Serotonin transporter promoter region promoter regions genetic. Medical search. Frequent questions

Existing studies of the effect on infant temperament of the 48 base pair variable number of tandem repeats polymorphism in exon 3 of the dopamine D4 receptor gene, DRD4 VNTR, and the serotonin transporter-linked polymorphic region, 5-HTTLPR, have provided contradictory results, and age seems to be an important factor. (ox.ac.uk)
Effects of Recent Stress and Variation in the Serotonin Transporter Polymorphism (5-HTTLPR) on Depressive Symptoms: A Repeated-Measures Study of Adults Age 50 and Older. (uofmhosting.net)
It has been demonstrated that the levels of monoamine metabolites in CSF varies with polymorphism of serotonin transporter protein. (your-doctor.net)
When the polymorphism occurs in more than 1% of a population, it can be considered as useful for genetic linkage analysis. (your-doctor.net)

Among them, polymorphisms in the promoter region of the serotonin transporter gene (SLC6A4) have attracted much attention. (bvsalud.org)
METHODS: Here, we took advantage of naturally occurring genetic polymorphisms in marmoset SLC6A4 gene that have been linked to anxiety-like behaviors. (bvsalud.org)
In this work we study the association between TMD and genetic polymorphisms of folate metabolism, neurotransmission, oxidative and hormonal metabolism. (biomedcentral.com)
A case-control study was designed to evaluate the impact of genetic polymorphisms above described on TMD. (biomedcentral.com)
Other seven genetic polymorphisms different from SNPs (deletions, insertions, tandem repeat, null genotype) were achieved by a multiplex-PCR. (biomedcentral.com)
We and others have previously shown that the dopamine D4 exon III repeat (D4DR) and the serotonin-transporter promoter region (5-HTTLPR) polymorphisms are not only associated with adult personality traits but also with temperament in 2-week-old neonates. (biu.ac.il)
Which of the following components of genetic apparatus is responsible for such polymorphisms ? (your-doctor.net)
SNPs seem to be one of the most common genetic variations and various SNP genotyping methods are being increasingly employed to study polymorphisms. (your-doctor.net)
Polymorphisms arise originally out of mutations but are maintained in populations due to factors such as founder effect, genetic drift, and natural selection. (your-doctor.net)
Note that most polymorphisms occur in non-coding regions (that is introns), as coding sequences (or exons) on mutation often produce disease phenotypes. (your-doctor.net)
Serotonin transporter polymorphisms have been identified in the promoter region, which is a non-coding part of DNA (5HTTLPR-5HT transporter linked promoter region). (your-doctor.net)
Although a large body of research, ranging from rodents to humans, has reported on the effects of OXT and AVP administration on affiliative and trust behaviors, and has highlighted the genetic contributions of OXT and AVP receptor polymorphisms to both social behaviors and to diseases related to social deficits, the consequences of peptide administration on psychiatric symptoms, and the impact of receptor polymorphisms on receptor function, are still unclear. (frontiersin.org)
In addition, we discuss reports on the interactions of OXT and AVP receptor genes and genes involved in other pathways (such as those of dopamine, serotonin, and reelin), as well as research that has shed some light on the impact of gene polymorphisms on the volume, connectivity, and activation of specific neural structures, differential receptor expression, and plasma levels of the OXT and AVP peptides. (frontiersin.org)

This may lead to increased transcriptional activity of the gene, increased reuptake of serotonin from synaptic clefts, and termination of the activity of serotonin. (tuni.fi)
The aim of the present study was to test a possible effect of the G-protein beta3-subunit (Gbeta3) C825T gene variant on the antidepressant activity of selective serotonin reuptake inhibitors (SSRIs) in a sample of major and bipolar depressives, with or without psychotic features. (neurotransmitter.net)

