• Such partial homology may result from a gene fusion event. (wikipedia.org)
  • Homologous sequences are orthologous if they are inferred to be descended from the same ancestral sequence separated by a speciation event: when a species diverges into two separate species, the copies of a single gene in the two resulting species are said to be orthologous. (wikipedia.org)
  • citation needed] Given their tremendous importance for biology and bioinformatics, orthologous genes have been organized in several specialized databases that provide tools to identify and analyze orthologous gene sequences. (wikipedia.org)
  • In this study, 331-bp fragment of the 18S rDNA gene showed 99.7% and we collected P . irritans (human fleas) and C . felis fleas on 99.4% homology with previous sequences of C . felis a pet monkey in Gabon and report for the first time the (GenBank accession no. (cdc.gov)
  • The gene, which was identified statistically in twins in a study published in 2005 , was recently cloned and sequenced, as reported in the online journal Nature Theology . (scienceblog.com)
  • The presence or absence of one exon by alternative splicing of the gamma-1 gene resulted in two transcript variants which code for predicted proteins containing 298 amino acids (4 cystathionine beta-synthase domains, CBSD) or 276 amino acids (3 CBSD). (usda.gov)
  • For the gamma-2 gene, use of an alternate initiation site and promoter and/or alternative splicing resulted in four different transcript variants which code for predicted proteins containing 567 (4 CBSD), 452 (4 CBSD), 328 (3 CBSD) and 158 (2 CBSD) amino acids. (usda.gov)
  • Alternative splicing of exon 3 in the gamma-3 gene resulted in a shift of the open reading frame and the production of 'long' and 'short' transcript variants that code for predicted proteins of 383 and 363 amino acids, both with 4 CBSD. (usda.gov)
  • Chicken gamma genes displayed similar structures and high sequence homology compared to corresponding mammalian gamma gene homologues. (usda.gov)
  • The best-aligned sequences were annotated with gene ontology groups. (frontiersin.org)
  • A putative late gene promoter motif sequence, AGTAT was found in the 3' upstream sequences of these genes. (umass.edu)
  • Twenty putative pre-microRNA sequences were predicted in Hz-2V by searching stem-loop structures with less than -25kcal/mol of free energy, and one of the microRNA candidates was predicted to target the Hz2V007 gene transcript, which codes for a putative juvenile hormone esterase. (umass.edu)
  • Gene probes are used in various blotting and in situ hybridization (ISH) techniques for the detection of nucleic acid sequences in food industry, environmental, medical, and veterinary applications to improve the specificity of the analyses. (enzolifesciences.com)
  • A DNA probe is a labeled fragment of DNA that contains a nucleotide sequence specific for the gene or chromosomal region of interest. (enzolifesciences.com)
  • In the present study, we characterized forty isolates of indigenous black gram bradyrhizobia from Myanmar based on the sequence analysis of the bacterial 16S rRNA gene. (scirp.org)
  • The result showed that the bacterium expression system was suitable for the virus gene expression. (scirp.org)
  • W. B. Wang, S. Y. Zhu, L. Q. Wang, F. Yu, Shen W. D. (2005) Cloning and sequence analysis of the Antheraea pernyi nucleo-polyhedrovirus gp64 gene. (scirp.org)
  • E. A. van Strien, D. Zuidema, R.W. Goldbach, Vlak, J. M. (1992) Nucleotide sequence and transcriptional analysis of the polyhedrin gene of Spodoptera exigua nuclear polyhedrosis vi-rus. (scirp.org)
  • Roughly 25.4% of the whole-insect genome appears to encode long interspersed nuclear elements (LINEs), and a total of 11,901 protein sequences predicted by automated gene finding exhibited homology with reference sequences in the NCBI NR and/or UniProtKB databases at the most stringent similarity cutoff level (i.e., the gold tier). (usda.gov)
  • Clonalilty and sequence similarity was determined by PCR followed by sequencing and comparing immunoglobulin heavy chain (IgH) gene rearrangement sequences to germline sequences and to each other. (bmj.com)
  • For example, students can analyze the six open reading frames for a given fragment of DNA, compare the results of various gene calling algorithms, assign function by sequence homology, and use gene ortholog neighborhoods for comparative genomics and annotate biochemical pathways, while learning the underlying biological concepts in a variety of science courses. (genomeweb.com)
  • Here, we report the draft genome sequence of Clostridium botulinum strain CDC76130, which harbors a rare botulinum toxin gene (bont) complex arrangement of bont/A5 and truncated bont/B2 within the same ha toxin gene cluster. (cdc.gov)
  • Gene segments were cloned and sequenced. (who.int)
