Sequences genes p53. Medical search. Frequent questions

In the free state, loop L1 adopted a recessed conformation, whereas upon DNA binding, two subunits switched to the extended loop L1 conformation, resulting in a final structure that was very similar to that of wild-type p53 bound to DNA. (rcsb.org)
The significant association of full-length (wild-type) p53 with HPV16 E6/E7 mRNA is further evidence for a functional relationship, which could contribute to the widely reported improved survival and prognosis. (biomedcentral.com)
Two mdm2 G/G SNP309 cancer cell lines, MANCA and A875, have compromised wild-type p53 that co-localizes with MDM2 on chromatin. (oncotarget.com)
The wild-type p53 protein is a tumor suppressor referred to as the "guardian of the genome" [ 4 ]. (oncotarget.com)
Under cellular stress conditions, such as DNA damage, wild-type p53 becomes activated and stabilized [ 5 , 6 ]. (oncotarget.com)
Further mechanistic studies revealed that p53R213*/R211* instead of wild-type p53 interacted with TANK-binding kinase 1 (TBK1) and suppressed the innate immune TBK1-Interferon regulatory factor 3 (IRF3)-Stimulator of interferon genes (STING) cascade. (bvsalud.org)

This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. (cancerindex.org)
Six proto-oncogenes (K-ras, c-myc, c-fos, c-jun, c-sis, and erbB), as well as the p53 tumor suppressor, were investigated for gene amplification using differential polymerase chain reaction (PCR), while the expression of the proteins produced by these genes was evaluated by Western blot analysis. (cdc.gov)
There were no point mutations observed in codons 12, 13, and 61 of K-ras or in exons 4-10 of p53 and no observed differences in the levels of any of the proteins studied. (cdc.gov)
This study aimed to evaluate the expression levels of miR-34a and 11 of its bioinformatically selected target genes and proteins to test their potential dysregulation in RCC. (hindawi.com)
We evaluated the expression of SALL4 using single-cell mass cytometry (CyTOF) utilizing 28 antibodies including surface lineage markers and intracellular proteins, such as p53, ki67, c-myc and pAKT to identify SALL4 expressed cells and related pathway in bone marrow (BM) for 10 MDS patients. (confex.com)
p53 is up-regulated in response to stress signals and stimulated to activate transcription of specific genes, resulting in expression of p21waf1 and other proteins involved in G1 or G2/M arrest. (thermofisher.com)
The key regulator of this process, hypoxia inducible factor 1 (HIF-1), can initiate apoptosis by inducing high concentrations of proapoptotic proteins, such as BNIP3, and can cause stabilisation of p53. (bmj.com)
Multiple proteins are involved in p53 regulation but one of the most critical negative regulators of p53 is the protein MDM2. (oncotarget.com)
SIRT1 is localized in the nucleus and can deacetylate numerous proteins such as tumor suppressor protein (p53), Ku70, NF-κB, and forkhead proteins which modulate genes that control cellular stress resistance ( Smith, 2002 ). (frontiersin.org)
HPV 16/18 infection was detected by nested-polymerase chain reaction (nested-PCR), the p53 mutation was detected by direct sequencing, and the p53 and the HPV 16/18 E6 proteins were studied using immunohistochemistry on 129 pterygial specimens and 20 normal conjunctivas. (molvis.org)
The research team says this work is important because while there are multiple ways for our RNA to encode the same proteins, the specific RNA sequence is important to regulate protein and RNA levels. (rna-seqblog.com)
Tumor suppressor genes provide instructions for making proteins that control how fast your cells grow and divide to make new cells. (medlineplus.gov)

Our results showed basal levels of NDRG1 expression in PC-3 (poorly differentiated, null p53), DU-145 (moderately differentiated, mutant p53) and LNCaP (well-differentiated, wiled type p53). (scirp.org)
Ectopic or endogenous VCP stabilized p53-R273H by binding to MDM2 and disrupting its association with mutant p53. (aacrjournals.org)

