• Objective -To determine the effects of UVB radiation produced by artificial lights on serum 25-hydroxyvitamin D concentrations in domestic rabbits ( Oryctolagus cuniculi ). (avma.org)
  • Age-related decreases in SMM, intestinal nutrient absorption rates, and serum 25-hydroxyvitamin D [25(OH)D] concentrations were significantly higher in women than in men. (tokushima-u.ac.jp)
  • Serum 25(OH)D concentrations were closely associated with SMM (kg, % of BW, kg / m2) and CHI (%) as well as the intestinal absorption rates of nitrogen (%) and phosphorus (%) in women, but not in men. (tokushima-u.ac.jp)
  • SGLT2i may alter renal tubular phosphate reabsorption and are associated with increased serum concentrations of phosphate, fibroblast growth factor-23 (FGF-23), parathyroid hormone (PTH), decreased 1,25-hydroxyvitamin D levels, as well as increased bone turnover. (lww.com)
  • This LC-MS/MS method provides a rapid, accurate, sensitive, and cost-effective alternative to other methods for detection of 25(OH)D(2) and 25(OH)D(3) at nanomolar concentrations. (nih.gov)
  • Serum concentrations of total calcium, ionic calcium, parathyroid hormone (PTH), 25-hydroxyvitamin-D3, and 1,25-dihydroxyvitamin-D3 were measured to monitor calcium homeostasis. (cdc.gov)
  • KT Khaw, from University of Cambridge (United Kingdom), and colleagues measured serum 25-hydroxyvitamin D [25(OH)D] concentrations [which comprised 25(OH)D3 and 25(OH)D2]) of the study subjects, and categorized each into 5 groups accordingly. (worldhealth.net)
  • Lowest mortality rates were observed in individuals with serum 25-hydroxyvitamin D concentrations above 90 nmol/L. The study authors submit that: "Plasma 25(OH)D concentrations predict subsequent lower 13-y total mortality and incident cardiovascular disease, respiratory disease, and fractures. (worldhealth.net)
  • Design Umbrella review of the evidence across systematic reviews and meta-analyses of observational studies of plasma 25-hydroxyvitamin D or 1,25-dihydroxyvitamin D concentrations and randomised controlled trials of vitamin D supplementation. (bmj.com)
  • Several medical societies have issued recommended minimum serum concentrations of 25(OH)D including the National Academy of Medicine (formerly the Institute of Medicine), Endocrine Society, International Osteoporosis Foundation, and American Geriatric Society. (reachmd.com)
  • This study will examine Mg status (Serum Ionized Mg concentrations, Red Blood cell Mg concentrations) in patients on EIAEDs and Non EIAEDs, and we propose that magnesium status is an important contributor of vitamin D and bone metabolism in patients on AEDs and should be routinely monitored in patients on AED therapy. (drexel.edu)
  • Serum 25-hydroxyvitamin D concentrations and risk for hip fractures. (prohealth.com)
  • A blood sample was collected to measure 25-hydroxyvitamin D (25(OH)D) concentrations. (hindawi.com)
  • A case control study of thirty-nine children with clinically controlled asthma was enrolled to assess the relationship between serum vitamin D concentrations and disease activity. (dovepress.com)
  • The mean 25(OH)D concentration was 34.7 nmol/L, and 83 subjects had 25(OH)D concentrations less than 50 nmol/L. Multiple linear regression analysis revealed that serum 25(OH)D level was positively related to plasma IL-17 level (β = 0.26, p = 0.025), after adjustment for gender, age, vitamin D intake, alcohol consumption, smoking status, and percent body fat. (elsevierpure.com)
  • Context Changes in vitamin D binding protein (DBP) concentrations and catabolism of 25-hydroxyvitamin D to 24,25-dihydroxyvitamin D (24,25D) after vitamin D2 supplementation may alter concentrations and bioavailability of circulating 25-hydroxyvitamin D (25D). (medscape.com)
  • Main outcome measures included concentrations of DBP, vitamin D metabolites, and bioavailable 25-hydroxyvitamin D (25D) in pre- and posttreatment serum samples. (medscape.com)
  • [ 9 ] In response to variations in exposure ( e.g., sunlight, diet) and exogenous supplementation, counter regulatory mechanisms are in place that maintain appropriate concentrations of 1,25-hydroxyvitamin D (1,25D) and its precursor 25-dihydroxyvitamin D (25D). (medscape.com)
  • The conversion to 1,25-dihydroxyvitamin D is regulated by its own concentration, parathyroid hormone (PTH), and serum concentrations of calcium and phosphate. (msdmanuals.com)
  • Median pre-randomisation vitamin D level was 56.5 (range 12.6-189.0 nmol/L). Vitamin D levels did not significantly vary over 12 months (p = 0.24). (whiterose.ac.uk)
  • The reliable evidence that excess vitamin D can cause hypercalcemia in generally healthy adults comes from daily intakes of vitamin D greater than 100,000 IU or serum 25(OH)D exceeding 240 nmol/L, which are far higher than those necessary to achieve the benefits. (naturalhealthperspective.com)
