• The aim of the study was to measure glial fibrillary acidic protein (GFAP) as a marker of brain damage in the serum of patients that underwent internal carotid endarterectomy (CEA). (viamedica.pl)
  • Serum GFAP levels were measured by a commercially available enzyme-linked immunosorbent assay (ELISA). (viamedica.pl)
  • The study revealed that CEA does not change serum GFAP levels. (viamedica.pl)
  • The sections were stained for the astrocyte marker glial fibrillary acidic protein (GFAP, green) and for viral capsid protein (rabbit serum 1:1,000, red). (cdc.gov)
  • Aim: To determine the ability of serum glial fibrillary acidic protein (GFAp) and tau protein to predict neurological outcome after out-of-hospital cardiac arrest (OHCA). (lu.se)
  • Conclusions: At 48 and 72 h, serum both GFAp and tau demonstrated excellent accuracy in predicting outcomes after OHCA but were not superior to NSE. (lu.se)
  • Background: Glial fibrillary acidic protein (GFAP) is a promising candidate blood-based biomarker for Alzheimer's disease (AD) diagnosis and prognostication. (edu.au)
  • Methods: We evaluated plasma, serum, and cerebrospinal fluid (CSF) GFAP in families with autosomal dominant AD (ADAD), leveraging the predictable age at symptom onset to determine changes by stage of disease. (edu.au)
  • Serum GFAP showed similar relationships, but these were less pronounced for CSF GFAP. (edu.au)
  • Highlights: Plasma glial fibrillary acidic protein (GFAP) elevations appear a decade before expected symptom onset in autosomal dominant Alzheimer's disease (ADAD). (edu.au)
  • Plasma and serum GFAP carried similar information in ADAD, while cerebrospinal fluid GFAP did not. (edu.au)
  • Regional and cellular dystrophin distribution was evaluated in both human and rat hippocampi and in rat cerebellar tissue by immunofluorescent colocalization with neuronal (NeuN and calbindin) and glial (GFAP) markers. (frontiersin.org)
  • Objective: To test the hypothesis that serum levels of glial fibrillary acidic protein (GFAP) and neurofilament light chain (NfL), which are intermediate astrocyte and neuron filaments, respectively, are clinically useful biomarkers of disease activity and disability in neuromyelitis optica spectrum disorders (NMOSD). (datadryad.org)
  • Results: For both GFAP and NfL, CSF and serum levels were strongly correlated. (datadryad.org)
  • This ELISA kit applies to the in vitro quantitative determination of Mouse GFAP concentrations in serum, plasma and other biological fluids. (elabscience.com)
  • Cells were initially studied for effects on proliferation, morphology, and glial fibrillary acidic protein (GFAP) staining. (northwestern.edu)
  • Multiparameter flow cytometry was then used to analyze GFAP, c-myc protein, and total cellular protein fluorescence and to relate them to changes in cell cycle distribution. (northwestern.edu)
  • Glial fibrillary acidic protein (GFAP) is a measure of damage to glial cells, which support neurons. (scitechdaily.com)
  • A secondary set of findings came from comparing NFL, GFAP, and UCHL1 levels in the serum of COVID-19 patients against levels of the same markers in the plasma of non-COVID Alzheimer's patients (figure 3). (scitechdaily.com)
  • Investigators sought to better understand the pathological correlates associated with increased serum GFAP in the normal appearing white matter of patients with multiple sclerosis. (neurologyadvisor.com)
  • Increased serum glial fibrillary acidic protein (GFAP) levels are associated with measurable microdamage in the normal appearing white matter (NAWM) of patients with multiple sclerosis (MS), suggesting that GFAP could be used as a biomarker for pathology-related astrocytopathy in MS, according to study results published in Multiple Sclerosis and Related Disorders . (neurologyadvisor.com)
  • The study researchers concluded that their study "supports the use of serum GFAP as a biomarker for MS-disease associated astrocytopathy and diffuse white matter damage. (neurologyadvisor.com)
  • High Plasma GFAP Level Predicts Disability in Progressive MS A high level of glial fibrillary acidic protein (GFAP) in the blood may predict worsening disability in patients with secondary progressive multiple sclerosis (MS), according to investigators. (medscape.com)