These findings indicate miR-34a along with its putative target genes could play a role in RCC tumorigenesis and progression. (hindawi.com)
An aberrant miRNA expression could contribute to cancer development and progression [ 6 , 7 ] and could affect their target genes that are involved in many biological processes, such as cell differentiation, proliferation, apoptosis, metabolism, and development [ 8 ]. (hindawi.com)
We examined the expression of a panel of 17 known SALL4 downstream target genes. (confex.com)
We hypothesized that MDM2 in these cells inhibited transcription initiation at the p53 target genes p21 and puma . (oncotarget.com)
Surprisingly, following etoposide treatment transcription initiation occurred at the compromised target genes in MANCA and A875 cells similar to the T/T ML-1 cell line. (oncotarget.com)
We found that knockdown of MDM2 in G/G cells moderately increased expression of subsets of p53 target genes without increasing p53 stability. (oncotarget.com)

Gradual reduction in rRNA transcription triggers p53 acetylation and apoptosis via MYBBP1A. (nih.gov)
The master tumor suppressor p53 controls transcription of a wide-ranging gene network involved in apoptosis, cell cycle arrest, DNA damage repair, and senescence. (whiterose.ac.uk)
p53 mediates cell cycle arrest or apoptosis in response to DNA damage or starvation for pyrimidine nucleotides. (thermofisher.com)
Upon treatment with Plk1 inhibitors, p53 in tumor cells is activated and induces strong apoptosis, whereas tumor cells with inactive p53 arrest in mitosis with DNA damage. (oncotarget.com)
In addition, compared to the mono-treatment, combination of Polo-like kinase 1 inhibition with anti-mitotic or DNA damaging agents boosts more severe mitotic defects, effectually triggers apoptosis and strongly inhibits proliferation of cancer cells with functional p53. (oncotarget.com)

P53 Mutations In Ovarian Tumors, Detected By Temperature‐gradient Gel. (keyopinionleaders.com)
Phosphorylation of Ser392 in p53 has been shown to associate with the formation of human tumors. (thermofisher.com)
Loss of heterozygosity at the p53 locus was not seen in the primary tumors of these women, but appeared as a partial loss of the wildtype allele in subsequent recurrent lesions of two gene carriers. (lu.se)

Because we showed that integration neither affects the levels of viral genes, nor those of virally disrupted human genes, a genome-wide screen was performed to identify human genes which expression is influenced by viral integration and have clinical relevance. (cancerindex.org)
Palaeohexaploid ancestry for Caryophyllales inferred from extensive gene-based physical and genetic mapping of the sugar beet genome (Beta vulgaris). (mpg.de)
Validation of whole genome amplification for analysis of the p53 tumor suppressor gene in limited amounts of tumor samples. (diva-portal.org)
We have presented a first catalogue of mutated lncRNA genes driving cancer, which will grow and improve with the application of ExInAtor to future tumour genome projects. (nature.com)
Whole genome sequencing makes it possible to comprehensively discover the mutations, and the mutated genes, that are responsible for tumour formation. (nature.com)
By sequencing pairs of normal and tumour genomes from large patient cohorts, projects such as the ICGC (International Cancer Genome Consortium) and TCGA (The Cancer Genome Atlas) aim to create definitive driver mutation catalogues for all common cancers 1 , 2 . (nature.com)
The analyzed gene datasets were downloaded from the Gene Expression Omnibus and The Cancer Genome Atlas (TCGA) database. (cancerindex.org)
p53, the guardian of the genome, is the most important tumor suppressor. (oncotarget.com)
Whole genome sequencing analysis of phenotypic heterogeneity and anticipation in Li-Fraumeni cancer predisposition syndrome. (cinj.org)

