• Such partial homology may result from a gene fusion event. (wikipedia.org)
  • Homologous sequences are orthologous if they are inferred to be descended from the same ancestral sequence separated by a speciation event: when a species diverges into two separate species, the copies of a single gene in the two resulting species are said to be orthologous. (wikipedia.org)
  • citation needed] Given their tremendous importance for biology and bioinformatics, orthologous genes have been organized in several specialized databases that provide tools to identify and analyze orthologous gene sequences. (wikipedia.org)
  • The presence or absence of one exon by alternative splicing of the gamma-1 gene resulted in two transcript variants which code for predicted proteins containing 298 amino acids (4 cystathionine beta-synthase domains, CBSD) or 276 amino acids (3 CBSD). (usda.gov)
  • For the gamma-2 gene, use of an alternate initiation site and promoter and/or alternative splicing resulted in four different transcript variants which code for predicted proteins containing 567 (4 CBSD), 452 (4 CBSD), 328 (3 CBSD) and 158 (2 CBSD) amino acids. (usda.gov)
  • Alternative splicing of exon 3 in the gamma-3 gene resulted in a shift of the open reading frame and the production of 'long' and 'short' transcript variants that code for predicted proteins of 383 and 363 amino acids, both with 4 CBSD. (usda.gov)
  • Chicken gamma genes displayed similar structures and high sequence homology compared to corresponding mammalian gamma gene homologues. (usda.gov)
  • The best-aligned sequences were annotated with gene ontology groups. (frontiersin.org)
  • A putative late gene promoter motif sequence, AGTAT was found in the 3' upstream sequences of these genes. (umass.edu)
  • Twenty putative pre-microRNA sequences were predicted in Hz-2V by searching stem-loop structures with less than -25kcal/mol of free energy, and one of the microRNA candidates was predicted to target the Hz2V007 gene transcript, which codes for a putative juvenile hormone esterase. (umass.edu)
  • Roughly 25.4% of the whole-insect genome appears to encode long interspersed nuclear elements (LINEs), and a total of 11,901 protein sequences predicted by automated gene finding exhibited homology with reference sequences in the NCBI NR and/or UniProtKB databases at the most stringent similarity cutoff level (i.e., the gold tier). (usda.gov)
  • For example, students can analyze the six open reading frames for a given fragment of DNA, compare the results of various gene calling algorithms, assign function by sequence homology, and use gene ortholog neighborhoods for comparative genomics and annotate biochemical pathways, while learning the underlying biological concepts in a variety of science courses. (genomeweb.com)
  • Southern blot analysis indicated that this gene shared limited nucleotide similarity with several other Drosophila genomic sequences. (marquette.edu)
  • Computer analysis of the DNA sequence of the 21C cDNA revealed a 76 percent 3$\sp\prime$ coding sequence similarity with the Drosophila acidic ribosomal protein gene, A1 (Qian et al. (marquette.edu)
  • This highly shows that the mGR as well as the cGR possess a higher sequence homology & most probably result from the same gene. (fabretp.org)
  • The hypothesis can be backed by These data how the mGR result from the NR3C1 gene, as the cytosolic receptor (12). (fabretp.org)
  • Sequence homology is the biological homology between DNA, RNA, or protein sequences, defined in terms of shared ancestry in the evolutionary history of life. (wikipedia.org)
  • A proportion of these will alter protein sequences, the most common of which is the non-synonymous single nucleotide polymorphism (nsSNP). (biomedcentral.com)
  • We performed a Basic Local Alignment Search Tool (BLAST) analysis to identify regions of local similarity between the human DBNDD1 and protein sequences from other species (Fig. 1 ). (springer.com)
  • 2019 ) was used, https://www.ebi.ac.uk/Tools/msa/clustalo/ ] of human DBNDD1 and similar protein sequences found by a BLAST search in other selected species. (springer.com)
  • Significant sequence similarity and shared functional domains indicate that these two genes are orthologous genes, inherited from the shared ancestor. (wikipedia.org)
  • Furthermore, comparative genomics through BES can be used for identifying positional candidate genes from QTL mapping studies, aid in future assembly of a reference genome sequence and elucidating sequence content and complexity in the rainbow trout genome. (biomedcentral.com)