  • 50 nmol/L), increasing to more than 50% in women during winter-spring and in people residing in southern states.1 This field of research is fast-moving, and it is timely to re-examine past recommendations 2 in light of the increasing number of medical conditions associated with low vitamin D status, and indications that higher levels of circulating serum 25-OHD may be required for optimal health. (vitamindwiki.com)
  • For all subjects ( n =38), the median baseline 25 hydroxyvitamin D (25OHD) level was 36.25 (27.5-48.12) nmol/l. (nature.com)
  • During 3 months, 250 μ g/day of vitamin D 2 most effectively raised 25OHD levels to 85 nmol/l in 75% of the postmenopausal osteopenic/osteoporotic women treated. (nature.com)
  • Traditionally living populations in East Africa have a mean serum 25-hydroxyvitamin D concentration of 115 nmol/l. (purehealthclinic.co.uk)
  • 30 ng/mL (75 nmol/L). A subgroup of participants (1,644 people) had vitamin D levels tested one year into the study. (greenmedinfo.com)
  • 50 nmol/L) and insufficiency (50-75 nmol/L) were 59.0% and 27.0% respectively in patients with type 2 DM, and 47.0% and 24.0% respectively in healthy subjects. (who.int)
  • 50 nmol/L) et de l'insuffisance en vitamine D (50-75 nmol/L) était respectivement de 59,0 % et de 27,0 % chez les patients diabétiques, contre 47,0 % et 24,0 % chez les sujets en bonne santé. (who.int)
  • Vitamin D deficiency was defined as a 25(OH)D below 20 ng/ml and insufficiency as a 25(OH) D of 20 29 ng/ml. (endocrine-abstracts.org)
  • Vitamin D deficiency was higher in TRAb-positive GD patients than TRAb-negative patients (respectively 75.5% (77/102) vs 24.5% (25/102) beside according to vitamin D insuffiency there was no difference between TRAb-positive and negative GD patients. (endocrine-abstracts.org)
  • The serum phosphorus level may vary based on the etiology, trending towards higher values with reduced kidney function and lower values with vitamin D deficiency. (medscape.com)
  • 8.1% (with deficiency defined as serum 25-hydroxyvitamin D level less than 12 ng/mL). (consumerlab.com)
  • Deficiency of 25(OH)D has been confirmed to affect the synthesis and secretion of insulin in both animal models and human studies 4− [4]. (researchsquare.com)
  • In vivo, subjects recently diagnosed T2D who were supplemented with 25(OH)D had a tendency toward a better insulin secretory response [ 8 ] , and people with 25(OH)D deficiency might predispose to glucose intolerance [ 9 ] . (researchsquare.com)
  • To compare the safety and efficacy of high-dose vitamin D supplementation tailored to baseline deficiency levels with conventional vitamin D supplementation in women with early breast cancer. (naturalmedicinejournal.com)
  • Vitamin D deficiency is more prevalent among people living in areas above the 40th parallel North and below the 40th parallel South or in areas of reduced sunlight, with higher levels of melanin, and who are 65 years and older. (reachmd.com)
  • In the large cross-sectional Rotterdam study, magnetic resonance imaging (MRI) in 2716 participants free of dementia showed that those with vitamin D deficiency had smaller hippocampus volume, brain volume, gray matter, and white matter compared with participants with normal vitamin D levels. (reachmd.com)
  • Vitamin D status in the elderly, seasonal substrate deficiency causes 1,25(OH)2 cholecalciferol deficiency. (nature.com)
  • Bottom line: The study aimed to investigate the correlation between vitamin D deficiency and diabetic foot osteomyelitis (DFO) in patients with type 2 diabetes mellitus (T2DM) and diabetic foot ulcer (DFU). (diabeticfootonline.com)
  • Ten of twelve (83%) of patients had vitamin D deficiency, and 92% had suboptimal vitamin D levels. (biomedcentral.com)
  • Of those not on vitamin D supplements, 100% had vitamin D deficiency, with vitamin D levels significantly below those of historical controls. (biomedcentral.com)
  • The diagnosis of osteomalacia was confirmed when in April 2008 her serum 25-hydroxyvitamin D level was found to be 10.5 nM, representing severe deficiency (Figure 2A ). (biomedcentral.com)
  • Vitamin D deficiency leads to rickets in children and osteomalacia in adults, and long-term insufficiency contributes to osteoporosis [ 2 , 3 ]. (hindawi.com)
  • Serum circulating 25-hydroxyvitamin D (25(OH)D) level is considered as the best indicator of the body vitamin D status, and although still debated, most experts defined vitamin D deficiency as 25(OH)D levels lower than 20 ng/mL [ 4 , 5 ]. (hindawi.com)
  • Hence, not surprisingly, postmenopausal women from different countries were reported to be particularly vulnerable to vitamin D deficiency, which leads numerous international health authorities and medical societies to produce recommendations for the management of postmenopausal osteoporosis by maintaining adequate vitamin D levels by supplementation. (hindawi.com)
  • For instance, in a European study involving more than 8500 postmenopausal women, the prevalence of 25(OH)D deficiency reached 32.1% when considering the cutoff value of 20 ng/mL [ 9 ], while in Indian, Chinese, and US populations of postmenopausal women, the estimated prevalence rates were 53.3%, 72.1%, and 53%, respectively [ 10 - 12 ]. (hindawi.com)