  • Homology among DNA, RNA, or proteins is typically inferred from their nucleotide or amino acid sequence similarity. (wikipedia.org)
  • Computational methods bridge this sequence-annotation gap typically through homology-based annotation transfer by identifying sequence-similar proteins with known function or through prediction methods using evolutionary information. (rostlab.org)
  • Here, we propose predicting GO terms through annotation transfer based on proximity of proteins in the SeqVec embedding rather than in sequence space. (rostlab.org)
  • The learned representation space has a multi-scale organization reflecting structure from the level of biochemical properties of amino acids to remote homology of proteins. (biorxiv.org)
  • Based on the genome sequencing results, an analysis of structural proteins and prediction of putative microRNAs of Hz-2V was performed. (umass.edu)
  • Alignment of the amino acid sequence of aprotinin with the Kunitz domains of human proteins allowed the identification and design of a family of peptides, named Angiopeps. (aspetjournals.org)
  • Total 38 nucleotides and 36 proteins sequences of linA and linB were used for constructing the phylogeny. (ispub.com)
  • At the amino acid sequence level, human beta-Defensin 2 shares 98% and 51% homology with the proteins from rhesus monkey and rat, respectively. (rndsystems.com)
  • Sequence homology is the biological homology between DNA, RNA, or protein sequences, defined in terms of shared ancestry in the evolutionary history of life. (wikipedia.org)
  • These embeddings originate from deep learned language models (LMs) for protein sequences (SeqVec) transferring the knowledge gained from predicting the next amino acid in 33 million protein sequences. (rostlab.org)
  • A proportion of these will alter protein sequences, the most common of which is the non-synonymous single nucleotide polymorphism (nsSNP). (biomedcentral.com)
  • To this end we use unsupervised learning to train a deep contextual language model on 86 billion amino acids across 250 million protein sequences spanning evolutionary diversity. (biorxiv.org)
  • However it is still not crystallized for birds and only advanced homology models are available. (nature.com)
  • This problem is magnified in organisms that have their genomes sequenced for the first time ( Fig. 1c ). (nature.com)
  • Sequencing of the whole-insect LDD genomes was also motivated by a desire to identify the genetic components associated with flight in Asian gypsy moth females, a characteristic which is absent in European gypsy moth females. (usda.gov)
  • The JGI's education program has started an "Adopt a GEBA Genome" project (GEBA is for the Genomic Encyclopedia of Bacteria and Archaea initiative) that "makes available a selection of recently sequenced genomes for use in undergraduate courses," Eisen writes. (genomeweb.com)
  • The sequence analysis confirmed that all isolates were categorized and identified as the genus Bradyrhizobium and they were conspecific with B . elkanii , B . sp. (scirp.org)
  • Draft whole genome sequencing was performed for 96 isolates that represent the breadth of predicted species and site diversity. (awri.com.au)
  • Infection control practices were observed, environmental samples obtained, a dietary case-control study completed, and whole genome sequencing performed on environmental and clinical Bacillus isolates. (bvsalud.org)
  • B cereus was identified in 7 of 61 environmental samples and 1 of 19 dietary protein samples-these were unrelated to clinical isolates via sequencing. (bvsalud.org)
  • RESULTS: Whole-genome sequencing confirmed homology among clinical isolates. (bvsalud.org)
  • Here, we present 20 draft genome sequences of Clostridium botulinum type A isolates originating from foodborne outbreaks in the United States and Ethiopia. (cdc.gov)
  • Significant sequence similarity and shared functional domains indicate that these two genes are orthologous genes, inherited from the shared ancestor. (wikipedia.org)
  • Furthermore, comparative genomics through BES can be used for identifying positional candidate genes from QTL mapping studies, aid in future assembly of a reference genome sequence and elucidating sequence content and complexity in the rainbow trout genome. (biomedcentral.com)
  • In the present report we have compared and contrasted structure- and sequence-based methods of prediction to over 5500 genes carrying nearly 24,000 nsSNPs, by employing an automatic comparative modelling procedure to build models for the genes. (biomedcentral.com)
  • Advantages of Zebrafish: The zebrafish has a sequenced genome and 80% homology of genes associated with human disease. (cdc.gov)
  • Homologies were found to 38 of the 113 ORFs predicted for genes with known functions. (umass.edu)
  • The first sequence targeted internal transcribed spacer regions of ribosomal genes and revealed up to 100% homology with D. immitis sequences from GenBank, whereas a maximum homology of 80% was observed with D. repens sequences from GenBank. (cdc.gov)
