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  • inhibitors
  • Materials and Methods: Segments taken from the rat duodenum, jejunum, mid and terminal ileum were vertically mounted, connected to a transducer and exposed to EFS with different frequencies in the absence and presence of various inhibitors of enteric mediators i. e. specific 5-HT receptor antagonists. (hud.ac.uk)
  • endogenous
  • Background: The main source of 5-HT in body is in enterchromafin cells of intestine, different studies mentioned different roles for endogenous 5-HT and receptors involved and it is not clearified the mechanism of action of endogenous 5-HT. (hud.ac.uk)
  • Objectives: To study the role of endogenous 5-HT on modulation of contraction and relaxation responses induced by electrical field stimulation (EFS) in different regions of the rat intestine. (hud.ac.uk)
  • Conclusions: The application of 5-HT1A, 5-HT2, 5-HT3, 5-HT4, 5-HT6 and 5-HT7 receptor antagonists, applied at concentrations lower than 1.0 µM did not modify the EFS-induced contraction and relaxation responses, whichsuggests the unlikely involvement of endogenous 5-HT in mediating responses to EFS in the described test conditions. (hud.ac.uk)
  • The application of 5-HT 1A , 5-HT 2 , 5-HT 3 , 5-HT 4 , 5-HT 6 and 5-HT 7 receptor antagonists, applied at concentrations lower than 1.0 µM did not modify the EFS-induced contraction and relaxation responses, whichsuggests the unlikely involvement of endogenous 5-HT in mediating responses to EFS in the described test conditions. (genecelltissue.com)
  • The difficulty encountered in establishing what endogenous 5-HT actually does in the gut may be due to the two different sites of 5-HT storage in the enterochromaffin cells of the mucosa ( 6 ) and in the enteric neurones, for which it serves a neurotransmitter role ( 7 ). (genecelltissue.com)
  • It isunknown whether endogenous 5-HT can access receptors available to stimulation by exogenous 5-HT to mediate the well-established contraction or relaxation response in the intestine. (genecelltissue.com)
  • vivo
  • McN-5652 is characterized by exceptionally high potency as an inhibitor of the uptake of serotonin by rat brain synaptosomes in vitro (Ki approximately 0.6 nM) and ex vivo (ED50 approximately 2 mg/kg p.o. (aspetjournals.org)
  • contraction
  • In the presence of SB258585 1.0 µM (a 5-HT6 receptor antagonist) there was a trend to enhance contraction in the proximal part of the intestine and reduce contraction in the distal part. (hud.ac.uk)
  • unknown
  • Although the 5-HT content of the gastrointestinal tract is higher than that of any other organ ( 5 ), the precise role of 5-HT in the physiology of the gut remains unknown. (genecelltissue.com)
  • multiple
  • The maximum observed effect (Emax), assessed by the maximum observed concentration of 5-HT in plasma measured at Baseline, after a single dose (Day 1) and after multiple doses (Day 14). (clinicaltrials.gov)
  • The time to reach maximum pharmacodynamic effect (Emax) was assessed by the time to maximum concentration of 5-HT in plasma at Baseline, after a single dose (Day 1) and after multiple doses (Day 14). (clinicaltrials.gov)
  • The maximum observed effect (Emax), assessed by the maximum concentration of 5-HT in cerebrospinal fluid (CSF) measured at Baseline, after a single dose (Day 1) and after multiple doses (Day 14). (clinicaltrials.gov)
  • Effects
  • The risk or severity of adverse effects can be increased when Alverine is combined with 2,5-Dimethoxy-4-ethylthioamphetamine. (drugbank.ca)
  • approximately
  • The estimated lifetime prevalence of major depression in the adult population is 5 to 25%, with approximately 2-fold higher prevalence in women than in men. (clinicaltrials.gov)
  • hours
  • Area Under the Effect Curve From Time Zero to 24 Hours Postdose of 5-hydroxytryptamine (5-HT) in Plasma [ Time Frame: Day -1 (Baseline), Day 1 and Day 14. (clinicaltrials.gov)
  • Human
  • Its ability to displace [(3)H]CP55940 from mouse CB(1) and human CB(2) cannabinoid receptors and to inhibit electrically evoked contractions of the mouse isolated vas deferens was also investigated. (nih.gov)