• As an example, cancer antigen 125 (CA125) and human epididymis protein 4 (HE4) have been detected in the serum of ovarian cancer patients. (biomedcentral.com)
  • In this study, we investigated the role of serum HE4 in comparison to CA125 in the detection of recurrent disease in patients during follow-up.615 ovarian cancer patients treated at Shandong Provincial Tumor Hospital between 2008 and 2014 were included in the retrospective study. (journalcra.com)
  • Serum HE4 and CA125 were analyzed during follow-up using the ARCHITECT assay. (journalcra.com)
  • Compared with the glycoantigen CA125, which is less disturbed by external factors, the cancer antigen 125 marker is generally disturbed by many factors such as inflammation, endometriosis, and pregnancy, which can cause elevation, whereas human epididymis protein 4 (HE4) is generally not affected by these factors. (sekbio.com)
  • The combined test of human epididymis protein 4 (HE4) and CA125 is more meaningful for detecting ovarian cancer. (sekbio.com)
  • Human epididymis protein 4 (HE4) combined with CA125 has high clinical value in the early diagnosis of epithelial ovarian cancer, disease monitoring, postoperative recurrence monitoring, as well as in the differential diagnosis of benign tumors. (sekbio.com)
  • The objective of this study was to investigate the sensitivity and specificity of CA125 and human epididymis protein 4 (HE4) in detection of EC. (ijwhr.net)
  • Our study showed that serum HE4 levels alone and in combination with CA125 are sensitive markers in diagnosing EC. (ijwhr.net)
  • There was a significant decrease in sperm density of the epididymis after exposure to 100, 200, or 400 mg ZnO NPs/kg/day compared to the vehicle control group (Physique 1B), indicating that ZnO NPs exposure significantly inhibited spermatogenesis. (irpa2006europe.com)
  • The sperm in the epididymis are indicated by an asterisk. (irpa2006europe.com)
  • among them, the glycoprotein IZUMO1 is the major protein involved in sperm-oocyte fusion. (ijbs.com)
  • In our work, we characterized subcellular organization of F-actin in human high- and low-quality spermatozoa (A- and B-SPZ), respectively, showing that F-actin over-expression in sperm head of B-SPZ affected IZUMO1 localization. (ijbs.com)
  • In mammalian spermatozoa, actin represents the most abundant cytoskeletal protein localized in sperm head which actively participates in several structural and biochemical functions such as: i) head shaping occurring during spermiogenesis, ii) sperm capacitation and iii) acrosome reaction (AR) [ 1 - 4 ]. (ijbs.com)
  • Here, we examined the expression of the HE4 gene and protein in a large series of normal and malignant adult tissues by oligonucleotide microarray and tissue microarray, respectively. (nature.com)
  • Using tissue microarrays and full tissue sections of normal and 448 neoplastic tissues, HE4 immunoreactivity was found in normal glandular epithelium of the female genital tract and breast, the epididymis and vas deferens, respiratory epithelium, distal renal tubules, colonic mucosa, and salivary glands, consistent with HE4 gene expression. (nature.com)
  • Here, we used oligonucleotide and tissue microarrays to survey HE4 gene and protein expression in a large group of malignant and normal tissues from adults. (nature.com)
  • The enriched proteins of M1-EVs were involved in proinflammatory pathways and those of M2-EVs were associated with immunomodulation and tissue remodeling. (bvsalud.org)
  • As can be seen from Physique 1C,D, ZnO NPs significantly increased the levels of apoptosis-related proteins, including cleaved Caspase-8, cleaved Caspase-3 and Bax, along with a decreased protein level of Bcl 2 in the testis tissue, which indicates that ZnO NPs induced apoptosis of the testis tissue. (irpa2006europe.com)
  • Intended Use Human APCS ELISA Kit allows for the in vitro quantitative determination of APCS , concentrations in serum, Plasma , tissue homogenates and Cell culture supernates and Other biological fluids. (biobool.com)
  • Tissue extracts of Mouse Testis (Lane 6) and Mouse Kidney (Lane 7) were electrophoresed using NuPAGE™ 3-8% Tris-Acetate Protein Gel (Product # EA0378BOX). (thermofisher.com)