  • The profiles of serum autoantibodies to neurofilament triplet proteins, myelin basic protein, and glial fibrillary acidic protein were measured in order to characterize changes occurring as a result of OPIDP. (cdc.gov)
  • Marked increases in serum immunoglobulin G (IgG) autoantibodies to glial fibrillary acidic protein and to neurofilament 200 were observed after the development of OPIDP. (cdc.gov)
  • 2023. Pediatric reference intervals for serum neurofilament light and glial fibrillary acidic protein using the Canadian Laboratory Initiative on Pediatric Reference Intervals (CALIPER) cohort. . (icord.org)
  • In this study, researchers investigated the use of serum neurofilament light chain (sNfL) and glial fibrillary acidic protein (sGFAP) as biomarkers to support diagnosis. (rarediseasesnetwork.org)
  • Kessler C, Ruschil C, Abdelhak A, Wilke C, Maleska A, Kuhle J, Krumbholz M, Kowarik MC, Schüle R. Serum Neurofilament Light Chain and Glial Fibrillary Acidic Protein as Biomarkers in Primary Progressive Multiple Sclerosis and Hereditary Spastic Paraplegia Type 4. (rarediseasesnetwork.org)
  • BACKGROUND AND AIMS: To investigate the prognostic value of blood neurofilament light chain protein (NfL) levels in the acute phase of coronavirus disease 2019 (COVID-19). (bvsalud.org)
  • Serum neurofilament light chain (sNfL) is an intensely investigated biomarker in multiple sclerosis (MS). The aim of this study was to explore the impact of cladribine (CLAD) on sNfL and the potential of sNfL as a predictor of long-term treatment response. (bvsalud.org)
  • Serum neurofilament light chain (sNfL) and serum glial fibrillary acidic protein (sGFAP) are markers of neurodegeneration and astrocytic activation, which are hallmarks of progression MS, the researchers noted. (neurodiem.gr)
  • ECTRIMS 2021 Serum Neurofilament Light Level May Predict MS Progression High serum levels of neurofilament light are associated with an increased risk for disease progression at 2 years. (medscape.com)
  • Current research is underway to diagnose the clinical traumatic encephalopathy syndrome, and subsequently chronic traumatic encephalopathy, in living patients using clinical evaluation criteria and biomarkers, such as serum, cerebrospinal fluid, and imaging studies. (medlink.com)
  • Serum biomarkers of neuronal injury will be measured at 0-, 24-, 48-, 72- and 96-h post-vigabatrin. (biomedcentral.com)
  • The levels of several glial and neuronal plasma biomarkers have been found to increase during the acute phase in COVID-19 patients with neurological symptoms. (bvsalud.org)
  • In patients with progressive multiple sclerosis (MS), serum biomarkers may help predict future disease activity and progression, according to researchers in Boston, USA. (neurodiem.gr)
  • validating variations in serum 100B levels with standard modalities for prognosticating the extent of CNS damage: alterations in neuroimaging, cerebrospinal pressure, and other brain molecular markers (neuron specific enolase and glial fibrillary acidic protein). (wikipedia.org)
  • Serum autoantibody titers to nervous system proteins may be useful markers of neuropathy. (cdc.gov)
  • Blood markers in the COVID patient group were measured in blood serum (the liquid part of blood that has been made to clot), while those in the Alzheimer's study were measured in plasma (the liquid blood fraction that remains when clotting is prevented). (scitechdaily.com)
  • OBJECTIVES: We determined MFAP4 CNS expression and measured cerebrospinal fluid (CSF) and serum levels. (bvsalud.org)
  • Autoimmune glial fibrillary acidic protein astrocytopathy is a form of monophasic or relapsing steroid-responsive meningoencephalomyelitis often accompanied by a hallmark radial periventricular brain MRI enhancement pattern and inflammatory cerebrospinal fluid with lymphocytic pleocytosis. (medlink.com)
  • In the developing CNS it acts as a neurotrophic factor and neuronal survival protein. (wikipedia.org)
  • The excellent negative predictive value of S100B in several neurological conditions is due to the fact that serum S100B levels reflect blood-brain barrier permeability changes even in absence of neuronal injury. (wikipedia.org)
