• Researchers used data from the National Health and Nutrition Examination Survey to look at the association between concentrations of triclosan in the urine with bone mineral density in women over age 20. (twournal.com)
  • The measurements revealed the higher the concentration of triclosan in the urine, the greater the risk of bone mineral density decline and osteoporosis. (twournal.com)
  • Elemental phosphorus was first isolated from human urine, and bone ash was an important early phosphate source. (wikipedia.org)
  • Here, we collected clinical evidence of bone loss by analyzing serum and X-rays of 25 non-bone metastatic gastric cancer patients. (aging-us.com)
  • Parathyroid hormone stimulates phosphate release from bone and inhibits renal reabsorption of phosphorus, resulting in phosphaturia. (medscape.com)
  • Serum 25(OH)D and bone mineral levels were measured in all subjects at the time of enrollment. (podiatryarena.com)
  • [1] Alkaline phosphatase is present in decreasing concentrations in the placenta, ileal mucosa, kidney, bone, and liver. (statpearls.com)
  • The majority of alkaline phosphatase in serum (more than 80%) is released from the liver and bone, and in small amounts from the intestine. (statpearls.com)
  • Vertebral fractures are the most common type of osteoporotic fracture in postmenopausal women.In both the osteoporosis treatment and prevention trials, raloxifene hydrochloride tablets therapy resulted in consistent, statistically significant suppression of bone resorption and bone formation, as reflected by changes in serum and urine markers of bone turnover (e.g., bone-specific alkaline phosphatase, osteocalcin, and collagen breakdown products). (drugcentral.org)
  • Patients with chronic kidney disease develop vascular calcification, owing to impaired calcium and phosphate metabolism. (bvsalud.org)
  • Rocaltrol is indicated for the correction of the abnormalities of calcium and phosphate metabolism in patients with renal osteodystrophy. (medicines.org.uk)
  • These conditions may result in failure of osteoid calcification (rickets) in children because of a disruption in the pathway of either vitamin D or phosphate metabolism. (medscape.com)
  • In addition, a renal tubular defect that reduces reabsorption may alter phosphate metabolism. (medscape.com)
  • Although phosphate production is a by-product of elemental phosphorus metabolism in humans, a normal phosphate concentration does not rule out an elemental phosphorus exposure. (cdc.gov)
  • Calcitriol increases inorganic phosphate levels in serumWhile this is desirable in patients with hypophosphatemiacaution is called for in patients with renal failure because of the danger of ectopic calcificationA non-aluminum phosphate-binding compound and a low-phosphate diet should be used to control serum phosphorus levels in patients undergoing dialysis. (izmirpersonelgiyim.com)
  • Prolonged storage at RT and delay testing/separation lead to hydrolysis of phosphate esters (eg, glucose phosphate, creatinine phosphate) and overestimation of phosphate concentration. (medscape.com)
  • they catalyze the hydrolysis of organic phosphate esters present in the extracellular space. (statpearls.com)
  • Increasing Pi concentration in OVX-simulated buffer solution increased the DS, with respect to OCP, upon the introduction of OCP and 44% OCP/Gel, but decreased the DS to a slightly saturated condition with 17% OCP/Gel, indicating that increasing the OCP in the Gel matrix tends to inhibit the hydrolysis of OCP into hydroxyapatite (HA). (elsevierpure.com)
  • In general, homeostasis of phosphate is regulated by the amount of phosphate in the plasma, which is mostly composed of inorganic phosphate. (medscape.com)
  • A phosphate in urine test measures the amount of phosphate in a urine (pee) sample that you collect over a 24-hour period. (medlineplus.gov)
  • Your kidneys control the amount of phosphate in your blood by removing most of the extra phosphate through your urine. (medlineplus.gov)
  • Further, the multivariate Cox regression analysis indicates that serum CD73 activity is an independent prognostic factor besides serum lactate dehydrogenase levels and the presence of brain metastases for both OS (p=0.009) and PFS (p=0.001). (bmj.com)
  • However, serum electrolytes levels were unchanged across groups. (researchsquare.com)
  • Low phosphate levels are an important limit to growth in a number of plant ecosystems. (wikipedia.org)