Applying the stress-diathesis hypothesis to older adults, we postulate: (1) recent stress will associate with increased depressive symptom levels and (2) this effect will be greater for individuals with at least one short allele of the serotonin transporter gene promoter region (5-HTTLPR). (uofmhosting.net)
Increased levels of pup licking/grooming by rat mothers in the first week of life alter DNA structure at a glucocorticoid receptor gene promoter in the hippocampus of the offspring. (deepdyve.com)

Dopamine D4 receptor and serotonin transporter gene effects on the longitudinal development of infant temperament. (ox.ac.uk)

The results emphasize the need for developmental studies of genetic effects on temperament. (ox.ac.uk)

We explored the effect of environmental stress on serotonin transporter gene (SLC6A4) promoter methylation among nurses from high and low work stress environments. (tuni.fi)
Methodology: Using bisulfite sequencing, we investigated the methylation status of five CpG residues of a CpG-rich region in the promoter of SLC6A4 by comparing female shift working nurses from a high work stress environment (n = 24) to low work stress environment (n = 25). (tuni.fi)
Conclusions: Our findings show that environmental stress is concurrent with decreased methylation of the SLC6A4 promoter. (tuni.fi)

Folate metabolism, which depends on genes variations and diet, is directly involved in genetic and epigenetic variations that can influence the changes of last growing period of development in human and the appearance of the TMD. (biomedcentral.com)
However, epigenetic changes in other candidate genes such as brain-derived neurotrophic factor ( BDNF ) and serotonin transporter are also implicated in early life stress (ELS) and susceptibility to adult psychiatric disorders. (biomedcentral.com)

FINDINGS: We revealed that marmosets bearing different SLC6A4 variants exhibit distinct microRNAs signatures in a region of the prefrontal cortex whose activity has been consistently altered in patients with depression/anxiety. (bvsalud.org)

and they are associated with altered histone acetylation and transcription factor (nerve growth factor-induced clone A [NGFIA]) binding to the glucocorticoid receptor promoter. (deepdyve.com)

In addition, structural brain changes in the form of gray matter volume reduction in areas important for emotional processing, such as the amygdala, have been noted in subjects with the short variant of the promoter region. (your-doctor.net)

[ 14 , 15 ] Nevertheless, mechanisms behind therapeutic agents used in patients with the disorder have lent support to the possible role of a few different genetic pathways and mutations. (medscape.com)

Human studies have identified a number of high-risk genetic variants for these diseases. (bvsalud.org)
However, due to the paucity of experimental models, molecular alterations induced by these genetic variants and how they correlate to behavioral deficits have not been examined. (bvsalud.org)
INTERPRETATION: Our findings establish links between genetic variants, molecular modifications in specific cortical regions and complex behavioral responses, providing new insights into gene-behavior relationships underlying human psychopathology. (bvsalud.org)
Early genetic association studies of psychiatric traits were predicated on optimism regarding the existence of common variants with substantial effects on disease liability [ 1 ]. (nature.com)

Significantly, we showed that levels of both microRNAs and DCC in this region were highly correlated to anxiety-like behaviors. (bvsalud.org)

Many chromosomal regions have shown linkage to bipolar disorder, but meta-analyses of microsatellite marker-based linkage studies have not provided consistent findings of susceptibility regions. (medscape.com)
A meta-analysis of original data from 11 previous linkage studies in 1067 bipolar disorder families yielded significant findings in chromosomal regions 6q for bipolar I and 8q for bipolar I/II, as well as suggestive findings at chromosomal regions 9p and 20p for bipolar I. (medscape.com)

Etiology of mood disorders is unclear, although a genetic component has been strongly suggested by family and twin studies. (medscape.com)

These effects are, in part, mediated by sustained alterations in gene expression in selected brain regions. (deepdyve.com)

Genetic information in an organism is inherited equally from parents of both sexes. (your-doctor.net)

La estancia postdoctoral que disfruté en el Dementia Research Laboratory (King's College, Londres), me permitió, además de desarrollar mi habilidades técnicas e intelectuales, el ponerme en contacto y comenzar colaboraciones de investigación, que se mantiene a dia de hoy. (unav.edu)

