• We wanted to find out if medicines called selective serotonin re-uptake inhibitors (SSRIs), which are used mostly to treat depression, can help men that ejaculate faster than they want, to slow down. (cochrane.org)
  • Selective serotonin re-uptake inhibitors (SSRIs), which are most commonly used as antidepressants are being used to treat this condition. (cochrane.org)
  • Early response to selective serotonin reuptake inhibitors (SSRIs) at 4 weeks may predict response at 12 weeks. (psychiatrist.com)
  • This understanding has led to the use of selective serotonin reuptake inhibitors (SSRIs) for treatment of OCD, which are efficacious and well tolerated. (psychiatrist.com)
  • The drug has been at the centre of a major Government investigation of all selective serotonin re-uptake inhibitors (SSRIs) in Britain over claims they increase suicide and cause withdrawal problems. (antidepressantsfacts.com)
  • The warning also says that children and adolescents taking the types of antidepressant known as "serotonin reuptake inhibitors" (SSRIs) should be carefully watched for increased depression, suicidal thoughts or behaviors, or "unusual changes in behavior, such as sleeplessness, agitation, or withdrawal from normal social situations. (center4research.org)
  • Tramadol should be used with caution in patients requiring selective serotonin re-uptake inhibitors (SSRIs), serotonin-noradrenaline re-uptake inhibitors (SNRIs) and tricyclic antidepressants. (medsafe.govt.nz)
  • Objective To establish whether an association exists between use of selective serotonin reuptake inhibitors (SSRIs) and suicide attempts. (bmj.com)
  • Worldwide, selective serotonin reuptake inhibitors (SSRIs) are prescribed for the treatment of depression and an expanding list of additional conditions. (bmj.com)
  • Evidence from case reports and epidemiologic studies suggests that selective serotonin reuptake inhibitors (SSRIs) alone may increase bleeding risk in susceptible patients. (pharmacytimes.com)
  • Although the mechanism has not been established, it has been proposed that the ability of SSRIs to inhibit the uptake of serotonin into platelets inhibits the ability of platelets to aggregate. (pharmacytimes.com)
  • Theoretically, SSRIs and other drugs that inhibit serotonin uptake would increase the risk of bleeding when combined with other anticoagulants, but little information is available. (pharmacytimes.com)
  • 7 8 A recent review of evidence from paediatric trials by the Committee on Safety of Medicines in Britain led to most selective serotonin re-uptake inhibitors (SSRIs) being contraindicated in people aged younger than 18. (bmj.com)
  • To determine whether mortality and recurrent infarction are reduced by treatment of depression and LPSS with cognitive behavior therapy (CBT), supplemented with a selective serotonin reuptake inhibitor (SSRI) antidepressant when indicated, in patients enrolled within 28 days after MI. (nih.gov)
  • Pimozide is often coprescribed with serotonin reuptake inhibitor (SSRI) antidepressants to treat depression in patients with Tourette's syndrome. (nih.gov)
  • Fluvoxamine, commonly sold under the brand names Luvox and Faverin, is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class. (wikipedia.org)
  • Prozac is an SSRI, or a selective serotonin re-uptake inhibitor. (escapistmagazine.com)
  • To compare the frequency of DSH in patients who had been prescribed a tricyclic antidepressant (TCA) or a selective serotonin reuptake inhibitor (SSRI) prior to the DSH event. (cambridge.org)
  • Tricyclic antidepressant (TCA) drugs are recognised to be inherently more toxic in overdose than the selective serotonin reuptake inhibitor (SSRI) class so that the risk of morbidity and mortality is significantly higher after TCA overdose than after SSRI overdose ( Reference Henry, Alexander and Sener Henry et al , 1995 ). (cambridge.org)
  • Concerns that Seroxat and others in the SSRI (selective serotonin re-uptake inhibitor) class, such as Prozac, could tip a minority towards suicide have been raised for a while. (ahrp.org)
  • Regulator of calcineurin 1 modulates expression of innate anxiety and anxiogenic responses to selective serotonin reuptake inhibitor treatment. (colorado.edu)
  • PROZAC ® (fluoxetine capsules, USP) is a selective serotonin reuptake inhibitor for oral administration. (rxlist.com)
  • Other antidepressants that inhibit serotonin uptake would also be expected to interact, such as serotonin-norepinephrine reuptake inhibitors and certain tricyclic antidepressants (eg, clomipramine, imipramine). (pharmacytimes.com)
  • The antidepressant mirtazapine is not considered an inhibitor of serotonin uptake (although it may cause release of serotonin), but in 1 study mirtazapine was associated with an increased risk of bleeding in patients taking warfarin. (pharmacytimes.com)
  • Use of fluoxitine, a selective serotonin uptake inhibitor, in the treatmente of obesity: A dose-response study. (bvsalud.org)
  • Patients with bulimia nervosa, regardless of the presence of anorexia nervosa or major depression, who have been relatively weight stable and free of binge/vomit episodes for at least 3 weeks, have significantly blunted prolactin responses to the serotonin agonists. (springer.com)
  • Apparently, so the story goes, depression is caused by an imbalance of the neurotransmitter serotonin and schizophrenia is caused by an imbalance of dopamine. (madinamerica.com)
  • Since these neurotransmitters are involved in maintaining high mood and reducing the sensation of pain, blocking their re-uptake into nerve cells can improve the symptoms of depression, anxiety and neuropathic pain. (europa.eu)
  • The most notable side effects of tramadol include serotonin syndrome/toxicity, seizures (including lowered seizure threshold), respiratory depression, increased intracranial pressure and anaphylactoid reactions. (medsafe.govt.nz)