  • When rapid elevations of serum phosphate levels are documented, the most urgent associated problem is typically hypocalcemia with tetany, seizures, and hypotension. (medscape.com)
  • Abnormalities in serum magnesium, calcium, and potassium levels may also occur. (medscape.com)
  • Contexts Proper noun An Ancient Greek name for the planet Venus Noun Planet seen at dawn Proper noun An Ancient Greek name for the planet Venus Eosphorus Lucifer morning star Heosphoros Morning Star Phosphor Serum levels of phosphorus, parathyroid hormone, and calcium and risks of death and cardiovascular disease in individuals with chronic kidney disease: a systematic review and meta-analysis. (glassreplacement.pro)
  • All are characterised by hypophosphatemia, which is a condition of low levels of soluble phosphate levels in the blood serum and inside the cells. (glassreplacement.pro)
  • As this elevation can persist for up to 12 hours in the serum, the recommendation is to check the serum enzyme levels in a fasting state. (statpearls.com)
  • If you have a problem with your kidneys or your parathyroid glands, the phosphate levels in your urine may be too high or too low. (medlineplus.gov)
  • Calcium and phosphate work together, so problems with calcium levels can mean problems with phosphate levels as well. (medlineplus.gov)
  • So, your results may say "phosphorous levels" or "phosphate levels. (medlineplus.gov)
  • If your phosphate/phosphorous levels are not normal, it doesn't always mean you have a medical condition that needs treatment. (medlineplus.gov)
  • Also, children often have higher phosphate levels because their bones are still growing. (medlineplus.gov)
  • In the course of 14 weeks exposure to mercury (7439976) compounds, including MetHg (a fluid seed dressing), mercuric-chloride (7487947), ethyl mercuric-chloride (107277) and phenyl-mercuric- chloride (100561), in doses corresponding to 5 percent of the median lethal dose three times a week, enhanced levels of activity of malate-dehydrogenase and glucose-phosphate isomerase in blood serum were observed. (cdc.gov)
  • During this period, serum calcium levels should be determined at least twice weekly. (medicines.org.uk)
  • Serum calcium and creatinine levels should be determined at 1, 3 and 6 months and at 6 monthly intervals thereafter. (medicines.org.uk)
  • In premenopausal and postmenopausal women, serum levels of 25-OHD, phosphorus and calcium were stable across the age span. (who.int)
  • After informed consent was addition, there is no consensus concerning obtained, history was taken, blood samples the relationship of age to serum calcium, were collected and a physical examination phosphorus and PTH levels. (who.int)
  • Vascular smooth muscle cells are sensitive to changes in inorganic phosphate (Pi) levels. (revistanefrologia.com)
  • In addition, diets of highly productive laying hen strains are supplemented with high-quality inorganic phosphates to meet required levels of dietary available P or nonphytate P. The inefficient use of P makes monogastric animal species significant P excretors and thus a major source of P input into the environment [ 6 ]. (biomedcentral.com)
  • This process depends on adequate levels of ionized calcium and phosphate in the extracellular fluid. (medscape.com)
  • Cells were harvested by centrifugation, suspended in 50 mmol/L sodium phosphate buffer (pH 7.8) containing protease inhibitor (lysis buffer), and lysed by using a French press. (cdc.gov)
  • Laboratories, Inc., Mountain View, CA, USA), loaded onto a gravity-flow column, and washed with 50 mmol/L sodium phosphate (pH 7.8) containing 0.3 mol/L NaCl and 1 mmol/L - mercaptoethanol. (cdc.gov)
  • Bound protein was eluted with 100 mmol/L sodium phosphate (pH 6.0) containing 0.6 mol/L NaCl, 240 mmol/L imidazole, and 1 mmol/L -mercaptoethanol. (cdc.gov)
  • MurA (100 nmol/L) was incubated with various concentrations of UDP-N- acetylglucosamine (UNAG) (0-3 mmol/L) or phosphoenolpyruvate (PEP) (0-1 mmol/L) in 50 mmol/L Tris-HCl buffer (pH 7.5) at 37°C for 10 min. (cdc.gov)
  • PEP (for various concentrations of UNAG) or 3 mmol/L UNAG (for various concentrations of PEP) at 37°C for 20 min. (cdc.gov)
  • For inhibition assays, 100 nmol/L of wild-type or mutant MurA was incubated with various concentrations of fosfomycin and 3 mmol/L UNAG at 37°C for 10 min. (cdc.gov)
  • Serum phosphate or phosphorus normally ranges from 2.5-4.5 mg/dL (0.81-1.45 mmol/L) in adults. (medscape.com)
