• Analysis of the structure and sequence of several different env genes suggests that Env proteins are type 1 fusion machines. (wikipedia.org)
  • Infection leads to injection of the virus nucleoprotein core (consisting of many gag-derived proteins, full-length genomic RNA, and the reverse transcriptase protein). (ukessays.com)
  • Unspliced full-length mRNA can give rise to gag-pol proteins. (ukessays.com)
  • Full-length genomic unspliced mRNA is bound by gag-derived proteins and incorporated into the budding particle. (ukessays.com)
  • gag gene codes for structural proteins which forms the 'body' of the viral particle, among other proteins. (proteopedia.org)
  • Pol gene on the other hand codes for three essential enzymes which are Reverse Transcriptase (RT), Integrase (IN) and Protease (PR), among other proteins. (proteopedia.org)
  • env gene codes for viral envelop proteins. (proteopedia.org)
  • The specificity towards RNA packaging requires higher order interactions of the retroviral gRNA with the structural Gag proteins. (uaeu.ac.ae)
  • Title: Differential gene expression and immunolocalization of insulin-like growth factors and insulin-like growth factor binding proteins between experimental nonunions and standard healing fractures. (genscript.com)
  • A mutant of Mo-MuSV strain 124 (designated MuSV ts110) is temperature-sensitive (ts) for transformation and encodes two proteins, P85('gag-mos) (an 85,000 M(,r) protein encoded by the gag and mos genes) and P58('gag), at the permissive temperature (28(DEGREES)C). At the nonpermissive temperature (39(DEGREES)C), only P58('gag) is found in MuSV ts110-infected NRK cells (6m2 cells). (tmc.edu)
  • Both P85('gag-mos) and P58('gag) were phosphorylated when anti-gag immune complexes containing these proteins were incubated at 22(DEGREES)C with (lamda)-('32)P -ATP and MnCl(,2). (tmc.edu)
  • Some MHC-linked genes encode proteins that interact with MHC molecules. (biomedcentral.com)
  • The inner nucleocapsid is formed by four proteins (p24, p15, p12, p10) encoded by the gag (group specific antigen) gene. (anipedia.org)
  • [ 5 ] Only 10% of amyloidosis deposits consist of components such as glycosaminoglycans (GAGs), apolipoprotein-E (apoE), and serum amyloid P-component (SAP), while nearly 90% of the deposits consist of amyloid fibrils that are formed by the aggregation of misfolded proteins. (medscape.com)
  • Figure 1 Homology in domain structures and amino acid sequences between human and mouse NLRP1 and the present knock-in mutation. (frontiersin.org)
  • Moreover, several retroviruses have been shown to have the ability to cross-/co-package gRNA from other retroviruses, despite little sequence homology. (uaeu.ac.ae)
  • 19 Further analysis of the BLV genome reveals a striking homology to HTLV-I in the gene arrangement, although their nucleotide sequence homology is limited. (anipedia.org)
  • Nucleotide sequencing of the gag gene and maximum likelihood phylogenetic analysis were used to investigate the relationships among sequences from the surgeon, the patient, and an anonymous blood donor from whom the patient had received blood products. (ox.ac.uk)
  • Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories. (lookformedical.com)
  • The Chilean GLRaV-7 sequence (GenBank Accession No. EU334662) showed 94% nucleotide and 95% amino acid identity when compared with a corresponding region of another GLRaV-7 isolate from Albania (GenBank Accession No. Y15987). (apsnet.org)
  • The RT-PCR product of 393 bp corresponding to a fragment of the HSP70h gene was cloned and sequenced (GenBank Accession No. EU334663), showing 94% nucleotide and 95% amino acid identity when compared with a corresponding region of another GLRaV-9 isolate from the United States (GenBank Accession No. AY297819). (apsnet.org)
  • The 301-bp product was cloned and sequenced (GenBank Accession No. EU588989) showing 93.7% nucleotide and 98% amino acid identity when compared with a corresponding region of another GLRaV-9 isolate (GenBank Accession No. AY297819). (apsnet.org)
  • Approximately 20% of LTR retrotransposon sequences lie within putative genes. (biomedcentral.com)
