Serovars host chlamydia trachomatis. Medical search. Frequent questions

Genus specific (C. trachomatis, C. pneumoniae & C. psittaci). (idhinhibitor.com)
Chlamydia (C.) psittaci , the causative agent of avian chlamydiosis and human psittacosis, is a genetically heterogeneous species. (biomedcentral.com)
To assess whether there are genetic markers associated with host tropism we comparatively analyzed whole-genome sequences of 61 C. psittaci strains, 47 of which carrying a 7.6-kbp plasmid. (biomedcentral.com)
Our study identified a number of genomic features that can be correlated with the phylogeny and host preference of C. psittaci strains. (biomedcentral.com)
Chlamydia (C.) psittaci is known as the etiological agent of avian chlamydiosis and human psittacosis [ 1 ]. (biomedcentral.com)
Like other chlamydiae, C. psittaci can also cause asymptomatic infections. (biomedcentral.com)
Use of HeLa cell guanine nucleotides by Chlamydia psittaci. (docksci.com)
Exogenous guanine was found to be incorporated into the nucleic acids of Chlamydia psittaci when the parasite was grown in HeLa cells containing hypoxanthine guanine phosphoribosyltransferase (EC 2.4.2.8) activity but not when the parasite was grown in transferase-deficient HeLa cells. (docksci.com)
It is concluded that C. psittaci is incapable of metabolizing guanine, but that the parasite can use host-generated guanine nucleotides as precursors for nucleic acid synthesis. (docksci.com)
Gill and Stewart (5) and Moulder (12) concluded that the enhanced rate of catabolism of glucose when L cells are infected with C. psittaci represents a host response to infection rather than independent parasite catabolic activity. (docksci.com)
Gill and Stewart (6) found antimycin, an inhibitor of electron transport, reduced the yield of C. psittaci grown in L cells even though cytochromes and flavoproteins have not been detected in chlamydiae (E. Weiss and L. A. Kriesow, Bacteriol. (docksci.com)
Since chlamydiae have not been propagated outside of host cells, Hatch (8) attempted to demonstrate indirectly that C. psittaci uses host-derived energy intermediates by showing that C. psittaci organisms multiplying within L cells incorporate exogenous uridine, guanine, and adenine labels into RNA at rates consistent with the parasites drawing exclusively on their host's ribonucleoside triphosphate pools for precursors. (docksci.com)
The present study was undertaken to eliminate the possibility that C. psittaci relies on host purine pools and to demonstrate that C. psittaci can and does draw on host guanine nucleotide pools for precursors for nucleic acid synthesis. (docksci.com)
It was found that C. psittaci can use guanine supplied in the culture medium only if the parasite is grown in a host cell capable of elevating guanine to the nucleotide level. (docksci.com)
Tetracyclines are highly effective in the treatment of most chlamydial infections, including urogenital infections caused by Chlamydia trachomatis, respiratory tract infections caused by C. pneumoniae, respiratory tract infections caused by C. psittaci (psittacosis), and lymphogranuloma venereum caused by invasive serovars of C. trachomatis. (antiinfectivemeds.com)
Chlamydia psittaci and Chlamydia pecorum are important veterinary pathogens, with the former also being responsible for zoonoses, and the latter adversely affecting koala populations in Australia and livestock globally. (peerj.com)
In order to evaluate pathogen detection in clinical samples, C. psittaci LAMP was evaluated using a total of 26 DNA extracts from clinical samples from equine and avian hosts, while for C. pecorum LAMP, we tested a total of 63 DNA extracts from clinical samples from koala, sheep and cattle hosts. (peerj.com)
The obligatory intracellular bacteria, Chlamydia psittaci and Chlamydia pecorum , are globally widespread veterinary pathogens that cause disease in an astonishing range of hosts. (peerj.com)