  • In this cross-sectional study in Tehran, Islamic Republic of Iran, a country with a high prevalence of vitamin D deficiency, we determined the prevalence of vitamin D deficiency among 90 type 2 DM patients and 90 healthy subjects. (who.int)
  • The prevalence of vitamin D deficiency in men with type 2 DM and healthy men were 42.7% and 22.2% respectively. (who.int)
  • Type 2 diabetes mellitus (DM) is a met- healthy subjects from the staff of Tehran D deficiency. (who.int)
  • Within the deficiency cat- abolic disorder which is a major health University of Medical Sciences were egory serum levels of 25(OH)D were problem in many countries in the world selected via random sampling methods. (who.int)
  • Furthermore, describing how vitamin D levels fluctuate month-to-month may provide a basis for implementing public health strategies to increase 25(OH)D levels when deficiency is most acute. (cdc.gov)
  • Deming regression of radioimmunoassay and LC-MS/MS methods for total 25(OH)D levels yielded a slope of 0.97 (95% confidence interval, 0.88-1.05) and y-intercept of -1.74 ng/mL. (nih.gov)
  • The variety of LC-MS/MS methods measuring total 25(OH)D used today is vast and the comparability among these methods is still not well assessed. (cdc.gov)
  • 25-OHD (25-hydroxyvitamin D), the major circulating metabolite of vitamin D, was measured in serum by competitive protein-binding (CPB) assay and radioimmunoassay kit (Nichols, San Juan Capistrano, California). (who.int)
  • Procedures -After an acclimation period, rabbits were anesthetized with isoflurane, and an initial blood sample was collected for determination of serum 25-hydroxyvitamin D concentration. (avma.org)
  • On day 14, another blood sample was collected from anesthetized rabbits for determination of serum 25-hydroxyvitamin D concentration. (avma.org)
  • However, data obtained from various populations of community-living postmenopausal women with or without osteoporosis highlight a wide disparity of prevalence rates of 25(OH)D concentration ≤ 20 ng/mL depending on the considered geographical areas [ 7 , 8 ]. (hindawi.com)
  • Therefore, in the present study, we examined the relationship between vitamin D status and circulating TSH levels in middle-aged and elderly individuals with thyroid autoimmunity, while taking thyroid function into considerationin addition to the relationship between vitamin D insufficiency and thyroid autoimmunity, the presence of thyroid nodule(s) and thyroid volume in a cross-sectional study. (hindawi.com)
  • As the incidence of vitamin D insufficiency is surprisingly high in the general population, experimental studies have started to investigate whether vitamin D levels (measured as serum 25 hydroxy vitamin D-25[OH]D) are correlated with immune cells and clinical parameters. (dovepress.com)
  • Individual pre-randomisation vitamin D levels did not differ significantly for Breslow thickness, tumour ulceration, or disease stage. (whiterose.ac.uk)
  • EPA levels alone were not significantly associated with AMD. (mdfoundation.com.au)
  • Also at this higher dose level liver weight was significantly reduced. (cdc.gov)
  • Fetal body weight and number of live fetuses were significantly reduced at a 50mg/kg dose level. (cdc.gov)
  • By day 21, there appeared to be a dose dependent effect of EGME treatment on most of these variables including a significant increase in total calcium and ionic calcium while 1,25- dihydroxyvitamin-D3 was significantly decreased in groups treated at the 100mg/kg level. (cdc.gov)
  • With increase in 25(OH)D level, FPG, HbA1c, glucagon and C-p were significantly decreased in trend in T2D patients. (researchsquare.com)
  • The moderate analyses revealed significantly interaction effect of 25(OH)D and glucagon on C-p ( P =0.0124), as well as the effect of 25(OH)D and duration of diabetes on glucagon/C-p in abdominal obesity group. (researchsquare.com)
  • According to the range of the duration of diabetes, the conditional indirect effect of 25(OH)D on glucagon/C-p was significantly at 1 SD below the mean ( P =0.0002) and the mean of the duration of diabetes ( P =0.0007). (researchsquare.com)
  • Studies show that maintaining healthy vitamin D levels or taking vitamin D supplements significantly improves mood and mental health conditions. (prohealth.com)
  • Individuals who supplement their diet with vitamin D have a significantly reduced incidence of respiratory tract infections, with some indication that the greatest positive effects of supplementation may be seen in individuals with the lowest 25(OH)D levels. (dsm.com)
  • Further research is necessary to investigate the possible association between 25(OH)D levels and AMD. (mdfoundation.com.au)
  • We aimed to investigate the association between 25(OH)D and islet function homeostasis in type 2 diabetes (T2D) patients. (researchsquare.com)