  • In adults, normal phosphate concentration in serum or plasma is 2.5 to 4.5 mg/dL (0.81 to 1.45 mmol/L) [10]. (glassreplacement.pro)
  • It appears that an HF concentration somewhere between 1.0 and 5.0 mmol/L (20 and 100 mg/L), applied to the stomach mucosa for at least 15 minutes, is the threshold for effects on the function and structure of the tissue (Whitford et al. (nationalacademies.org)
  • Treatment with Pi significantly increased intracellular calcium deposition and ALP activity, which were suppressed by PQS in a concentration-dependent manner. (biomedcentral.com)
  • Phosphate is the most abundant intracellular anion and is essential for membrane structure, energy storage, and transport in all cells. (medscape.com)
  • As in the case of other intracellular ions (eg, potassium, magnesium), a decrease in the level of serum phosphate ( hypophosphatemia ) should be distinguished from a decrease in total body storage of phosphate (phosphate deficiency). (medscape.com)
  • Hypophosphatemia is caused by the intracellular shift of phosphate from serum, increased urinary excretion of phosphate, decreased intestinal absorption of phosphate, or decreased dietary intake. (medscape.com)
  • Transient but pronounced hypophosphatemia, however, was also shown to occur in previously mastectomized periparturient cows, indicating that other mechanisms, such as depressed feed intake around calving, decreased GI motility related to the concomitantly occurring hypocalcemia, or hormonally driven shifts of inorganic phosphorus toward the intracellular space are likely to be at least equally important causal factors. (merckvetmanual.com)
  • The elemental phosphorus is only present as part of organic and inorganic compounds, and it is not present in a "free" form in the human body. (medscape.com)
  • Changes in activity of malate dehydrogenase and glucosephosphate isomerase in serum of rats exposed chronically to inorganic mercury and its aryl and alkyl compounds. (cdc.gov)
  • Inorganic mercury was found in the livers of animals given any of the compounds. (cdc.gov)
  • In this study, we investigated whether treatment with FYB-931, a novel bisphosphonate compound, prevents vascular calcification in rat aortic rings cultured in high-phosphate medium for 9 days, assessed by measurement of the calcium content and the degree of calcium deposition, visualized using von Kossa staining. (bvsalud.org)
  • Study reports suggested that high blood level of phosphate causes vascular ossification through the deposition of Ca 2+ and substantially alters fibroblast growth factor-23 (FGF23) and calcitriol. (diabeets.com)
  • Vascular calcification is a pathology characterized by the deposition of calcium-phosphate in cardiovascular structures, mainly in the form of hydroxyapatite crystals, resulting in ectopic calcification. (revistanefrologia.com)
  • The present study used calcification medium containing 3 mM inorganic phosphate (Pi) to induce rat VSMCs calcification. (biomedcentral.com)
  • FYB-931 dose-dependently prevented high phosphate-induced aortic calcification, but failed to rapidly cause the regression of high phosphate-induced vascular calcification once it had developed. (bvsalud.org)
  • In conclusion, treatment with FYB-931 prevents high phosphate-induced rat aortic vascular calcification by altering the dynamics of CPP transformation. (bvsalud.org)
  • Depending on the clinical situation, replacement options include dietary phosphate, oral phosphate preparations, and intravenous phosphate. (medscape.com)
  • Additional studies are needed on the link between phosphate concentrations and both CKD risk and morbidity in patients with CKD as well as the impact of dietary phosphorus restriction in patients with this disease. (glassreplacement.pro)
  • Dietary phosphate excess often leads to phosphate toxicity, ultimately potentiating kidney disease development. (diabeets.com)
  • Водно-натрієвий баланс Body fluid volume and electrolyte concentration are normally maintained within very narrow limits despite wide variations in dietary intake, metabolic activity, and environmental stresses. (msdmanuals.com)
  • Inorganic phosphate forms an ammonium phosphomolybdate complex having the formula ((NH4)3[PO4] (MoO3)12) with ammonium molybdate in the presence of sulfuric acid. (cdc.gov)
  • The most common assay for phosphate determination in clinical laboratories is based on a spectrophotometric method of complexing the serum inorganic phosphate with ammonium molibdate at low pH and formation of an absorbent phosphomolibdate complex that is measured by the spectrophotometer instrument. (medscape.com)
