium and vitamin E (either together or separately), and future rates of prostate cancer in men over 55 years of age. (chriskresser.com)
  • 60th percentile), selenium supplementation of 200 mcg/d increased the risk of high-grade prostate cancer by 62% when taken alone, and by 224% when taken with vitamin E. (chriskresser.com)
  • 60th percentile), selenium supplementation of 200 mcg/d (either alone or with vitamin E) did not substantially increase or decrease the risk of prostate cancer. (chriskresser.com)
  • 6 ) If baseline levels of a particular nutrient are low, supplementation may lead to improved outcomes. (chriskresser.com)
  • But if baseline levels are normal or high, supplementation may cause harm-as it appears to have done in this study. (chriskresser.com)
  • At least one study found that selenium supplementation produced these benefits even when selenium levels were normal at baseline. (chriskresser.com)
  • We studied the efficacy and safety of selenium supplementation in patients who had peripartum cardiomyopathy (PPCM) and selenium deficiency. (biomedcentral.com)
  • In this study, selenium supplementation did not reduce the risk of the primary outcome, but it significantly reduced HF symptoms, and there was a trend towards a reduction of all-cause mortality. (biomedcentral.com)
  • We designed this proof-of-concept trial to prospectively study the efficacy and safety of selenium supplementation on clinical outcomes in selenium deficient PPCM patients who had not recovered left ventricular (LV) systolic function at six months after delivery. (biomedcentral.com)
  • So selenium supplementation might be helpful for people wanting to detox mercury (and possibly. (raypeatforum.com)
  • You'll need to have it tested to be sure, but as an example, if it contained 0.1 ppm of selenium, 15 lbs of that hay would provide 0.68 mg of selenium, putting the total diet at 1.22 mg of selenium per day - right within the 1-3 mg per day recommended range, and thus not requiring any additional supplementation. (horsefeedblog.com)
  • The importance of vitamin and mineral supplementation for the performance horse is often overlooked because of the difficulty in determining proper levels. (vitaflex.com)
  • The isotopes measured by this method include zinc (m/z 64), copper (m/z 65), and selenium (m/z 78) and the internal standard gallium (m/z 71). (cdc.gov)
  • The study was proposed to evaluate serum selenium, copper, zinc, vitamin C and E in benign prostatic hyperplasia patients in AL-Hilla city. (teikyomedicaljournal.com)
  • The study results revealed a significant reduction in serum selenium, zinc, vitamin C and E concentrations in BPH patients in comparison with those of control group and the copper/zinc ratio were significantly increased in BPH patients group in comparison with those of control group, while serum copper concentration were non-significantly increased in BPH patients group in comparison with those of control group. (teikyomedicaljournal.com)
  • Iron - Iron deficiency anemia Phosphorus - Hypophosphatemia, causing Oesteopenia Zinc - Zinc deficiencies are believed to be associated with increased risk of Esophagus Carcinoma Copper - Deficiency Selenium - Deficiency - Selenium and zinc deficiencies may play a role increasing risk of cancer. (wikipedia.org)
  • Copper, selenium, and zinc measurements were conducted by inductively coupled plasma-dynamic reaction cell-mass spectrometry (ICP-DRC-MS). Thyroid stimulating hormone (TSH) and thyroglobulin (Tg) concentrations were analyzed using different commercially available immunoassay kits and serum dilution factors to explore potential inaccuracies. (nist.gov)
  • Deficiency of the trace elements cobalt, iodine, selenium, and copper are major factors in the raising of healthy livestock. (country-wide.co.nz)
  • Because trace elements such as selenium, zinc, manganese and copper protect the body from oxidative stress, one research group in Iran recently explored the hypothesis that oxidation status may contribute to cribbing. (horse-canada.com)
  • It showed a significant decrease in the serum concentration of zinc, selenium, phosphorus and magnesium while a significant increase in serum level was observed for copper, iron, cadmium and selenium. (uwi.edu)
  • Taking zinc by mouth or giving zinc by IV helps to restore zinc levels in people who are zinc deficient. (medlineplus.gov)
  • Serum concentrations less than 50nmol/l are deficient, greater than 100nmol/L are adequate. (country-wide.co.nz)
  • Liver selenium levels of less than 250nmol/l are deficient, and greater than 450nmol/l adequate. (country-wide.co.nz)
  • Cattle are deficient when selenium concentration in the blood is less than 130nmol/l. (country-wide.co.nz)
  • Standard selenium dosage when you're deficient, is important for overall health. (chriskresser.com)
  • An average of fourteen months following their injuries, 73 percent of the burn patients were found to have deficient blood levels of 25-hydroxyvitamin-D, the form of the vitamin that is the main criterion for determining vitamin D deficiency. (lifeextension.com)