  • A mutation or deletion of any of the genes that code for enzymes involved in cortisol or aldosterone synthesis results in congenital adrenal hyperplasia. (medscape.com)
  • Samples that display microbial growth are returned to the AWRI, where a combination of metagenomic DNA sequencing, strain isolation and whole-genome sequencing are used to identify and characterise the species present in each sample. (awri.com.au)
  • Whole-genome sequencing confirmed the presence of a genetically identical element in ice and water machine and patient specimens. (bvsalud.org)
  • However, the lack of a reference genome sequence hampers research progress for both academic and applied purposes. (biomedcentral.com)
  • The discovery of specific repeat elements will facilitate analyses of sequence content (e.g. for SNPs discovery and for transcriptome characterization) and future genome sequence assemblies. (biomedcentral.com)
  • The genome sequence of the multinucleocapsid nucleo-polyhedrovirus of the Chinese oak silkworm Antheraea pernyi. (scirp.org)
  • A genome sequence was recently reported for a gypsy moth cell line, which was derived from LDD ovary tissues over 40 years ago. (usda.gov)
  • In order to enrich the genomic tools already available in this species and provide further insight on the complexity of its genome, we sequenced a large number of rainbow trout BAC-end sequences (BES) and characterized their contents. (biomedcentral.com)
  • On January 7, 2021, the team downloaded all B.1.1.7 lineage SARS-CoV-2 genomic sequences available on the GISAID public database - about 8,786 full-length genome sequences from 29 countries. (news-medical.net)
  • Map of the B.1.1.7 genomic sequences available on GISAID as of January 7, 2020. (news-medical.net)
  • Errors may be the result of poor indexing of sequences deposited in sequence databases or inaccurate estimation of the degree of genomic polymorphisms within a species and between closely related species. (cdc.gov)
  • Furthermore, using sequence analysis of human genomic DNA, researchers concluded that the amino acids important for catalysis by COX-1 are conserved and are equally important for catalysis by COX-2. (medscape.com)
  • Prediction of protein antigenic determinants from amino acid sequences. (scirp.org)
  • Areas covered include sequence databases, pairwise and multiple sequence alignment, homology searches in sequence databases and subcellular localization prediction. (lu.se)
  • Nucleic acid probes are either a single stranded DNA or RNA with a strong affinity towards a specific DNA or RNA target sequence. (enzolifesciences.com)
  • In theory, any nucleic acid can be used as a probe provided it can be labeled to permit detection and quantitation of the hybrid molecules formed between the probe and sequence to be identified. (enzolifesciences.com)
  • Significant similarity is strong evidence that two sequences are related by evolutionary changes from a common ancestral sequence. (wikipedia.org)
  • The term "percent homology" is often used to mean "sequence similarity", that is the percentage of identical residues (percent identity), or the percentage of residues conserved with similar physicochemical properties (percent similarity), e.g. leucine and isoleucine, is usually used to "quantify the homology. (wikipedia.org)
  • Based on the definition of homology specified above this terminology is incorrect since sequence similarity is the observation, homology is the conclusion. (wikipedia.org)
  • As with morphological and anatomical structures, sequence similarity might occur because of convergent evolution, or, as with shorter sequences, by chance, meaning that they are not homologous. (wikipedia.org)
  • When the biologists get an unknown sequence, in general they would compare this unknown sequence (denoted as query sequence) with the known database of sequences (denoted as database sequences) to find the similarity scores and then identify the evolutionary relationships among them. (hindawi.com)
  • Multiple clonal bands in HT had sequence similarity (homology) of 62-100% with the clonal band in the lymphoma from the same patient. (bmj.com)
  • At least one clonal band in HT had more than 96% similarity (homology) with the clonal band of lymphoma in all three cases. (bmj.com)
  • Sequence similarity between the clonal bands in HT and subsequently developed thyroid lymphoma is supportive of the argument that primary thyroid lymphoma may evolve from HT. (bmj.com)
  • The 16S rDNA sequencing of lyophilized treated sample was carried out to correlate the phylogenetic relationship of P. vulgaris with other bacterial species after treatment. (slideserve.com)
