• SERT inhibitor, with an approximate 10:1 DAT:SERT affinity ratio (inhibitory constants (Ki) of 307 and 3830 nM, respectively). (edu.au)
  • These data indicate that dual DAT and SERT inhibitors effectively enhance l-DOPA anti-parkinsonian action without worsening dyskinesia and that compounds with such a pharmacological profile represent promising agents against wearing-off in PD. (edu.au)
  • Serotonin or 5-Hydroxytryptamine (5-HT) and Serotonin Transporter (SERT) are essential for nervous system ontogenesis and maturation [ 1 ]. (scielo.br)
  • The physiological responses promoted by serotonin on intake control decrease when requested by acute stimuli or stress, demonstrating that animals or individuals develop adaptations in response to the environmental insults they experience during the development period. (scielo.br)
  • These findings demonstrate the importance of the level of serotonin in the perinatal period to the development of molecular and morphological aspects of food intake control, and its decisive role in understanding the possible environmental factors that cause diseases in adulthood. (scielo.br)
  • Baldwin, David , Hutchison, John , Donaldson, Kirsteen , Shaw, Bob and Smithers, Andrew (2008) Selective serotonin re-uptake inhibitor treatment-emergent sexual dysfunction: randomized double-blind placebo-controlled parallel-group fixed-dose study of a potential adjuvant compound, VML-670. (soton.ac.uk)