Chlamydia trachomatis are obligate intracellular bacterial pathogens that cause ocular and genital infections, which are a significant public health concern worldwide. (europa.eu)
C. trachomatis are bacteria in the genus Chlamydia, a group of obligate intracellular parasites of eukaryotic cells. (wikipedia.org)
Chlamydiae are nonmotile, obligate intracellular bacteria. (msdmanuals.com)
Chlamydia trachomatis is an obligate intracellular human pathogen that exhibits stage-specific gene transcription throughout a biphasic developmental cycle. (plos.org)
In our laboratory, we are interested in the study of cell and molecular events associated to virulence, pathogenesis and host-pathogen interactions of C. trachomatis , which is an obligate intracellular bacterium with a high impact in public health globally. (unc.edu.ar)
All chlamydia, including those serovars causing LGV, are obligate intracellular microorganisms but LGV serovars are lymphotropic. (hopkinsguides.com)
Members of the genus Chlamydia are obligate intracellular parasitic bacteria which have not been propagated outside of eucaryotic host cells. (docksci.com)

This form can initiate a new infection if it comes into contact with a susceptible host cell. (wikipedia.org)
Serovars L1 through L3 cause an invasive infection of the lymph nodes near the genitals, called lymphogranuloma venereum. (wikipedia.org)
citation needed] Clinical signs and symptoms of C. trachomatis infection in the genitalia present as the chlamydia infection, which may be asymptomatic or may resemble a gonorrhea infection. (wikipedia.org)
C. trachomatis in the lungs presents as the chlamydia pneumoniae respiratory infection and can affect all ages. (wikipedia.org)
However, analogous effects of NET-EN treatment on antivirus immunity and host susceptibility to genital infection are much less explored. (stanford.edu)
Likewise, we detected comparable mortality rates in DMPA- and NET-EN-treated wild-type and humanized mice after intravaginal infection with HSV type 2 or cell-associated HIV type 1, respectively, but NET-EN treatment was associated with slower onset of HSV-induced genital pathology and lower burden of systemic HIV disease. (stanford.edu)
Chlamydia, or more specifically a chlamydia infection, is a sexually transmitted infection caused by the bacterium Chlamydia trachomatis. (anhourago.eu)
He has served as Secretary-Treasurer of the Chlamydia Basic Research Society and Mini-reviews Editor for Infection and Immunity. (ufl.edu)
The aims of this study were to determine the frequency of the sac-4 gene in a larger sample of isolates of different serovars and to assess the prevalence of sac-4 in gonococcal isolates from patients with and without coexisting chlamydial infection. (bmj.com)
Dual infection of the genital tract with Chlamydia trachomatis and Neisseria gonorrhoeae is well established with a prevalence ranging from 14-43% but little is known of the epidemiology and associated clinical features of such co-existing infections. (bmj.com)
Chlamydia trachomatis is the leading cause of both bacterial sexually transmitted infection and infection-derived blindness world-wide. (plos.org)
Differences in somatometric measurements and clinical variables in newborns with respiratory distress and infection between different Chlamydia trachomatis genotypes. (analesdepediatria.org)
We tested 1062 bronchial lavage samples from neonates with respiratory distress syndrome for Chlamydia infection. (analesdepediatria.org)

C. trachomatis along with C. pneumoniae have been found to infect humans to a greater extent. (wikipedia.org)
The sequential incubation of anti-GLXA antibody and complement with Chlamydia trachomatis serovar K or C. pneumoniae AR-39-infected HeLa 229 or macrophage cells resulted in significant cellular cytotoxicity, which preceded the formation of mature elementary bodies. (umass.edu)
For uninfected cells, co-incubation of GLXA, purified from supernatants of either C. trachomatis or C. pneumoniae-infected HeLa 229 cells, followed by the successive addition of mouse anti-GLXA antibody and complement, yielded similar levels of cellular cytotoxicity. (umass.edu)

To study the function of known effectors, we focused on the C. trachomatis Inc proteins, an important group of potential chlamydial virulence factors. (europa.eu)
However, they depend on the host cell for 3 of their 4 nucleoside triphosphates and use host adenosine triphosphate (ATP) to synthesize chlamydial protein. (msdmanuals.com)
Their developmental cycle is associated with the formation and release of the broadly conserved glycolipid exoantigen (GLXA), which has been implicated in the chlamydial elementary body-host cell interaction. (umass.edu)
LGV is distinct from other chlamydia serovars causing either common genital chlamydial disease (serovars D-K) or trachoma (serovars A-C). (hopkinsguides.com)

