• In any case, of the wide assortment of antidepressants assessed in the study, sertraline showed the highest affinity of them all for the DAT, even higher than the norepinephrine-dopamine reuptake inhibitors (NDRIs) nomifensine (Ki = 56 nM) and bupropion (Ki = 520 nM). (wikipedia.org)
  • As such, it seems unlikely that sertraline would produce much inhibition of dopamine reuptake even at clinically used dosages well in excess of the recommended maximum clinical dosage. (wikipedia.org)
  • In accordance, while sertraline has very low abuse potential and may even be aversive at clinical dosages, a case report of sertraline abuse described dopaminergic-like effects such as euphoria, mental overactivity, and hallucinations only at a dosage 56 times the normal maximum and 224 times the normal minimum. (wikipedia.org)
  • Sertraline, as per the latest studies has been found to be ineffective in improving cognitive outcomes in patients with Alzheimer's disease. (wikipedia.org)
  • sertraline is known to cause gastrointestinal issues (diarrhea), but may improve with time. (drugs.com)
  • Treatment of panic disorder with sertraline results in a decrease of the number of panic attacks and an improved quality of life. (wikipedia.org)
  • This was the reason why sertraline was made only as monomethylated because apparently according to the orders the 1° amine is inactive therefore the drug would have a shorter duration of activity. (wikipedia.org)
  • A very high dosage of sertraline of 400 mg/day has been found to produce peak plasma concentrations of about 250 ng/mL (816 nM). (wikipedia.org)