• Predicted to enable serine-type endopeptidase inhibitor activity. (nih.gov)
  • Alpha-1-proteinase inhibitor may increase the thrombogenic activities of Prothrombin. (drugbank.com)
  • This endopeptidase inhibitor is utilized in the process of isolating and purifying protein to slow down the activity of serine protease. (herbs2000.com)
  • The protein encoded by this gene is a member of the serpin (serine proteinase inhibitor) superfamily, and ovalbumin(ov)-serpin subfamily. (modellab.cn)
  • it promotes cell death by binding to and inhibiting INHIBITOR OF APOPTOSIS PROTEINS, resulting in an increase in activity of CASPASES. (bvsalud.org)
  • FUNCTIONS IN: hydrolase activity, inositol or phosphatidylinosi. (riken.jp)
  • The catalytic activity of the serine proteases from the trypsin family is provided by a charge relay system involving an aspartic acid residue hydrogen-bonded to a histidine, which itself is hydrogen-bonded to a serine. (embl.de)
  • The protein is primarily secreted by axons in the brain, and preferentially reacts with and inhibits tissue-type plasminogen activator. (avivasysbio.com)
  • Glandular (tissue) kallikreins (including EGF-binding protein types A, B, and C, NGF-gamma chain, gamma-renin, prostate specific antigen (PSA) and tonin). (embl.de)
  • Fibroblast activation protein (FAP) is overexpressed in cancer-associated fibroblasts and is involved in a variety of tumor-promoting activities such as matrix remodeling, angiogenesis, chemotherapy resistance, and immunosuppression. (snmjournals.org)
  • One of these proteins is the fibroblast activation protein (FAP), a type II transmembrane serine protease with both dipeptidyl peptidase activity and endopeptidase activity ( 2 - 4 ). (snmjournals.org)
  • Endopeptidases break the amino acids' peptide bonds inside protein molecules. (herbs2000.com)
  • Encodes a protein with nicotianamine synthase activity. (or.jp)
  • The protein encoded by this gene is a cytosolic prolyl endopeptidase that cleaves peptide bonds on the C-terminal side of prolyl residues within peptides that are up to approximately 30 amino acids long. (blogspot.com)
  • GeneCards Summary for PREP Gene: PREP (Prolyl Endopeptidase) is a Protein Coding gene. (blogspot.com)
  • X-linked hypophosphatemic rickets and autosomal recessive hypophosphatemic rickets are the result of mutations in PHEX (a phosphate-regulating gene with homologies to endopeptidases on the X chromosome) and dentin matrix protein 1 ( DMP1 ), respectively. (medscape.com)
  • One such example of the growing medical interest is prolyl endopeptidase, which especially cleaves after the amino acid called proline . (herbs2000.com)
  • Similarly, prolyl endopeptidase inhibitors are also of great medical interest because it is regarded as a potential anti-depressant remedy. (herbs2000.com)
  • In fact, prolyl endopeptidase is major and large cytosolic enzyme belonging to a separate serine peptidase class. (herbs2000.com)
  • When it was discovered, prolyl endopeptidase was found in the rabbit brain's cytosol in the form of an oligopeptidase that breaks down the non-peptide known as bradykinin present in the Pro-Phe bond. (herbs2000.com)
  • Endopeptidases belonging to the serine family include proteases involved in the digestive process, such as chymotrypsin and trypsin, in addition to prolyl endopeptidase. (herbs2000.com)
  • The gene ontology (GO) terms associated with monooxygenase, iron binding, and passive transmembrane transporter activities were significantly enriched in four out of six resistant vs. susceptible comparisons while serine protease activity was elevated in all insecticide-resistant groups relative to the susceptible strain. (cdc.gov)
  • 4 usually cause human botulism (A, B, E, and F). We developed a rapid, mass spectrometry-based method (Endopep-MS) to detect and differentiate active BoNTs A, B, E, and F. This method uses the highly specific protease activity of the toxins with target peptides specific for each toxin serotype. (cdc.gov)
  • CONTAINS InterPro DOMAIN/s: Zinc finger, RING-type (InterPro:IPR0. (riken.jp)
  • Endopeptidase, also known as endoproteinase, is basically proteolytic peptidases that split peptide bonds in the molecules of non-terminal amino acids. (herbs2000.com)
  • Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase activity and serine-type exopeptidase activity . (blogspot.com)
  • Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. (yeastgenome.org)
  • This is the reason why endopeptidase is unable to degrade peptides into monomers. (herbs2000.com)
  • oligopeptidase ( PREP ) is a serine protease that hydrolyzes peptides shorter. (blogspot.com)
  • The product peptides derived from the endopeptidase activities of BoNTs are detected by matrix-assisted laser-desorption ionization time-of-flight mass spectrometry. (cdc.gov)
  • Degradation of matrix extracellular phosphoglycoprotein (MEPE) and DMP-1 and release of acidic serine-rich and aspartate-rich MEPE-associated motif (ASARM) peptides are chiefly responsible for the hypophosphatemic rickets mineralization defect and changes in osteoblast-osteoclast differentiation. (medscape.com)
  • As proteases play a wide assortment of roles in the normal functioning of the cells, the medical community has expressed much interest in the activities of endopeptidase. (herbs2000.com)
  • One of these endopeptidase inhibitors is highly toxic and is often used for research in biochemical laboratories. (herbs2000.com)
  • Oligopeptidase is a specific example of endopeptidase. (herbs2000.com)
  • FUNCTIONS IN: transcription regulator activity, DNA. (riken.jp)
  • Body weight, general condition and plasma enzyme activities of the mice were observed to evaluate heart function. (bvsalud.org)
  • Predicted to be involved in negative regulation of endopeptidase activity and response to xenobiotic stimulus. (nih.gov)
  • The expanded line was evaluated for viability surface antigen expression and alkaline phosphatase activity. (coriell.org)
  • For instance, one family of endopeptide belongs to the serine family, which contain an amino acid called serine at the protease's active site. (herbs2000.com)
  • Goat anti Human Urokinase antibody detects an epitope within the C-terminal of urokinase, a potent ~50 kDa serine protease also known as urokinase plasminogen activator (uPA). (bio-rad-antibodies.com)
  • The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
  • Two-Hybrid), annotation type (e.g., manual or high-throughput), and a reference, as well as other experimental details. (yeastgenome.org)
  • Assembled in the genome of the clavibacter michiganensis specie, It is a putative serine protease gene that belongs to the PTHR10795 family, which contains 23545 species. (wikipedia.org)
  • Plasminogen activators (urokinase-type, and tissue-type). (embl.de)
  • Mutants accumulate excess iron, manganese and zinc, and express root Fe(III) chelatase activity even under iron sufficiency conditions. (or.jp)
  • In H9c2 cardiomyocyte cells, cell viability, generation of ROS, mitochondrial activity and cellular Fe2+ levels were measured. (bvsalud.org)
  • The heavy chain contains two fibronectin-type domains, two epidermal growth factor (EGF)-like domains, a kringle domain and a proline-rich domain, whereas the light chain contains only a catalytic domain. (nih.gov)
  • A serine peptidase that contains a C-terminal PDZ domain. (bvsalud.org)
  • Menadione is a synthetic naphthoquinone without the isoprenoid side chain and biological activity, but can be converted to active vitamin K2, menaquinone, after alkylation in vivo. (t3db.ca)