  • Amino acid sequences of the putative serine protease open up studying frames FN1426 (Fsp25586) (A), and FNV0835 (Fsp49256) (B). Crimson emphasize signifies sequences recognized by mass spectrometry of the ninety nine kDa serine protease of F. nucleatum ATCC 25586 (A), and of the fifty five kDa serine protease of F. nucleatum ATCC 49256 (B). doi:10.1371/journal.pone.0111329.g003 DNA was isolated from F. nucleatum ATCC 25586 as explained above. (caspase1inhibitor.com)
  • Because of degeneracy, one protein can be encoded by many alternative nucleic acid sequences. (thermofisher.com)
  • Computer based sequence similarity searches of the nucleic acid databases are considered to be a more accurate method to identify retrotransposon families and estimate TE content and distribution in rice genome [ 28 - 31 ]. (biomedcentral.com)
  • Gag is a polyprotein and is an acronym for Group Antigens (ag). (ukessays.com)
  • Based on the results of phylogenetic similarity of 16SrDNA gene sequences, strain DB17 was identified to be Pseudomonas putida. (omicsonline.org)
  • Phylogenetic analysis revealed that 12 of 14 hemophiliac patients who had been exposed to a single common batch of factor VIII had closely related gag gene sequences. (ox.ac.uk)
  • We found that the three phylogenetic trees based respectively on Gag, Pol and Env common motifs are congruent, which suggest a monophyletic origin for these elements. (lookformedical.com)
  • Closest alignment was located with the partial sequence of 16S ribosomal RNA gene of F. nucleatum JCM 6328 subsp. (caspase1inhibitor.com)
  • Species identification was performed according to morphological features and the sequence of the ribosomal RNA gene. (blogspot.com)
  • DNA amplification of the ribosomal genes was performed using a set of PCR Master Mix reagents (Thermo Scientific, USA) with fungal primers ITS1f (ctt ggt cat tta gag gaa gta a) and NL-4 (ggt ccg tgt ttc aag g) as well as bacterial primers 27f (aga gtt tga tcc tgg ctcag) and 1492r (tac ggy tac ctt gtt acg act t). (blogspot.com)
  • In addition, analysis of the gag sequence phylogeny in one family demonstrated that CTL escape variants can be successfully transmitted both horizontally and vertically. (ox.ac.uk)
  • Translated partial amino acid sequence of pln A gene in MCC4246 displayed 48 amino acid sequences showing 100% similarity with plantaricin A of Lactobacillus plantarum (WP_0036419). (researchsquare.com)
  • Env is a viral gene that encodes the protein forming the viral envelope. (wikipedia.org)
  • In contrast, a spontaneous revertant of MuSV ts110 encodes a larger gag-mos protein (termed P100('gag-mos)) which contained a kinase activity stable to 39(DEGREES)C. Using the optimal conditions developed for the P85('gag-mos) kinase, Mo-MuSV-encoded p37('mos) was also found to be associated with a serine kinase activity. (tmc.edu)
  • This inhibitory action by antibodies to the C-terminus of p37('mos), when considered with all the other data reported here, provides convincing evidence that the v-mos gene encodes a serine protein kinase activity. (tmc.edu)
  • This gene encodes one of four subunits of the splicing factor 3B. (nih.gov)
  • ABSTRACT The emergence and rapid spread of antibiotic-resistant Klebsiella pneumoniae isolates harbouring the blaKPC gene that encodes for carbapenemase production have complicated the management of patient infections. (who.int)
  • Further support to this similarity has been provided by the ability of the env-like gene of DmeGypV (the Gypsy endogenous retrovirus of Drosophila melanogaster) to promote infection of Drosophila cells by a pseudotyped vertebrate retrovirus vector. (lookformedical.com)
  • The following Igfbp5 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). (genscript.com)
  • Then 50 human genes were chosen from the NCBI database to represent the five protein classes. (thermofisher.com)
  • For comparison, the corresponding wild type genes were subcloned using native sequences available from the NCBI database. (thermofisher.com)
  • Equally important to most researchers, however, is obtaining high yields of mRNA and ultimately protein from synthetic genes. (thermofisher.com)