  • Our objectives were to examine the association between 25(OH)D and traditional and novel biomarkers of cardiometabolic disease and to describe the extent of the month-to-month fluctuations of 25(OH)D in a representative sample of the general Canadian population. (cdc.gov)
  • But what are the latest scientific findings behind the 'sunshine' vitamin's role in immunity and how can dietary supplement manufacturers take innovation to the next level with calcifediol, the bioavailable form of vitamin D? (dsm.com)
  • The role of vitamin D in immunity is regulated by the availability of 25(OH)D - also known as calcifediol or calcidiol - in the bloodstream (i.e. the active form of vitamin D in the body), which is further converted to 1,25-dihydroxyvitamin D and utilized by immune cells. (dsm.com)
  • Vitamin D is metabolized by the liver to 25(OH)D (calcifediol, calcidiol, 25-hydroxycholecalciferol, or 25-hydroxyvitamin D), which is then converted by the kidneys to 1,25-dihydroxyvitamin D (1,25-dihydroxycholecalciferol, calcitriol , or active vitamin D hormone). (msdmanuals.com)
  • Median age (25-75th percentile) was 61.5 (57.00-66.25) years, and mean bone mineral density (BMD) was 0.902 (0.800-1.042)g/cm 2 . (nature.com)
  • When 25(OH)D levels in the blood are insufficient or deficient, immune responses can be limited, leading to increased risk of infection incidence and severity. (dsm.com)
  • 11 Individuals with deficient 25(OH)D levels had a 54% higher rate of a positive test than those who had adequate levels. (dsm.com)
  • Rabbits were randomly assigned to receive 12-hour exposure to UVB radiation produced by 2 compact fluorescent lights daily (n = 5) or no UVB supplementation (4) commencing on day 1. (avma.org)
  • For most people, supplementation with vitamin D-3 supplements is the most practical and cost effective method of boosting their serum 25(OH)D levels so that they can experience the simply amazing health benefits of vitamin D . (naturalhealthperspective.com)
  • Some people reach their target blood serum levels with very little supplementation, whereas others turn out to be non-responders which require much higher amounts. (naturalhealthperspective.com)
  • Ten outcomes were examined by both meta-analyses of observational studies and meta-analyses of randomised controlled trials, but the direction of the effect and level of statistical significance was concordant only for birth weight (maternal vitamin D status or supplementation). (bmj.com)
  • Impact of a tailored oral vitamin D supplementation regimen on serum 25-hydroxyvitamin D levels in early breast cancer patients: a randomized phase III study. (naturalmedicinejournal.com)
  • Always have the blood levels checked again after 4-8 weeks of supplementation to assure the levels are coming up to sufficient status. (peoplesrx.com)
  • Determination of adequate supplementation levels of more than 1000 IU requires further research to achieve normal vitamin D levels during the duration of treatment for pulmonary TB in children. (vitamindwiki.com)
  • Conclusion Changes after vitamin D2 supplementation involve acute rise in serum DBP and 24,25D, both of which may attenuate the rise in bioavailable 25D and 1,25D. (medscape.com)
  • [ 16 ] It is unknown, however, whether and to what extent vitamin D supplementation affects DBP levels following routine supplementation. (medscape.com)
  • The Diasorin (formerly Incstar) 25-OH- Vitamin D assay consists of a two-step procedure. (cdc.gov)
  • Ferritin, folic acid and TSH were measured in serum by immunoradiometric assay (IRMA), charcoal boil and double antibody assay kit (DPC, Los Angeles, California), respectively. (who.int)
  • 1994). Quantification of skeletal alkaline phosphatase in osteoporotic serum by wheat germ agglutinin precipitation, heat inactivation, and a two-site immunoradiomeric assay. (nature.com)
  • The assay under-recovers plant-derived 25-hydroxyvitamin D 2 but not 25-hydroxyvitamin D 3 (for assay specifications see [ 2 ] and the manufacturer's data at http://www.idsplc.com/z_includes/z_assets/asset_file.php?id=8843 ). (biomedcentral.com)
  • Age and assay variation values for 25(OH)D from the third national Surveil ance of sex were matched between the 2 groups. (who.int)
  • Inter-assay and intra- about 4.4 million people, had impaired disorders such as hypo- or hyperthy- assay variations for PTH were 8.9% and fasting glucose [2,3]. (who.int)
  • Historically, vitamin D had been linked to skeletal disease including calcium, phosphorus, and bone metabolism, 1 2 osteoporosis, 3 fractures, 4 5 muscle strength, 6 and falls. (bmj.com)
  • Subjects were randomly divided into three groups: control group ( n =13): no vitamin D 2 , 125 μ g/day ( n =13) and 250 μ g/day ( n =12) of vitamin D 2 groups, all receiving 500 mg calcium/day. (nature.com)
  • Serum calcium remained within normal range during the follow-up. (nature.com)
  • Diagnosis is typically based on elevated blood levels of 25(OH)D. Treatment consists of stopping vitamin D, restricting dietary calcium, restoring intravascular volume deficits, and, if toxicity is severe, giving corticosteroids or bisphosphonates. (msdmanuals.com)