  • In the present report we have compared and contrasted structure- and sequence-based methods of prediction to over 5500 genes carrying nearly 24,000 nsSNPs, by employing an automatic comparative modelling procedure to build models for the genes. (biomedcentral.com)
  • Advantages of Zebrafish: The zebrafish has a sequenced genome and 80% homology of genes associated with human disease. (cdc.gov)
  • Homologies were found to 38 of the 113 ORFs predicted for genes with known functions. (umass.edu)
  • These species differences in UGT genes could result in species differences in UGT activities. (aspetjournals.org)
  • The aim of this study was to identify and compare regions of nucleotide sequence homology between similar genes that are abundantly expressed and maternally transmitted during Drosophila oogenesis. (marquette.edu)
  • To identify such genes, a Drosophila egg chamber cDNA library was differentially screened such that maternal RNA sequences were readily identified and selected from the recombinant population. (marquette.edu)
  • PCR arrays looking into target genes from the main signaling pathways indicated how the mGR will not exert its results through the transcriptional activity of the most common kinases in these leukemic cells, but RhoA signaling surfaced from our pathway evaluation. (fabretp.org)
  • A mutation or deletion of any of the genes that code for enzymes involved in cortisol or aldosterone synthesis results in congenital adrenal hyperplasia. (medscape.com)
  • The first sequence targeted internal transcribed spacer regions of ribosomal genes and revealed up to 100% homology with D. immitis sequences from GenBank, whereas a maximum homology of 80% was observed with D. repens sequences from GenBank. (cdc.gov)
  • The term "percent homology" is often used to mean "sequence similarity", that is the percentage of identical residues (percent identity), or the percentage of residues conserved with similar physicochemical properties (percent similarity), e.g. leucine and isoleucine, is usually used to "quantify the homology. (wikipedia.org)
  • This involves that the term "percent homology" is a misnomer. (wikipedia.org)
  • While both new isolates are of the Asian genotype, DNA sequencing shows only 98 percent homology--potentially indicating they are the result of two separate introductions. (vin.com)
  • Homology among DNA, RNA, or proteins is typically inferred from their nucleotide or amino acid sequence similarity. (wikipedia.org)
  • Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. (nih.gov)
  • Based on the genome sequencing results, an analysis of structural proteins and prediction of putative microRNAs of Hz-2V was performed. (umass.edu)
  • Their amino acid sequences suggest that they are mainly cytosolic or nuclear proteins partly associating with membranes (Talbot et al. (springer.com)
  • 2009 ). The designated dysbindin paralogs show very limited sequence homology which raised the question whether DBNDD1 and DBNDD2 are dysbindin-like proteins or proteins that share a less conserved domain with DTNBP1 in the context of otherwise unrelated sequences (Ghiani and Dell'Angelica 2011 ). (springer.com)
  • As an outcome human DBNDD1 revealed a high sequence identity to dysbindin domain-containing proteins from other Hominidae (e.g. (springer.com)
  • Proteins with high sequence identity to human DBNDD1 can also be found in evolutionarily more distant species (e.g. (springer.com)
  • 1984). These results suggest that the 3$\sp\prime$ sequences common to the genomic clones define a subset of Drosophila ribosomal proteins that share similar functional residues. (marquette.edu)
  • Pleckstrin homology (PH) domains are small modular domains that occur in a large variety of proteins. (embl.de)
  • Alignment of the amino acid sequence of aprotinin with the Kunitz domains of human proteins allowed the identification and design of a family of peptides, named Angiopeps. (aspetjournals.org)
  • This problem is magnified in organisms that have their genomes sequenced for the first time ( Fig. 1c ). (nature.com)
  • Sequencing of the whole-insect LDD genomes was also motivated by a desire to identify the genetic components associated with flight in Asian gypsy moth females, a characteristic which is absent in European gypsy moth females. (usda.gov)
  • The JGI's education program has started an "Adopt a GEBA Genome" project (GEBA is for the Genomic Encyclopedia of Bacteria and Archaea initiative) that "makes available a selection of recently sequenced genomes for use in undergraduate courses," Eisen writes. (genomeweb.com)
  • On January 7, 2021, the team downloaded all B.1.1.7 lineage SARS-CoV-2 genomic sequences available on the GISAID public database - about 8,786 full-length genome sequences from 29 countries. (news-medical.net)