  • Serum electrolyte concentrations, and CSF and serum cell counts within 1-day of clinical sampling were obtained from clinical charts. (researchsquare.com)
  • The tissue-nonspecific alkaline phosphatases form most of the fraction circulating in serum and, therefore, are of clinical interest. (statpearls.com)
  • In practice, however, it is common to consider hypophosphatemia as a synonym for phosphorus deficiency, which is incorrect and potentially misleading, because blood phosphate concentration is a poor surrogate marker for the phosphorous level in the body. (merckvetmanual.com)
  • The exposure of rats to the test substance for 28 days by inhalation caused concentration-related lesions in larynx, trachea and lung. (europa.eu)
  • After 7 weeks of exposure about a four fold increase of malate-dehydrogenase (9001643) and two to three fold enhancement of glucose-phosphate isomerase activities were found relative to controls. (cdc.gov)
  • After 14 weeks of exposure to MetHg or ethyl mercuric- chloride, organic mercury was found in the liver at concentrations of 28.8 and 4 micrograms per gram of tissue, respectively. (cdc.gov)
  • Chronic exposure to inorganic arsenic (iAs) elevates reactive oxygen species (ROS) generation and up-regulates TGF-β signalling. (jcpjournal.org)
  • however, an elevated serum phosphate level might indicate that an exposure has occurred. (cdc.gov)
  • Finally, the nasal lesions associated with exposure to high concentrations of MeI in rats are best supported by a mode of action that involves glutathione (GSH) depletion in the nasal epithelial tissue. (cdc.gov)
  • The critical role phosphate plays in every cell, tissue, and organ explains the systemic nature of injury caused by phosphate deficiency. (medscape.com)
  • Causes of rickets related to phosphate deficiency are discussed in the article Hypophosphatemic Rickets . (medscape.com)
  • At the start of the study one sample of each concentration was sent to the analytical laboratory for determination of the correctness of the concentration of the test substance preparations. (europa.eu)
  • Phosphate concentration increases by 4-5 mg/dl per day in hemolyzed samples stored at 4°C or RT. (medscape.com)
  • An increase in serum albumin concentration of 1 g/dL increases protein-bound calcium by 0.8 mg/dL, whereas an increase of 1 g/dL of globulin increases protein-bound calcium by 0.16 mg/dL. (abdominalkey.com)
  • The degrees of supersaturation (DS) of the OVX-simulated buffer solutions, containing distinct inorganic phosphate (Pi) ion concentrations, after immersing OCP or OCP/Gel, were determined. (elsevierpure.com)
  • from Aeropyrum pernix and hence the reaction does not produce adequate quantities of inorganic phosphate in the buffer. (hifpathway.com)
  • Normal physiology and homeostasis of phosphate is complicated and is controlled by many different hormones. (medscape.com)
  • Due to the stoichiometric equilibrium of Ca and P and the tight regulation of the Ca/P ratio in serum and body fluids, measures to maintain mineral homeostasis during the laying period will affect both minerals. (biomedcentral.com)
  • The dimeric phosphoric anhydride inorganic pyrophosphate is then addressed as the central functional group that enables the POP anhydride linkage to function throughout biology via the dual properties of thermodynamic activation coupled to kinetic stability in aqueous medial at physiological pH values. (tutordale.com)
  • From inorganic pyrophosphate with one POP anhydride bond it is a short chemical traverse to ATP with two POP anhydride bonds in its kinetically stable tetra-anionic triphosphate side chain. (tutordale.com)
  • Treatment of hypophosphatemia is twofold: (1) correct any precipitating causes of hypophosphatemia, and (2) replace total body phosphates. (medscape.com)
  • Finally, a new class of phosphate-regulating factors, the so-called phosphatonins, have been shown to be important in phosphate-wasting diseases, such as oncogenic osteomalacia, X-linked hypophosphatemic rickets , autosomal dominant hypophosphatemic rickets , autosomal recessive hypophosphatemia, and tumoral calcinosis. (medscape.com)
  • Hypophosphatemia in the strict sense of the term refers to subnormal phosphorus concentrations in blood. (merckvetmanual.com)