  • 0.001 μW/cm 2 for the control rabbits. (avma.org)
  • Methods: Vitamin D was measured in serum from 341 patients with resected stage IIB-IIIC melanoma recruited to the AVAST-M adjuvant melanoma randomised trial, collected prior to randomisation, then at 3 and 12 months. (whiterose.ac.uk)
  • 122 of 429 patients had vitamin D levels were enrolled in this study. (endocrine-abstracts.org)
  • Normal vitamin D levels were found in 4.9% (6/122) of the patients. (endocrine-abstracts.org)
  • Indeed, nowadays psoriasis is considered a systemic pathology, including also other conditions, from psoriatic arthritis to obesity and metabolic disease (MetS), which increased cardiovascular risk in psoriatic patients [ 2 - 4 ]. (springer.com)
  • Patients with HS had lower serum 25-hydroxyvitamin D levels and a higher percentage of degraded and partially degraded bone microarchitecture than controls. (medpagetoday.com)
  • 2 The results of their findings, which were recently published in the Swedish journal Acta Dermato-Venereologica , suggest that patients with HS have lower trabecular bone score (TBS) and total hip bone mineral density (BMD) values than population-based controls. (medpagetoday.com)
  • 2 In fact, TBS has been evaluated in several rheumatic diseases, and values consistent with degraded microarchitecture have been linked to disease activity in patients with ankylosing spondylitis, systemic sclerosis, and RA. (medpagetoday.com)
  • The aim of this study was to determine the 25-hydroxy vitamin D (25(OH)D) levels in age-related macular degeneration (AMD) patients. (mdfoundation.com.au)
  • From a random control group of 326 patients whose 25(OH)D levels had been measured, a group of 93 were selected to match the age range of the AMD group. (mdfoundation.com.au)
  • The patients affected by AMD had statistically significant lower 25(OH)D levels (15 ± 10 ng/mL) than the healthy subjects control group (21 ± 14 ng/mL) (p = 0.004). (mdfoundation.com.au)
  • This study shows that patients affected by AMD had lower vitamin D levels compared to healthy subjects. (mdfoundation.com.au)
  • Cytokines and chemokines in cerebrospinal fluid and serum of adult patients with acute disseminated encephalomyelitis. (medscape.com)
  • The OLS regression and quantile regression further showed that 25(OH)D was associated with glucagon and fasting C-p levels in T2D patients with abdominal obesity. (researchsquare.com)
  • 25(OH)D was negatively associated with glucagon and C-p in T2D patients with abdominal obesity. (researchsquare.com)
  • Duration of diabetes influence the effect of 25(OH)D on the ratio of glucagon/C-p, on behalf of islet function homeostasis, in T2D patients with abdominal obesity. (researchsquare.com)
  • Secondary measures included percentage by arm of patients with a normal vitamin D value at 12, 18, and 24 months and percentage of 25(OH)D serum normalization after 6 months of crossover in the C arm population. (naturalmedicinejournal.com)
  • 1,6 Landel et al 6 noted that studies on vitamin D and AD date back to 1992 with reporting of "…decreased vitamin D receptor (VDR) mRNA levels in the hippocampus of AD patients. (reachmd.com)
  • There are few reports on the association between nutritional status and foot risk in patients with type 2 diabetes (T2D). (diabeticfootonline.com)
  • Eighty patients (95,2%) completed the six months follow-up. (vitamindwiki.com)
  • We assayed the serum 25-hydroxyvitamin D levels of all patients under our care on one old-age psychiatry rehabilitation unit. (biomedcentral.com)
  • We measured the vitamin D status (serum 25-hydroxyvitamin D level) in April-May 2008 of all patients under our care on the same psychogeriatric rehabilitation ward ( n = 12). (biomedcentral.com)
  • Dans le cadre de la présente étude transversale menée à Téhéran (République islamique d'Iran), dans un pays où la prévalence du déficit en vitamine D est élevée, nous avons mesuré cette prévalence chez 90 patients souffrant d'un diabète de type 2 et 90 sujets en bonne santé. (who.int)
  • Proinsulin-expressing dendritic cells in type 2 neuropathic diabetic patients with and without foot lesions. (cdc.gov)
  • Association between a novel G94A single nucleotide polymorphism in ATP1A1 gene and type 2 diabetes mellitus among Egyptian patients. (cdc.gov)
  • Association of the Vascular Endothelial Growth Factor Gene Polymorphism +936 C/T with Diabetic Neuropathy in Patients with Type 2 Diabetes Mellitus. (cdc.gov)
  • Association of Pro198Leu polymorphism in glutathione peroxidase one (GPX1) gene with peripheral neuropathy in type 2 diabetic patients. (cdc.gov)
  • The first procedure involves an extraction of 25-OH-D and other hydroxylated metabolites from serum with acetonitrile. (cdc.gov)
  • Vitamin D is the general term for a group of secosteroid metabolites whose active form is 1α-25-dihydroxyvitamin D (1,25(OH)D) [ 15 ]. (biomedcentral.com)