  • Recently, metagenomics a new approach to identify culturable and non culturable bacteria with the help of 16S rDNA sequences isolate total DNA from HCH contaminated soil and amplified 16S rDNA through universal primers and confirmed its total population with denaturing gradient gel electrophoresis and sequencing. (ispub.com)
  • Preliminary results show 85% homology with a Presbyterian minister from Des Moines. (scienceblog.com)
  • Preliminary results from CAFA4 appear to confirm these findings. (rostlab.org)
  • Although the C-terminal sequences adjacent to the bHLH domain, constitute a protein interaction site essential for TWIST function [4] [5] , we reasoned that a structural model restricted to the bHLH domains should provide additional insights into the TWIST-DNA interface and highlight functional differences between TWIST1 complexes. (proteopedia.org)
  • These ribosomal sequences was functional for the phylogenetic analysis and molecular taxonomic of any bacteria. (ispub.com)
  • However, we have recently report- sequencing ready reaction kit with Amplitaq Polymerase ed molecular detection of several Bartonella species, FS (Perkin-Elmer, Coignieres, France) as described by the including B. quintana, in Ctenocephalides felis fleas from manufacturer. (cdc.gov)
  • The diagnosis of measles is confirmed by laboratory test results, including a positive result for measles-specific immunoglobulin M (IgM) titre, significant increase in measles-specific immunoglobulin G (IgG) titre using paired serum, the detection of measles virus (MV) by reverse transcription polymerase chain reaction (RT-PCR) or isolation of MV in cell culture. (who.int)
  • New samples obtained twelve months later also showed a predominance of RNA and were used for metagenomic analysis by deep sequencing. (virology.ws)
  • For both analyzed targets, GenBank contained several sequences for D. immitis and D. repens that were deposited by various investigators, and all sequences yielded consistent results. (cdc.gov)
  • Therefore, there is no basis to suggest that the sequences deposited in GenBank were incorrect. (cdc.gov)
  • One assembled sequence of 5,662 nucleotides, believed to be a complete viral genome, encodes a single open reading frame containing a RdRp and a putative capsid protein similar to that of the positive-strand RNA containing nodaviruses, tetraviruses, and birnaviruses. (virology.ws)
  • This affinity and complementary sequence allow binding to specific regions of a target sequence of nucleotides. (enzolifesciences.com)
  • In developing a probe, a sequence of nucleotides must be identified, isolated, reproduced in sufficient quantity, and tagged with a label that can be detected. (enzolifesciences.com)
  • Orthologous sequences provide useful information in taxonomic classification and phylogenetic studies of organisms. (wikipedia.org)
  • These resources employ approaches that can be generally classified into those that use heuristic analysis of all pairwise sequence comparisons, and those that use phylogenetic methods. (wikipedia.org)
  • In a recent bioRxiv * preprint paper, researchers from Belgium and the USA discuss a study in which they used sophisticated phylodynamic methods to confirm the rapid rise of SARS-CoV-2 B.1.1.7 'Variant of Concern' is most likely a result of global dispersal rather than convergent evolution from various sources. (news-medical.net)
  • Alignments of multiple sequences are used to indicate which regions of each sequence are homologous. (wikipedia.org)
  • These new architectures make it possible to enhance the performance of sequence alignments by using the parallel computing technologies. (hindawi.com)
  • it is generally believed that all the copies in an organism are identical or nearly identical in nucleotide sequence. (ispub.com)
  • Mutations in MYH9 result in the May-Hegglin anomaly, and Fechtner and Sebastian syndromes. (nih.gov)
  • Thus, our results suggest that mutations in MYH9 result in three megakaryocyte/platelet/leukocyte syndromes and are important in the pathogenesis of sensorineural deafness, cataracts and nephritis. (nih.gov)
  • Some mutations result in pleiotropy, although this is variable depending on genetic background, type of mutation, and location of the mutation. (creation.com)
  • Mutations also result in interesting variety including white animals and white spotting phenotypes. (creation.com)
  • 5 This explains why heritable loss-of-function mutations sometimes have pleiotropic effects, not only resulting in white color patterns, but also anemia and/or infertility. (creation.com)
  • The study results did not suggest that the established mutations of VOC B.1.1.7 independently evolved in many different locations. (news-medical.net)
  • Deficiency of 21-hydroxylase, resulting from mutations or deletions of CYP21A, is the most common form of CAH, accounting for more than 90% of cases. (medscape.com)
  • Identification of Bruton tyrosine kinase mutations in 12 Chinese patients with X-linked agammaglobulinaemia by long PCR-direct sequencing. (lu.se)
