• Adenovirus has been associated with both sporadic and epidemic disease and, with regard to infections among military recruits, who were routinely immunized against types 4 and 7 from 1971 until the cessation of vaccine production in 1996. (medscape.com)
  • A live oral vaccine against adenovirus types 4 and 7 was approved for use in this population by the US Food and Drug Administration (FDA) in 2011, and subsequent incidence of acute respiratory disease declined. (medscape.com)
  • The Advertisement5-centered hexon-modified vectors which contain subgroup D hypervariable areas (Advertisement43 or Advertisement48) induced powerful transgene-specific immune reactions which were unaffected by Advertisement5-particular NAb in murine and SLC2A3 non-human primate vaccine versions. (synanet2020.com)
  • The lab is applying its adenovirus vaccine expertise against SARS-CoV-2, utilizing a modified chimpanzee virus as a vaccine delivery vehicle to induce an immune response. (wistar.org)
  • The laboratory developed an adenovirus-based vaccine against rabies virus that can provide rapid immunity following a single administration. (wistar.org)
  • This vaccine also achieves long-term protection in non-human primates after a single dose. (wistar.org)
  • Efficacy of a quadrivalent rhesus rotavirus-based human rotavirus vaccine aimed at preventing severe rotavirus diarrhea in infants and young children. (microbiologyresearch.org)
  • Recombinant adenovirus type 5 (rAd) has been used as a vaccine platform against many infectious diseases and has been shown to be an effective vaccine vector. (mdpi.com)
  • Plasmodium falciparum parasites are the causative agent of the most severe form of human malaria, and the development of an effective vaccine remains a key strategic goal to aid the control, local elimination and eventual eradication of this disease. (nature.com)
  • Anti-merozoite vaccine studies have long relied on the standardized in vitro assay of growth inhibition activity (GIA) 12 , whereby purified IgG antibodies are tested against parasites cultured in human red blood cells (RBC) in the absence of other cell types. (nature.com)
  • Serotype identity is clinically relevant because it predicts vaccine efficacy and correlates strongly with both clinical presentation and epidemiological pattern. (utmb.edu)
  • Findings from an early Phase I/IIa primate and human trial of the so-called mosaic HIV vaccine showed encouraging signs of the vaccine's ability to prompt an immune response to the virus and backed the ongoing human efficacy trial of the vaccine currently running in sub-Saharan Africa, MedPage Today reports. (poz.com)
  • The best immune response among the human subjects occurred among those who received at least one dose of the mosaic adenovirus serotype 26 (Ad26) as well as a high dose of the gp140 boost vaccine. (poz.com)
  • The monkey study gave one of five vaccine regimens or a placebo to the animals in order to settle on a preferred regimen for the advanced human trials. (poz.com)
  • These peptides were then tested in our previously described oncolytic cancer vaccine platform PeptiCRAd, a vaccine platform that combines an immunogenic oncolytic adenovirus (OAd) coated with tumor antigen peptides. (elifesciences.org)
  • These results confirmed the feasibility of applying the described pipeline for the selection of peptide candidates and generation of therapeutic oncolytic cancer vaccine, filling a gap in the field of cancer immunotherapy, and paving the way to translate our pipeline into human therapeutic approach. (elifesciences.org)
  • The therapeutic efficacy of Adenovirus type 7 vaccine live can be decreased when used in combination with Sorivudine. (drugbank.com)
  • Phase 1 safety and immunogenicity evaluation of a multiclade HIV-1 candidate vaccine delivered by a replication-defective recombinant adenovirus vector. (emmes.com)
  • The development of an effective human immunodeficiency virus (HIV) vaccine is a high global priority. (emmes.com)
  • Here, we report the safety, tolerability, and immunogenicity of a replication-defective recombinant adenovirus serotype 5 (rAd5) vector HIV-1 candidate vaccine. (emmes.com)