Serovars A through C cause trachoma, which is the world's leading cause of preventable infectious blindness. (wikipedia.org)
C. trachomatis is the single most important infectious agent associated with blindness (trachoma), and it also affects the eyes in the form of inclusion conjunctivitis and is responsible for about 19% of adult cases of conjunctivitis. (wikipedia.org)
Trachoma is a chronic conjunctivitis caused by Chlamydia trachomatis. (anhourago.eu)

The closest relative to C. trachomatis is C. muridarum, which infects mice. (wikipedia.org)

Neisseria gonorrhoeae and C. trachomatis are the two pathogens most commonly isolated from women with positive cultures for PID. (pediagenosis.com)

In addition to the chromosome that contains most of the genome, nearly all C. trachomatis strains carry a 7.5 kilobase plasmid that contains 8 genes. (wikipedia.org)
C. trachomatis strains are generally divided into three biovars based on the type of disease they cause. (wikipedia.org)
Lymphogranuloma Venereum (LGV) Lymphogranuloma venereum (LGV) is a disease caused by 3 unique strains of Chlamydia trachomatis and characterized by a small, often asymptomatic skin lesion, followed by regional lymphadenopathy. (msdmanuals.com)
LGV strains infect macrophages and spread to lymph nodes which are different from other C. trachomatis strains that are usually restricted to the epithelial cells of the conjunctiva and urogenital mucosa. (hopkinsguides.com)
Strains from different non-psittacine hosts clustered in Clades 2- 4. (biomedcentral.com)

A better understanding of C. trachomatis basic biology is important to eventually develop new ways to combat infections caused by these bacteria. (europa.eu)
Over the course of the C. trachomatis life cycle, the bacteria take on two distinct forms. (wikipedia.org)
The C. trachomatis genome is substantially smaller than that of many other bacteria at approximately 1.04 megabases, encoding approximately 900 genes. (wikipedia.org)
If during replication Chlamydia encounters stress factors, like those resulting from exposure to INF-gamma (a key cytokine in the immune response) or beta-lactam antibiotics, these bacteria enter in a viable/ non-culturable state which is also known as "persistent form" or "aberrant body", usually much bigger than the RBs. (unc.edu.ar)
Tetracyclines are used principally in the treatment of infections caused by susceptible Rickettsia, Chlamydia, Mycoplasma, and a variety of uncommon gram-negative and gram-positive bacteria. (antiinfectivemeds.com)

C. trachomatis is the most common infectious cause of blindness and the most common sexually transmitted bacterium. (wikipedia.org)
Chlamydia trachomatis is a gram-negative bacterium that can replicate only within a host cell. (wikipedia.org)

About 70-90% of women with endocervical infections due to C. trachomatis are asymptomatic and thereby do not seek medical treatment and become a reservoir for transmission. (unc.edu.ar)
To a lesser extent, genital infections due to C. trachomatis in males may also be asymptomatic and chronic, which also contributes to spreading and sometimes lead to complications like epididymitis and prostatitis. (unc.edu.ar)

Multiplex PCR Assay for Clade Typing of Salmonella enterica Serovar Enteritidis. (cdc.gov)
enterica serovar Dublin str. (up.ac.za)
enterica serovar Paratyphi B str. (up.ac.za)
enterica serovar Newport str. (up.ac.za)

Exact logistic regression analysis indicated significant differences in sac-4 prevalence in isolates of different serovars. (bmj.com)
The isolates represented 19 different serovars. (bmj.com)
The prevalence of sac-4 was determined for each of the common serovars, arbitrarily defined as comprising more than 15 isolates each: serovars represented by less than 15 isolates were grouped together as "other 1A" and "other 1B" serovars (see table 1). (bmj.com)

Lymphogranuloma venereum (LGV) is a sexually transmitted disease caused by Chlamydia trachomatis- specifically, serovars L1, L2, and L3. (medscape.com)

Between 20 and 30% of heterosexual men with symptomatic gonococcal urethritis are simultaneously infected with Chlamydia trachomatis . (pediagenosis.com)

These new elementary bodies are then shed in the semen or released from epithelial cells of the female genital tract, and attach to new host cells. (wikipedia.org)
Serovars D through K infect the genital tract, causing pelvic inflammatory disease, ectopic pregnancies, and infertility. (wikipedia.org)

