Granulomas in CD have been postulated to represent an adaptive mechanism for removal or localization of the causative agent because patients with a long clinical history show fewer granulomas than do those with a shorter clinical history. (medscape.com)
Infections5
Chlamydia trachomatis are obligate intracellular bacterial pathogens that cause ocular and genital infections, which are a significant public health concern worldwide. (europa.eu)
A better understanding of C. trachomatis basic biology is important to eventually develop new ways to combat infections caused by these bacteria. (europa.eu)
Chlamydia trachomatis is a global cause of blinding trachoma and sexually transmitted infections (STIs). (cdc.gov)
Worldwide, C. trachomatis is the leading preventable cause of blindness and bacterial sexually transmitted infections (STIs). (cdc.gov)
Chlamydia is a major cause of sexually transmitted infections worldwide. (ufl.edu)
Bacterial2
To screen for novel T3S effectors of C. trachomatis, we used Yersinia enterocolitica as a genetically tractable surrogate bacterial species assembling a T3S apparatus, which has been shown to recognise heterologous T3S substrates. (europa.eu)
Dr. Maurelli has over 30 years of research experience in the field of molecular genetics of bacterial pathogenesis, specifically in the study of Shigella and Chlamydia. (ufl.edu)
Specifically2
For this, specifically we aimed to (i) identify novel C. trachomatis type III secretion (T3S) effectors and (ii) further understand the secretion and function of known effectors. (europa.eu)
Lymphogranuloma venereum (LGV) is a sexually transmitted disease caused by Chlamydia trachomatis- specifically, serovars L1, L2, and L3. (medscape.com)
Close1
Chlamydia trachomatis is spread by close social contact or sexual activity. (cdc.gov)
Study1
To study the function of known effectors, we focused on the C. trachomatis Inc proteins, an important group of potential chlamydial virulence factors. (europa.eu)
Worldwide1
Multilocus and SNP typing can now be used to detect diverse and emerging C. trachomatis strains for epidemiologic and evolutionary studies of trachoma and STI populations worldwide. (cdc.gov)
Obligate intracellular pathogen2
Chlamydia trachomatis is an obligate intracellular pathogen that replicates in a membrane-bound vacuole termed the inclusion. (nih.gov)
Enzootic abortion of ewes (EAE) due to infection with the obligate intracellular pathogen Chlamydia (C.) abortus is an important zoonosis leading to considerable economic loss to agriculture worldwide. (infektiologie.tirol)
Pathogen3
Chlamydia trachomatis replicates primarily in the epithelial cells lining the genital tract and induces the innate immune response by triggering cellular pathogen recognition receptors (PRRs). (madridge.org)
Chlamydia trachomatis is a gram-negative, obligate intracellular bacterial pathogen causing the most common sexually transmitted infections (STI) worldwide, particularly among young women [1] . (madridge.org)
As per CDCʼs estimate, nearly 20 million healthy individuals are infected every year, accounting for almost $16 billion in health care costs annually (CDC 2016) [5] .The asymptomatic nature of C. trachomatis infection means that the pathogen persists for a long time in some individuals, which suggests the effective evasion of host immune systems [6 , 7] . (madridge.org)
In women, chronic infection with the urogenital serovars (D-K) can cause pelvic inflammatory diseases (PID) and chronic pelvic pain, which can culminate into scarring and fibrosis of the Fallopian tubes leading to infertility or ectopic pregnancy [2 - 4] . (madridge.org)
Strains1
Multilocus and SNP typing can now be used to detect diverse and emerging C. trachomatis strains for epidemiologic and evolutionary studies of trachoma and STI populations worldwide. (cdc.gov)
Outer membrane1
Certainly, the serovar-defining major outer membrane protein (MOMP) is a prime example of point mutation accumulation resulting in genetic variants, especially in the surface-exposed segments of this molecule. (medscape.com)
however, the global effects of TLR3 signaling in the cellular response to Chlamydia infection in murine OE cells has not yet been investigated. (madridge.org)
To determine the impact of TLR3 signaling on Chlamydia infection in OE cell at the transcriptome level, we infected wild-type (OE-WT) and TLR3-deficient (OE-TLR3KO) cells with Cm , and performed transcriptome analyses using microarray. (madridge.org)
Sexually1
Lymphogranuloma venereum (LGV) is a sexually transmitted disease caused by Chlamydia trachomatis-specifically, serovars L1, L2, and L3. (medscape.com)
Clinical1
We used comparative genomics of the family Chlamydiaceae to select conserved housekeeping genes for C. trachomatis multilocus sequencing, characterizing 19 reference and 68 clinical isolates from 6 continental/subcontinental regions. (cdc.gov)
Responses2
Genetic variation allows Chlamydia trachomatis to exploit diverse niches within a host (tissue tropism) and to avoid, escape or resist host responses. (medscape.com)
Genetic variation (lightning bolts) results in serovar-specific differences in invasiveness, evasion of host responses and tissue tropism. (medscape.com)
Protein1
Analysis of the subcellular localization of both proteins throughout the developmental cycle revealed CAB063 being the first C. abortus protein shown to be translocated to the host cell nucleus. (infektiologie.tirol)
Disease2
[ 35 ] There has also been strong bioinformatics evidence after whole-genome sequencing that chlamydiae have undergone a number of gene duplication events resulting in the creation of several families of proteins important for intracellular survival in cell culture and possibly in disease severity differences. (medscape.com)
There are a number of C. trachomatis gene products that exhibit variability and may modulate disease severity (Figure 3). (medscape.com)