• Citron kinase, which resembles the ROCK family of kinases and by comparison to it, is therefore a multiple domain protein containing an N-terminal kinase domain, an internal coiled-coil (CC) domain with Rho/Rac interacting site, and a C-terminal region consisting of a Zn finger, a pleckstrin homology (PH) domain, a Citron homology domain (CNH), a putative SH3 binding domain, and a PDZ-targeting motif. (wikipedia.org)
  • Despite the increasing use of high-throughput sequencing technologies, the DNA microarrays still remain a popular gene expression tool, because they are cheaper and less demanding regarding bioinformatics skills and computational effort. (biomedcentral.com)
  • In conclusion, testing of the two Web tools using both fully assembled plasmid sequences and WGS-generated draft genomes showed them to be able to detect a broad variety of plasmids that are often associated with antimicrobial resistance in clinically relevant bacterial pathogens. (asm.org)
  • For targeted sequencing using hybridization capture, a probe designed against the gBlocks control sequences should be spiked into the panel. (idtdna.com)
  • Sample tracking can also be used when detecting single nucleotide polymorphisms (SNPs) by amplicon sequencing techniques, such as the rhAmpSeq™ system . (idtdna.com)
  • Data in lilac represent the genomic exon structure projected onto the UniProt sequence. (rcsb.org)
  • Predicting the genes in the human genome is one of the most substantial applications of the sequence data, but is also the most difficult. (biomedcentral.com)
  • The Online Encyclopedia of Integer Sequences [Slowas invaluable for connecting our data with previously known sequences. (oeis.org)
  • The latter technique directly reveals the sequence of transcripts and is becoming increasingly popular, as a result of continuous improvements in both the sequencing technology and the data analysis software. (biomedcentral.com)
  • To mitigate this risk, a unique gBlocks control fragment are spiked into each sample and used to track the presence of its associated target DNA sequence during data analysis to readily identify any sample swap events. (idtdna.com)
  • I am also a developer (Python / C++) with a solid interest in optimization as well as in developing usable tools for final user such as automated pipeline for metagenomics sequence analysis. (pasteur.fr)
  • By 16S rRNA gene sequence analysis of various strains, Brettar et al. (hindawi.com)
  • Yet the exploration of its transcriptome has lagged behind due to the lack of both adequate sequence information and genome-wide analysis tools, such as DNA microarrays. (biomedcentral.com)
  • Sequence analysis predicts that CAP1 is a secreted and/or glycosylphosphatidylinositol-anchored protein: ENaC activity would thus be regulated by the activity of a protease expressed at the surface of the same cell. (nih.gov)
  • By combining analysis of 54 C1 domain sequences with information from previously reported solution and crystal structure determinations and site-directed mutagenesis, profiles are derived and used to classify C1 domains. (embl.de)
  • We reported the first chromosome genome assembly of C. lucidus using Illumina short-read, PacBio long-read sequencing and Hi-C technology. (bvsalud.org)
  • By using the method of this study, the effects of administration period, intra-individual variability, and sequence of administration on bioequivalence were avoided. (bvsalud.org)
  • Sequence Mismatches It is now possible to see information about expression tags, cloning artifacts, and many other details related to sequence mismatches. (rcsb.org)
  • T represents expression tags that have been added to the sequence. (rcsb.org)
  • When new sequences are submitted to GenBank, the submission is checked for new organism names, which are then classified and added to the Taxonomy database. (re3data.org)
  • We also compare cytochrome c oxidase subunit 1 ( cox 1) gene sequences from 2 nematodes with sequences from parasites in Europe to determine possible recent introduction of this filarioid from Europe to the United States. (cdc.gov)
  • We discover direct interaction between CCM2 harmonin homology domain (HHD) and the N terminus of MEKK3, and determine a 2.35 Å cocrystal structure. (rcsb.org)
  • We tested the proposed method on three benchmark datasets in low homology and achieved the overall prediction accuracies of 82.9%, 83.1% and 81.3%, respectively. (ntu.edu.sg)
  • The recent advances in homology modeling, particularly in detecting and aligning sequences with template structures, distant homologues, modeling of loops and side chains as well as detecting errors in a model contributed to consistent prediction of protein structure, which was not possible even several years ago. (ijpsonline.com)
  • This gene encodes a protein with an arfaptin homology domain that is found both in the cytosol and as membrane-bound form on the Golgi complex and immature secretory granules. (utsouthwestern.edu)
  • One of the greatest advantages of NGS is the ability to sequence and analyze large numbers of samples simultaneously. (idtdna.com)
  • The protein encoded by this gene is localized to the mitochondrion, is highly similar to members of the inorganic pyrophosphatase (PPase) family, and contains the signature sequence essential for the catalytic activity of PPase. (nih.gov)