  • Our GeneOptimizer algorithm enables true multiparametric optimization, dealing with a large number of sequence-related parameters involved in different aspects of gene expression, such as transcription, splicing, translation, and mRNA degradation. (thermofisher.com)
  • The average mRNA level of Dnmt1 gene from cancerous tissue was higher and that of mbd2 gene from cancerous tissue was lower than that from non-cancerous tissue, respectively. (wjgnet.com)
  • The hepatocyte has been suggested as a suita- characterised with respect to insulin mRNA transcription, ble target cell for such gene therapy [1-9]. (deepdyve.com)
  • The protein encoded by this gene cross-links to a region in the pre-mRNA immediately upstream of the branchpoint sequence in pre-mRNA in the prespliceosomal complex A. It also may be involved in the assembly of the B, C and E spliceosomal complexes. (nih.gov)
  • RÉSUMÉ L'émergence et la propagation rapide des souches de Klebsiella pneumoniae résistantes aux antibiotiques et porteuses du gène blaKPC codant la production de carbapénèmases ont compliqué la prise en charge des infections des patients. (who.int)
  • The retroviral promoter can direct high-level, efficient expression of genes encoded within the viral capsid of its genome using chromatin. (ukessays.com)
  • Although epigenetically silenced, endogenous retroviral (ERV) genes become activated in tumors and function to ignite immune responses. (frontiersin.org)
  • Species affiliation was confirmed by the structure of the 16S rRNA gene. (blogspot.com)
  • The expression of the env gene enables retroviruses to target and attach to specific cell types, and to infiltrate the target cell membrane. (wikipedia.org)
  • While there are significant differences in sequence of the env gene between retroviruses, the gene is always located downstream of gag, pro, and pol. (wikipedia.org)
  • Retroviruses have various characteristics that make them unique as gene delivery vehicles. (ukessays.com)
  • At the same time, however, an enhanced understanding of the molecular mechanisms involved in these specific interactions makes retroviruses an attractive target for anti-viral drugs, vaccines, and vectors for human gene therapy. (uaeu.ac.ae)
  • Those containing three open reading frames (ORFs), including an env-like gene, may well be considered as endogenous retroviruses. (lookformedical.com)
  • RESULTS: To gain insights into their evolutionary story, a sample of thirteen insect endogenous retroviruses, which represents the largest sample analysed until now, was studied by computer-assisted comparison of the translated products of their gag, pol and env genes, as well as their LTR structural features. (lookformedical.com)
  • CONCLUSIONS: We showed that most of the insect endogenous retroviruses belong to a major clade group which can be further divided into two main subgroups which also differ by the sequence of their primer binding sites (PBS). (lookformedical.com)
  • Mother-to-child transmission of HIV infection and CTL escape through HLA-A2-SLYNTVATL epitope sequence variation. (ox.ac.uk)
  • In order to test this hypothesis, escape through the dominant HLA-A2-restricted CTL epitope SLYNTVATL (p17 Gag residues 77-85 SL9) in the setting of mother-to-child-transmission (MTCT) was investigated. (ox.ac.uk)
  • Variation within the SL9 epitope was associated with expression of HLA-A2 (P=0.04) but overall no clear link between variation from the SL9 consensus sequence and MTCT was established. (ox.ac.uk)
  • A subset of patients developed broad responses, which selected for consensus B epitope variants in Gag, Pol, and Nef, suggesting CTL-induced adaptation of HIV-1 at the population level. (jenner.ac.uk)
  • This conserved sequence is commonly known as the shared epitope (SE). (exposed-skin-care.net)
  • Due to recombination events between 5' and 3' LTRs, throughout evolution internal genes were lost resulting in ERV solitary LTRs (solo-LTRs). (frontiersin.org)
  • During an in vitro comparison of HIV-1 and Ty3 nucleoprotein function in RNA dimerization and cDNA synthesis, we discovered a bipartite primer-binding site (PBS) for Ty3 composed of sequences located at opposite ends of the genome. (cnrs.fr)
  • The viral gene sequences identified in CFS patients clustered with sequences from PC and both sequences were virtually identical. (phoenixrising.me)
