OrganismsDiseasesChemicals and DrugsPsychiatry and PsychologyPhenomena and ProcessesInformation Science
AminorexAppetite DepressantsFenfluramineDexfenfluraminePhenmetrazineAppetiteSerotoninNaphthoquinonesAntitussive AgentsAppetite RegulationAntacidsInhibitor of Apoptosis ProteinsDextromethorphanSerotonin Plasma Membrane Transport ProteinsOrganic Cation Transporter 1Receptors, SerotoninReceptor, Serotonin, 5-HT2AReceptor, Serotonin, 5-HT1ASerotonin Uptake InhibitorsImidazolesSerotonin AntagonistsAppetite StimulantsEatingHistamine H2 AntagonistsReceptor, Serotonin, 5-HT2CReceptor, Serotonin, 5-HT2BReceptor, Serotonin, 5-HT1BReceptors, Serotonin, 5-HT2Serotonin AgentsSerotonin Receptor AgonistsDose-Response Relationship, DrugReceptors, Serotonin, 5-HT1Rats, Sprague-DawleySerotonin SyndromeSerotonin 5-HT2 Receptor AntagonistsSatiationHungerSatiety ResponseReceptors, Serotonin, 5-HT3Serotonin 5-HT2 Receptor AgonistsTryptaminesChlorphentermineBufoteninPhentermineDesigner DrugsEncyclopedias as TopicPsilocybine
PsychoactiveStimulantsReleaseRelativeFenfluramineChlorphentermineLevels
Psychoactive1
  • This article provides information on 4,4′-DMAR, a new psychoactive substance that is a derivative of aminorex, an amphetamine-like appetite suppressant. (safrole.com)
Stimulants1
  • It is a derivative of aminorex and 4-methylaminorex (4-MAR), two synthetic stimulants that are strictly controlled under the 1971 United Nations Convention on Psychotropic Substances, with 4-MAR listed in Schedule I and aminorex listed in Schedule IV. (safrole.com)
Release2
  • A serotonin releasing agent (SRA) is a type of drug that induces the release of serotonin into the neuronal synaptic cleft. (wikipedia.org)
  • This study analyzed the effects of (±)-cis-4,4′-DMAR on dopamine, noradrenaline, and serotonin release at the dopamine transporter (DAT), noradrenaline transporter (NET), and serotonin transporter (SERT) using rat brain synaptosomes. (safrole.com)
Relative1
  • SSRAs have been used clinically as appetite suppressants, and they have also been proposed as novel antidepressants and anxiolytics with the potential for a faster onset of action and superior efficacy relative to the selective serotonin reuptake inhibitors (SSRIs). (wikipedia.org)
Fenfluramine5
  • Fenfluramine, chlorphentermine, and aminorex, which are also amphetamines and relatives, were formerly used as appetite suppressants but were discontinued due to concerns of cardiac valvulopathy. (wikipedia.org)
  • Epidemiological studies have established that fenfluramine, D-fenfluramine, and aminorex, but not other appetite suppressants, increase the risk of primary pulmonary hypertension (PH). (nih.gov)
  • One current hypothesis suggests that fenfluramine-like medications may act through interactions with the serotonin (5-hydroxytryptamine [5-HT]) transporter (5-HTT) located on pulmonary artery smooth muscle cells and responsible for the mitogenic action of 5-HT. (nih.gov)
  • It is no longer used due mainly to safety concerns, as it has a serotonergic effects profile similar to other withdrawn appetite suppressants such as fenfluramine and aminorex which were found to cause pulmonary hypertension and cardiac fibrosis following prolonged use. (wikidoc.org)
  • Aminorex, fenfluramine, and chlorphentermine are serotonin transporter substrates. (wikidoc.org)
Chlorphentermine2
  • Chlorphentermine (Apsedon, Desopimon, Lucofen) is a stimulant drug which was used as an appetite suppressant . (wikidoc.org)
  • Chlorphentermine itself is a relatively weak stimulant with little abuse potential, but is classed as a Schedule 3 drug in the USA due mainly to its similarity to other appetite suppressants such as diethylpropion which have been more widely abused. (wikidoc.org)
Levels1