  • This Human PFN1 ELISA Kit was designed for the quantitative measurement of Human PFN1 protein in serum, plasma, tissue homogenates. (cusabio.com)
  • A live attenuated virus vaccine of duck embryo or human diploid cell tissue culture origin, used for routine immunization of children and for immunization of nonpregnant adolescent and adult females of childbearing age who are unimmunized and do not have serum antibodies to rubella. (lookformedical.com)
  • We discuss the implications of our results in terms of the potential role for HE4 in histopathologic diagnosis, as a serum tumor biomarker, and as a therapeutic target. (nature.com)
  • Negativization of CA 125 and HE4 following the third cycle of chemotherapy correlated with long progression-free survival (the odds ratios [ORs] being 9.1 and 5.5, respectively), as did "biomarker serum levels lower than the mean value in the affected population at the time of diagnosis" (ORs = 3.7 and 3.4, respectively). (medscape.com)
  • Human Epididymis Protein (HE4) is a new promising biomarker in detecting recurrent ovarian cancer. (journalcra.com)
  • Ulas KUMBASAR, Zeliha G. DIKMEN, Yigit YILMAZ, Burcu ANCIN, Erkan DIKMEN, Rıza DOGAN Serum Human Epididymis Protein 4 (HE4) As A Diagnostic And Follow-Up Biomarker in Patients With Non-Small Cell Lung Cancer. (thod.org)
  • Human epididymis protein 4 (HE4) is a tumor cell surface antigen in female ovarian cancer. (whdsbio.cn)
  • HE4, called human epididymis protein 4, is a sensitive indicator for detecting ovarian cancer and is one of the antigen markers . (sekbio.com)
  • This test measures the amount of a protein called CA-125 (cancer antigen 125) in a sample of your blood. (medlineplus.gov)
  • The Prostate-Specific Antigen (PSA) Serum Test measures PSA levels in the blood to screen for prostate cancer or other benign prostate conditions. (walkinlab.com)
  • Cancer antigen 125 (CA-125) is a protein found in ovarian cancer cells. (walkinlab.com)
  • This CEA Blood Test measures the protein in the blood called carcinoembryonic antigen (CEA). (walkinlab.com)
  • The Prostate-specific Antigen (PSA) Free:Total Ratio Blood Test compares Total PSA (the amount that is bound to blood proteins) to Free PSA (floats unbound in the blood). (walkinlab.com)
  • G) The serum testosterone concentration. (irpa2006europe.com)
  • Scientists additionally discovered 25 and 50mg/kg measurements prompted expanded testicular and serum testosterone, testicular phosphatase action, FSH, and LH focuses each day of the study while 100mg/kg prompted a heartbeat reaction on the first and seventh days. (proteinfactory.com)
  • In any case, serum testosterone, progesterone, LH, and FSH expanded in the 25 and 50mg/kg body weight bunches. (proteinfactory.com)
  • Serum testosterone levels are generally above the normal range for women, while serum estradiol levels are normal or high and serum LH and FSH levels are also high 7 . (bvsalud.org)
  • In addition, these proteins can also associate with claudin, occludin and F-actin, at tight junction stands, where they provide a linkage between the actin cytoskeleton and the tight junction. (thermofisher.com)
  • The role of single preoperative serum CA-125 levels in predicting pelvic or paraaortic lymph node metastasis in patients operated for epithelial ovarian cancer has been investigated. (hindawi.com)
  • Currently, serum CA-125 levels, also accepted as a predictive and prognostic factor for ovarian cancers, are used for monitoring response after treatment and survival of patients. (hindawi.com)
  • Up to 80% of women with ovarian carcinoma of epithelial origin have elevated serum CA 125 levels, with the frequency of elevation correlating with the clinically detected stage. (medscape.com)
  • However, tumor recurrence may occur in the setting of normal CA 125 levels, and serum measurements do not replace imaging and physical examination of the patient. (medscape.com)
  • HE4 tumour marker is expressed at high levels in ovarian cancer tissues and serum, as well as in endometrial, lung, colon, and breast cancers. (sekbio.com)
  • Increased percentage of detectable serum human epididymis protein 4 (HE4) levels have been used as an aid to monitor the recurrence and progression of disease in patients with invasive epithelial ovarian cancer. (sekbio.com)
