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  • gene
  • Since the development of methods of high-throughput production of gene and protein sequences, the rate of addition of new sequences to the databases increased exponentially. (wikipedia.org)
  • These sequences fall into many groups of related sequences known as protein families or gene families. (wikipedia.org)
  • Learn about the advantages of targeted single-cell analysis for designing gene panels and maximizing data accuracy with this eBook from The Scientist and BD Biosciences. (the-scientist.com)
  • Previous phylogenetic analyses of 16S rRNA, recA , gyrB , rpoB , and acdS gene sequences as well as genome sequence comparisons of different Burkholderia species have revealed two major species clusters. (springer.com)
  • In this study, we undertook a multilocus sequence analysis of 77 type and reference strains of Burkholderia using atpD , gltB , lepA , and recA genes in combination with the 16S rRNA gene sequence and employed maximum likelihood and neighbor-joining criteria to test this further. (springer.com)
  • The housekeeping gene sequences were provided from the ongoing sequencing project of B. unamae MTl-641 T , B. tuberum STM678 T , B. silvatlantica SRMrh-20 T , and B. silvatlantica PVA5 from a project, funded in part by the U.S. National Science Foundation (Grant IOB-0537497) to George Weinstock (Washington University, St. Louis, MO) and AMH. (springer.com)
  • Ait-Tayeb L, Lefevre M, Passet V, Diancourt L, Brisse S, Grimont PAD (2008) Comparative phylogenies of Burkholderia , Ralstonia , Comamonas , Brevundimonas and related organism derived from rpoB , gyrB and rrs gene sequences. (springer.com)
  • The gene has 97% sequence homology with the glycophorin A gene from the 5' UTR approximately 1 kilobase upstream from the exon encoding the transmembrane regions to the portion of the coding sequence encoding the first 45 amino acids. (wikipedia.org)
  • It seems likely that this gene evolved by gene duplication and subsequent mutation of glycophorin A. The transition site from homologous to nonhomologous sequences can be localized within Alu repeat sequences. (wikipedia.org)
  • Bækkedal and Haugen made a Spot42 consensus secondary structure based on all known "spf" sequences at the time (2015) and found that the spot42 gene is highly conserved across the 5 orders it is identified. (wikipedia.org)
  • The gene tends to have expression correlated to lymphatic system, vascular/arterial endothelial tissue, and notable expression in the bladder based on expression profiles and microarray analysis. (wikipedia.org)
  • The cyanobacteria provide the most plausible case for evolution of a permuted gene from a standard gene, due to remarkable sequence similarities between the two gene types as they occur in different Synechococcus strains. (wikipedia.org)
  • citation needed] The nucleic acid sequence of a protein coding gene may also be conserved by other selective pressures. (wikipedia.org)
  • Nucleic acid sequences that cause secondary structure in the mRNA of a coding gene may be selected against, as some structures may negatively affect translation, or conserved where the mRNA also acts as a functional non-coding RNA. (wikipedia.org)
  • Non-coding sequences important for gene regulation, such as the binding or recognition sites of ribosomes and transcription factors, may be conserved within a genome. (wikipedia.org)
  • genomics
  • Although these methods are not, in themselves, part of genomics, no reasonable genome analysis and annotation would be possible without understanding how these methods work and some practical experience with their use. (springer.com)
  • detects
  • tRNAscan-SE - tRNA detection in genome sequences, detects ~99% of eukaryotic nuclear or prokaryotic tRNA genes, with a false positive rate of less than one per 15 gigabases, and with a search speed of about 30 kb/second. (bioinformatics.org)
  • Targeted sequencing detects and provides understanding of cell-to-cell differences, which is essential to not only identifying key mechanisms of pathogenesis, but developing therapeutic strategies with an eye towards personalized medicine. (the-scientist.com)
  • trajectories
  • Sequence analysis, originally developed in biology to analyse DNA sequences, is a longitudinal method that allows to analyse such trajectories, or sequences of different states in a life course, different states in a country's development or any other sequence of interest. (wzb.eu)
  • There has been a great deal of work on the sequential development of careers, and there is increasing interest in how career trajectories intertwine with life-course sequences. (wikipedia.org)
  • nucleotides
  • Ping Pong The piRNA Ping-Pong pathway was first proposed from studies in Drosophila where the piRNA associated with the two cytoplasmic Piwi proteins, Aubergine (Aub) and Argonaute-3 (Ago3) exhibited a high frequency of sequence complementarity over exactly 10 nucleotides at their 5' ends. (wikipedia.org)
  • regulatory
  • Transcription factor binding sites ( TFBSs ) are the functional elements that determine transcriptional activity, and the identification of individual TFBS in genome sequences is a major goal to inferring regulatory networks. (plantcell.org)
  • Toucan - A Java tool for regulatory sequence analysis: detecting over-represented motifs and modules in sets of co-regulated genes. (bioinformatics.org)
  • somatic
  • The main focus of the workshop will be on variant calling and the analyses of somatic and germline mutations. (ncbs.res.in)
  • biology
  • Such a collection of sequences does not, by itself, increase the scientist's understanding of the biology of organisms. (wikipedia.org)
  • However, comparing these new sequences to those with known functions is a key way of understanding the biology of an organism from which the new sequence comes. (wikipedia.org)
  • Thus
  • Thus each sequence is represented in the form of numeric vector of size 2·4k containing μ and σ of 4k RTDs. (wikipedia.org)
  • Thus far, over 50,000 unique piRNA sequences have been discovered in mice and more than 13,000 in D. melanogaster. (wikipedia.org)