  • A recombinant adenovirus serotype 5 (rAd5) vector-based vaccine for HIV-1 has recently failed in a phase 2b efficacy study in humans. (escholarship.org)
  • Here we show that an improved T-cell-based vaccine regimen using two serologically distinct adenovirus vectors afforded substantially improved protective efficacy in this challenge model. (escholarship.org)
  • Sinovac's PPV23 Pneumococcal Vaccine consists of 23 pneumococcal serotypes that are most frequently found in China. (precisionvaccinations.com)
  • Sputnik Light vaccine is the first component (recombinant human adenovirus 26 serotype (rAd26) of the Sputnik V vaccine. (precisionvaccinations.com)
  • Efficacy and Synergy with Cisplatin of an Adenovirus Vectored Therapeutic E1E2E6E7 Vaccine against HPV Genome-Positive C3 Cancers in Mice. (hervolutiontx.com)
  • Human conjunctival epithelial cells in primary culture were infected with Ad19 at multiplicities of infection (MOI) of 0, 0.1 or 1.0 and harvested at 1.5h, 6h or 16h post-infection. (arvojournals.org)
  • In contrast to the respiratory serotype Ad5, the preferential ocular tropism of Ad19 and subsequent productive infection likely depends both on its control of some host differentiation/development genes and on the different host defense /inflammatory responses it elicits. (arvojournals.org)
  • These primary cell cultures were often noted to spontaneously degenerate over time, and adenoviruses are now known to be a common cause of asymptomatic respiratory tract infection that produces in vitro cytolysis in these tissues. (medscape.com)
  • Adenovirus is often cultured from the pharynx and stool of asymptomatic children, and most adults have measurable titers of anti-adenovirus antibodies, implying prior infection. (medscape.com)
  • Certain serotypes are associated with distinct clinical manifestations, reflecting preferential infection of the respiratory, gastrointestinal, and urinary tracts and conjunctiva. (medscape.com)
  • Recovery from adenovirus infection is associated with the development of serotype-specific neutralizing antibodies. (medscape.com)
  • Upon infection with adenovirus, one of three different interactions with the cells may occur. (medscape.com)
  • The first is lytic infection, which occurs when an adenovirus enters human epithelial cells and continues through an entire replication cycle, which results in cytolysis, cytokine production, and induction of host inflammatory response. (medscape.com)
  • Human adenovirus (Adv) infection is responsible for most community-acquired pneumonia in infants and children, which results in significant morbidity and mortality in children every year. (hindawi.com)
  • Knowing the miRNA expression profile will help understand the role of miRNAs in modulating the host response to adenovirus infection and possibly improve the diagnosis of adenovirus-infected pneumonia. (hindawi.com)
  • Human adenovirus (Adv) infection is responsible for most community-acquired pneumonia in infants and children [ 1 , 2 ]. (hindawi.com)
  • They are applying this platform to develop HIV vaccines and creating new therapeutic vaccines against human papillomavirus (HPV), a leading cause of cervical cancer, and chronic hepatitis B virus infection, a major cause of hepatocellular carcinoma. (wistar.org)
  • 2021. The fiber knob protein of human adenovirus type 49 mediates highly efficient and promiscuous infection of cancer cell lines using a novel cell entry mechanism . (cardiff.ac.uk)
  • In this study the tropism of the human adenoviruses type 4, 5, 7 to primary cultures of murine neurons and the influence of infection on the neuron morphology and actin cytoskeleton was examined. (elis.sk)
  • We also observed accumulation of nuclear actin within nuclei of infected cells which may indicate that it plays role in adenovirus infection and replication in neurons and A549 cells. (elis.sk)
  • The coxsackievirus-adenovirus receptor (CAR) appears to play a major role during infection of most human serotypes, whereas the alpha (v)beta (3/5) integrins have been reported to play a significant auxiliary role. (cnrs.fr)
  • Replication deficient human adenovirus vector serotype 19a/64: Immunogenicity in mice and female cynomolgus macaques. (hervolutiontx.com)
  • four (8%) did not test positive for adenovirus. (cdc.gov)