  • Furthermore, the treatment dose-dependently inhibited the high phosphate-induced transformation from primary to secondary CPPs. (bvsalud.org)
  • Phosphate concentration is characterized by a high physiologic variation, depending on age, gender, physiologic state (eg, pregnancy), and even season (due to the seasonal variation of vitamin D, which is directly involved in the regulation of phosphate concentration). (medscape.com)
  • Processed foods contain high calories and are often enhanced with excess refined sugar, saturated and trans fat, Na + and phosphate-containing taste enhancers, and preservatives. (diabeets.com)
  • Eating a meal high in phosphorous or using laxatives with sodium phosphate can affect your results. (medlineplus.gov)
  • Lipemia (lactescence) is caused by increased triglycerides (usually as chylomicrons and, infrequently, from high concentrations of very low density lipoproteins). (eclinpath.com)
  • This will manifest as a high mean cell hemoglobin (MCH) and mean cell hemoglobin concentration (MCHC) so these results are often cancelled. (eclinpath.com)
  • Results in falsely increased absorbance readings of some analytes, particularly those that are endpoint reactions that are not blanked, e.g. total bilirubin, resulting in high concentrations of bilirubin. (eclinpath.com)
  • This is done by refrigerating and centrifuging the plasma/serum at high-speed, which forms a fat layer at the top of the sample. (eclinpath.com)
  • it can attach to negatively charged proteins and, in high concentrations, alter their overall charge, configuration, and function. (msdmanuals.com)
  • In this study, we analyzed the expression and activity of soluble CD73 in sera of patients with melanoma undergoing anti-PD-1± cytotoxic T-lymphocyte-associated antigen 4 therapy. (bmj.com)
  • Methods Soluble CD73 expression and activity were retrospectively analyzed in serum of a total of 546 patients with melanoma from different centers before starting treatment (baseline) with anti-PD-1 agents, nivolumab or pembrolizumab, and compared with those of 96 healthy subjects. (bmj.com)
  • Increased concentration of lipids and/or bilirubin (lipemic and icteric specimens) can interfere with accurate laboratory results. (medscape.com)
  • Solubility and stability of the test substance in the solvent/vehicle: Stability of formulations over 6 hours at room temperature under normal laboratory light conditions (concentration range 1-200 mg/mL) was determined as part of the analytical method development and validation study (Test Facility Study No. 513680). (europa.eu)
  • The normal range for total serum calcium must be established for each laboratory and varies according to the method used. (abdominalkey.com)
  • If previous treatment with estrogen resulted in hypertriglyceridemia, monitor serum triglycerides. (nih.gov)
  • Protein concentration was determined by using a Bradford assay with bovine serum albumin as the standard. (cdc.gov)
  • The standard line calibration material is human serum albumin with a range of 0.5 to 20 µg/mL. (cdc.gov)
  • Approximately 40% of total calcium is bound to serum proteins, and 80% to 90% of this calcium is bound to albumin. (abdominalkey.com)
  • Thus, it is obvious that changes in total serum calcium concentration cannot be used for the assessment of the effect on bound calcium concentration unless the changes in albumin and globulin concentrations also are determined. (abdominalkey.com)
  • The NOAEC for systemic toxicity is the highest tested concentration of 150 mg/m 3 . (europa.eu)
  • Serum white blood cell count increased in PHH compared to control (p=0.042) but there were no differences in serum cell differential across groups. (researchsquare.com)
  • Phosphate is also necessary in red blood cells for production of 2,3-diphosphoglycerate (2,3-DPG), which facilitates release of oxygen from hemoglobin. (medscape.com)
  • Correction of subnormal blood phosphate concentrations can be readily achieved through oral or parenteral administration of phosphate salts. (merckvetmanual.com)
  • Phosphorus blood test, phosphate test What is this test? (glassreplacement.pro)
  • Ionized calcium in normal serum, ultrafiltrates and whole blood determined by ion-exchange electrode. (abdominalkey.com)
  • To maintain cellular function, the body has elaborate mechanisms that maintain blood H + concentration within a narrow range-typically 37 to 43 nEq/L (37 to 43 nmol/L) with a pH of 7.43 to 7.37, where pH = − log [H + ]. Ideally, H + is 40 nEq/L (40 nmol/L) and pH = 7.40. (msdmanuals.com)