  • Map of the B.1.1.7 genomic sequences available on GISAID as of January 7, 2020. (news-medical.net)
  • Two transmembrane domains were predicted in p11.7, and a DNA binding motif was found in p31.7 by amino acid sequence analysis, therefore p11.7 and p31.7 were predicted to be envelope and capsid protein, respectively. (umass.edu)
  • Electron microscopic analysis of the resulting heteroduplexes facilitates the mapping of regions of base sequence homology of nucleic acids. (umassmed.edu)
  • Significant similarity is strong evidence that two sequences are related by evolutionary changes from a common ancestral sequence. (wikipedia.org)
  • Based on the definition of homology specified above this terminology is incorrect since sequence similarity is the observation, homology is the conclusion. (wikipedia.org)
  • As with morphological and anatomical structures, sequence similarity might occur because of convergent evolution, or, as with shorter sequences, by chance, meaning that they are not homologous. (wikipedia.org)
  • Additionally, five representative, cross hybridizing genomic clones were isolated based upon 3$\sp\prime$ nucleotide similarity with 21C cDNA sequences. (marquette.edu)
  • The Mubende variant glycoprotein amino acid sequences exhibited 99.7% similarity altogether and a maximum of 96.1% glycoprotein similarity compared to historical SUDV strains from 1976. (cdc.gov)
  • The Mubende variant exhibited 96% amino acid similarity with historic SUDV sequences from the 1970s and a high degree of conservation throughout the outbreak, which was important for ongoing diagnostics and highly promising for future therapy development. (cdc.gov)
  • A comparison of the nucleotide genetic relatedness for the newly emerged Mubende variant indicated that it was most closely related to the Nakisamata SUDV sequence from 2011, represented a likely new zoonotic spillover event, and exhibited an inter- and intra-outbreak substitution rate consistent with previous outbreaks. (cdc.gov)
  • Infection control practices were observed, environmental samples obtained, a dietary case-control study completed, and whole genome sequencing performed on environmental and clinical Bacillus isolates. (bvsalud.org)
  • B cereus was identified in 7 of 61 environmental samples and 1 of 19 dietary protein samples-these were unrelated to clinical isolates via sequencing. (bvsalud.org)
  • RESULTS: Whole-genome sequencing confirmed homology among clinical isolates. (bvsalud.org)
  • One assembled sequence of 5,662 nucleotides, believed to be a complete viral genome, encodes a single open reading frame containing a RdRp and a putative capsid protein similar to that of the positive-strand RNA containing nodaviruses, tetraviruses, and birnaviruses. (virology.ws)
  • Conversely, the transcription of COX-2 yields a 4.5-kb mRNA that encodes a 70-kd protein with roughly 70-75% homology to the COX-1 protein. (medscape.com)
  • Two organisms that are very closely related are likely to display very similar DNA sequences between two orthologs. (wikipedia.org)
  • Conversely, an organism that is further removed evolutionarily from another organism is likely to display a greater divergence in the sequence of the orthologs being studied. (wikipedia.org)
  • The recent sequencing of the human genome has provided a wealth of information detailing several million genetic variations between individuals. (biomedcentral.com)
  • A region of the genome of BVDV recovered from PI crias was sequenced to determine genetic homology. (avma.org)
  • Infections in 3 of the 4 herds with PI crias were linked as evidence by the genetic homologies of viruses. (avma.org)
  • Some mutations result in pleiotropy, although this is variable depending on genetic background, type of mutation, and location of the mutation. (creation.com)
  • The terminal regions of human chromosomes are known to contain specialised DNA sequences and may be vulnerable to rearrangements causing human genetic diseases and particularly idiopathic mental impairment. (bmj.com)
  • The particular phenotype that results depends on the sex of the individual, the location of the block in synthesis, and the severity of the genetic deletion or mutation. (medscape.com)
  • Integrating the genetic sequence and epidemiological data into the response activities generated a broad overview of the outbreak, allowing for quick fact-checking of epidemiological connections between the identified patients. (cdc.gov)
  • This condition results from a combination of genetic, environmental, and lifestyle factors, many of which have not been identified. (medlineplus.gov)