  • Deficient levels of serum vitamin D have also been noted in these patients. (lifeextension.com)
  • Most of the U.S. is selenium deficient in soils (and thus toxicity is not an issue in those areas), but there are some areas with high selenium in the soil where some plants accumulate unacceptable levels of selenium in forage and may cause chronic toxicity. (horsefeedblog.com)
  • Due to a confirmed association between serum selenium levels and age-related cataract, low serum selenium levels may constitute a potential risk factor of age-related cataract. (aaem.pl)
  • Objectives: To examine the association between serum mercury levels with the incidence of ischemic stroke and to explore the possible effect modifications by serum selenium levels and demographic and geographic factors. (cdc.gov)
  • B12 deficiency Megaloblastic anemia Pernicious anemia Vitamin D - Vitamin D deficiency can result in osteopenia and osteoporosis Hypocalcemia Vitamin K - Coeliac disease has been identified in patients with a pattern of bleeding that treatment of vitamin K increased levels of prothrombin. (wikipedia.org)
  • Selenium deficiency may also be an aggravating factor for autoimmune hyperthyroidism (Graves disease). (wikipedia.org)
  • Iron-deficiency anemia (IDA) may be the only symptom for CD, detected in subclinical CD and is accompanied by a decrease in serum ferritin levels. (wikipedia.org)
  • Selenium (Se) deficiency is said to contribute to the atrophy of the thyroid gland in certain endemic goiter areas in Africa. (lu.se)
  • Deficiency tends to occur in growthy seasons when trace element levels in pasture are diluted, and less soil is ingested. (country-wide.co.nz)
  • Selenium deficiency is more prevalent in growthy summers for sheep. (country-wide.co.nz)
  • An increased risk of selenium deficiency can be alerted to by pasture analysis. (country-wide.co.nz)
  • For cattle, selenium deficiency reduces conception rate, calf survival and growth rates. (country-wide.co.nz)
  • However, in the United States, selenium levels are typically much higher than they are in Holland, where deficiency is widespread. (chriskresser.com)
  • Researchers still don't understand exactly what causes cribbing in horses, but they now suspect selenium deficiency might be one reason. (horse-canada.com)
  • Although reasons for the regional disparity are not yet clear, reports from Niamey (southern Niger Republic) and Kano (northern Nigeria) suggest that selenium deficiency is common in PPCM patients in the regions, with critically low levels of serum selenium in up to 76.9% of the patients [ 5 , 6 ]. (biomedcentral.com)
  • Earlier epidemiological studies in the Keshan and neighbouring counties in northeastern China had established a causal relationship between selenium deficiency and a rapidly progressive and fatal type of cardiomyopathy, the Keshan disease [ 7 ]. (biomedcentral.com)
  • The magnitude of folate deficiency throughout the world is poorly known: few countries have surveyed the folate status of at least one population group at the national level, and most national surveys have been conducted in the Americas and Europe. (who.int)
  • There was no difference in the S-Se concentration and the triiodothyronine (T3), thyroxine (T4), thyrotropin (TSH) or thyroglobulin concentrations in serum. (lu.se)
  • Serum mercury concentration and the risk of ischemic stroke: The REasons for Geographic and Racial Differences in Stroke Trace Element study. (cdc.gov)
  • The most important finding in this study was that blood serum selenium concentration was significantly lower in cribbing horses than in controls, with the lowest levels measured while horses were actually cribbing. (horse-canada.com)
  • FDA requirement limits added selenium in feed to a maximum of 0.3 ppm concentration in total diet. (horsefeedblog.com)
  • Selenium has an anti-oxidant role. (nature.com)
  • The effects of methylmercury may be modified by selenium, which is an anti-oxidant that often co-exists with mercury in fish. (cdc.gov)
  • Selenium and Vitamin E together are essential for both anti-oxidant benefits and for reducing the risk of certain muscle problems such as white muscle disease and exertional rhabdomyolysis syndrome. (horsefeedblog.com)
  • Its prevalence is influenced by ethnicity, environmental factors, such as iodine and selenium status, age and gender [ 1,2 ]. (karger.com)
  • Sampling of biological material for determination of total selenium concentrations does not usually pose a problem unless specific selenium compounds are to be identified (Bem 1981). (cdc.gov)
  • Karaküçük S, Ertugrul Mirza G, Faruk Ekinciler O, Saraymen R, Karaküçük I, Ustdal M. Selenium concentrations in serum, lens and aqueous humour of patients with senile cataract. (aaem.pl)
  • The immune system relies on adequate dietary selenium intake and this nutrient exerts its biological effects mostly through its incorporation into selenoproteins. (mdpi.com)