Genetic effects were stable across age. (ox.ac.uk)

Significant Group X Region X Hemisphere interactions were found consistently for alpha band power only. (virginia.edu)

Depending on genetic sensitivity to it, stress may affect depressive symptomatology differentially. (uofmhosting.net)

It is considered the most common cause of chronic pain in the orofacial region. (biomedcentral.com)

Recent research has shown that a functional polymorphism in the promoter region of the serotonin transporter gene was found to moderate the influence of stressful life events on depression. (nih.gov)
2006 . The association between a genetic polymorphism of coproporphyrinogen oxidase, dental mercury exposure and neurobehavioral response in humans. (nih.gov)
The length polymorphism of the serotonin (5-HT) transporter gene promoter region has been implicated in altered 5-HT function and, in turn, neuropsychiatric illnesses, such as anxiety and depression. (virginia.edu)
The nonhuman primate has been used as a model to study anxiety-related mechanisms in humans based upon similarities in behavior and the presence of a similar 5-HT transporter gene polymorphism. (virginia.edu)
BDNF variation and mood disorders: a novel functional promoter polymorphism and Val66Met are associated with anxiety but have opposing effects. (neurotransmitter.net)
In this study, we used single-nucleotide polymorphism (SNP) discovery, functional analyses, and genetic association studies to better understand the potential role of BDNF sequence variation in behavior. (neurotransmitter.net)

G (rs6295) and the dopamine transporter ( DAT1) repeat allele, with BPD in a major depressive disorder cohort of 367 patients. (frontiersin.org)
BVD was not associated with any significant differences in dopamine beta-hydroxylase or the dopamine transporter in any brain region studied. (pkainhibitors.com)

Novel approaches to gene discovery, the identification of epigenetic mechanisms, elucidation of environmental risk factors, characterization of the genetic aspects of response to environmental change, and the use of biomarkers and other intermediate phenotypes correlated with the clinical disorder are encouraged. (nih.gov)
Failure to carefully consider gene-environment factors often results in the inability to detect or accurately quantify the underlying genetic contribution to phenotypic variability in the timing and appearance of depressive disorders. (nih.gov)
Studies are needed to investigate the gene-environment interactions between substance exposure and genetic vulnerability to depression, including possible intermediate phenotypes or factors such as sleep disturbances. (nih.gov)
These translational data suggest that genetic variation in CRHR1 affects the risk for affective disorders by influencing the function of the neural circuit underlying AT and that differences in gene expression or the protein sequence involving exon 6 may be important. (virginia.edu)
A variant allele in the promoter region of the serotonin transporter gene, SLC6A4, the s allele, is associated with increased vulnerability to develop anxiety-related traits and depression. (virginia.edu)
In order to identify gene(s) and mechanisms associated with substance addiction, a custom platform array search for a genetic association in a case/control of homogenous Jordanian Arab population was undertaken. (biomedcentral.com)
A) in promoter 1 was discovered that had decreased DNA binding in vitro and decreased basal reporter gene activity in transfected rat hippocampal neurons. (neurotransmitter.net)
Functional polymorphisms in the MAO-A uVNTR promoter gene, the COMT gene (Val158Met) exon 4, and the 5-HTT promoter gene (44 bp ins/del) were investigated in 101 patients with phobic disorders of the anxiety spectrum and 202 controls matched to the patients for sex, age and ethnicity. (neurotransmitter.net)

