• DBP is a member of the PAR bZIP (proline and acidic amino acid-rich basic leucine zipper) transcription factor family. (avivasysbio.com)
  • The protein is not essential for circadian rhythm generation, but modulates important clock output genes.DBP is a member of the PAR bZIP (proline and acidic amino acid-rich basic leucine zipper) transcription factor family (Khatib et al. (avivasysbio.com)
  • Thyrotroph embryonic factor isoform 1, also known as TEF, is a 303 amino acid nuclear transcription factor that belongs to the bZIP (basic region/leucine zipper) family and PAR (proline and acidic amino acid-rich) subfamily. (creativebiomart.net)
  • To describe the clinical phenotype and genetic basis of non-syndromic retinitis pigmentosa (RP) in one family and two sporadic cases with biallelic mutations in the transcription factor neural retina leucine zipper ( NRL) . (molvis.org)
  • Gene-regulatory properties of Myc helix-loop-helix/leucine zipper mutants: Max-dependent DNA binding and transcriptional activation in yeast correlates with transforming capacity. (ox.ac.uk)
  • Max is a basic helix-loop-helix/leucine zipper (bHLH/LZ) protein that forms sequence-specific DNA-binding complexes with the c-Myc oncoprotein (Myc). (ox.ac.uk)
  • In addition, we have used yeast to investigate the role of the Myc helix-loop-helix (HLH) and leucine zipper (LZ) motifs in mediating Max-dependent DNA-binding and transcriptional activation in vivo using HLH/LZ mutants generated by site-directed mutagenesis. (ox.ac.uk)
  • Here, TcMYC2a was identified to contain a basic helix-loop-helix (bHLH)-leucine zipper domain, a bHLH-MYC_N domain, and a BIF/ACT-like domain. (frontiersin.org)
  • Encodes a basic helix-loop-helix transcription factor whose activity is required to promote differentiation of stomatal guard cells and to halt proliferative divisions in their immediate precursors. (or.jp)
  • AP4 (TFAP4) encodes a basic helix-loop-helix leucine zipper (bHLH-LZ) transcription factor and is a direct target gene of the oncogenic transcription factor c-MYC. (biomedcentral.com)
  • AP4 (TFAP4) is a basic helix-loop-helix leucine zipper (bHLH-LZ) transcription factor that exclusively forms homodimers, which bind to the E-box motif CAGCTG [ 3 ]. (biomedcentral.com)
  • These transcriptional factors belong to the basic helix-loop-helix-leucine zipper (bHLH-LZ) transcription factor family and bind the E-box DNA motifs in the promoter regions of target genes to enhance transcription. (molcells.org)
  • Conclusions: In summary, this genome-wide identification, characterization and expression analysis of legume bZIP genes provides valuable information for understanding the molecular functions and evolution of the legume bZIP transcription factor family, and highlights potential legume bZIP genes involved in regulating tissue development and abiotic stress responses. (datadryad.org)
  • It is transcriptional activator that recognizes and binds to the sequence 5'-RTTAYGTAAY-3' found in the promoter of genes such as albumin, CYP2A4 and CYP2A5. (avivasysbio.com)
  • BMAL1 is a core clock transcription factor, which promotes the transcription of downstream clock-controlled genes (CCGs) by targeting the E-box structure in their promoter region to regulate the physiological functions of the body. (biomedcentral.com)
  • The common plant regulatory factors (CPRFs) from parsley are transcription factors with a basic-leucine-zipper motif that bind to cis-regulatory elements frequently found in promoters of light-regulated genes. (embl-heidelberg.de)
  • Proposed to function in concert with members of other transcription factor families, CPRFs regulate the transcriptional activity of many target genes. (embl-heidelberg.de)
  • 2018 ). The apple bZIP protein MdHY5 regulates the transcription of MdMYB10 and anthocyanin biosynthesis genes, promoting the expression of nitrate reductase genes and nitrate uptake genes and thereby playing essential roles in anthocyanin accumulation and nitrate assimilation (An et al. (biomedcentral.com)
  • String-based protein-protein interaction analysis suggested that bZIP53, a transcription factor might be involved in the activation of transcription of ELO / KCS genes. (nature.com)
  • Genome-wide identification and expression analysis of the bZIP transcription factor family genes in response to abiotic stress in Nicotiana tabacum L. (biomedcentral.com)
  • Important regulatory factors, TFs bind to the promoter regions of target genes and activate or inhibit their transcription. (biomedcentral.com)