In this study, amplification, expression, and point mutation of cancer-related genes associated with Cd-induced cell transformation in BALB/c-3T3 cells were studied. (cdc.gov)
In 2012, two siblings who were homozygous for a mutation that created a stop codon in the Ras homolog gene family member H ( RHOH ) gene exhibited an epidermodysplasia verruciformis phenotype and their T cells exhibited impaired T-cell receptor (TCR) signaling. (medscape.com)
Genetic interaction can be defined as a deviation of the phenotypic quantitative effect of a double gene mutation from the effect predicted from single mutations using a simple (e.g., multiplicative or linear additive) statistical model. (researchgate.net)
In addition, it can be used to predict genetic interactions [3] by comparing the sensitivity value of a double gene mutation from the value predicted from single mutations, and reveal the network intervention [4] by applying the state-flip mutation subject to a single gene. (researchgate.net)
In this regard, restoration of p53 in tumor cells with loss or mutation of p53 will reinforce the cytotoxicity of combined Polo-like kinase 1 therapy and provide a proficient strategy for combating relapse and metastasis of cancer. (oncotarget.com)
The family manifested no linkage to the p53 gene (a two-point LOD-score of -0.41), and has previously also been excluded for linkage to the BRCA1 and BRCA2 loci, as well as being carrier of a BRCA1 germline mutation. (lu.se)
Although it seems unlikely that the p53 germline mutation is the major cause of disease predisposition in Lund 5, the data suggest that some p53 alteration may confer a subtle influence on breast cancer development and progression. (lu.se)
In addition, p53 protein negative expression in pterygium was correlated with HPV16/18 E6 oncoprotein expression but not with a p53 mutation. (molvis.org)
In this report, we analyzed p53 protein expression and gene mutation in pterygium in comparison with HPV 16/18 infection and E6 oncoprotein expression in pterygium tissues to understand whether the HPV infection was involved in pterygium pathogenesis. (molvis.org)

Why are there hot spot mutations in the p53 gene in human cancers? (cinj.org)
Germline mutations in the p53 tumor suppressor gene are associated with the Li-Fraumeni syndrome, characterized by childhood sarcoma, leukemia and early onset breast cancer and has occasionally been found also in familial breast-ovarian cancer. (lu.se)

The gene encoding the p53 tumor suppressor protein, a sequence-specific DNA binding transcription factor, is the most frequently mutated gene in human cancer. (rcsb.org)
We designed and executed a massively parallel reporter assay (MPRA) to investigate the effect of transcription factor binding motifs and local sequence context on p53-bound CRE activity. (whiterose.ac.uk)
The tumor suppressor protein, p53, is a sequence specific transcription factor that is activated by cellular stress. (thermofisher.com)

Although the role of p53 as a strong trans-activator of gene expression is well known, the co-regulatory factors and local sequences acting at p53-bound CREs are comparatively understudied. (whiterose.ac.uk)

Thus, altering the apo structure of p53 changed its DNA binding properties, even though the DNA-bound structure was not altered. (rcsb.org)
The structure of p53 comprises an N-terminal transactivation domain, a central DNA-binding domain, an oligomerisation domain, and a C-terminal regulatory domain. (thermofisher.com)

Alterations of the TP53 gene occur not only as somatic mutations in human malignancies, but also as germline mutations in some cancer-prone families such as Li-Fraumeni syndrome. (thermofisher.com)
A TP53 genetic test usually uses a sample of your blood to look for changes in the tumor protein 53 gene, or TP53 for short. (medlineplus.gov)
Changes in the TP53 gene are linked to many different types of cancer . (medlineplus.gov)
TP53 is a type of gene called a "tumor suppressor. (medlineplus.gov)
If you have certain changes in a TP53 gene, the gene or the protein it makes may not work well or may stop working completely. (medlineplus.gov)
Changes in your TP53 gene can be acquired or inherited. (medlineplus.gov)
Most changes in TP53 genes are acquired changes. (medlineplus.gov)
Inherited changes in the TP53 gene cause a rare genetic condition called Li-Fraumeni syndrome (LFS). (medlineplus.gov)
A TP53 genetic test is used to look for changes in your TP53 genes. (medlineplus.gov)
The test can check whether an acquired change in your TP53 gene is causing your cancer. (medlineplus.gov)

What pathways are this gene/protein implicaed in? (cancerindex.org)
Knockout of Trp53 or miR-34 in organoids results in Wnt-independence, corroborating a functional interplay between the p53 and Wnt pathways. (uni-muenchen.de)
It is involved in p53 pathways and is implicated in cell death/survival signaling, the cell cycle, and differentiation, thereby playing a regulatory role in carcinogenesis [ 12 ]. (hindawi.com)
Total RNA sequencing analysis identified the correlation of p53R211* with immune-related pathways. (bvsalud.org)