  • When confronted with the task of finding homology to large numbers of sequences, database searching tools such as Blast and Fasta generate prohibitively large amounts of information. (aaai.org)
  • BES analyses identified 6,848 simple sequence repeats (SSRs), of which 3,854 had high quality flanking sequences for PCR primers design. (biomedcentral.com)
  • Random priming is a type of primer extension in which a mixture of small oligonucleotide sequences, acting as primers, anneal to a heat-denatured double-stranded template. (enzolifesciences.com)
  • Ideally, the solution of these protein structures will also contribute to the understanding of protein sequence-structure relationships in general. (nih.gov)
  • The recent sequencing of the human genome has provided a wealth of information detailing several million genetic variations between individuals. (biomedcentral.com)
  • A region of the genome of BVDV recovered from PI crias was sequenced to determine genetic homology. (avma.org)
  • Infections in 3 of the 4 herds with PI crias were linked as evidence by the genetic homologies of viruses. (avma.org)
  • The particular phenotype that results depends on the sex of the individual, the location of the block in synthesis, and the severity of the genetic deletion or mutation. (medscape.com)
  • This condition results from a combination of genetic, environmental, and lifestyle factors, many of which have not been identified. (medlineplus.gov)
  • The Smith-Waterman (SW) algorithm has been widely utilized for searching biological sequence databases in bioinformatics. (hindawi.com)
  • The resulting model contains information about biological properties in its representations. (biorxiv.org)
  • Sequence analysis was performed by plague caused by Yersinia pestis (3), murine typhus caused using the software package ABI Prism DNA Sequencing by Rickettsia typhi , and fleaborne spotted fever caused by Analysis Software version 3.0 (Perkin-Elmer). (cdc.gov)
  • Analysis of the RNA viral sequences revealed coding regions for a predicted RNA dependent RNA polymerase (RdRp), a hallmark of RNA viruses. (virology.ws)
  • Two transmembrane domains were predicted in p11.7, and a DNA binding motif was found in p31.7 by amino acid sequence analysis, therefore p11.7 and p31.7 were predicted to be envelope and capsid protein, respectively. (umass.edu)
  • S. Gomi, K. Majima, Maeda S. (1999) Sequence analysis of the genome of Bombyx mori nucleopolyhedrovirus. (scirp.org)
  • Homology analysis indicates at least 37 different species of yeast across the dataset, with some species present in more than one sample. (awri.com.au)
  • The degree of homology between target and probe results in stable hybridization. (enzolifesciences.com)
  • Two organisms that are very closely related are likely to display very similar DNA sequences between two orthologs. (wikipedia.org)
  • c), Number of reactions KEGG added or removed for selected organismal networks over the course of the same period for two recently sequenced organisms. (nature.com)
  • The majority (96.4%, n=8468) of the sequences were from the UK, and about 318 sequences were from other countries, with 13 from North America - 8 from the US and 5 from Canada. (news-medical.net)
  • We predict organismal metabolic networks using sequence homology and a global metabolic network constructed from all available organismal networks. (nature.com)
  • We show, however, that when homology is used with a global metabolic network one is able to predict organismal metabolic networks that have enhanced network connectivity. (nature.com)
  • PCR products were purified, and DNA sequencing was natural reservoir of B . quintana and that the human body carried out by using the d-Rhodamine Terminator cycle louse is the vector (1). (cdc.gov)
  • Sequencing products of human disease (2). (cdc.gov)
  • We have established homology models of the human TWIST1 homodimer and heterodimers (formed with the E12 partner) bound to their target DNA sequences. (proteopedia.org)
  • A molecular cloning strategy involving primer-directed RT-PCR and 3'- and 5'-RACE was developed to sequence chicken cDNAs corresponding to complete coding regions and portions of the 5'- and 3'-untranslated regions of AMPK gamma-1, -2 and -3 mRNA transcripts. (usda.gov)
  • Methods: A single-center retrospective review was conducted to evaluate patients with acute leukemia, positive blood or cerebrospinal fluid test results for B cereus, and abnormal neuroradiographic findings between January 2018 and October 2022. (bvsalud.org)
  • Results: Five patients with B cereus neuroinvasive disease were identified. (bvsalud.org)
  • Results: Nine of the 13 EVD patients (age range: 22-70 years) survived. (bvsalud.org)
  • More than 2,000 species of fleas exist world- obtained sequences were compared with those available in wide. (cdc.gov)