  • they can combine with the promoter regions of key genes in signaling pathways to regulate their transcription levels and, in turn, plant resistance to stress. (biomedcentral.com)
  • 1991. A differentiation stage-specific factor interacts with mouse carbonic anhydrase form I gene and a conserved sequence in mammalian beta-globin genes. . (cornell.edu)
  • This file includes the bZIPs protein sequences from Arabidopsis thaliana and six legume genomes (Glycine max,Medicago truncatula,Cajanus cajan,Cicer arietinum,Phaseolus vulgaris and Lotus japonicus). (datadryad.org)
  • Interferon regulatory factor 4 (IRF4) and IRF8 regulate B, T, macrophage, and dendritic cell differentiation. (nih.gov)
  • Chromatin immunoprecipitation sequencing in T helper 17 (T(H)17) cells reveals that IRF4 targets sequences enriched for activating protein 1 (AP-1)-IRF composite elements (AICEs) that are co-bound by BATF, an AP-1 factor required for T(H)17, B, and dendritic cell differentiation. (nih.gov)
  • This condition is caused by mutations in the transcription factor MafB, or V-maf musculoaponeurotic fibrosarcoma oncogene homolog B (MAFB), gene. (wikipedia.org)
  • 2000). "The leucine zipper of NRL interacts with the CRX homeodomain. (en-academic.com)
  • X-ray crystal studies have demonstrated that the leucine zipper is a dimeric parallel coiled coil (7, 8) that structurally repeats itself every two α-helical turns or every heptad (seven amino acids). (neighborshateus.com)
  • The ZIP domain is found in the alpha-helix of each monomer, and contains leucines, or leucine-like amino acids. (neighborshateus.com)
  • Where are leucine like amino acids found in DNA? (neighborshateus.com)
  • The specific sequence of AMINO ACIDS determines the shape the polypeptide will take, during PROTEIN FOLDING, and the function of the protein. (lookformedical.com)
  • The bZIP protein sequence contains 2 conserved bZIP domains with a total length of ~ 60-80 amino acids. (biomedcentral.com)
  • The second is a relatively poorly conserved leucine zipper region characterised by leucine in the last position of every seven amino acids, and hydrophobic residues at positions 3 and 4. (biomedcentral.com)
  • We evaluated the characteristics of CCAAT/enhancer-binding protein α ( CEBPA ) mutations and the significance of a basic leucine zipper in-frame mutation (bZIP in-f ) of CEBPA in patients with acute myeloid leukemia with a normal karyotype. (e-crt.org)
  • We predicted the DNA-binding patterns and the dimerization properties, based on the characteristic features in the basic and hinge regions and the Leu zipper, respectively, which indicated that some highly conserved amino acid residues existed across each major group. (datadryad.org)
  • The helices are held together by hydrophobic interactions between leucine residues, which are located on one side of each helix. (neighborshateus.com)
  • Leucine zipper domains are made up of two motifs: a basic region that recognizes a specific DNA sequence and a series of leucines spaced 7 residues apart along an α-helix (leucine zipper) that mediate dimerization. (neighborshateus.com)
  • The Leucine Zipper and the Basic DNA-Binding Domain (bZIP) This leucine zipper facilitates the dimerization of the protein by interdigitation of two leucine containing helices on different molecules and these residues form the buried subunit interface of the coiled-coil dimer. (neighborshateus.com)
  • These basic residues interact in the major groove of the DNA, forming sequence-specific interactions. (neighborshateus.com)
  • A zinc containing enzyme of the hydrolase class that catalyzes the removal of the N-terminal amino acid from most L-peptides, particularly those with N-terminal leucine residues but not those with N-terminal lysine or arginine residues. (lookformedical.com)
  • A large superfamily of transcription factors that contain a region rich in BASIC AMINO ACID residues followed by a LEUCINE ZIPPER domain. (lookformedical.com)
  • Furthermore, the ability of Myc HLH/LZ mutants to bind DNA and activate transcription in collaboration with Max correlates closely with their neoplastic transforming activity in higher eukaryotic cells. (ox.ac.uk)
  • Aptamers have been selected that bind tightly to the nuclear factor for human IL6 (NF-IL6), a basic leucine zipper transcription factor involved in the induction of acute-phase responsive and cytokine gene promotors in response to inflammation. (utmb.edu)
  • Unlike the wild-type 10-mer sequences, which bind 1 protein dimer/duplex, these 22-mer thiophosphate aptamers bind with a stoichiometry of 2 dimers/duplex. (utmb.edu)
  • CRTC1 increases the transcription from CRE (cAMP response element) through the interaction with bZIP (the basic-leucine zipper) CREB domain. (biopticka.cz)