  • [ 32 ] In contrast, 25-hydroxyvitamin D 24-hydroxylase (CYP24A1) is highly expressed in the kidney and converts 1,25D and 25D to the inactive metabolites 1,24,25-trihydroxyvitamin D and 24,25D, respectively. (medscape.com)
  • Longitudinal associations of plasma metabolites with persistent fatigue among colorectal cancer survivors up to 2 years after treatment. (who.int)
  • Anthropometric indices, biochemical parameters, serum 25(OH)D, and islet function including C-peptide (C-p) and glucagon were measured. (researchsquare.com)
  • Her case is unusual because she has been an inpatient for more than 35 years, meaning that her diet and activity have in large part been under hospital supervision, and that she has had frequent surveillance of serum biochemical indices relevant to osteomalacia. (biomedcentral.com)
  • Our analysis suggests increasing levels of DHA are associated with reduced risk for early AMD in a multi-ethnic cohort. (mdfoundation.com.au)
  • Allergic (or atopic) asthma is characterized by the presence of ILC2 and T helper 2 (Th2) response that covers the production of cytokines such as, interleukin (IL)-4, IL-5 and IL-13 which all together orchestrate the migration of eosinophils, mast cells activation and Immunoglobulin E (IgE) production [ 5 , 6 ]. (biomedcentral.com)
  • Here, we aimed to examine the associations between levels of serum 25-hydroxyvitamin D [25(OH)D] and inflammatory cytokines in healthy Japanese adults. (elsevierpure.com)
  • BSMI single nucleotide polymorphism in vitamin D receptor gene is associated with decreased circulatory levels of serum 25-hydroxyvitamin D among micro and macrovascular complications of type 2 diabetes mellitus. (cdc.gov)
  • its association with type 2 diabetes mellitus and its complication (neuropathy) in Egyptian subjects. (cdc.gov)
  • Serum creatinine may increase by 2 mg/dL or more over a 2-week period. (health.am)
  • Urinary neutrophil gelatinase-associated lipocalin (NGAL), serum creatinine, urine protein, serum and urine catalytic iron, 25-hydroxyvitamin D3, 1,25-dihydroxyvitamin D3 and tissue lipid peroxidation were assayed. (alliedacademies.org)
  • Rats injected with iohexol showed elevated urinary NGAL (11.94±6.79 ng/mL), serum creatinine (2.92±0.91 mg/dL) and urinary protein levels (11.03±9.68 mg/mg creatinine) together with histological evidence of tubular injury and iron accumulation. (alliedacademies.org)
  • Sodium-glucose cotransporter 2 inhibitors (SGLT2i) represent a relatively new class of oral glucose-lowering agents that reduce adverse cardiovascular and kidney outcomes among individuals with chronic kidney disease (CKD). (lww.com)
  • Individuals with CKD have disproportionately high rates of cardiovascular disease, progression to end-stage kidney disease requiring renal replacement therapy, and death [2-5] . (lww.com)
  • In recent randomized controlled clinical trials, medications within the sodium-glucose cotransporter (SGLT) 2 inhibitors (SGLT2i) class have shown improvements in adverse cardiovascular and kidney outcomes among individuals with CKD [7▪▪,8,9▪▪,10▪] . (lww.com)
  • For instance, in the CREDENCE (Canagliflozin and Renal Events in Diabetes with Established Nephropathy Clinical Evaluation) trial, canagliflozin was associated with a reduction in the risks of kidney failure and cardiovascular events among participants with type 2 diabetes and CKD [8] . (lww.com)
  • This approach will provide a non-pharmacological, non-surgical, cost effective and simple means to reduce sPTH levels in the obese population, thereby lowering their cardiovascular risk. (drexel.edu)
  • Fasting blood samples were analyzed for 25(OH)D, 1,25-dihydroxyvitamin D [1,25(OH)2D], interferon-γ (IFN-γ), interleukin-6 (IL-6), and interleukin-17 (IL-17) levels using enzyme-linked immunosorbent assays kits. (elsevierpure.com)
  • None of the differences between the 2 groups was statistically significant. (who.int)
  • However, no significant association was found between serum 25(OH)D level and plasma IFN-γ or IL-6 levels. (elsevierpure.com)
  • Therefore, the purpose of this study is to investigate vitamin D status in Thais according to geographical region by assessing levels of serum 25-hydroxyvitamin D (which is the major metabolite and represents the stored form of vitamin D) by a reference method, liquid chromatography/tandem mass spectrometry (LC-MS/MS). (biomedcentral.com)
  • Because synthesis of 1,25-dihydroxyvitamin D (the most active metabolite of vitamin D) is tightly regulated, vitamin D toxicity usually occurs only if excessive doses (prescription or megavitamin) are taken. (msdmanuals.com)
  • Hip fractures occurred in 4 of 48 placebo group and 0 in 48 vitamin D2 group during the 2-year study period (log-rank, p = 0.049). (scienceopen.com)
  • The aim of this study was to investigate the association of 25-hydroxy-vitamin D (25[OH]D) levels and TSH receptor antibody (TRab) levels in GD. (endocrine-abstracts.org)
  • Assessment of the effectiveness and safety of high daily 125 μ g (5000 IU) or 250 μ g (10 000IU) doses of vitamin D 2 during 3 months, in rapidly obtaining adequate 25 hydroxyvitamin D (25OHD) levels. (nature.com)
