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  • genome
  • Phylogenetic analyses were performed on 130 homeodomains from the sequenced genome of the sea anemone Nematostella vectensis along with 228 homeodomains from human and 97 homeodomains from Drosophila . (biomedcentral.com)
  • We sequenced the genome of the sand rat, a desert rodent susceptible to nutritionally induced diabetes, and discovered an unusual chromosome region skewed toward G and C nucleotides. (pnas.org)
  • We thank Nik Putnam, Dan Rokshar, and other members of the amphioxus team at the Joint Genome Institute, Walnut Creek, California, for their very considerable efforts in determining the B. floridae genome sequence and making it available to the research community, and Linda Holland, Nori Satoh and Jeremy Gibson-Brown for important contributions to promotion and coordination of the project. (springer.com)
  • gene
  • This region includes the Pdx1 homeobox gene, a transcriptional activator of insulin , which has undergone massive sequence change, likely contributing to diabetes and adaptation to low caloric intake. (pnas.org)
  • Gene family support nodes are shown, except in cases where these are not recovered as monophyletic (Hox families, NK2, NK4, and Vent) due to uneven rates of sequence evolution and complex histories. (springer.com)
  • Accumulating evidence has suggested that homeodomain-containing proteins play critical roles in regulating the tissue-specific gene expression essential for tissue differentiation and in determining the temporal and spatial patterns of development. (ahajournals.org)
  • These new gene sequences provide a first step towards comparative Hox gene studies in insects. (nih.gov)
  • For these gene fragments more sequence information is required to distinguish between the two alternatives, since amino acid substitutions have been known to occur at positions 1, 4, 6, 7 and 60 only (Fig. 3). (nih.gov)
  • Each Hox gene contains a well-conserved DNA sequence known as the homeobox . (hitchhikersgui.de)
  • homologs
  • Note that all new sequences group to expected homologs. (nih.gov)
  • A Neighbour Joining analysis of only the six potentially unambiguous new homeobox sequences (lab, pb, Dfd, Ubx, Abd-B) groups all new fragments into the expected clades of homologs from other insects and thus confirms the results of NCBI Blast (Fig. 2), except for abd-A which appears paraphyletic. (nih.gov)
  • whereas
  • In the absence of the TALE class homeodomain cofactors Exd and Hth, Ubx and Abd-A bind at a very similar set of target sites in accessible chromatin, whereas Abd-B binds at an additional specific set of targets. (biomedcentral.com)
  • different
  • Different 3rd party annotations can be graphically mapped on the sequence and displayed in the Jmol viewer. (rcsb.org)