In conclusion for cancer cells overexpressing MDM2, targeting MDM2 may be less effective than inducing p53-independent cell death. (oncotarget.com)
However, chemoresistant cancers often have sustained changes that block activation of the p53 pathway either by missense mutations in p53 or by overexpression of MDM2 [ 3 ]. (oncotarget.com)

And so we're able to sequence highly penetrant gene mutations like BRCA1 , BRCA2 , P10 , P53 , PALB2 , and CDH1 , and more moderately penetrant genes like CHECK2 and ATM . (medpagetoday.com)

Cullin-9 is a protein that in humans is encoded by the CUL9 gene. (wikipedia.org)
There has been a pervasive thought in both biology and medicine that humans are limited by their genes. (queensledger.com)

These results revealed that NDRG1 is functional in prostate cancer cells and able to induce expression of differentiation factors through p53 independent pathway. (scirp.org)
The mechanism of synergism may be through IM to inhibit p53, a signal pathway of radiation damage repair. (researchsquare.com)
Following this, the differentially expressed genes (DEGs) were included in Gene Ontology enrichment, and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway, protein‑protein interaction network and survival analyses. (cancerindex.org)
However, SALL4 expression status and related pathway in bone marrow (BM) cells and relationship with somatic gene mutations in MDS patients has not been explored. (confex.com)
Therefore, this study proves that Rh4 inhibits cancer cell proliferation by activating the ROS/p53 signaling pathway and activating autophagy to induce ferroptosis, which provides necessary scientific evidence of the great anticancer potential of Rh4. (hindawi.com)
Chemotherapeutic agents that damage DNA activate the p53 pathway and can initiate cancer cell death [ 1 , 2 ]. (oncotarget.com)

Thus, inactive p53 is not associated with a susceptible cytotoxicity of Polo-like kinase 1 inhibition and could rather foster the induction of polyploidy/aneuploidy in surviving cells. (oncotarget.com)
We therefore tested a chemotherapeutic agent (8-amino-adenosine) that induces p53-independent cell death for higher clinically relevant cytotoxicity. (oncotarget.com)
METHODS: The cytotoxicity of disease-modifying anti-rheumatic drugs (DMARDs) against p53 wild-type (WT)/mutant-transfected RA fibroblast-like synoviocytes (RAFLSs) was evaluated by MTT assay. (bvsalud.org)

DNA from 123 lung cancers specimens and corresponding normal tissue were used and evaluated by Sanger sequencing of the p53 exons 5-8. (diva-portal.org)
Most mutations found are of missense type and located in the central region of the gene (exons 5 to 8). (lu.se)

N. van Belzen, W. N. Dinjens, B. H. Eussen and F. T. Bosman, "Expression of Differentiation-Related Genes in Colorectal Cancer: Possible Implications for Prognosis," Histology and Histopathology, Vol. 13, No. 4, 1998, pp. 1233-1242. (scirp.org)
The main aims of the study was to test the hypotheses that HPV16 E6/E7 oncogene and p53 function within tumours were associated with the widely reported improved patient survival and prognosis in head and neck cancer. (biomedcentral.com)
Whole-exome sequencing in osteosarcoma with distinct prognosis reveals disparate genetic heterogeneity. (cdc.gov)

N-myc downstream regulated gene 1 (NDRG1), also known as differentiation related gene 1, was previously identified as an up - regulated gene upon cellular differentiation. (scirp.org)
T. Napso, N. Azzam, A. Lerner and F. Fares, " N-myc Downstream Regulated Gene 1 Increases Differentiation Factors Level in Human Prostate Cancer Cells without Affecting Cell Proliferation and Cell Cycle Profiles," Journal of Cancer Therapy , Vol. 4 No. 2, 2013, pp. 568-574. (scirp.org)
This synthetic genetic interaction is seen at the level of single genes and acts downstream of promoter nucleosome reorganization. (sdbonline.org)