  • Of patients tested, 268 were positive for adenovirus. (wikipedia.org)
  • In immunocompetent hosts, most adenovirus infections are asymptomatic. (msdmanuals.com)
  • We utilized established viral vectors, the replication-deficient chimpanzee adenovirus serotype 63 (ChAd63), and the attenuated orthopoxvirus modified vaccinia virus Ankara (MVA), encoding RH5 from the 3D7 clone of P. falciparum. (jci.org)
  • Application of the method allowed an inclusive determination of the serotypes found in the Egyptian respiratory sample set and demonstrated that coinfections are common and may play a previously unrecognized role in adenovirus pathogenesis, evolution, and epidemiology. (utmb.edu)
  • Of interest is the role of adenoviruses as viral vectors in vaccination and in gene therapy.For example, in viral vector vaccines against SARS-CoV2, the vector virus is used to deliver RNA encoding SARS-CoV2 spike protein into target cells. (medscape.com)
  • Intro Adenovirus vectors are believed a respected viral vector system for vaccines for their powerful immunogenicity and making feasibility. (synanet2020.com)
  • The strongest adenovirus vectors for make use of as vaccines derive from adenovirus serotype 5 (Advertisement5) (1C6). (synanet2020.com)
  • Adenovirus-based vectors can handle generating powerful and protecting T cell and antibody reactions in animal versions (7C17), and medical data conclusively display that Advertisement5 vectors can induce powerful Compact disc8+ and Compact disc4+ T cell and antibody reactions in vaccinated volunteers (18C25). (synanet2020.com)
  • They support the development of E1/E4-removed vectors predicated on Advertisement5 aswell as choice adenovirus serotypes (43C46). (synanet2020.com)
  • Canine adenovirus type 2 (CAV-2) vectors may be attractive tools for gene transfer thanks to the lack of preexisting immunity in humans, and because of the preferential transduction of neurons when the vector is injected into the brain and some innervated tissues. (cnrs.fr)
  • Human adenoviruses (HAdVs) are well known pathogens that cause a variety of human illnesses. (annals.edu.sg)
  • Other recently identified pathogens include the enteric adenoviruses, calicivirus, astrovirus, and the Norwalk family of agents. (cdc.gov)
  • Human adenoviruses (HAdVs) are common pathogens associated with a variety of clinical manifestations. (unicatt.it)
  • Application of artificial intelligence to the in silico assessment of antimicrobial resistance and risks to human and animal health presented by priority enteric bacterial pathogens. (cdc.gov)
  • Isolates from 50 (74%) of these patients were available for further adenovirus typing at either CDC or OSPHL. (cdc.gov)
  • Genetic variation among 166 isolates of human adenovirus 7 (Ad7) obtained from 1966 to 2000 from the United States and Eastern Ontario, Canada, was determined by genome restriction analysis. (cdc.gov)
  • The deduced amino acid sequences of the outer capsid protein, VP7, of serotype G1 rotavirus clinical isolates collected over a 6 year period (1990-1995) in Melbourne, Australia, were examined. (microbiologyresearch.org)
  • Antigenic characterization using a panel of serotype G1-specific neutralizing monoclonal antibodies classified lineage II isolates (1990-1993) as monotype G1a while lineage I isolates were classified as monotype G1b (1993-1995). (microbiologyresearch.org)
  • Our results indicated that temporal genetic variation of the VP7 of serotype G1 rotaviruses was associated with changes in the antigenicity of these isolates. (microbiologyresearch.org)
  • Eighty-eight adenovirus (Ad) isolates and associated clinical data were collected from walk-in patients with influenza-like illness in Egypt during routine influenza surveillance from 1999 through 2002. (utmb.edu)
  • The isolates included common species B1 serotypes (Ad3 and Ad7), common species C serotypes (Ad1, Ad2, and Ad5), the less common species B2 serotype Ad11, and three isolates of the rare species B1 serotype Ad16. (utmb.edu)
  • 2018. Ad5NULL-A20 - a tropism-modified, αvβ6 integrin-selective oncolytic adenovirus for epithelial ovarian cancer therapies . (cardiff.ac.uk)
  • Oncolytic adenovirus loaded with L-carnosine as a drug delivery system for cancer therapy. (unina.it)