  • The development of high-throughput omic approaches and novel bioinformatics tools has led to new insights regarding the effects of selenium and selenoproteins in human immuno-biology. (mdpi.com)
  • the variations in zinc levels over the course of anti-TB therapy after 1 and 4 months. (who.int)
  • Included in the study correlation of low zinc levels and active were 30 children in the age range 2-12 years pulmonary TB in adults [7,8]. (who.int)
  • This case-control study during 2003-04 compared serum zinc levels and other variables in 23 mothers of neonates affected with NTD and 36 mothers with normal healthy neonates in Dezyani hospital in Gorgan. (who.int)
  • Further studies are needed to explore the possibility of mercury -induced ischemic stroke toxicity in other populations at higher exposure levels. (cdc.gov)
  • Warning - selenium toxicity is possible if treatments are administered incorrectly. (country-wide.co.nz)
  • Chronic selenium toxicity occurs at about 10X the FDA limit, so there is a pretty good safety margin. (horsefeedblog.com)
  • While high blood levels of heavy metals increased the risk of CKD, elevated plasma selenium and serum zinc may interact with low-toxicity heavy metals to reduce CKD risk. (annals.edu.sg)
  • The purpose of this chapter is to describe the analytical methods that are available for detecting, measuring, and/or monitoring selenium, its metabolites, and other biomarkers of exposure and effect to selenium. (cdc.gov)
  • Pregnancy urinary concentrations of bisphenol A, parabens and other phenols in relation to serum levels of lipid biomarkers: Results from the EARTH study. (cdc.gov)
  • Relationship in humans between ascorbic acid consumption and levels of total and reduced ascorbic acid in lens, aqueous humour, and plasma. (nature.com)
  • Almost every other studies(all on animals) reported positive connection between selenium intake and t3 levels, but this on on humans is opposite! (raypeatforum.com)
  • Equally important is that magnesium acts to release calcium from marrow when blood serum levels are low. (newrootsherbal.com)
  • Dietary selenium intake modulates thyroid hormone and energy metabolism in men. (raypeatforum.com)
  • Protein and energy intake have a great influence on growth speed 14 - 16 , which is determined by the dietary nutrient level and feed intake. (scialert.net)
  • Ideally, selenium should be measured in 24-hour urine samples that have been stored in polyethylene containers in acid medium (Sanz Alaejos and Diaz Romero 1993). (cdc.gov)
  • Inductively coupled plasma dynamic reaction cell mass spectrometry (ICP-DRC-MS) is a multi-element analytical technique capable of trace level elemental analysis. (cdc.gov)
  • Blood samples should be separated into plasma or serum and cell fractions prior to freezing if the selenium levels in these components are to be measured separately. (cdc.gov)
  • To facilitate the accurate quantification of total bile acids in serum and plasma, the 5th Generation Total Bile Acids Assay has emerged as a reliable and advanced diagnostic tool. (randox.com)
  • The most commonly used measures of selenium status are plasma and serum selenium concentrations. (biomedcentral.com)
  • Objective: The purpose of this study was to evaluate the antioxidant levels in plasma and saliva of patients with recurrent aphthous stomatitis (RAS) and healthy controls. (bvsalud.org)
  • Results: Plasma analysis showed significantly decreased SOD and CAT activities, and UA level in RAS patients compared to control group. (bvsalud.org)
  • However, there is paucity of research concerning plasma and salivary antioxidant levels with RAS. (bvsalud.org)
  • MIXED15+15) 0.15 ppm sodium selenite + 0.15 ppm selenium metal-amino acid and (COMP15) 0.15 ppm selenium metal-amino acid. (scielo.br)
  • In this way, it was possible to verify that the metal amino acid of selenium at the dose of 0.15 ppm promotes the same effect as the diets formulated with 0.30 ppm of sodium selenite. (scielo.br)
  • A while back I wrote an article on the role of selenium in autoimmune thyroid disease . (chriskresser.com)
  • On the other hand, several studies indicate that supplementing with selenium has several benefits for people with autoimmune thyroid disease, including reduced inflammation and damage to thyroid tissue. (chriskresser.com)
  • Additionally, we compared the content of micronutrients and contaminants in the salmon fish protein supplement to the recommended intake (RI) of micronutrients in the Nordic Nutrition Recommendations (NNR) [ 16 ] and the tolerable weekly intake (TWI) levels of contaminants set by the European Food Safety Authorities Panel on Contaminants in the Food Chain (EFSA CONTAM Panel) [ 17 , 18 , 19 , 20 , 21 ]. (springer.com)
  • Selenium is an essential trace element that is required for the correct functioning of the immune system with a recommended daily intake for adults of 55 μg [ 4 ]. (karger.com)