This gene encodes a nucleolar transcriptional regulator that was first identified by its ability to bind specifically to the Myb proto-oncogene protein. (nih.gov)
The role of a pseudo-response regulator gene in life cycle adaptation and domestication of beet. (mpg.de)
Here we identify valosin-containing protein (VCP) as a regulator of p53-R273H by conducting immunoprecipitation-tandem mass spectrometry analysis. (aacrjournals.org)
NAT10 (N-acetyltransferase 10) has been reported to promote transcription of RNA polymerase I and is a critical regulator of p53 homeostasis. (confex.com)
SIRT6 Antibody: The Silent Information Regulator (SIR2) family of genes are highly conserved from prokaryotes to eukaryotes and have important functions in the regulation of metabolism, growth and differentiation, inflammation, cellular survival, as well as in senescence and lifespan extension. (prosci-inc.com)

Inhibition of VCP either by genetic depletion or the pharmacologic inhibitor CB-5083 increased ubiquitination and degradation of p53-R273H, leading to cell death. (aacrjournals.org)
2 In addition, hypoxia induces genetic instability by the induction of fragile sites causing gene amplification. (bmj.com)
A recent publication from researchers at the University of Kentucky explains the importance of identifying and understanding how differences between tissues and cells alter gene expression without changing the underlying genetic code. (rna-seqblog.com)
So, the researchers believe that COVID-19 genes have genetic biases (ramp sequences) that allow them to use the available cellular machinery to increase their expression. (rna-seqblog.com)

Our pipeline, ExInAtor, identifies genes with excess load of somatic single nucleotide variants (SNVs) across panels of tumour genomes. (nature.com)
Accepted 1 August 2008 the same methodology described in the previously that somatic sequence variants occur with high published reports. (cdc.gov)
Two synonymous germline in a majority of these patients.10 13 The same sequence variants were identified in two separate investigators also found somatic sequence variants patients. (cdc.gov)
Based on the TBX5, GATA4, and HEY2, often simultaneously incidence of somatic mutations described in the within the same patient.9-13 The observation of two previously published reports, our study was adequately or more somatic sequence variants in the same powered to replicate the previous studies. (cdc.gov)
No evidence of patients and even within the same gene is expected somatic mutations was found in this study. (cdc.gov)
The somatic NKX2-5 sequence variants were defects. (cdc.gov)