  • In a recent bioRxiv * preprint paper, researchers from Belgium and the USA discuss a study in which they used sophisticated phylodynamic methods to confirm the rapid rise of SARS-CoV-2 B.1.1.7 'Variant of Concern' is most likely a result of global dispersal rather than convergent evolution from various sources. (news-medical.net)
  • Mutations in MYH9 result in the May-Hegglin anomaly, and Fechtner and Sebastian syndromes. (nih.gov)
  • Thus, our results suggest that mutations in MYH9 result in three megakaryocyte/platelet/leukocyte syndromes and are important in the pathogenesis of sensorineural deafness, cataracts and nephritis. (nih.gov)
  • Mutations also result in interesting variety including white animals and white spotting phenotypes. (creation.com)
  • 5 This explains why heritable loss-of-function mutations sometimes have pleiotropic effects, not only resulting in white color patterns, but also anemia and/or infertility. (creation.com)
  • The study results did not suggest that the established mutations of VOC B.1.1.7 independently evolved in many different locations. (news-medical.net)
  • Deficiency of 21-hydroxylase, resulting from mutations or deletions of CYP21A, is the most common form of CAH, accounting for more than 90% of cases. (medscape.com)
  • Sequence alignment [Clustal Omega (Madeira et al. (springer.com)
  • It covers stencil computations, auto-tuning, optimizations of a computational kernel, sequence alignment and homology, and pairwise computations. (routledge.com)
  • Areas covered include sequence databases, pairwise and multiple sequence alignment, homology searches in sequence databases and subcellular localization prediction. (lu.se)
  • When confronted with the task of finding homology to large numbers of sequences, database searching tools such as Blast and Fasta generate prohibitively large amounts of information. (aaai.org)
  • These resources employ approaches that can be generally classified into those that use heuristic analysis of all pairwise sequence comparisons, and those that use phylogenetic methods. (wikipedia.org)
  • 3 ). We report by using ethidium bromide under UV light and sequenced the molecular detection of 3 zoonotic Bartonella spp. (cdc.gov)
  • A molecular cloning strategy involving primer-directed RT-PCR and 3'- and 5'-RACE was developed to sequence chicken cDNAs corresponding to complete coding regions and portions of the 5'- and 3'-untranslated regions of AMPK gamma-1, -2 and -3 mRNA transcripts. (usda.gov)
  • The molecular characterization was based on the RAPD markers, telomeric fingerprinting and ITS sequencing. (scielo.br)
  • In order to enrich the genomic tools already available in this species and provide further insight on the complexity of its genome, we sequenced a large number of rainbow trout BAC-end sequences (BES) and characterized their contents. (biomedcentral.com)
  • The 16S rDNA sequencing of lyophilized treated sample was carried out to correlate the phylogenetic relationship of P. vulgaris with other bacterial species after treatment. (slideserve.com)
  • The sequence conservation of the putative dysbindin domain across all selected species is notable (Fig. 1 shaded region). (springer.com)
  • Errors may be the result of poor indexing of sequences deposited in sequence databases or inaccurate estimation of the degree of genomic polymorphisms within a species and between closely related species. (cdc.gov)
  • This damage results from a buildup of harmful molecules called reactive oxygen species, which are byproducts of energy production in mitochondria. (medlineplus.gov)
  • As a result, reactive oxygen species easily damage mitochondrial DNA, causing cells to malfunction and ultimately to die. (medlineplus.gov)
  • However, the lack of a reference genome sequence hampers research progress for both academic and applied purposes. (biomedcentral.com)
  • The discovery of specific repeat elements will facilitate analyses of sequence content (e.g. for SNPs discovery and for transcriptome characterization) and future genome sequence assemblies. (biomedcentral.com)
  • A genome sequence was recently reported for a gypsy moth cell line, which was derived from LDD ovary tissues over 40 years ago. (usda.gov)
  • The first rainbow trout repeat elements database (INRA RT rep1.0) containing 735 putative repeat elements was developed, and identified almost 59.5% of the BES database in base-pairs as repetitive sequence. (biomedcentral.com)
  • For both analyzed targets, GenBank contained several sequences for D. immitis and D. repens that were deposited by various investigators, and all sequences yielded consistent results. (cdc.gov)
  • Therefore, there is no basis to suggest that the sequences deposited in GenBank were incorrect. (cdc.gov)