  • and Group 6, polyclonal (non-specific) immunoglobulin G (IgG)-positive serums. (bvsalud.org)
  • Dermal sensitization (50% and 25% w/v) with TMA and an inhalation challenge of 15 mg/m3 TMA-induced apneas, laryngeal inflammation, increased numbers of eosinophils, neutrophils and macrophages in bronchoalveolar lavage (BAL), and increased immunoglobulin E levels in serum and lung tissue. (cdc.gov)
  • Candidate models for hazard identification investigate respira- ment of HMW asthma is associated with elevated tory allergic potential in rodents on the basis of serum IgE or immunoglobulin E (IgE) levels, the predominance of Th2 cytokine fingerprinting in skin and skin-draining lymph nodes following dermal application of the chemical (Dearman, Skinner, and Humphreys 2003). (cdc.gov)
  • Dystrophin is part of a protein complex that connects the cytoskeleton to the extracellular matrix. (frontiersin.org)
  • BACKGROUND: Microfibrillar-associated protein 4 (MFAP4) is an extracellular matrix protein not previously described in the human central nervous system (CNS). (bvsalud.org)
  • Serum levels of S100B increase in patients during the acute phase of brain damage. (wikipedia.org)
  • An extremely important application of serum S100B testing is in the selection of patients with minor head injury who do not need further neuroradiological evaluation, as studies comparing CT scans and S100B levels have demonstrated S100B values below 0.12 ng/mL are associated with low risk of obvious neuroradiological changes (such as intracranial hemorrhage or brain swelling) or significant clinical sequelae. (wikipedia.org)
  • Both were higher in the serum of patients with NMOSD than in HCs (both p (datadryad.org)
  • Amyloid Beta 40 and 42 are proteins are known to build up in patients Alzheimer's disease. (scitechdaily.com)
  • In this repeated cross-sectional cohort study, anonymous residual blood samples from pediatric patients aged 0-17 years were collected in three time-periods (Oct.-Nov. 2020, April 2021, and June-July 2021) and analyzed for SARS-CoV-2 Spike protein (anti-S) and nucleocapsid (anti-N) antibodies using commercial antibody assays. (degruyter.com)
  • To evaluate the measurement of zonulin level and antibodies of zonulin and other tight junction proteins in the blood of controls and celiac disease patients. (drperlmutter.com)
  • Elevation of zonulin level at 2SD above the mean was demonstrated in 37% of celiac disease patients, while antibodies against zonulin, occludin and other tight junction proteins was detected in up to 86% of patients with celiac disease. (drperlmutter.com)
  • 2023. Roles of peripheral lipoproteins and cholesteryl ester transfer protein in the vascular contributions to cognitive impairment and dementia. . (icord.org)
  • Background: Purkinje cytoplasmic autoantibody type 1 (PCA-1)/anti-Yo autoimmunity is a common high-risk paraneoplastic neurological disorder, traditionally attributed antigenically to cerebellar degeneration-related protein 2 (CDR2), predominantly affecting women with gynecologic or breast adenocarcinoma. (bvsalud.org)
  • This protein may function in neurite extension, proliferation of melanoma cells, stimulation of Ca2+ fluxes, inhibition of PKC-mediated phosphorylation, astrocytosis and axonal proliferation, and inhibition of microtubule assembly. (wikipedia.org)
  • Immunoalkaline phosphatase stain with viral capsid antibodies ( rabbit serum 1:1,000) and naphthol-fast red with hematoxylin counterstain. (cdc.gov)
  • Measurement of IgG and IgA antibodies against zonulin, occludin, and other tight junction proteins is proposed for the evaluation of the loss of intestinal barrier integrity. (drperlmutter.com)
  • Spinal muscular atrophy (SMA) is a neurodegenerative disease produced by low levels of Survival Motor Neuron (SMN) protein that affects alpha motoneurons in the spinal cord. (mdpi.com)
  • Because of its favorable safety profile and the involvement of misfolded proteins, oxidative damage, and inflammation in multiple chronic degenerative diseases, these data relating curcumin dosing to the blood and tissue levels required for efficacy should help translation efforts from multiple successful preclinical models. (aspetjournals.org)