Search the gene expression profiles from curated DataSets in the Gene Expression Omnibus (GEO) repository. (cancerindex.org)
These elements are involved in control of gene expression which governs the phenotype and also plays role in disease biology. (researchgate.net)
Both known and novel driver lncRNAs are distinguished by elevated gene length, evolutionary conservation and expression. (nature.com)
This class of noncoding RNAs is small, single stranded, and 19-25 nucleotide long that act as negative regulators involved in posttranscriptional silencing of the gene expression [ 5 ]. (hindawi.com)
Expression profiles analysis identifies the values of carcinogenesis and the prognostic prediction of three genes in adrenocortical carcinoma. (cancerindex.org)
Malignant Transformation Rate And P53, And P16 Expression In Teratomatous Skin Of. (keyopinionleaders.com)
OBJECTIVE: To investigate the incidence of malignant transformation and P53 and P16 expression in teratomatous skin of ovarian mature cystic teratoma. (keyopinionleaders.com)
The detection of HPV DNA alone, in the absence of evidence for viral gene expression, is not unequivocal molecular evidence that HPV infection either causes or promotes malignant progression in a lesion. (biomedcentral.com)
In this study, we evaluated the expression of SALL4 and related factors using single-cell mass cytometry (CyTOF) and NanoString technology in MDS patients alongside with target sequence for MDS-related mutations. (confex.com)
SALL4 expression was also analyzed in formalin-fixed paraffin-embedded (FFPE) 14 patient samples utilizing two SALL4 probes designed for NanoString technology alongside with target sequence for MDS-related mutations. (confex.com)
The reduced expression of most of these genes in htz1Delta cells was reversed by the deletion of SIR2 (sir2Delta) suggesting that H2A.Z antagonizes telomeric silencing. (sdbonline.org)
The conserved histone variant H2AZ has an important role in the regulation of gene expression and the establishment of a buffer to the spread of silent heterochromatin. (sdbonline.org)
Recent studies have revealed that variants of histone H2A and histone H3 play important roles not only in gene expression but also in the repair of DNA breaks and the assembly of chromosome centromeres. (sdbonline.org)
Cells will adapt by activating the expression of genes involved in metabolic adaptation, such as those involved in glycolysis. (bmj.com)
Our data shows that SIRT1 expression increases with age, concurrently with increased acetylated p53 levels in all brain regions investigated. (frontiersin.org)
Our recent report indicated that tumor suppressor gene ( p53 ) mutations and protein aberrant expression were detected in pterygium. (molvis.org)
To investigate the involvement of HPV 16/18 E6 in p53 inactivation in pterygium, the association between HPV 16 or HPV 18 infection, the HPV E6 oncoprotein, and p53 protein expression was analyzed in this study. (molvis.org)
Gene expression looks at the differences in RNA concentrations within a cell, and it can help scientists know which genes are active within that tissue or cell. (rna-seqblog.com)
Ramp sequences counterintuitively increase overall gene expression by evenly spacing the translational machinery and preventing collisions later in translation. (rna-seqblog.com)
In their recent publication in NAR Genomics and Bioinformatics , the researchers present the first comprehensive analysis of tissue- and cell type-specific ramp sequences and report more than 3,000 genes with ramp sequences that change between tissues and cell types, which correspond with increased gene expression within those tissues and cells. (rna-seqblog.com)
Our comprehensive web interface allows other researchers to creatively explore ramp sequences and gene expression," said Miller. (rna-seqblog.com)
Together, the group created a web interface for people to see how ramp sequences correspond with human and COVID-19 gene expression in different tissues and cells. (rna-seqblog.com)
Our research may help us better predict which tissues and cells new viruses will infect and also provides a potential therapeutic target to regulate tissue-specific gene expression without changing the translated protein," said Miller. (rna-seqblog.com)
Allelic Expression Imbalance Analysis Identified YAP1 Amplification in p53- Dependent Osteosarcoma. (cdc.gov)
Transcription factors (TFs) are critical for B-cell differentiation, affecting gene expression both by repres- sion and transcriptional activation. (lu.se)
In the last decade, diagnostic and prognostic evaluation has been facilitated by global gene expression profiling (GEP), provid- ing a new powerful means for the classification, prediction of survival, and response to treatment of lym- phomas. (lu.se)
The identified transcription factors influence both the global and specific gene expression of the BCLs and have possible implications for diagnosis and treat- ment. (lu.se)

Even though its sequence along with its expressional pattern in cancer cell lines are evident, the functional aspects concerning cell proliferation, viability, differentiation and cell cycle regulation of NDRG1 remains vague. (scirp.org)
p53 represses the promoter of Polo-like kinase 1, whereas Polo-like kinase 1 inhibits p53 and its family members p63 and p73 in cancer cells lacking functional p53. (oncotarget.com)

Three transcript variants encoding different isoforms have been found for this gene. (cancerindex.org)
Dr Michael Mitchell, Division of Cardiothoracic Surgery, defects (ASD, n = 13), ventricular septal defects (VSD, NKX2-5 sequence variants were found in .95% of Department of Surgery, Medical n = 5), and atrioventricular canal defects (AVCD, n = 10). (cdc.gov)
Germline predisposition to pediatric Ewing sarcoma is characterized by inherited pathogenic variants in DNA damage repair genes. (cdc.gov)
Changes in your genes are also called gene variants or mutations. (medlineplus.gov)

Our data suggest p53 has the flexibility to cooperate with a variety of transcription factors in order to regulate CRE activity. (whiterose.ac.uk)
Swr1 is required for the deposition of histone H2AZ at specific chromosome locations in vivo, and Swr1 and H2AZ commonly regulate a subset of yeast genes. (sdbonline.org)