  • The zebra finch MHC differs markedly from that of the chicken, the only other bird species with a complete genome sequence. (biomedcentral.com)
  • To determine if other GLRaVs were present, 21 dormant cane samples were screened with a comprehensive 70-mer oligonucleotide microarray designed to simultaneously detect all grapevine viruses with total or partial genomic sequence available. (apsnet.org)
  • Black Seedless) showing a microarray hybridization pattern compatible with a mixed infection of GLRaV-7 and GLRaV-1 was analyzed by ELISA using GLRaV-7 specific antibodies (Agritest, Valenzano, Italy) and reverse transcription (RT)-PCR using virus-specific primers LR7-F: 5′- TAT ATC CCA ACG GAG ATG GC -3′ and LR7-R: 5′- ATG TTC CTC CAC CAA AAT CG -3′ (based on GenBank Accession No. Y15987). (apsnet.org)
  • The ensuing solution was sequenced (gene lender accession quantity KM023647) and blasted from the National Middle for Figure four. (caspase1inhibitor.com)
  • While we found non-cyanobacterial homologs of these enzymes to be rare, we identified a large number of genes encoding CylC-like enzymes in publicly available cyanobacterial genomes and in our in-house culture collection of cyanobacteria. (biomedcentral.com)
  • However, with the full-length proviral sequences of BoRV CH15 genomes, we provide the basis for a molecular clone and further in vitro investigation. (biomedcentral.com)
  • XMRV is a simple retrovirus with gag, pol and env genes and unlike HIV or HTLV, has no accessory or regulatory genes. (phoenixrising.me)
  • Using high-throughput sequencing (HTS) and bioinformatics, we discovered a new retrovirus, bovine retrovirus CH15 (BoRV CH15), in the CNS of a cow with non-suppurative encephalitis. (biomedcentral.com)
  • Genetic structure, transforming sequence, and gene product of avian sarcoma virus UR1. (wikidata.org)
  • Gene optimization takes advantage of the degeneracy of the genetic code. (thermofisher.com)
  • Comparative genetic maps within the grass family indicate extensive regions of conserved gene content and orders [ 16 ]. (biomedcentral.com)
  • The chicken in ovo model is an attractive system to explore underlying mechanisms of neural and brain development, and it is important to develop effective genetic modification techniques that permit analyses of gene functions in vivo. (biomedcentral.com)
  • Genetic studies have exhibited multiple HLA- em DRB1 /em alleles encoding a conserved sequence at amino acid positions 70C74 are associated with susceptibility and severity of RA. (exposed-skin-care.net)
  • On the other hand, LTR-retrotransposons, so called mammalian apparent LTR retrotransposons (MaLRs) represent 3.6% of the genome and lack primer binding sites and gag-pol genes ( 1 ). (frontiersin.org)
  • In a study of 114 epidemiologically linked Zambian transmission pairs, we evaluated the impact of human leukocyte antigen class I (HLA-I)-associated amino acid polymorphisms, presumed to reflect cytotoxic T lymphocyte (CTL) escape in Gag and Nef of the virus transmitted from the chronically infected donor, on the plasma viral load (VL) in matched recipients 6 mo after infection. (ox.ac.uk)
  • They use an integrase that acts in a site-specific manner to join the ends of the viral cDNA to target sequences in host cell DNA. (ukessays.com)
  • These sequences represent the protein coding region of the Igfbp5 cDNA ORF which is encoded by the open reading frame (ORF) sequence. (genscript.com)
  • XMRV was identified using a viral detection DNA microarray composed of oligonucleotides corresponding to the most conserved sequences of all known viruses (1). (phoenixrising.me)
  • These solo-LTRs contain functional sequences like promoters, enhancers, polyadenylation signals and are frequently located near cellular genes. (frontiersin.org)
  • Various Moloney murine sarcoma virus (Mo-MuSV) isolates contain a cellular sequence, termed mos, which is responsible for the transforming ability of Mo-MuSV. (tmc.edu)
  • Faster and more accessible DNA sequencing technologies have enabled, in the past decade, a large number of genomics and metagenomics projects focused on the microbial world [ 3 ]. (biomedcentral.com)