  • Complement, also known as alexin, cytase, or addiment, is generally defined as the portion of fresh blood serum or plasma which is not increased on immunization and which, when added to certain sensitized cells, combines with these sensitized cells and, under appropriate conditions, results in their destruction or death. (datapdf.com)
  • LOUIS PILLEMER independently showed that defibrinated blood, peptone blood, and blood serum exert measurable destructive influence upon bacteria. (datapdf.com)
  • This mode of action dictates the use of an internal dose measure in the risk assessment that is indicative of fetal iodide status, such as cumulative iodide concentration (area-under-the-curve or AUC) for iodide in fetal blood. (cdc.gov)
  • X-linked hypophosphatemic rickets and autosomal recessive hypophosphatemic rickets are the result of mutations in PHEX (a phosphate-regulating gene with homologies to endopeptidases on the X chromosome) and dentin matrix protein 1 ( DMP1 ), respectively. (medscape.com)
  • Globally, excessive utilization of phosphate-containing preservatives and additives contributes unswervingly to excessive phosphate intake through food. (diabeets.com)
  • Reactions were then quenched, and inorganic phosphate was quantified by using the Malachite Green Phosphate Assay Kit, (BioAssay Systems, Hayward, CA, USA) per the manufacturer's recommendations. (cdc.gov)
  • Determinations are best made on freshly separated serum, because heparin creates complexes with calcium, and the presence of fibrin may interfere with the structural integrity of the porous membrane used in the procedure. (abdominalkey.com)
  • In both groups of animals, plasma tyrosine decreased significantly from pre-TPN values despite a doubling of plasma phenylalanine concentrations suggesting that tyrosine may become a conditionally essential amino acid in rats provided TPN. (elsevierpure.com)
  • Rats receiving the TPN solutions containing 'conversion products' had fatty changes in periportal hepatocytes and increased serum activity of enzymes reflective of hepatic dysfunction. (elsevierpure.com)
  • Before filling, each serum bottle was fixed with a contactless optical oxygen sensor (Pyroscience, Aachen, Germany) on the inner side with silicone glue, and afterward were cleaned from organic contaminants with triple rinses of ethanol, 3% hydrogen peroxide, 10% hydrochloric acid, and MilliQ water, and were sterilized via autoclave. (bco-dmo.org)
  • In addition, communities and even health experts, including medical doctors, are not well-informed about the adverse effects of phosphate preservatives on human health. (diabeets.com)
  • The mechanisms involved in phosphate-related adverse effects are not explainable. (diabeets.com)
  • Phosphate concentration in plasma and serum will increased in unseparated specimens stored at room temperature for longer time. (medscape.com)
  • If the specimen cannot be analyzed within 1 hour, the specimens should be centrifuge and the serum or plasma should be removed from the cells within 2 hours of collection. (medscape.com)
  • As phosphates concentration is higher inside RBC, hemolysis will lead to increase in phosphates plasma/serum concentration. (medscape.com)
  • Increased androgen plasma concentrations suppress gonadotropin-releasing hormone (reducing endogenous testosterone), luteinizing hormone, and follicle-stimulating hormone by a negative-feedback mechanism. (empowerpharmacy.com)
  • Generally, the amount of this sex-hormone binding globulin in the plasma will determine the distribution of testosterone between free and bound forms, and the free testosterone concentration will determine its half-life. (nih.gov)
  • We observed a distinct peak in CH 4 concentration at the chlorophyll- a maximum, caused by either in situ CH 4 production or other CH 4 inputs such as lateral transport from the littoral zone. (copernicus.org)
  • Transfer of P as the PO32 group opens the biological world of phosphate monoesters brought about by phosphoryl transfer enzymes and includes all the kinases for low molecular weight metabolites and for proteins in their myriads. (tutordale.com)
  • There was no significant correlation between creatinine clear- ance or serum PTH ( r = -0.016, P = 0.66) and 25-OHD ( r = 0.012, P = 0.74). (who.int)
  • Reactions were initiated with 300 mol/L PEP, and inorganic phosphate was quantified as described. (cdc.gov)