  • This damage results from a buildup of harmful molecules called reactive oxygen species, which are byproducts of energy production in mitochondria. (medlineplus.gov)
  • As a result, reactive oxygen species easily damage mitochondrial DNA, causing cells to malfunction and ultimately to die. (medlineplus.gov)
  • Various software resources are also required to enable users to conveniently connect their experimental results with publicly, and application specific, bioinformatics databases and tools. (lu.se)
  • Conclusions and Clinical Relevance -Results confirmed the importance of BVDV infections in alpacas in the United States and highlighted the importance of determining the BVDV infection status of animals before they are commingled to limit exposure of herds to BVDV infection. (avma.org)
  • worm in our clinical case was made on the basis of 2 distinct sequences, each of which exhibited marked differences between D. immitis and D. repens ( 2 ). (cdc.gov)
  • A minimally hypomorphic mutation in Btk resulting in reduced B cell numbers but no clinical disease. (lu.se)
  • This bleeding is painful and leads to long-term inflammation and deterioration of the joint (typically the ankles in children, and the ankles, knees, and elbows in adolescents and adults), resulting in permanent deformities, misalignment, loss of mobility, and extremities of unequal lengths. (medscape.com)
  • One of the most important rules for reducing the amount of output is to linlit the number of overlapping matches to the same region of the query sequence. (aaai.org)
  • Direct sequencing of viral communities from the environment, known as viral metagenomics, is one approach being taken to discover archaeal viruses. (virology.ws)
  • These results clearly show that at least two related but distinct RNA viruses are present in Nymph Lake. (virology.ws)
  • Sequences obtained clustered tightly with those of Israeli origin as well as Lebanese H9N2 viruses from 2010. (who.int)
  • In bioinformatics, the sequence alignment has become one of the most important issues. (hindawi.com)
  • Needleman and Wunsch [ 1 ] proposed a dynamic programming method (abbreviated to NW algorithm) to solve the global alignment problem between two sequences in 1970. (hindawi.com)
  • SNP in DFR1 Coding Sequence Is Tightly Associated with Anthocyanin Accumulation in Cabbage ( B. oleracea var. (mdpi.com)
  • The third difference is the very high proportion of proline residues in the sequence accounting for about one-third of the sequence. (springer.com)
  • Diagnosis of Lassa fever has also advanced from basic serological tests to more sophisticated methods such as quantitative real time polymerase chain reaction (qRT-PCR) and sequencing, which are particularly useful for identifying outbreak strains. (bvsalud.org)
  • This set of rules proved to be robust for most cases and gives high fidelity separation between real homologies and spurious matches. (aaai.org)
  • In the life sciences, the anticipated growth of sequencing promises unprecedented data on natural sequence diversity. (biorxiv.org)
  • That's scale - the amount of data I can afford to carry with me has changed dramatically, and as a result, my expectations about what's normal have changed. (scienceblogs.com)
  • Such a phenotypic variation may be the result of a single mutation or deletion. (cdc.gov)
  • Spontaneous mutation and acquired immunologic processes can result in this disorder, as well. (medscape.com)
  • v3 (Aug 2020): Paper thoroughly revised, with improved results and updated methodology. (biorxiv.org)
  • Using a homology strategy, in silico models based on the murine NEUROD1/E47 X-ray structure were established and also subjected to dynamics simulations. (proteopedia.org)
  • The established homology models (including DNA sequences) were visualized with the VMD 1.9.1 software. (proteopedia.org)
  • The results obtained with in vitro and in vivo models provided evidence for greater passage of aprotinin across the BBB than of holo-transferrin. (aspetjournals.org)
  • Sequence comparison methods were first pioneered in the COGs database in 1997. (wikipedia.org)
  • For over 40% of the nsSNPs, structure-based methods predicted which of these sequence changes are likely to either disrupt the structure of the protein or interfere with the function or interactions of the protein. (biomedcentral.com)
  • Finally, these new peptides reveal a carbohydrate moiety, indicating a glycosylation in the sequence. (springer.com)
  • Peptides were characterized by a combined use of MALDI- TOF/TOF and nanoESI-IT-ETD experiments to determine not only the peptide sequence but also the composition and the position of the carbohydrate moiety. (springer.com)
  • Overall, these results suggest that these Kunitz-derived peptides could be advantageously used as a new brain delivery system for pharmacological agents that do not readily enter the brain. (aspetjournals.org)