There are many similarities between the infections caused by N. gonorrhoeae and Chlamydia trachomatis (CT) . (pediagenosis.com)

This mode of growth is known as persistence and how C . trachomatis senses stress and responds in this manner is an important area of research. (plos.org)
Besides persistence, we are also interested in studying other key aspects of C. trachomatis pathogenesis such as nutrient acquisition, immune evasion and Chlamydia -induced reprogramming of the host cell machinery during the infectious cycle. (unc.edu.ar)

In addition, mannosebinding-lectin (MBL) is an epithelial-cell associated host protein that binds to Candida mannan, activates complement, and thus inhibits Candida growth. (paperzz.com)

Then, we selected 48 genes that may encode uncharacterised effectors (e. g. no detectable amino acid identity to other proteins or with a particular putative biochemical activity) from the genome of C. trachomatis strain L2/434/Bu. (europa.eu)
Several important metabolic functions are not encoded in the C. trachomatis genome, and instead, are likely scavenged from the host cell. (wikipedia.org)
The relatively small genome size of approximately 1 Mbp implies the absence of essential cellular pathways and, consequently, reliance on host cells for nutrients, such as amino acids, nucleotides and lipids [ 18 , 19 ]. (biomedcentral.com)

The L serovars are invasive and cause severe inflammation with granuloma formation. (medscape.com)

Like other Chlamydia species, the C. trachomatis life cycle consists of two morphologically distinct life stages: elementary bodies and reticulate bodies. (wikipedia.org)
Like other Chlamydia species, C. trachomatis has a life cycle consisting of two morphologically distinct forms. (wikipedia.org)
Our data show that intra-species genomic divergence is associated with past host change and includes deletions in the plasticity zone, structural variations in immunogenic domains and distinct repertoires of virulence factors. (biomedcentral.com)

Chlamydiae access the body by invading the same epithelial cells of the endocervix, urethra, endometrium, fallopian tubes, rectum and conjunctivae that are host to the gonococcus. (pediagenosis.com)

C. trachomatis exclusively infects humans. (wikipedia.org)
7] Chlamydia trachomatis only occurs in humans. (anhourago.eu)
Its broad host range includes parrots and many other birds, but occasionally also humans (via zoonotic transmission), ruminants, horses, swine and rodents. (biomedcentral.com)

Chlamydia is one of the most common sexually transmitted infections, affecting about 4.2% of women and 2.7% of men worldwide. (anhourago.eu)
Three species of Chlamydia cause human disease, including sexually transmitted infections and respiratory infections. (msdmanuals.com)
Chlamydia is a major cause of sexually transmitted infections worldwide. (ufl.edu)
C. trachomatis is the main bacterial cause of sexually transmitted infections and of infectious blindness worldwide. (unc.edu.ar)

To screen for novel T3S effectors of C. trachomatis, we used Yersinia enterocolitica as a genetically tractable surrogate bacterial species assembling a T3S apparatus, which has been shown to recognise heterologous T3S substrates. (europa.eu)
C. trachomatis is thought to have diverged from other Chlamydia species around 6 million years ago. (wikipedia.org)

Application Instructions These antibodies have been qualified for use in ELISA to detect Chlamydia trachomatis elementary bodies and reticulate bodies. (qedbio.com)

12] Chlamydia is also a potential cause of prostatic inflammation in men, although the exact relevance in prostatitis is difficult to ascertain due to possible contamination from urethritis. (anhourago.eu)

As negative control, we used a fusion between the first 20 amino acids of a C. trachomatis ribosomal protein and TEM-1 (RplJ20-TEM-1). (europa.eu)
This study provides evidence that a switch-protein kinase regulatory network controls availability of σ 66 , the main sigma subunit for transcription in Chlamydia . (plos.org)
A model is proposed where the relative levels of active antagonist (RsbV1) and switch-protein anti-sigma factor (RsbW) control the availability of σ 66 and subsequently act as a molecular 'throttle' for Chlamydia growth and development. (plos.org)

Dr. Maurelli has over 30 years of research experience in the field of molecular genetics of bacterial pathogenesis, specifically in the study of Shigella and Chlamydia. (ufl.edu)