But it's felt that knowledge from the PRS in a given woman may help to explain up to 20% of breast cancers that are unexplainable by the highly penetrant and moderately penetrant genes and may help newly diagnosed breast cancer patients make decisions about contralateral mastectomy because it may help predict the risk on the other side. (medpagetoday.com)
Proto-oncogene lncRNAs include HOTAIR, upregulated in multiple cancers, which recruits the repressive PRC2 chromatin regulatory complex to hundreds of genes 11 . (nature.com)
Mutants of p53 that frequently occur in a number of different human cancers fail to bind the consensus DNA binding site, and cause the loss of tumor suppressor activity. (thermofisher.com)
More than half of all adult cancers involve a change in this gene. (medlineplus.gov)

Using a competition assay on agarose gels we found that the p53 consensus sequences in longer DNA fragments are better targets than the same sequences in shorter DNAs. (nih.gov)
Nevertheless, NDRG1 sequencing assay disclosed no mutations in the gene. (scirp.org)
The expressions of cytokines and immune-related genes were examined by qPCR, ELISA assay and immunofluorescence. (bvsalud.org)

however, the possible mechanism of carcinogenesis with regards to the activation and inactivation of cancer-related genes has not yet been fully elucidated. (cdc.gov)
Using a stratified approach, we identify 15 high-confidence candidates: 9 novel and 6 known cancer-related genes, including MALAT1, NEAT1 and SAMMSON . (nature.com)

Characterization of the impact of the MYBBP1A gene and rs3809849 on asparaginase sensitivity and cellular functions. (nih.gov)
Characterization of a human gene with sequence homology to Saccharomyces cerevisiae Sir 2. (prosci-inc.com)

Sequence analysis of Wnt-independent organoids reveals an enhanced mutational burden, including chromosomal aberrations typical of genomic instability. (uni-muenchen.de)

Dudgeon C * , Chan CS * , Kang W, Sun Y, Emerson R, Robins H, Levine A. The evolution of thymic lymphomas in p53 knock-out mice. (cinj.org)

Among 10 Cd-induced transformed cell lines, significant gene amplification was found for c-myc and c-jun in 50% and 80% of the cell lines, respectively. (cdc.gov)
These results suggest that cell transformation induced by Cd may be attributed, at least in part, to gene amplification of c-myc and c-jun and that some of the Cd-transformed cells may possess neoplastic potential resulting from genomic instability. (cdc.gov)

p53 mutants are commonly described as the guardian of cancer cells by conferring them drug-resistance and immune evasion. (bvsalud.org)
RESULTS: Among p53 mutants, p53R213* exhibited remarkable DMARD-resistance in RAFLSs. (bvsalud.org)
Differential Gain-of-Function Activity of Three p53 Hotspot Mutants In Vivo. (cdc.gov)

Previous research found p53 disrupted in early stage tumours and p16 and HTERT in later stage, suggesting that the genes might be damaged in a particular sequence as the disease progresses. (cancerresearchuk.org)

Inactivation of p53 by Human papillomavirus (HPV) 16/18 E6 plays a crucial role in cervical tumorigenesis. (molvis.org)
In this study, we further speculate that p53 inactivation may be linked with HPV infection in pterygium pathogenesis. (molvis.org)
HPV 16/18 E6 contributes to HPV-mediated pterygium pathogenesis as it is partly involved in p53 inactivation and is expressed in HPV DNA-positive pterygium. (molvis.org)

One of the most important functions of the tumor suppressor p53 protein is its sequence-specific binding to DNA. (nih.gov)

These two substitutions enhanced the affinity of p53 for specific DNA yet, counterintuitively, decreased the residency time of p53 on DNA. (rcsb.org)

This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. (cancerindex.org)
MicroRNA-34a gene (MIR-34A) that is located on chromosome 1p36 belongs to one of evolutionary-conserved miRNA families (MIR-34 family) that consists of three members: MIR-34A, MIR-34B, and MIR-34C [ 10 ]. (hindawi.com)
This gene is localized to chromosome 20 and has pseudogenes which reside on chromosomes 1 and 22. (cancerindex.org)
The identified DEGs included 20 downregulated genes and 51 upregulated genes, which were highly associated with the cell cycle, organelle fission, chromosome segregation, cell division and spindle stability. (cancerindex.org)

Exome sequencing identifies recurrent mutations of the splicing factor SF3B1 gene in chronic lymphocytic leukemia. (mpg.de)