  • The association of human epididymis protein 4 (HE4) levels with clinical responsiveness to treatment or recurrence status in patients with ovarian cancer examined by CT imaging suggests that human epididymis protein 4 (HE4) may be an important indicator of ovarian cancer recurrence. (sekbio.com)
  • Human investigations suggest that fenugreek can be beneficial as an adjunct in controlling high blood glucose and lipid levels in people with diabetes. (lww.com)
  • Significantly, these investigations found that high blood ethanol levels, rather than acetaldehyde levels, were related with acute liver injury as measured by increased serum transaminases and hepatic Endoplasmic Reticulum (ER) stress. (scholarsresearchlibrary.com)
  • Importantly, high-fat diet feeding combined with acute ethanol binge had the most pronounced effect of elevating serum transaminases and acetaldehyde levels compared with binge or high-fat diet challenge alone, thus confirming the aforementioned comorbidity of obesity in humans that take in binge drinking compared the effects of intragastric and intraperitoneal injection of ethanol in wild-type mice to the effects of intraperitoneal administration of acetaldehyde in wild-type mice. (scholarsresearchlibrary.com)
  • thus, high blood ethanol levels were related with hepatic fatty acid production as well as enhanced lipolysis and adipocyte mortality in epididymis fat. (scholarsresearchlibrary.com)
  • This resulted in higher serum levels of free fatty acids and significant increases in FAEEs (palmitic, stearic, and oleic acid ethyl esters). (scholarsresearchlibrary.com)
  • Finasteride causes a decrease in serum PSA levels. (nih.gov)
  • Every one of the three measurements of Bulbine Natalensis expanded gonad size and protein levels in the testicles, yet just in the 25 and 50mg/kg doses expanded testicular glycogen and cholesterol levels. (proteinfactory.com)
  • The percentage of PAS-positive glycogen areas were correlated with the immunoexpression of GLUT-2, serum levels of T and DHT were correlated with GLUT-2, IR, and AR transcript levels, and serum glucose concentration was correlated with the age of animals and with the GLUT-2 mRNA by Spearman's rank correlation coefficients. (nih.gov)
  • In F1:Fin rats the serum levels of T and DHT negatively correlated with androgen receptor mRNA. (nih.gov)
  • Public health officials and others concerned with appropriate actions to take at hazardous waste sites may want information on levels of exposure associated with more subtle effects in humans or animals (LOAELs) or exposure levels below which no adverse effects (NOAELs) have been observed. (cdc.gov)
  • A study by Potenza et al indicated that in patients with epithelial ovarian cancer, combined analysis of CA 125 and human epididymis protein 4 (HE4) is an effective indicator of success in chemotherapy. (medscape.com)
  • Transient Receptor Potential Vanilloid subfamily member 6 (TRPV6) is an epithelial Ca2+ channel that belongs to the transient receptor potential family (TRP) of proteins. (wikipedia.org)
  • TRPV6 was also called calcium transport protein 1 (CaT1) initially although the names epithelial calcium channel 2 (ECaC2) and CaT1-like (CaT-L) were also used in early studies to describe the channel. (wikipedia.org)
  • More importantly, proteins in M1-EVs promoted viability, proliferation, and activation of T lymphocytes, whereas proteins in M2-EVs potently protected the tight junction structure and barrier integrity of epithelial cells from disruption. (bvsalud.org)
  • Human epithelial protein (HE4) also has some sensitivity in the diagnosis of endometrial cancer. (sekbio.com)
  • human, mouse or other beta β- and alpha α- defensins are expressed by neutrophils ( α- ), lymphocytes and epithelial cells. (b-defensin.com)
  • However, it is still to be determined whether the long version of the TRPV6 protein is the dominant form in different tissues. (wikipedia.org)
  • We tested various specimens (blood, cerebrospinal fluid, intraocular fluid, serum, and tissues) from the organ donor and recipients by serology, RT-PCR, immunohistochemistry, metagenomic next-generation sequencing, and host gene expression, and conducted a traceback of blood transfusions received by the organ donor. (cdc.gov)