  • This review examined the relationship between clinical response to selective serotonin re-uptake inhibitors in patients with depression and genetic polymorphisms (SERTPR and STin2) in the serotonin transporter gene. (york.ac.uk)
  • Use of tramadol is contraindicated in patients also taking monoamine oxidase inhibitors (MAOIs) and those who have taken MAOIs within the last 14 days 2 . (medsafe.govt.nz)
  • Antidepressants, such as serotonin uptake inhibitors, address this problem by cutting off water flow. (dictionary.com)
  • In this process, serotonin may interact antagonistically with noradrenaline (norepinephrine) and its α 2 -noradrenergic receptors that normally function to enhance carbohydrate intake at the onset of the natural feeding cycle. (springer.com)
  • The active substance in Duloxetine Sandoz, duloxetine, is a serotonin-noradrenaline re-uptake inhibitor. (europa.eu)
  • It works by preventing the neurotransmitters serotonin and noradrenaline from being taken back up into nerve cells in the brain and spinal cord. (europa.eu)
  • Tramadol is a centrally-acting synthetic analgesic with a dual mechanism of action - binding at µ-opioid receptors and inhibiting noradrenaline and serotonin re-uptake. (medsafe.govt.nz)
  • In addition to its opioid actions, tramadol also inhibits the neuronal re-uptake of noradrenaline (NA) and serotonin (5-HT). (medsafe.govt.nz)
  • Serotonin Syndrome and MAOIs: Do not use MAOIs intended to treat psychiatric disorders with fluoxetine or within 5 weeks of stopping treatment with fluoxetine. (nih.gov)
  • As tramadol inhibits re-uptake of NA and 5-HT, use with other serotonergic agents increases the risk of serotonin syndrome/ toxicity. (medsafe.govt.nz)
  • On the other side of the synapse are transporters, which re-uptake the dopamine so that it doesn't continue to just sit around the synapse, stimulating neurons endlessly. (escapistmagazine.com)
  • The two most commonly identified culprits are serotonin and dopamine. (madinamerica.com)
  • At this time, carbohydrate is found to be the naturally preferred macronutrient, and it appears that serotonin becomes most activated under these conditions to terminate the carbohydrate-rich meal, possibly by activating satiety neurons localised in the medial hypothalamus. (springer.com)
  • CARM has received six reports since 2000 where tramadol use may have contributed to serotonin syndrome/toxicity. (medsafe.govt.nz)
  • If serotonin syndrome/toxicity is suspected, prompt withdrawal of the serotonergic medicines is recommended. (medsafe.govt.nz)
  • Serotonin syndrome/ toxicity usually occurs after initiating or increasing the dose of a serotonergic medicine. (medsafe.govt.nz)
  • Anorectic activities of serotonin uptake inhibitors: correlation with their potencies at inhibiting serotonin uptake in vivo and 3 H-mazindol binding in vitro. (springer.com)
  • Thus, the brain sites and receptors involved have been identified, and a possible physiological role of endogenous serotonin in controlling natural patterns of eating and nutrient selection has been defined. (springer.com)
  • MDMA, a potent monoamine-releaser with particularly pronounced serotonin- releasing properties, has unique subjective effects that include: marked positive mood, pleasant/unusual bodily sensations and pro-social, empathic feelings. (researchgate.net)
  • Serotonergic stimulation of these 3 nuclei with exogenous serotonin or drugs that release endogenous serotonin, preferentially reduces carbohydrate intake in naturally feeding animals through satiety mechanisms involved in the termination of feeding. (springer.com)
  • Since 5-HTP increases serotonin levels, it is used for conditions in which serotonin is believed to play an important role. (medlineplus.gov)
  • By blocking their re-uptake, duloxetine increases the amount of these neurotransmitters available for communication between the cells. (europa.eu)
  • Similar alterations in other serotonin pathways at or above the level of the hypothalamus may contribute to binge eating and other behavioural symptoms in bulimic patients. (springer.com)
  • The clinical response to several psychotropic agents known to potentiate serotonergic transmission further substantiates a serotonin dysregulation hypothesis of bulimia nervosa. (springer.com)
  • H(2)(15)O]-Positron Emission Tomography (PET) was used to examine regional cerebral blood flow (rCBF) after administration of a single oral dose of the serotonin realeaser and uptake inhibitor MDMA (1.7 mg/kg) or placebo to 16 MDMA-naïve subjects. (researchgate.net)
  • Endeavor's new treatment candidate, called "taladegib," is an inhibitor that addresses what's known as the "hedgehog" pathway for IPF. (dictionary.com)
  • Studies that assessed the relationship between treatment response and genetic polymorphism of the serotonin transporter gene were eligible for inclusion. (york.ac.uk)
  • When inserted into introns, for instance, they can enhance a gene's expression, or they can guide inhibitors to shut the gene down. (dictionary.com)
  • A teleprompter oxalate, is an orally administered, selective serotonin re uptake inhibitor Ss RI, available as tablets or as an oral solution. (voices.com)
  • Org 34167 is a broad-spectrum inhibitor of HCN channels, slowing activation and causing a hyperpolarising shift in voltage-dependence of activation. (frontiersin.org)
  • Recent pharmacological studies have more precisely characterised the nature of the inhibitory effect of brain serotonin (5-hydroxytryptamine) on feeding behaviour. (springer.com)
  • New Zealand authorities are collecting publications on the safety of selective serotonin re-uptake inhibitors and may seek data from the European agency after the latest warning on Seroxat (known here as Aropax). (antidepressantsfacts.com)