The top 14 hub genes were subsequently confirmed by reverse transcription‑quantitative polymerase chain reaction in ACC and adrenocortical adenoma samples. (cancerindex.org)
LOCUS KF768512 2586 bp RNA linear VRL 30-JUN-2014 DEFINITION Norovirus Hu/GII.4/P53/2012/Gothenburg/Sweden RNA-dependent RNA polymerase and capsid protein genes, partial cds. (cdc.gov)

And so it's felt in 2021 that we've probably identified most, if not all, of the highly penetrant and moderately penetrant genes, and the remaining mystery of heritability is probably largely explainable by this genomic combination of single nucleotide polymorphisms. (medpagetoday.com)

Results: One non-synonymous germline sequence variant iants as well as multiple haplotypes were observed was identified in one patient. (cdc.gov)

hSIR2 (SIRT1) functions as an NAD-dependent p53 deacetylase. (prosci-inc.com)

T. Okuda and H. Kondoh, "Identification of New Genes ndr2 and ndr3 Which Are Related to Ndr1/RTP/Drg1 but Show Distinct Tissue Specificity and Response to Nmyc," Biochemical and Biophysical Research Communications, Vol. 266, No. 1, 1999, pp. 208-215. (scirp.org)

In addition, a more detailed analysis of exon 7 amplicons were performed followed by extensive cloning and Sanger sequencing. (diva-portal.org)
Sanger dideoxy sequencing ##Assembly-Data-END## FEATURES Location/Qualifiers source 1. (cdc.gov)

Importantly, p53 mutations have also been identified in RA patients, and this prompts the investigation of its role in RA pathogenesis. (bvsalud.org)

Brain cancer develops when genes that limit the number of times a cell can divide are faulty - allowing cells to multiply endlessly. (cancerresearchuk.org)
The pathophysiology of epidermodysplasia verruciformis is linked to defective cell-mediated immunity, with elucidation of mutations in EVER1 ( TMC6 ) and EVER2 ( TMC8 ) genes (band 17q25). (medscape.com)
p53 is found in very low levels in normal cells, however, in a variety of transformed cell lines, it is expressed in high amounts, and believed to contribute to transformation and malignancy. (thermofisher.com)
The percent of ramp sequences present in one tissue-stratified cell type that are also present in another cell type. (rna-seqblog.com)
Red indicates fewer shared ramp sequences (i.e. more cell type-specific usage of ramp sequences). (rna-seqblog.com)
Tissue-stratified cell type comparisons that are blue have more shared ramp sequences. (rna-seqblog.com)
Essentially, a ramp sequence works like an on-ramp to a freeway so that ribosomes do not crash into each other, but the length and speed limit of that onramp can change depending on the cell and the available resources within that cell," Miller explained. (rna-seqblog.com)
2022) The Ramp Atlas: facilitating tissue and cell-specific ramp sequence analyses through an intuitive web interface . (rna-seqblog.com)

Semi-quantitative evaluation of the competition experiments showed a correlation between the relative p53-DNA binding and the DNA lengths. (nih.gov)
In contrast to full-length p53, the isolated core domain did not show any significant correlation between sequence-specific DNA binding and fragment length. (nih.gov)

Chemicals and Drugs5

Phenomena and Processes2

Wild-type p536

Proteins12

Mutant p532

Target genes6

Apoptosis5

Tumors3

Genome9

Mutation9

Mutations in the p532

Transcription factor3

Role of p531

Structure of p532

TP5310

Pathways4

MDM22

BRCA11

Humans2

Pathway6

Cytotoxicity3

Exons2

Prognosis3

Downstream3

Regulator5

Genetic4

Somatic6

Expression27

Functional2

Variants4

Regulate2

Cancers4

Assay3

Cancer-related genes2

Characterization2

Chromosomal1

Lymphomas1

Amplification2

Mutants3

Tumours1

Inactivation3

Suppressor1

Counterintuitively1

Chromosome4

Recurrent1

Polymerase2

Moderately1

Germline1

Deacetylase1

Distinct1

Sanger2

Importantly1

Cell8

Correlation2