  • GENTAUR supplies anti-defensins, monclonals, polyclonals antisera and recombinant DEFs or peptides of defensin.Rhesus Monkeys proteins are often measured by ELISA on serum or plasma since consensus epitopes with the human ELISA are used for producing the antibodies of these ELISA test kits. (b-defensin.com)
  • A live attenuated virus vaccine of chick embryo origin, used for routine immunization of children and for immunization of adolescents and adults who have not had measles or been immunized with live measles vaccine and have no serum antibodies against measles. (lookformedical.com)
  • HE4 is one of more than 8900 different human genes represented on U95a GeneChips (Affymetrix, Santa Clara, CA, USA), which we used previously to develop a molecular classification of 175 human carcinomas based on patterns of gene expression. (nature.com)
  • The effects of PTE on osteoclast differentiation and the expression of osteoclast-specific genes and proteins were determined. (researchgate.net)
  • Additionally, PTE efficaciously suppressed the expression of key osteoclast-specific genes and proteins. (researchgate.net)
  • Guido D'ANGELO, Claudio VILLA, Maria Antonietta ALBERTI, Isabella SPERDUTI, Annarita SFERRAZZO, Silvia VILLA Serum and Urine Free Light Chain Cut-off Detection for a Rational Employment of the Bence- Jones Proteinuria Test in Presence of Monoclonal Gammopathy. (thod.org)
  • The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera. (pp1b.com)
  • The aim of this study was to perform the proteomic analysis of ascitic fluids of Mexican patients with ovarian carcinoma, in order to detect proteins with a differential expression pattern in the continuing search to identify biomarkers for this disease. (biomedcentral.com)
  • It is usually related to infections in the URINARY TRACT, which likely spread to the EPIDIDYMIS and then the TESTIS through either the VAS DEFERENS or the lymphatics of the SPERMATIC CORD. (lookformedical.com)
  • Specificity This assay has high sensitivity and excellent specificity for detection of Human APCS. (biobool.com)
  • TRPV6 protein bears a 40-a.a-long N-terminal extension in placenta and in some physiological settings in comparison to the annotated version of the protein used in biological studies. (wikipedia.org)
  • The HE4 (WFDC2) gene encodes a WAP-type four disulphide core domain-containing protein with a presumptive role in natural immunity. (nature.com)
  • In a series of 175 human adult tumors, gene expression was highest in ovarian serous carcinomas. (nature.com)
  • What does this gene/protein do? (cancerindex.org)
  • The human TRPV6 gene is located on chromosomal locus 7q33-34 close to its homolog TRPV5 on 7q35. (wikipedia.org)
  • The TRPV6 gene in human encodes for 2906 bp-long mRNA. (wikipedia.org)
  • Two alleles of the TRPV6 gene have been identified in humans (originally noted as CaT-La and CaT-Lb). These alleles exhibit coupled polymorphisms generating two versions of the same gene. (wikipedia.org)
  • The antibody prepared with this protein can be used as the core material of the early diagnosis kit for ovarian cancer, and the protein itself can also be used as a calibrator. (whdsbio.cn)
  • 1992) that chloroquine treatment of rats eventually would lead to infertility by resulting in late germ cell developmental with depletion of spermatids (Abayomi O, 1992).This suggested the requirement for the quinine to occupied a place as a male contraceptive agent in humans (Osinubi et al. (researchgate.net)
  • Due to species-specific findings, which are considered as not relevant for humans, a NOAEL could not be determined for male rats. (europa.eu)
  • Our research has also shown that the offspring of rats exposed to finasteride have an altered T-DHT ratio and show changes in their testes and epididymides. (nih.gov)
  • ZO-1 is a protein located on a cytoplasmic membrane surface of intercellular tight junctions. (thermofisher.com)
  • Humans are the only natural host of the mumps virus, an RNA virus in the family Paramyxoviridae. (covid19liveupdates.org)
  • Following 7 days, in every one of the three gatherings devouring Bulbine Natalensis, testicles weight expanded however epididymis, fundamental vesicle, and prostate weights stayed unaltered. (proteinfactory.com)