  • However, the amount of digestible energy or protein that fish need to retain a determined level of growth depends not only on the initial body weight and temperature but also on the efficiency of the retention of the digestible energy intake or digestible protein intake 14 , 22 . (scialert.net)
  • Biopsy samples were taken from scar tissue and adjacent areas over a year after their injuries and levels of levels of the vitamin D3 precursors 7-dehydrocholesterol, and its conversion product previtamin D3 were determined. (lifeextension.com)
  • Selenium Blood Test measures the amount of selenium in the blood. (bajajfinservhealth.in)
  • The level of blood Se necessary for saturation of GSHPx of about 100 ng Se/ml whole blood confirms observations in earlier studies. (cambridge.org)
  • HIV antibodies generally do not reach detectable levels in the blood for one to three months following infection. (digitalnaturopath.com)
  • It is a multifactorial disorder characterised by elevated levels of bile acids in the blood, particularly chenodeoxycholic acid (CDCA) and cholic acid (CA) 4 . (randox.com)
  • Blood samples drawn at the beginning of the study provided serum folate and total homocysteine levels. (lifeextension.com)
  • Men who experienced acute coronary events were older, had higher systolic blood pressures and higher cholesterol levels, and had lower lycopene levels than those who remained event-free. (lifeextension.com)
  • Serum elements are used to assess the status of key elements and electrolytes that have important functions in the extracellular fluid compartment of blood. (doctorsdata.com)
  • Whole Blood and Serum Elements tests are available separately or as part of the Comprehensive Blood Elements profile. (doctorsdata.com)
  • Methods: Standard methods were adopted to collect an early morning fasting blood sample for serum selenium concentrations, determined by atomic absorption spectrometry (AAS), and albumin, determined by the bro mocresol green method. (clin-lab-publications.com)
  • In total, 88 adults were randomised to a salmon fish protein supplement or placebo, and 74 participants were included in the analysis of vitamin D, omega-3, vitamin B12, selenium, folate, zinc, homocysteine and mercury. (springer.com)
  • Serum mercury was measured using samples collected at recruitment. (cdc.gov)
  • a more evident trend toward lower incidence of ischemic stroke with higher mercury levels was observed among women. (cdc.gov)
  • Conclusion: This study does not support an association between mercury and the incidence of ischemic stroke within a population with low-to-moderate level of exposure. (cdc.gov)
  • During the intervention period, geometric mean (GSD) of serum vitamin B12 concentrations increased from 304 (1.40) to 359 (1.42) pmol/L in the fish protein group ( P vs. controls = 0.004) and mean (SD) serum selenium increased from 1.18 (0.22) to 1.30 (0.20) μmol/L ( P vs. controls = 0.002). (springer.com)
  • Including a salmon fish protein supplement in the daily diet for 8 weeks, increases serum vitamin B12 and selenium concentrations. (springer.com)
  • The research team, led by Baylor College of Medicine's diabetes, endocrinology and metabolism division chief, Dr Lawrence Chan, found high levels of the arterial wall cell surface protein known as angiotensin type 1 receptor in the plaques of the mice expressing CRP, and lower levels in the mice who did not express CRP. (lifeextension.com)
  • This study was conducted to evaluate the effect of protein levels and energy levels on the growth, feed efficiency and survival of O. vittatus fingerlings. (scialert.net)
  • Six diets containing 3 protein levels (28, 30 and 32%) and 2 protein-energy ratios (12 and 14) were formulated and fed to triplicate groups of O. vittatus fingerlings (3.77±0.02 g/fish) for 60 days. (scialert.net)
  • The success of aquaculture operations not only depends on the fish species, feeding rate, stocking density, integrated multi-trophic aquaculture, water quality management, feed type and feed conversion ratio 1 - 10 , but also on the protein level and protein to energy ratio 11 - 13 . (scialert.net)
  • The protein level and protein to energy ratio is one of the most important variables in aquaculture because it directly affects the specific growth rate, condition factor, viscerosomatic index and gonadosomatic index of female Nile tilapia 13 , the growth and feed conversion ratio of juvenile spotted Babylon 11 and the whole body composition of gilthead sea bream 14 . (scialert.net)
  • Therefore, the optimum protein levels and energy for each species, as well as the cultivation phase needs, must be determined to allow for maximum profitability. (scialert.net)
  • The analytical methods used to quantify selenium in biological and environmental samples are summarized below. (cdc.gov)
  • Table 7-1 lists the applicable analytical methods used for determining selenium and selenium compounds in biological fluids and tissues, and Table 7-2 lists the methods used for determining selenium in environmental samples. (cdc.gov)