The role of serotonin in emotional regulation is well established, but little is known about the postnatal development of the raphe where serotonin is made. (jneurosci.org)
Using whole-cell patch-clamp recording and immunohistochemistry, we tested whether serotonin circuitry in the dorsal and median raphe was functionally mature during the first 3 postnatal weeks in mice. (jneurosci.org)
RESULTS: There were no significant differences when comparing l/l homozygotes with s-carriers in the regions of the brain implicated in anxiety and mood related illnesses (amygdala, striatum, thalamus, raphe nuclei, temporal and prefrontal cortex). (virginia.edu)
In the first category, we included dopamine (DA) neurons of the substantia nigra, noradrenergic neurons of the locus coeruleus (LC), serotonin neurons of the raphe nuclei (R), and cholinergic neurons of the dorsal motor nucleus of the vagus (DMV). (eneuro.org)

Serotonin [5-hydroxytryptomine(5-HT)] likely plays a critical role in the etiology of anxiety and mood disorders as drugs that affect 5-HT physiology (e.g., selective serotonin reuptake inhibitors) are among the most efficacious in treating such disorders ( Koen and Stein, 2011 ) and have anxiolytic properties in rodent anxiety models ( Carr and Lucki, 2011 ). (jneurosci.org)

Recent studies provide evidence that anxiety disorders may be linked to malfunction of serotonin neurotransmission or impaired activity of enzymes metabolising the catecholamines. (neurotransmitter.net)
In this study we investigated whether chronic bilateral vestibular deafferentation (BVD) would affect the expression of several biogenic amine enzymes and transporters in the medial temporal lobe (CA1, CA2/3, dentate gyrus (DG), entorhinal (EC) and perirhinal cortices (PRC)) and frontal lobes (FL) of rats. (pkainhibitors.com)

Deciphering the genetic blueprint for depression is complicated by the fact that complex interactions between genes and the environment are not adequately assessed or understood. (nih.gov)
Both depression and alcohol abuse/dependence have genetic and environmental components that may interact. (nih.gov)
Another fruitful line of scientific inquiry is the genetic characterization of individuals who respond favorably to short-term pharmacologic or other environmental treatment interventions for depression. (nih.gov)
Identification of 15 genetic loci associated with risk of major depression in individuals of European descent. (pharmaceuticalintelligence.com)

Stressful and threatening contexts in the nonhuman primate model have revealed 5-HT transporter genotype dependent differences in regional glucose metabolism. (virginia.edu)

Serotonin neurons at postnatal day 4 (P4) were hyperexcitable. (jneurosci.org)

Both environmental and genetic factors contribute to individual susceptibility to initiation of substance use and vulnerability to addiction. (biomedcentral.com)
Genetic susceptibility to addiction is the result of the interaction of many genes related to the central nervous system (CNS) [ 9 - 12 ]. (biomedcentral.com)

2 Stress-induced responses of the HPA system involve afferent inputs from numerous other brain regions including noradrenergic innervation from the brainstem A1 and A2 cell groups and the pontine locus coeruleus, 3 the amygdala, 4 , 5 cerebral cortex and hippocampus. (jpn.ca)

Because serotonin affects circuit development in other brain regions, altering the developmental trajectory of serotonin neuron excitability and release could have many downstream consequences. (jneurosci.org)

Modeling Genetic and Environmental Influences on Stability and Change (Finkel). (nih.gov)
Genetic influences on the retention of inorganic mercury. (nih.gov)

The strongest statistical evidence for these new association signals were from rs1799732 in the C/−C promoter and rs1125394 in A/G intron 1 regions of DRD2 , with the overall estimate of effects returning an odds ratio of 3.37 ( χ2 (2, N = 460) = 21, p-value = 0.000026) and 1.78 ( χ2 (2, N = 460) = 8, p-value = 0.001), respectively. (biomedcentral.com)

and the refinement of economic phenotypes for genetic analyses. (nih.gov)
The team then created a weighted genetic risk score (GRS) in which they compared the 17 SNPs with factors including medication use, comorbid diseases and behavioral phenotypes, all of which were correlated with the GRS. (pharmaceuticalintelligence.com)

To explore potential mechanisms, we used a validated rhesus macaque model to investigate association between genetic variation in CRHR1, anxious temperament (AT) and brain metabolic activity. (virginia.edu)