  • The oral dose of vitamin D 2 required to rapidly achieve adequate levels of 25OHD is seemingly much higher than the usual recommended vitamin D 3 dose (20 μ g/day). (nature.com)
  • A recent study has reported that high circulating 25-hydroxyvitamin D [25(OH)D] is associated with low circulating thyroid-stimulating hormone (TSH) levels, but only in younger individuals. (hindawi.com)
  • The goal of the present study was to explore the relationship between vitamin D status and circulating TSH levels with thyroid autoimmunity and thyroid hormone levels taken into consideration in a population-based health survey of middle-aged and elderly individuals. (hindawi.com)
  • Recent studies showed that glucagon served as an insulinotropic hormone rather than counter-regulatory hormone to insulin [ 3 ] , which suggested that both a-and β-cells dysfunction contribute to the development of type 2 diabetes (T2D). (researchsquare.com)
  • Vitamin D was discovered to be a steroid-like hormone in 1968 and later was isolated as the active hormonal form of vitamin D 3 , chemically known as 1,25(OH) 2 D 3 . (reachmd.com)
  • [8] The half-life of the active form of vitamin D is about 4 hours, and the half-life of the pre-hormone form of vitamin D is 2-3 weeks. (greenmedinfo.com)
  • We conducted linear regressions analyses (adjusted for sex, waist circumference, physical activity, hormone use, and season) to assess the relationship between 25-hydroxyvitamin D and biomarkers of dysglycemia, dyslipidemia, and inflammation in the study population. (cdc.gov)
  • Serum samples were collected from all 1,424 participants in the morning and all venous blood samples after an overnight fast. (hindawi.com)
  • In that a number of previous studies suggest a wide range of beneficial health effects of Vitamin D, data from a 13-year long prospective population study involving 14,641 adult residents of the United Kingdom help to elucidate the optimal blood levels of the vitamin. (worldhealth.net)
  • Dosing with 10,000 IU a day should be reserved ONLY for those individuals having a hard time raising their blood levels of vitamin D. (naturalhealthperspective.com)
  • That leaves only 500 IU a day to build up your body's blood levels . (naturalhealthperspective.com)
  • The horizontal axis in the chart below gives you an estimate of the number of days that it will take you to get to your target blood levels. (naturalhealthperspective.com)
  • The primary outcome measure was percentage increase of normalization of serum 25(OH)D, defined as a 25(OH)D blood level minimum target of 30 ng/mL. (naturalmedicinejournal.com)
  • It has now been published that people with vitamin D blood levels under 30 ng/mL were more likely to have upper respiratory tract infections than those with sufficient levels. (peoplesrx.com)
  • (2) Ideally, having the blood levels tested by your doctor will determine the dose to take. (peoplesrx.com)
  • Anyone presenting with blood levels under 30 ng/mL may have to take between 5,000-10,000 IU per day for several weeks. (peoplesrx.com)
  • It is just as effective and gives you the same total Vitamin D, D2 and D3 status as a normal blood serum test and costs just £39 instead of the usual £66. (purehealthclinic.co.uk)
  • I have left the blood serum test on the shop for that reason. (purehealthclinic.co.uk)
  • Blood levels up to 100 ng/mL are generally safe with adequate vitamin K2. (greenmedinfo.com)
  • The RIA method is based on an antibody with specificity to 25-OH-D. The sample, antibody, and tracer are incubated for 90 min at 20-25 °C. Phase separation is accomplished after a 20-minute incubation at 20-25 °C with a second antibody-precipitating complex. (cdc.gov)
  • In a prospective study of 16,818 adults, there was an inverse association between vitamin D levels and colorectal cancer mortality. (vitality101.com)
  • Although this study did not show a decrease in overall cancer deaths associated with vitamin D levels, a sister study showed a 26% lower overall mortality rate for those with higher vitamin D levels. (vitality101.com)
  • 2 " 25-hydroxyvitamin D levels and the risk of mortality in the general population ," Arch Intern Med . (vitality101.com)
  • A 2021 meta-analysis of 54 observational clinical studies representing 1.4 million people provided further strong evidence that low 25(OH)D levels are associated with greater COVID-19 incidence, severity and mortality. (dsm.com)
  • The distribution of light-skinned populations is highly correlated with the low ultraviolet radiation levels of the regions inhabited by them. (wikipedia.org)
  • In the present study, age-related changes in SMM, the threshold of SMM with walking difficulty, intestinal nutrient absorption rate, and various serum factors were examined in Japanese populations of different ages. (tokushima-u.ac.jp)