  • 60 serotypes, divided into seven subgroups or species (A through G). Measuring 70-90 nm, its double-stranded DNA genome is surrounded by a non-enveloped icosahedron capsid with fiber-like projections from each of its 12 vertices. (medscape.com)
  • Adenoviruses are DNA viruses classified according to 3 major capsid antigens (hexon, penton, and fiber). (msdmanuals.com)
  • AAV8-Syn-Luc is a pre-packaged rAAV in 8 (with capsid from AAV serotype 8 and 2xITR from AAV serotype 2) which over-expresses firefly luciferase (fLuc) under the human Synapsin promoter for neuronal specific expression. (signagen.com)
  • Immunogenicity of Human Endogenous Retroviral Proteins in Cancer and Discussion of Therapeutic Approaches. (hervolutiontx.com)
  • Nevertheless, the high prevalence of Advertisement5-particular neutralizing antibodies (NAb) in human being populations, in sub-Saharan Africa especially, gets the potential to limit the potency of Advertisement5-centered vaccines (23, 27C30). (synanet2020.com)
  • Derivation of neutralizing monoclonal antibodies to human rotaviruses and evidence that an immunodominant neutralization site is shared between serotypes 1 and 3. (microbiologyresearch.org)
  • Simple and specific enzyme immunoassay using monoclonal antibodies for serotyping of human rotaviruses. (microbiologyresearch.org)
  • In this review article, we outline key characteristics of major gene therapy viruses-adenovirus, adeno-associated virus (AAV), and lentivirus-and summarize the mechanisms regulating important steps in the virus journey from binding at peripheral nerve terminals to nuclear delivery. (frontiersin.org)
  • Adv infects the host cells through binding to different cellular receptors such as coxsackievirus and adenovirus receptor (CAR) [ 12 ]. (hindawi.com)
  • 2019. Diversity within the adenovirus fiber knob hypervariable loops influences primary receptor interactions . (cardiff.ac.uk)
  • A crosslinking study revealed that recombinant human (rh) BMP-9 bound to ALK1, ALK2, bone morphogenetic protein receptor (BMPR)2, ACVR2A/B and endoglin on primary HSVSMCs. (gla.ac.uk)
  • Structural analysis of the mechanism of adenovirus binding to its human cellular receptor, CAR. (expasy.org)
  • Although miRNAs have been examined in Adv type 3-infected human laryngeal epithelial cells and Adv type 2-infected human lung fibroblast cells [ 19 , 20 ], there is no research about small RNA profiling in whole blood of Adv-infected pneumonia children. (hindawi.com)
  • We while others have shown that it's possible to displace the nine hypervariable parts of the Advertisement5 hexon with those produced from group C (31) or group D (34, 35) serotypes. (synanet2020.com)
  • Species and serotype identities were determined using several well-validated multiplex PCR protocols culled from the literature and supplemented with a few novel primer sets designed to identify rare types. (utmb.edu)
  • There are 7 human adenovirus species (A to G) and 57 serotypes. (msdmanuals.com)
  • Discovery of new adenovirus types, together with methodological advances in structural biology techniques, in particular cryo-EM, has lately produced a considerable amount of new, high-resolution data on the organization of adenoviruses belonging to different species. (bvsalud.org)
  • Two co-infections were detected, each with two serotypes within species C (types 1/2 and 2/6). (unicatt.it)
  • Enterovirus C105 (EV-C105) is a member of the human enterovirus group C species and was first identified in the Democratic Republic of Congo in late 2010 in a faecal sample collected from a fatal acute flaccid paralysis patient during a poliomyelitis outbreak. (who.int)
  • Adenovirus serotype 14 (Ad14) is a rarely reported but emerging serotype of adenovirus that can cause severe and sometimes fatal respiratory illness in patients of all ages, including healthy young adults. (cdc.gov)
  • Adenovirus also was isolated by culture, confirmed by immunofluorescence assay (IFA), and typed as Ad14 by antibody neutralization assay. (cdc.gov)
  • In comparison with the Ad14 patients, among the 12 adenovirus non-type 14 patients (i.e., all but three) whose medical charts were reviewed, nine (75%) were male. (cdc.gov)