  • Comparative genomics of Salmonella enterica serovar Montevideo reveals lineage-specific gene differences that may influence ecological niche association. (cdc.gov)
  • A serine kinase activity has been found to be associated with mos gene products of several isolates of Mo-MuSV. (tmc.edu)
  • This study in a tertiary care hospital in Egypt used real-time PCR assay to test ertapenem-nonsusceptible isolates of K. pneumoniae for the presence of the blaKPC gene and compared the results with modified Hodge test. (who.int)
  • The blaKPC gene was confirmed in 14/20 (70.0%) of these isolates. (who.int)
  • Transmission of HIV-1 Gag immune escape mutations is associated with reduced viral load in linked recipients. (ox.ac.uk)
  • The kinase detected in anti-gag complexes from 6m2 cells at permissive temperature was associated with P85('gag-mos) since immune complexes from 39(DEGREES)C 6m2 cells, which lack P85('gag-mos), produced no phosphorylated P58('gag) molecules. (tmc.edu)
  • The major histocompatibility complex ( MHC ) is a gene-dense genomic region within which many genes play a role in vertebrate immune response. (biomedcentral.com)
  • MHC Class I genes encode surface receptors in most nucleated cell types and facilitate immune responses to intracellular pathogens. (biomedcentral.com)
  • MHC Class II genes also encode receptors but are restricted to antigen presenting cells of the immune system where they play a role in combating extracellular pathogens. (biomedcentral.com)
  • In addition to Class I and Class II genes, many of the other genes in the MHC region also play a role in immune response. (biomedcentral.com)
  • Like Class I and Class II genes, CD1 genes (which are MHC-linked in the chicken but not in mammals) play a role in the adaptive immune response. (biomedcentral.com)
  • Env expression is regulated by the gene product of rev. (wikipedia.org)
  • However, other mechanisms of disease causation have also been described where (1) a breakpoint disrupts or alters gene expression via a position effect 7 or (2) a cryptic deletion or duplication is identified at the translocation breakpoint. (bmj.com)
  • Hence, this study was conducted to examine the changes in PAL activity and gene expression patterns in relation to texture in the edible branchlet tissues during early postharvest handling. (scialert.net)
  • We developed GeneArt GeneOptimizer software to maximize expression of synthetic genes in all available expression systems. (thermofisher.com)
  • This may also be true for autologous expression, since wild type sequences are not necessarily optimized for expression yield but also for degradation, regulation, and other properties. (thermofisher.com)
  • Design your synthetic gene by uploading your sequence, selecting your expression system, and specifying your cloning vector and your sequence details (including open reading frames, untranslated regions, and cloning sites). (thermofisher.com)
  • We have conducted several internal studies, and many customers have reported independently that GeneArt codon and sequence optimization results in higher protein expression without losing protein function. (thermofisher.com)
  • Following optimization, the 50 genes all showed reliable expression and 86% exhibited elevated expression (example in Figure 2 ). (thermofisher.com)
  • ORF sequences can be delivered in our standard vector, pcDNA3.1 + /C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. (genscript.com)
  • The up-regulation of proto-oncogene may be the consequence of epigenetic control of gene expression by demethylase, and mbd2 is involved in the regulation of hMSH2 expression in human gastric cancer. (wjgnet.com)
  • In the present study, we performed a comparative study of the ubiquitous CMV promoter and three neuron-specific promoters, chicken Ca2+/calmodulin-dependent kinase (cCaMKII), chicken Nestin (cNestin), and human synapsin I. We explored the possibility of manipulating gene expression in chicken embryonic brain cells using in ovo electroporation with the selected promoters. (biomedcentral.com)
  • Overexpression of the FOXP2 gene driven by the cNestin promoter in brain cells significantly affected expression levels of target genes, CNTNAP2 and ELAVL4 . (biomedcentral.com)
