• The pilot phase of the Project is focused on a specified 30 megabases (∼1%) of the human genome sequence and is organized as an international consortium of computational and laboratory-based scientists working to develop and apply high-throughput approaches for detecting all sequence elements that confer biological function. (sciencemag.org)
  • These sequences consist of four stretches of G residues (each stretch with two or more G residues) interspersed by sequences of variable composition that form the loops. (biomedcentral.com)
  • Several genome-wide studies directed towards mapping of nucleosome positions have revealed periodicity associated with certain stretches of sequences. (ebscohost.com)
  • We describe an ancient regulatory code that patterns the gene expression required for the efficient C 4 pathway. (pnas.org)
  • As these regulators are located in gene bodies they determine amino acid sequence as well as gene expression and so are known as duons. (pnas.org)
  • C 4 photosynthesis therefore appears to have coopted an ancient regulatory code to generate the spatial patterning of gene expression that is a hallmark of C 4 photosynthesis. (pnas.org)
  • However, most of these studies involved the use of yeast which has much simpler regulatory networks than human and has many genome wide binding data and gene expression data under diverse conditions. (biomedcentral.com)
  • Therefore, rich in vivo datasets of pharmacological time-series with two dosing regimens sampled from rat liver are examined for temporal patterns of changes in gene expression and their regulatory commonalities. (springer.com)
  • The higher the stacking energy the more rigid the DNA helix, thus it is natural to expect that sequences that are involved in wrapping around the histone octamer should be unstacked and possess intrinsic curvature. (ebscohost.com)
  • The bifunctional aspartokinase-homoserine dehydrogenase (AK-HSD) enzyme has a regulatory domain that consists of two subdomains with a common loop-alpha helix-loop-beta strand loop-beta strand motif. (wikipedia.org)
  • Find this article online O'Keefe RT, Henderson SC, Spector DL (1992) Dynamic organization of DNA replication in mammalian cell nuclei: Spatially and temporally defined replication of chromosome-specific alpha-satellite DNA sequences. (thefullwiki.org)
  • LANA binds with two LANA-binding sites (LBS1/2) within a terminal repeat (TR) sequence and is indispensable for viral genome replication in latency. (frontiersin.org)
  • We describe Ca 2+ signals reported by Salsa6f during T cell receptor activation in naive T cells, helper Th17 T cells and regulatory T cells, and Ca 2+ signals mediated in T cells by an activator of mechanosensitive Piezo1 channels. (elifesciences.org)
  • Huang ZM, Yen TS (1994) Hepatitis B virus RNA element that facilitates accumulation of surface gene transcripts in the cytoplasm. (springer.com)
  • Transcripts belonging to other gene categories found to be differentially expressed in our array studies include those associated with (i) H 2 O 2 resistance, (ii) repair of DNA damage, (iii) sugar transport and capsule biosynthesis, and (iv) two-component signal transduction elements. (asm.org)