  • Adenovirus serotype 14 (Ad14) is a serovar of adenovirus which, unlike other adenovirus serovars, is known to cause potentially fatal adenovirus infections. (wikipedia.org)
  • Of 118 serotyped patients, 106 (90%) were identified as Ad14. (wikipedia.org)
  • BACKGROUND: In 2007, a US Air Force training facility reported a cluster of severe respiratory illnesses associated with a rare human adenovirus (Ad) serotype, Ad14. (itg.be)
  • CONCLUSIONS: Emergence of Ad14, a rare Ad serotype, caused a protracted outbreak of respiratory illness among military recruits. (itg.be)
  • Postmortem tracheal and gastric swabs from the infant were sent to the Wadsworth Center laboratory of the New York State Department of Health, where adenovirus was detected by polymerase chain reaction (PCR). (cdc.gov)
  • Human Advs are nonenveloped double-stranded DNA viruses and belong to the Adenoviridae family [ 7 , 8 ]. (hindawi.com)
  • More recently recognized viruses, such as human metapneumovirus and bocavirus can also cause the common cold. (mhmedical.com)
  • Adenoviruses are large (~950 Å) and complex non-enveloped, dsDNA icosahedral viruses. (bvsalud.org)
  • Similarly, direct injection of viruses into the cerebrospinal fluid (e.g., via lumbar puncture in humans) also permits targeting of the peripheral (PNS) and central nervous systems (CNS). (frontiersin.org)
  • Water samples were assayed for potential respiratory viruses (adenoviruses and enteroviruses), but none were detected. (cdc.gov)
  • The nasopharyngeal swab tested negative for influenza, adenovirus, respiratory syncytial virus, human metapneumovirus, parainfluenza viruses 1-3 and rhinovirus. (who.int)
  • These data support the progression of RH5-based vaccines to human efficacy testing. (jci.org)
  • MHC class II invariant chain-adjuvanted viral vectored vaccines enhances T cell responses in humans. (hervolutiontx.com)
  • Adenovirus based virus-like-vaccines targeting endogenous retroviruses can eliminate growing colorectal cancers in mice. (hervolutiontx.com)
  • Case clusters of severe respiratory disease, caused by specific adenoviruses (particularly types 7, 14, and 55), have occurred in healthy adults. (msdmanuals.com)
  • Human adenoviruses (HAdVs) can cause a variety of human illnesses, with associated temporal and geographic changes in disease incidence. (annals.edu.sg)
  • The genome of adenovirus is well known and can be modified with relative ease to induce lysis or cytotoxicity of a specified cell line without affecting others. (medscape.com)
  • The Plasmodium falciparum reticulocyte-binding protein homolog 5 (PfRH5) has recently emerged as a leading candidate antigen against the blood-stage human malaria parasite. (nature.com)
  • 2019. Human cytomegalovirus interactome analysis identifies degradation hubs, domain associations and viral protein functions . (cardiff.ac.uk)
  • In this study, we designed and studied adenovirus protein fiber constructs with potential applications as carriers for the delivery of protein and nanoparticle cargoes. (bvsalud.org)
  • We used as a basic structural framework the fibrous shaft segment of the adenovirus fiber protein comprising of residues 61-392, connected to the fibritin foldon trimerization motif at the C-terminal end. (bvsalud.org)
  • This work is aimed at establishing the proof-of-principle for the rational engineering of diverse functionalities onto the initial protein structural framework and the use of adenovirus fiber-based proteins as nanorods for the delivery of nanoparticles and model proteins. (bvsalud.org)
  • Ad11 triggered short-term cytokine and cellular responses equal to Ad5 in both human CD46-positive and -negative mice. (ox.ac.uk)
  • 2022. Development of a low seroprevalence, αvβ6 integrin selective virotherapy based on human adenovirus type 10 . (cardiff.ac.uk)
  • Adenoviruses are immunogenic and elicit strong innate and adaptive immune responses. (medscape.com)
  • The therapeutic efficacy of Human adenovirus e serotype 4 strain cl-68578 antigen can be decreased when used in combination with Sorivudine. (drugbank.com)
  • Novel adenovirus encoded virus-like particles displaying the placental malaria associated VAR2CSA antigen. (hervolutiontx.com)