Proving that chlamydiae are energy parasites requires demonstrating a direct requirement of nucleotides by chlamydiae growing in a hostfree system. (docksci.com)

Association between Chlamydia trachomatis genotypes and clinical features of the newborn. (analesdepediatria.org)

The diagnosis of Chlamydia was made by plasmid detection with an in-house PCR assay, and genotypes were identified using a PCR-RFLP assay for the ompA gene. (analesdepediatria.org)

Identification and characterization of mixed infections of Chlamydia trachomatis via high-throughput sequencing. (cdc.gov)

They share a unique hydrophobic motif thought to target them to the membrane of the large vacuole where Chlamydia resides intracellularly. (europa.eu)
The elementary body enters the host cell, surrounded by a host vacuole, called an inclusion. (wikipedia.org)

Elementary bodies are spore-like and infectious, whereas reticulate bodies are in the replicative stage and are seen only within host cells. (wikipedia.org)
Reticulate bodies are 600 to 1500 nanometers across, and are found only within host cells. (wikipedia.org)
Within the inclusion, C. trachomatis transforms into a larger, more metabolically active form called the reticulate body. (wikipedia.org)
C. trachomatis propagates through a biphasic cycle involving the elementary body (EB) and the reticulate body (RB). (unc.edu.ar)

Elementary bodies are 200 to 400 nanometers across, and are surrounded by a rigid cell wall that allows them to survive outside of a host cell. (wikipedia.org)
First, C. trachomatis attaches to a new host cell as a small spore-like form called the elementary body. (wikipedia.org)

In summary, we have identified 22 novel putative C. trachomatis T3S effectors, seven of which were also secreted as full-length proteins by Y. enterocolitica in different experimental conditions. (europa.eu)

Culture-Independent Detection and Identification of Leptospira Serovars. (cdc.gov)

The prevalence was not the same in all serovars and ranged from 34.9% in serovar 1B2 to 100% in serovar 1B18. (bmj.com)

Recent advances in genetic manipulation of Chlamydia were employed to inactivate rsbV1 , as well as to increase the expression levels of rsbW or rsbV1 , in vivo . (plos.org)

we tested if these 22 C. trachomatis proteins with an N-terminal T3S signal were also secreted as full-length proteins after PyopE-dependent expression in Y. enterocolitica. (europa.eu)
Thirteen proteins showed a statistically significant higher level of secretion than full-length C. trachomatis RplJ. (europa.eu)
Therefore, these 7 proteins are very likely novel effectors of C. trachomatis. (europa.eu)
We have raised rabbit polyclonal antibodies against 5 of these proteins and we are currently analysing their subcellular localisation in C. trachomatis infected cells. (europa.eu)

We first confirmed that known T3S substrates (IncA and IncC effectors) of C. trachomatis possess a T3S signal within their first 20 amino acids, which is recognised by the Y. enterocolitica T3SS as efficiently as a Yersinia endogenous T3S substrate. (europa.eu)

These effectors manipulate host cell processes to enable e. g. bacterial invasion, acquisition of nutrients, inhibition of apoptosis, or interference with immune signalling. (europa.eu)
These are further subdivided into several serovars based on the surface antigens recognized by the immune system. (wikipedia.org)

No evidence for a chlamydia-specific transferase activity was found in either transferase-containing or transferase-deficient infected HeLa cells. (docksci.com)

1] Chlamydia can be cured by antibiotics with typically either azithromycin or doxycycline being used. (anhourago.eu)

If left untreated, chlamydia in men can spread to the testicles causing epididymitis, which in rare cases can lead to sterility if not treated. (anhourago.eu)

Chlamydia can be spread during vaginal, anal, or oral sex, and can be passed from an infected mother to her baby during childbirth. (anhourago.eu)
can be present as either a commensal organism or a pathogen in the vagina, and dogma dictates that changes in the host vaginal environment are necessary for the organism to induce pathological effects. (paperzz.com)

Although it was deemed unlikely, the possibility that chlamydiae are purine and pyrimidine nucleoside auxotrophs, rather than dependent on host ribonucleotides, could not be ruled out with certainty. (docksci.com)

Anatomy12

Organisms19

Diseases49

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