  • Infection rates among lung transplant recipients appear to be higher than those encountered in other solid organ transplant populations, likely related to the unique exposure of the lung allograft to the external environment and to the greater magnitude of immunosuppression employed 1 , 2 . (ersjournals.com)
  • [ 2 ] Other boundaries of ADEM merge indistinctly with a wide variety of inflammatory encephalitic and vasculitic illnesses as well as monosymptomatic, postinfectious illnesses that should remain distinctfromADEM, such as acute cerebellar ataxia (ACA). (medscape.com)
  • RANKL Gene Polymorphism as a Potential Biomarker to Identify Acute Charcot Foot Among Indian Population With Type 2 Diabetes: A Preliminary Report. (cdc.gov)
  • However, it remains unknown as to why no relationship between vitamin D status and serum TSH levels in middle-aged and elderly individuals was found in this study. (hindawi.com)
  • The present study used a subsample collected from September to November 2011 to detect serum 25-hydroxyvitamin D [25(OH)D] levels, thyroid function, and thyroid autoantibodies. (hindawi.com)
  • The purposes of this study were to develop a sensitive, specific liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for detection of 25-hydroxyvitamin D(2) and D(3) and establish reference intervals for these analytes. (nih.gov)
  • Reference interval study results were compared with current 25(OH)D recommendations. (nih.gov)
  • Data from a 1981 United Arab Emirates study suggested that 45% of United Arab Emirates schoolchildren have a haemoglobin level of below 11 g/dl [2]. (who.int)
  • This study is examining whether dietary interventions to decrease sPTH levels will be associated with reductions in CVD risk. (drexel.edu)
  • The secondary outcome in this study was 25-hydroxyvitamin D serum level and nutritional status which was reviewed at the end of the trial. (vitamindwiki.com)
  • In a study of more than 190,000 Americans, researchers found that reduced 25(OH)D status was strongly associated with increased risk of a positive COVID-19 PCR test. (dsm.com)
  • The aim of the present research was to investigate serum vitamin D status in a case-control study in children with asthma and to study associations between vitamin D levels and certain immunological parameters. (dovepress.com)
  • To address this matter, we performed a method comparison study between the currently used routine 25(OH)D LC-MS/MS methods in the Netherlands and the UGhent RPM using healthy donor serum samples and an inter-laboratory method comparison to assess agreement between the different laboratories using routine patient serum samples. (cdc.gov)
  • Higher 25(OH)D levels were associated with lower TSH levels after controlling for age, FT4 and FT3 levels, thyroid volume, the presence of thyroid nodule(s), and smoking status in males. (hindawi.com)
  • Furthermore, it will always be easier to maintain higher levels of vitamin D during the summertime than it is in the winter. (naturalhealthperspective.com)
  • Although it is likely that higher serum 25-OHD levels play a role in the prevention of some disease states, there is insufficient evidence from randomised controlled trials to recommend higher targets. (vitamindwiki.com)
  • Correction of seasonal variation of 25-hydroxycalciferol with U.V. radiation dose. (cdc.gov)
  • We measured 25(OH)D levels during the same period to rule out seasonal variation. (mdfoundation.com.au)
  • 11 Several factors have been identified that increase the risk of obesity among refugees, including length of stay in the host country 12 - 14 , level of acculturation to U.S. lifestyles 15 - 17 , existing cultural beliefs and values 18 , and poor quality of housing. (cdc.gov)
  • A multiple regression analysis using the 25(OH)D cutoff value of 17 ng/mL instead of the generally admitted level of 20 ng/mL was performed to increase statistical power. (hindawi.com)
  • 25(OH)D was quantified from 968 of 11-17 years old individuals by ELISA. (biomedcentral.com)
  • 2 (16.60%), where most of the individuals with normal level were grouped. (bvsalud.org)
  • In conclusion, five diagnostic centers have performed a comparison with the 25(OH)D Ghent University reference measurement procedure in healthy donor serum samples and a comparison among themselves in patient serum samples. (cdc.gov)
  • So in response to high glucose level or in type 2 diabetes, how 25(OH)D impact glucagon secretion from islet α-cells as well as the islet function homeostasis between islet α-cells and β-cells should be elucidated, which can provide new strategies for treating glucose metabolism disorders. (researchsquare.com)
  • It has been recognized for some time that at temperate latitudes serum 25-hydroxyvitamin D [25(OH)D] exhibits an annual cyclic variation, with a peak in late summer and a nadir in late winter. (naturalhealthperspective.com)
  • Gut Microbiota and Complications of Type-2 Diabetes The gut microbiota has been linked to the emergence of obesity, metabolic syndrome and the onset of type 2 diabetes through decreased glucose tolerance and insulin resistance. (diabeticfootonline.com)