  • In ovo electroporation offers an easier and more efficient way to manipulate gene expression during embryonic development, and this technique will be useful for neuron-targeted transgene expression. (biomedcentral.com)
  • To investigate the possibility that a novel candidate gene for XLMR was disrupted at the X chromosome translocation breakpoint, we mapped the breakpoint using fluorescence in situ hybridisation (FISH). (bmj.com)
  • Characterisation of breakpoints in patients with apparently balanced constitutional chromosome rearrangements and phenotypic abnormalities has proved an invaluable strategy for identifying disease causing genes, especially those on the X chromosome. (bmj.com)
  • 3- 6 Phenotypic abnormalities seen in cases with apparently balanced chromosome rearrangements have usually been explained by the disruption of a gene at the breakpoint causing the loss of gene function. (bmj.com)
  • 18- 21 Xq28 is a highly gene rich region of the human X chromosome and we focused on the X chromosome breakpoint as the identification of a disrupted gene here would be a rapid way to identify a further candidate gene for X linked mental retardation within Xq28. (bmj.com)
  • In order to gain insight into the chromosomal distribution of LTR-retrotransposons in the rice genome, a detailed examination of LTR-retrotransposon sequences on Chromosome 10 was carried out. (biomedcentral.com)
  • The sequencing of the zebra finch Taeniopygia guttata genome, in combination with targeted bacterial artificial chromosome (BAC) sequencing, has allowed us to characterize an MHC from a highly divergent and diverse avian lineage, the passerines. (biomedcentral.com)
  • ClustalW alignment of Fsp25586, the obtainable partial sequence of the homologues serine protease Fsp23726, Fsp10953 and Fsp49256. (caspase1inhibitor.com)
  • and VP2 (ORF3) gene, partial cds. (cdc.gov)
  • Characterization of a 105,000 molecular weight gag-related phosphoprotein from cells transformed by the defective avian sarcoma virus PRCII. (wikidata.org)
  • MHC genes are perhaps the most thoroughly studied example of adaptive molecular evolution, representing a classic example of balancing selection [ 2 - 4 ]. (biomedcentral.com)
  • Characterization of protein kinase activity associated with the transforming gene product of Fujinami sarcoma virus. (wikidata.org)
  • Promoter methylation of p16 INK4A , c-myc and hMSH2 genes was assayed by methylation-specific PCR (MSP) and sequencing (mapping). (wjgnet.com)
  • Methods: To address this question, transgenic Non-Obese Diabetic (NOD) mice which express insulin in the liver were made using the Phosphoenolpyruvate Carboxykinase (PEPCK) promoter to drive the mouse insulin I gene (Ins). (deepdyve.com)
  • Human immunodeficiency virus (HIV) type 1 sequences obtained from HIV-infected persons in different risk groups in Edinburgh were studied to determine the number and origin of virus variants and patterns of virus transmission. (ox.ac.uk)
  • Native or wild-type quaternary protein structure is usually born from a single translated protein sequence with one ordered conformation with downstream protein interactions. (medscape.com)
  • Natural products classed as polyketides, nonribosomal peptides and hybrids of both are often biosynthesized by giant, complex enzymes known as polyketide synthases (PKS) and nonribosomal peptide synthetases (NRPS). (iucr.org)
  • Xq28 appears to be an unstable region of the human genome and genomic rearrangements are recognised as major causes of two single gene defects, haemophilia A and incontinentia pigmenti, which map within Xq28. (bmj.com)
  • The cornea is one of the most transparent and non-vascularized tissues in the human body, and several active genes [ 1 , 2 ] are thought to be involved in maintaining the homeostasis of the cornea. (molvis.org)
  • The attitude towards unacceptance of food products containing some of the artificial preservatives has increased due to growing awareness of its ill-effect on human and animal health. (researchsquare.com)