  • BES analyses identified 6,848 simple sequence repeats (SSRs), of which 3,854 had high quality flanking sequences for PCR primers design. (biomedcentral.com)
  • These results clearly show that at least two related but distinct RNA viruses are present in Nymph Lake. (virology.ws)
  • A distinct group of 22q13 monosomies has been reported that result from the formation of a ring chromosome which combines loss of some long arm material with loss of part of the short arm, with no clinical consequences. (bmj.com)
  • worm in our clinical case was made on the basis of 2 distinct sequences, each of which exhibited marked differences between D. immitis and D. repens ( 2 ). (cdc.gov)
  • The majority (96.4%, n=8468) of the sequences were from the UK, and about 318 sequences were from other countries, with 13 from North America - 8 from the US and 5 from Canada. (news-medical.net)
  • Although the C-terminal sequences adjacent to the bHLH domain, constitute a protein interaction site essential for TWIST function [4] [5] , we reasoned that a structural model restricted to the bHLH domains should provide additional insights into the TWIST-DNA interface and highlight functional differences between TWIST1 complexes. (proteopedia.org)
  • 1, 2 During the last decade, there have been several reports of patients who are described as having a 22q13 monosomy resulting from simple terminal deletions. (bmj.com)
  • Orthologous sequences provide useful information in taxonomic classification and phylogenetic studies of organisms. (wikipedia.org)
  • Partial homology can occur where a segment of the compared sequences has a shared origin, while the rest does not. (wikipedia.org)
  • However, there is certainly raising proof GCs results on a lot of organs and cells, which are 3rd party of transcriptional adjustments and occur quickly, within a few minutes or mere seconds of contact with GCs (2C4). (fabretp.org)
  • Such a phenotypic variation may be the result of a single mutation or deletion. (cdc.gov)
  • Spontaneous mutation and acquired immunologic processes can result in this disorder, as well. (medscape.com)
  • To obtain these structures, we applied UV-fluorescence microscopy, video analysis and highly automated goniometer-based instrumentation to map and rapidly position individual crystals randomly-located on fixed target holders, resulting in the highest indexing-rates observed for a serial femtosecond crystallography (SFX) experiment. (biorxiv.org)
  • Despite sequence identities ranging from 87% to 91% between caprine and bovine caseins, these patients possess IgE antibodies that bind specifically to the caprine caseins without recognizing the bovine ones. (cea.fr)
  • These results are in line with oral food challenges performed with peanut allergic patients showing that objective symptoms occurred at higher doses after inclusion in fat-rich matrices, but were also more severe, thus underlying the complex role of food matrices in peanut food allergy. (cea.fr)
  • Methods: A single-center retrospective review was conducted to evaluate patients with acute leukemia, positive blood or cerebrospinal fluid test results for B cereus, and abnormal neuroradiographic findings between January 2018 and October 2022. (bvsalud.org)
  • Results: Five patients with B cereus neuroinvasive disease were identified. (bvsalud.org)
  • Results: Nine of the 13 EVD patients (age range: 22-70 years) survived. (bvsalud.org)
  • Direct sequencing of viral communities from the environment, known as viral metagenomics, is one approach being taken to discover archaeal viruses. (virology.ws)
  • Analysis of the RNA viral sequences revealed coding regions for a predicted RNA dependent RNA polymerase (RdRp), a hallmark of RNA viruses. (virology.ws)
  • Another viral sequence encoded a protein with 70% amino acid homology to the predicted RdRp. (virology.ws)
  • This methodology should be used to better integrate discrete epidemiological and sequence data for future viral outbreaks. (cdc.gov)
  • Alternative splicing results in multiple transcript variants. (nih.gov)
  • This is not to be confused with conservation in amino acid sequences, where the amino acid at a specific position has been substituted with a different one that has functionally equivalent physicochemical properties. (wikipedia.org)
  • New samples obtained twelve months later also showed a predominance of RNA and were used for metagenomic analysis by deep sequencing. (virology.ws)
  • Using a homology strategy, in silico models based on the murine NEUROD1/E47 X-ray structure were established and also subjected to dynamics simulations. (proteopedia.org)