  • This NIH -funded research aimed to test adenoviral recombinants based on simian serotypes for induction of immune responses to gag/pol/rev/env of HIV -1 or SIV -1 in mouse and primate models. (wistar.org)
  • A simian adenoviral vector termed adenovirus C68 (AdC68) was generated as a molecular clone to express the glycoprotein of rabies virus. (wistar.org)
  • Among recognized serotypes, Ad type 7 (Ad7) (and to a lesser extent Ad type 3) is most often associated with severe disease ( 2 ) . (cdc.gov)
  • In the current study we demonstrated for the first time that human adenovirus (HAdV) type 4, 5 and 7 exhibits tropism for neurons cultured in vitro followed by the extensive replication of all serotypes in the primary culture of murine neurons. (elis.sk)
  • This Human Mastadenovirus C, Type 2 (isolate 2879/08) is preserved under Viral Storage Medium -80C. (european-virus-archive.com)
  • This Human Mastadenovirus B, Type 3 (isolate 2936/08) is preserved under Viral Storage Medium -80°C. Tests for the presence of mycoplasmae were negative. (european-virus-archive.com)
  • An outstanding event was the first near-atomic resolution structure of human adenovirus type 5 (HAdV-C5), solved by cryo-electron microscopy (cryo-EM) in 2010. (bvsalud.org)
  • More than 50 distinct serotypes have been identified since the early 1950s. (annals.edu.sg)
  • Adenovirus types 3 and 7 cause a distinct syndrome of conjunctivitis, pharyngitis, and fever (pharyngoconjunctival fever). (msdmanuals.com)
  • Serotype-specific clinical manifestations may be partially determined by differences in cell tropism. (medscape.com)
  • When infections are symptomatic, a broad spectrum of clinical manifestations is possible because most adenoviruses that cause mild disease have affinity for a variety of tissues. (msdmanuals.com)
  • Adenovirus is known to be oncogenic in rodents but not in humans. (medscape.com)
  • 2018. Suppression of costimulation by human cytomegalovirus promotes evasion of cellular immune defenses . (cardiff.ac.uk)
  • An extremely hardy virus, adenovirus is ubiquitous in human and animal populations, survives long periods outside a host, and is endemic throughout the year. (medscape.com)
  • These highly upregulated microRNAs may have crucial roles in Adv pathogenesis and are potential biomarkers for adenovirus-infected pneumonia. (hindawi.com)
  • Adenovirus serotype 11 causes less long-term intraperitoneal inflammation than serotype 5: implications for ovarian cancer therapy. (ox.ac.uk)
  • However, we had found that i.p. group B, in contrast to group C adenoviruses, did not cause adhesions in nude BALB/c ovarian cancer models, prompting further investigation. (ox.ac.uk)
  • This is the first time to our knowledge that substantial RH5-specific responses have been induced by immunization in humans, with levels greatly exceeding the serum antibody responses observed in African adults following years of natural malaria exposure. (jci.org)
  • Human Gene Therapy , 19(4), p. 40. (gla.ac.uk)
  • Immunohistochemistry (IHC) demonstrated that BMP-9 was present in human pre-implantation SVGs and murine carotid arteries. (gla.ac.uk)
  • Human Advs are divided into seven subgroups including 53 serotypes based on immunologic and biological characteristics. (hindawi.com)
  • For hundreds of years, harmful algal blooms (HABs) and HAB-related toxins have been associated with incidents of wild and domestic animal poisonings and outbreaks of human illnesses [ 1 , 2 , 3 , 4 ]. (cdc.gov)
  • Respiratory Ad distributions are geographically variable, and serotype prevalence has not been previously characterized in this region. (utmb.edu)
  • Possessing over60 serotypes, adenovirus is recognized as the etiologic agent of various diverse syndromes. (medscape.com)
  • In our study, total RNA extracted from whole blood of adenovirus-infected pneumonia children and healthy controls were analyzed by small RNA deep sequencing. (hindawi.com)
  • Adv replicates efficiently in human cells and triggers an innate immune response such as inflammatory response in the host cells. (hindawi.com)
  • MyD88-dependent silencing of transgene expression during the innate and adaptive immune response to Helper-dependent adenovirus. (unina.it)