  • ERVs and related sequences are estimated at ~400,000 copies or 4.6% of the human genome, including genomic proviruses like 5' long terminal repeat (LTR)-gag-pol-env-3' LTR ( 1 ). (frontiersin.org)
  • (B) Similar and conserved amino acid sequences between human NLRP1 and mouse NLRP1B. (frontiersin.org)
  • The remarkable diversity of natural products (NPs) results from a similarly diverse pool of biosynthetic enzymes [ 2 ]. (biomedcentral.com)
  • The resulting sequence data holds immense opportunities for the discovery of new microbial enzymes and their associated NPs [ 4 ]. (biomedcentral.com)
  • KPCs) are Ambler class A plasmid- gene by polymerase chain reaction cin, imipenem, ertapenem, meropenem, encoded enzymes that are capable of (PCR) assay provides laboratories trimethoprim/sulfamethoxazole, piper- hydrolyzing all beta-lactam antibiotics, with a means to quickly identify the acillin, piperacillin/tazobactam and including monobactams, extended- presence of this important resistance tobramycin (Oxoid). (who.int)
  • Fleck corneal dystrophy (FCD, Online Mendelian Inheritance in Man (OMIM) #121850) was first reported in 1957 by Francois and Neetens [ 9 ], and is one of the hereditary corneal dystrophies in which the causative genes have already been identified. (molvis.org)
  • Once you submit your request, the GeneOptimizer software generates the DNA sequence that best suits your research requirements, based on consideration of all parameters that are relevant for the given host organism plus your individual sequence requirements. (thermofisher.com)
  • H) DNA sequence of another PCR product clone showing the hemoglobin S mutation GTG at position 7 of the hemoglobin beta gene. (cdc.gov)
  • Our analyses of the zebra finch MHC suggest a complex history involving chromosomal fission, gene duplication and translocation in the history of the MHC in birds, and highlight striking differences in MHC structure and organization among avian lineages. (biomedcentral.com)
  • Selection analyses of paired HIV-1 gag and gp41 sequences obtained before and after antiretroviral therapy. (cdc.gov)
  • However, the transcription level of the above genes was not associated with biological behaviours of gastric cancers. (wjgnet.com)
  • Our results also demonstrate that CTL pressures help to maintain certain elements of consensus viral sequence, which likely represent viral escape from common HLA-restricted CTL responses. (jenner.ac.uk)
  • This CD4-independence is associated with spontaneous mutation in the env gene. (wikipedia.org)
  • The purpose of this study is to report a novel mutation of the PIKFYVE gene in a Japanese patient with fleck corneal dystrophy. (molvis.org)
  • DNA was extracted from the blood and subjected to mutation analysis by sequencing of the PIKFYVE gene. (molvis.org)
  • Sequence analysis revealed that the patient has a heterozygous c.4166_4169delAAGT mutation located at exon 24 of the PIKFYVE gene that may cause p.Glu1389AspfsX16 flame-shift mutation, which has never before been reported for FCD. (molvis.org)
  • In this study, we report a case of FCD bearing a heterozygous flame-shift mutation within the phosphoinositide kinase, FYVE finger containing ( PIKFYVE ) gene. (molvis.org)
  • Using this array, gammaretroviral sequences were identified in samples from 7/11 prostate cancer (PC) patients that were homozygous (QQ) for the R462 mutation for RNAse L which is an important molecule in the innate antiviral response (2). (phoenixrising.me)
  • 78, 79 The BLV genes, their arrangement, the protein products and their functions are schematically shown in Figure Figure 58.2 . (anipedia.org)
  • This negative correlation was most evident in newly infected individuals, whose HLA alleles were unable to effectively target Gag and select for CTL escape mutations in this gene. (ox.ac.uk)
  • The sequencing results were validated with a PCR-fragment length polymorphism analysis. (molvis.org)
  • nylon membrane for the Southern Blot and ribonuclease protection assay (RPA) was from Amersham International For this gene therapy approach to be viable, the insulin (Bucks, UK). (deepdyve.com)
  • Sequence optimization using the GeneOptimizer software is included as an optional step with all GeneArt Gene Synthesis and DNA fragments services. (thermofisher.com)