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  • intrinsic
  • About 50% of animals reconstituted with BM cells expressing "gain-of-function" Notch alleles developed CD4 + -CD8 + T-ALLs closely resembling their human counterparts by 10 to 40 weeks posttransplantation, whereas animals reconstituted with cells expressing full-length Notch1, which lacks intrinsic signaling activity, remained healthy ( 38 ). (asm.org)
  • pore complex
  • A paper in 1988 used a range of gold particles to measure the size able to enter through the nuclear pore complex [ 1 ] and found that the limiting size was 26 nm. (openwetware.org)
  • Literature Review: In general, some better indications that the origami can be functionalized with cationic peptides to facilitate transport across the nuclear pore complex. (openwetware.org)
  • peptides
  • Also did a nuclear transport inhibition protocol by Sebestyen [ 5 ], which had also showed linking of peptides to plasmids by the cyclo-propayrroloindole cross-linker. (openwetware.org)
  • functional
  • The N-terminal portion of human ICN1 consists of an ∼110 amino acid RAM domain (amino acids 1757 to 1865), which contains a high-affinity binding site for Su(H)/CBF1 ( 51 ), and a functional nuclear localization signal sequence ( 3 , 19 ). (asm.org)
  • The functional importance of the nuclear lamins has been emphasized by the recent discovery of many different heritable diseases that are caused by mutations in the human LMNA gene, encoding lamins A/C, which are collectively termed `laminopathies' ( Worman and Courvalin, 2005 ). (biologists.org)
  • cancers
  • For example, a number of the major oncogenes and tumor suppressors such as p53, BCRA1, APC, and retinoblastoma (Rb), β-catenin, NF-κB, survivin and cyclin D1 have been reported to have aberrant Subcellular localization in various types of cancers [3,. (ommegaonline.org)
  • Thus, nEGFR has an old origin resembling the cancer evolution, but TM may interfere NLS driven signaling for natural selection of survival to evade NLS induced aggressive cancers. (jcancer.org)
  • For example, dysregulated nuclear transport of NF- κB is associated with cancers ( 2 , 7 , 8 ). (jcancer.org)
  • found
  • Nuclear localized EGFR has been found in regenerated hepatocytes, benign and cancerous tumors ( 9 , 11 , 13 , 14 , 15 ). (jcancer.org)
  • cell
  • Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. (uniprot.org)
  • Both the ankyrin repeat and C-terminal transactivation domains were required for T-cell leukemogenesis, whereas the N-terminal RAM domain and a C-terminal domain that includes a PEST sequence were nonessential. (asm.org)
  • products
  • We PCR-amplified 105 kb of the genomic 11D region DNA from radish flies and from the parental wild-type Canton-S (C-S) flies, sequenced the products, and compared the sequences. (pnas.org)
  • healthy
  • The distribution of the conjugate after i.p. or i.v. injection in nude mice bearing human LN-229 glioma xenografts was confirmed by magnetic resonance imaging, with an increase in signal intensity in all the organs and tumors except for healthy brain parenchyma with an intact blood-brain barrier. (aspetjournals.org)