We previously reported that serotonin, a major neurotransmitter involved in mood disorders, regulates GSK3 by acutely increasing its N-terminal serine phosphorylation. (researchgate.net)

Such studies should take into account genetic predisposition to both depressive and substance use disorders, due to assortative mating that has been identified between drug abusing men and depressed women. (nih.gov)

Because genetic methods can deepen the level of analysis in many of these studies, the BSR has begun to explore ways to better merge or integrate genetic analyses into social and behavioral research. (nih.gov)

However, there is also evidence for shared genetic vulnerability to two or more drugs such as cannabis, sedatives, stimulants and opiates which may explain the finding that addicted patients are often dependent on more than one category of drug [ 2 - 9 ]. (biomedcentral.com)

Determining genetic risk factors can make an important contribution to understanding the processes leading to addiction. (biomedcentral.com)

Researchers from Pfizer Global Research and Development, 23andMe, and the Massachusetts General Hospital have published a study in Nature Genetics, pinpointing 15 genetic loci associated with the risk of developing major depressive disorder (MDD) in individuals of European ancestry. (pharmaceuticalintelligence.com)

Using the rhesus monkey, we examined the extent to which serotonin transporter genotype is associated with 5-HT transporter binding in brain regions implicated in emotion-related pathology. (virginia.edu)

This study is the first to show a genetic link to substance addiction in a Jordanian population of Arab descent. (biomedcentral.com)

This is the first study investigating comprehensively how interareal connections among cortical and thalamic regions are formed during development. (brainminds.jp)
The participants of this study had agreed to provide the results of their genetic testing for scientific research. (pharmaceuticalintelligence.com)

Animal studies supported under this RFA are expected to focus primarily on the identification and characterization of underlying molecular genetic mechanisms that mediate effects of environment on depressive pheontypes. (nih.gov)

A rare one, found in three families in the old settlement region in southwestern Finland, shared a four-marker (0.5 cM) core haplotype with the Icelandic 999del5 haplotype. (nih.gov)

There was a significant sex difference in 5-HT transporter binding in all regions with females having 18%-28% higher DVR than males. (virginia.edu)

We conclude that serotonin neuron structure and function change substantially during the first 3 weeks of life during which external stressors could potentially alter circuit formation. (jneurosci.org)

C-11]DASB dynamic PET scans were acquired for 90 min in the anesthetized animals and images of distribution volume ratio (DVR) were created to serve as a metric of 5-HT transporter binding for group comparison based on a reference region method of analysis. (virginia.edu)

The dopaminergic system is involved in cognitive and emotional processing and the regulation of impulsive behaviors: dysfunction of these processes have been related to BPD symptoms ( Friedel, 2004 ), which may stem from multiple factors, including a genetic component. (frontiersin.org)

Centre d'etude du polymorphisme humain (CEPH): collaborative genetic mapping of the human genome. (nih.gov)

Anatomy1

Chemicals and Drugs31

Analytical, Diagnostic and Therapeutic Techniques and Equipment4

Phenomena and Processes21

Information Science3

Polymorphism4

Polymorphisms13

Reuptake2

Gene promoter2

Dopamine1

Temperament1

Methylation3

Genes2

SLC6A41

Receptor1

Variant1

Pathways1

Variants4

Behaviors1

Linkage2

Etiology1

Alterations1

Equally1

Research1

Effects1

Consistently1

Stress1

Common1

Polymorphism6

Dopamine transporter2

Gene8

Raphe4

Selective1

Enzymes2

Depression4

Stressful1

Neurons1

Susceptibility2

Noradrenergic1

Affects1

Influences2

Drd21

Phenotypes2

Variation1

Mood1

Disorders1

Analyses1

Vulnerability1

Contribution1

Risk1

Brain1

Substance1

Study2

Identification1

Found1

Significant1

Function1

Group1

Component1

Human1