  • However, hormone receptor negative (triple negative) tumors overwhelmingly overexpress p53 protein in tumor cells. (cancerindex.org)
  • The proteins of EVs and their parental macrophages were subjected to quantitative proteomics analyses, followed by bioinformatic analyses. (bvsalud.org)
  • The signature proteins of EVs shared a limited subset of the proteins of their respective progenitor macrophages, but they covered many of the typical pathways and functions of their parental cells, suggesting their respective M1-like and M2-like phenotypes and functions. (bvsalud.org)
  • After elimination of abundant proteins (Albumin/IgGs) samples were processed for 2D electrophoresis and further protein identification by Mass Spectrometry (MALDI-TOF). (biomedcentral.com)
  • The Beta 2 Microglobulin Serum Test helps evaluate the severity and prognosis of certain cancers and screens for kidney disorders. (walkinlab.com)
  • The human genome encodes for 28 TRP channels, which include six TRPV channels. (wikipedia.org)
  • The patient tested negative for hantavirus RNA, but next-generation sequencing of a serum sample yielded a complete genome for Rio Negro virus. (cdc.gov)
  • Human epidemiological studies reveal that a p53 single-nucleotide polymorphism (SNP) at codon 72, encoding proline (P72) or arginine (R72), is associated with differential risk of several cancers, including BrCa. (cancerindex.org)
  • The Alpha-Fetoprotein Serum Test helps to screen for and monitor the treatment of liver, testicular, and ovarian cancers. (walkinlab.com)
  • A Chromogranin A Serum Test is used to detect neuroendocrine cancers. (walkinlab.com)
  • Reactive oxygen species produced by CYP 2 E 1 create oxidative stress, which leads to peroxidation of lipids, proteins, and DNA, resulting in cellular stress and injury. (scholarsresearchlibrary.com)
  • The type species of RUBULAVIRUS that causes an acute infectious disease in humans, affecting mainly children. (lookformedical.com)
  • A genus of the family PARAMYXOVIRIDAE (subfamily PARAMYXOVIRINAE) where all the species have hemagglutinin and neuraminidase activities but lack a C protein. (lookformedical.com)
  • CONCLUSION: This study has yielded a comprehensive unbiased dataset of protein cargos in macrophage-derived EVs, provided a systemic view of their potential functions, and highlighted the important engagement of protein cargos in the pathophysiological functions of these EVs. (bvsalud.org)
  • References tries, where few resources are available to ensure proper treatment and where human immunodeficiency virus (HIV) infection may be common. (cdc.gov)
  • Although there are limitations to this study, such as the use of rodents with different metabolic capacities than humans, it identifies novel targets that should be further explored using more translational approaches aimed at preventing acute alcohol toxicity or treating alcohol-associated liver disease. (scholarsresearchlibrary.com)
  • Research on humans, rodents, and cell lines have each confirmed that Pu-erh tea indeed displays weight-loss and blood lipid lowering effects. (researchgate.net)
  • No significant cross-reactivity or interference between Human APCS and analogues was observed. (biobool.com)
  • Loss of PFN1 in tumor cells has been associated with lymph node invasion and metastasis in other tumor types, strengthening the argument that the protein has the potential to be a tumor suppressor in late-stage oral squamous cell carcinoma. (cusabio.com)
  • Human epididymis protein 4 (HE4) is not expressed in the normal ovarian surface epithelium, while it is significantly highly expressed in serous ovarian cancer and endometrioid ovarian cancer. (sekbio.com)
  • T he HE4 protein is detected in large amounts in the serum of patients with ovarian cancer. (medicinesonline.org.uk)
  • This protein can be found on some cancer cell types. (walkinlab.com)
  • The purpose of the current study was to investigate single preoperative serum CA-125 level in predicting lymph node metastases in Turkish patients with EOC. (hindawi.com)
  • Serum samples were prospectively obtained from all patients. (ijwhr.net)
  • Scope includes mutations and abnormal protein expression. (cancerindex.org)