  • This set of rules proved to be robust for most cases and gives high fidelity separation between real homologies and spurious matches. (aaai.org)
  • The hybrid/heterogeneous nature of future microprocessors and large high-performance computing systems will result in a reliance on two major types of components: multicore/manycore central processing units and special purpose hardware/massively parallel accelerators. (routledge.com)
  • From the 142 confirmed cases, we performed unbiased (Illumina) and SUDV-amplicon-specific (Minion) high-throughput sequencing to obtain 120 SUDV genome-and coding-complete sequences, representing 95.4% (104/109) of SVD-confirmed individuals within a sequence-able range (Ct 30) and 10 genome sequences outside of this range and 6 duplicate genome sequences. (cdc.gov)
  • However, native GLP-1 is degraded rapidly by the ubiquitous enzyme dipeptidyl peptidase-4 (DPP-4), resulting in a half-life of no more than 1~2 minutes [ 10 ], which limits its therapeutic usefulness in clinic. (hindawi.com)
  • From our results and the sequence homology, weconclude that PGRP is a ubiquitous protein involved in innate immunity,conserved from insects to humans. (embl-heidelberg.de)
  • One of the most important rules for reducing the amount of output is to linlit the number of overlapping matches to the same region of the query sequence. (aaai.org)
  • Alignments of multiple sequences are used to indicate which regions of each sequence are homologous. (wikipedia.org)
  • Homologous sequence regions are also called conserved. (wikipedia.org)
  • The diagnosis of measles is confirmed by laboratory test results, including a positive result for measles-specific immunoglobulin M (IgM) titre, significant increase in measles-specific immunoglobulin G (IgG) titre using paired serum, the detection of measles virus (MV) by reverse transcription polymerase chain reaction (RT-PCR) or isolation of MV in cell culture. (who.int)
  • In contrast, isoform 3 (UniProtKB: Q9H9R9-3) carries a 100 amino acids long N-terminal sequence extension. (springer.com)
  • Cannon W, Gallegos MT, Casaz P, Buck M. Amino-terminal sequences of sigmaN (sigma54) inhibit RNA polymerase isomerization. (umassmed.edu)
  • Diagnosis of Lassa fever has also advanced from basic serological tests to more sophisticated methods such as quantitative real time polymerase chain reaction (qRT-PCR) and sequencing, which are particularly useful for identifying outbreak strains. (bvsalud.org)
  • These results may be highly clinically significant, because in the United States alone, f10,000 women are diagnosed annually with ERa-negative/ERh-positive breast carcinoma and may benefit from adjuvant tamoxifen. (lu.se)
  • We predict organismal metabolic networks using sequence homology and a global metabolic network constructed from all available organismal networks. (nature.com)
  • While sequence homology has been a standard to annotate metabolic networks it has been faulted for its lack of predictive power. (nature.com)
  • We show, however, that when homology is used with a global metabolic network one is able to predict organismal metabolic networks that have enhanced network connectivity. (nature.com)
  • metabolic results aligning with and perhaps priming traditional activities Pyrantel pamoate from the cytosolic glucocorticoid receptor (cGR). (fabretp.org)
  • The most identifiable category of SNP is the small proportion (less than 1%) that change protein sequence, the most common of which is the non-synonymous SNP. (biomedcentral.com)
  • On 20 September 2022, Uganda declared a fifth Sudan virus disease outbreak in the Mubende district, resulting in 142 confirmed and 22 probable cases by the end of the outbreak declaration on 11 January 2023. (cdc.gov)
  • The results found relevant by the system are presented in a very concise and clear way, so that the homology can be assessed with minimum effort. (aaai.org)
  • mGluR1 has large hydrophilic sequences in both the N- and C-terminal sides of the seven transmembrane domains. (bdbiosciences.com)
  • Overall, these results suggest that these Kunitz-derived peptides could be advantageously used as a new brain delivery system for pharmacological agents that do not readily enter the brain. (aspetjournals.org)
  • We obtained identical results when working with three specific anti-GR monoclonal antibodies aimed against Pyrantel pamoate the N-terminal half from the cGR. (fabretp.org)
  • Whole-genome sequencing confirmed the presence of a genetically identical element in ice and water machine and patient specimens. (bvsalud.org)
  • Sequence comparison methods were first pioneered in the COGs database in 1997. (wikipedia.org)