  • Thus, the major advantage of using S100B is that elevations in serum or CSF levels provide a sensitive measure for determining CNS injury at the molecular level before gross changes develop, enabling timely delivery of crucial medical intervention before irreversible damage occurs. (wikipedia.org)
  • S100B serum levels are elevated before seizures suggesting that BBB leakage may be an early event in seizure development. (wikipedia.org)
  • Binding of a miRNA to a complementary sequence in a target mRNA is mediated by Argonaute proteins leading to degradation of the mRNA or translational inhibition, thereby lowering protein levels in cells [ 7 ]. (researchsquare.com)
  • Interleukin 1 and interleukin 6 levels were unchanged in the noise group, whereas both tumour necrosis factor alpha and C-reactive protein were significantly reduced in noise exposed rats. (noiseandhealth.org)
  • S100 proteins are localized in the cytoplasm and nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. (wikipedia.org)
  • S100 calcium-binding protein B (S100B) is a protein of the S-100 protein family. (wikipedia.org)
  • In addition, S100B, which is also present in human melanocytes, is a reliable marker for melanoma malignancy both in bioptic tissue and in serum. (wikipedia.org)
  • 53 CSF and 91 serum samples) by ultrasensitive single-molecule array (Simoa) assays. (datadryad.org)
  • Conclusion: CDR2L provides additional PCA-1/anti-Yo sensitivity in CSF, and dual positivity with CDR2 provides additional specificity assurance in serum. (bvsalud.org)
  • The inhibition could be mimicked by the L-type calcium channel blocker nimodipine (1 μ m ) as well as by protein kinase C (PKC) activators phorbol 12,13-dibutyrate (10 μ m ) and phorbol 12-myristate 13-acetate (500 n m ), and blocked by the PKC inactivator (±)-1-(5-isoquinolinesulfonyl)-2-methylpiperazine (200 μ m ), suggesting a mechanism involving PKC modulation of L-type calcium channels. (jneurosci.org)
  • In hypothalamic neurons, modulators such as neuropeptide Y (NPY) and adenosine depress glutamatergic transmission by either a pertussis toxin (PTx)-sensitive G-protein-coupled pathway or by inhibition of voltage-activated calcium channels (VACCs). (jneurosci.org)
  • METHODS: A subline of U138 MG cells ('U138B') was treated with 0 to 4 mmol/L sodium butyrate (or serum deprivation) for up to 96 hours. (northwestern.edu)
  • The two "CDR2L-only" positives were CSF samples with low titer PCA-1/Yo by IFA with serum negativity but with typical clinical phenotype. (bvsalud.org)
  • Based on our identified miRNA-regulated molecular machinery, an inhibitor of PDK1/Akt BX-912, an anthracycline antibiotic daunorubicin, and a multi-targeted protein kinase inhibitor midostaurin were discovered as potential repositioning drugs for treating lung cancer. (cdc.gov)
  • Pansensitive and panresistant genes to 21 NCCN-recommended drugs with concordant mRNA and protein expression were identified. (cdc.gov)
  • Lambs treated with the wild-type and complemented strains showed perivascular and mural vascular edema, as well as serum albumin extravasation, particularly severe in the cerebral white matter, midbrain, medulla oblongata, and cerebellum. (monash.edu)
  • These data indicate that the dienone bridge present in curcumin, but not in TC, is necessary to reduce plaque deposition and protein oxidation in an Alzheimer's model. (aspetjournals.org)
  • The effects of butyrate were distinct from those of serum deprivation and were not simply the result of cells shifting into G 0 /G 1 . (northwestern.edu)
  • The effects of butyrate were distinct from those of serum deprivation and were not simply the result of cells shifting into G0/G1. (northwestern.edu)
  • The other 20% binds with TCII, the physiologic transport protein produced by endothelial cells. (medscape.com)
  • The primary barriers for invading respiratory pathogens are the respiratory tract epithelial cells and antimicrobial proteins generated by these cells. (cdc.gov)
  • Small noncoding RNAs called microRNAs (miRNA) negatively regulate gene expression by sequence-specific targeting of protein-coding transcripts [ 6 ]. (researchsquare.com)