  • Methods Serum pools from non-pregnant women and women in each trimester were bottled into four levels. (nist.gov)
  • Women on different contraceptive methods have been linked with the development of various diseases and possible changes in serum trace elements and vitamins of women on contraceptives have been postulated. (uwi.edu)
  • Patients were recruited from three tertiary-level hospitals in Kano, Nigeria between June 2017 and December 2017: Aminu Kano Teaching Hospital, Murtala Mohammed Specialist Hospital and Mohammed Abdullahi Wase Specialist Hospital. (biomedcentral.com)
  • Based on these data, the researchers concluded "that alterations in serum selenium, an important component of the antioxidant system, may play a role in the pathophysiology of cribbing behaviour in horses, adding further evidence to the theory that cribbing may be related to increased oxidative stress and alterations in essential trace elements. (horse-canada.com)
  • ICP manifests in the second or third trimester and can lead to various symptoms such as pruritus (itching), abnormal liver enzyme levels, jaundice, abdominal pain, and depression. (randox.com)
  • Some chronic selenium symptoms might appear above 10-15 mg/head per day. (horsefeedblog.com)
  • A study published in the August 2004 issue of The American Journal of Clinical Nutrition examined folate and homocysteine levels in a group of Finnish men and found that folate, but not homocysteine, had a significant inverse association with the risk of experiencing an acute coronary event (defined as a heart attack or prolonged episode of chest pain). (lifeextension.com)
  • In contrast with other studies, homocysteine levels were not associated with acute coronary event risk in this study, although when smokers were separately analzyed, high homocysteine was associated with almost double the risk of an acute coronary event compared to the risk experienced by smokers with low homocysteine. (lifeextension.com)
  • The authors recommend intervention studies to determine the effect of folic acid supplements on cardiovascular health, and to ascertain whether the vitamin's ability to reduce homocysteine prevents heart disease or if high homocysteine and low folate levels are markers of atherosclerosis or an unhealthy lifestyle. (lifeextension.com)
  • It is next to impossible to determine in a controlled, experimental environment whether the addition of a specific nutrient at a specific level will affect the athletic ability and health of a horse under all conditions. (vitaflex.com)
  • When determining the amounts of a nutrient to add into a horse ration, it is essential to allow for margins of safety over the levels necessary to meet the bare requirements. (vitaflex.com)
  • Table 2 contains the nutrient levels that have been used with good results by some of the most successful Standardbred owners and trainers in New Jersey, Pennsylvania, and New York. (vitaflex.com)
  • Selenium in Nutrition and Health. (scielo.br)
  • 3 , 4 ) In addition, a large Dutch study including over 58,000 participants found that those with the highest toenail selenium status had a 37% lower risk of prostate cancer than those with the lowest selenium status. (chriskresser.com)
  • A nested case-control study of serum polychlorinated biphenyls and papillary thyroid cancer risk among U.S. military service members. (cdc.gov)
  • One exception is the collection and storage of urine samples without loss of volatile selenium compounds (Bem 1981). (cdc.gov)
  • Freezing of biological samples immediately following collection is recommended to reduce enzymatic formation of volatile selenium compounds. (cdc.gov)
  • A reduced risk, of macular degeneration is found in relation to a high serum level. (nature.com)
  • Those whose serum levels were in the highest one-third of the group had a risk of undergoing an acute coronary event that was 65 percent lower than that experienced by men whose folate was in the lowest third. (lifeextension.com)
  • Baseline selenium status alone was not associated with prostate cancer risk. (chriskresser.com)
  • It's worth pointing out that these findings contradict two previous (and considerably smaller) observational studies in the United States, which found that low toenail selenium status increases the risk of prostate cancer. (chriskresser.com)
  • While it's entirely possible that the very low selenium levels seen in Holland are associated with increased prostate cancer risk, there does not appear to be a correlation between selenium and prostate cancer in the United States-at least within the ranges of toenail selenium found in U.S. men over 55 years of age. (chriskresser.com)
  • The researchers conclude, "Our finding of an increased risk only among current long-term statin users suggests that the chronic dysregulation of the mevalonate pathway and/or long-term lowering of serum cholesterol may contribute to breast carcinogenesis . (tenpennyimc.com)