  • Fusion protein CRTC1/MAML2 has N - terminal basic domain of the gene MAML2 replaced by CREB-binding domain of the gene CRTC1. (biopticka.cz)
  • The following BATF2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). (genscript.com)
  • Using Saccharomyces cerevisiae, we have shown that the Max bHLH/LZ domain enables Myc to activate transcription through CACGTG and CACATG sequences in vivo, and that the number and context of such sites determines the level of activation. (ox.ac.uk)
  • Altogether, these results indicate that C3 is a downstream target of C/EBPβ, and it could be a mediator of the pro-inflammatory effects of this transcription factor in neural cells. (biomedcentral.com)
  • Neural retina-specific leucine zipper protein is a protein that in humans is encoded by the NRL gene . (en-academic.com)
  • These sequences represent the protein coding region of the BATF2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. (genscript.com)
  • c-maf is the cellular counterpart of oncogenic v-maf that belongs to the family of basic region leucine zipper domain transcription factors. (thermofisher.com)
  • CEBPA mutations affect either the N-terminus with nonsense mutations, leading to a dominant negative protein, or the C-terminus, resulting in decreased DNA binding of a leucine zipper region. (e-crt.org)
  • Leucines occurring in heptad repeats end up on the same sides of the helixes and are adjacent to each other in the stem of the Y (the "zipper" region). (lookformedical.com)
  • Three of these factors represent new parsley bZIP factors, designated CPRF5-CPRF7, whereas the fourth, named CPRF1-interacting protein (CIP), shows no homology to any other known protein. (embl-heidelberg.de)
  • The complete cDNA template sequence was obtained from the information from the publication as described in Trevers et al. (arizona.edu)
  • 2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . (en-academic.com)
  • Sterol regulatory element binding protein (SREBP)-1 is a transcription factor with important roles in the control of fatty acid metabolism and adipogenesis. (diabetesjournals.org)
  • Next, we explored the mechanism of dampened clock-induced IDD and found that knockdown of Bmal1 decreased the expression of nuclear factor erythroid2-related factor 2 (NRF2), a downstream target gene of Bmal1 , and increased inflammatory response, oxidative stress reaction, and apoptosis of NP cells. (biomedcentral.com)
  • These findings suggest that the gut microbiome, under specific dietary exposures, stimulates a reprogramming of the enhancer landscape in the colon, with downstream effects on transcription factors. (biomedcentral.com)
  • Among all JA downstream transcription factors, MYC2 is considered as the fatal point of the entire JA signaling pathway ( Kazan and Manners, 2013 ). (frontiersin.org)
  • Rapid and transient activation of myelin basic protein kinase in tobacco leaves treated with hairpin from Erwinia amylovora . (springer.com)
  • Differential regulation of IL-12 and IL-10 gene expression in macrophages by the basic leucine zipper transcription factor c-Maf fibrosarcoma. (cornell.edu)
  • The Plus3 domain structure consists of six alpha helices intervened by a sequence of six beta strands in a mixed alpha/beta topology. (embl-heidelberg.de)
  • When these alpha helices dimerize, the zipper is formed. (neighborshateus.com)
  • They are characterized by a 60-80 amino acid bZIP domain: a basic DNA binding domain followed by a leucine zipper dimerization domain. (neighborshateus.com)
  • Owing to the stability of their coiled coil structure leucine zipper (LZ) domains of bZIP factors are widely employed as dimerization motifs in protein engineering studies. (neighborshateus.com)
  • This record is derived from a genomic sequence (NC_006478.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. (genscript.com)
  • Recent global analyses of gene transcripts revealed that specific transcription factors (TFs) and their networking systems physiologically correspond to the onset of human diseases, including cancer. (intechopen.com)
  • Based on updated knowledge of CEBPA mutations, we conducted next-generation sequencing analyses in a previously established real-world cohort. (e-crt.org)
  • Based on sequence analyses, all serpins so far described have been classified into one of 16 clades, designated A to P, plus 10 unclassified 'orphan' sequences and this classification system is called as "clade-based classification" system [ 8 ]. (jgenomics.com)
  • Also see: Documentation of NCBI's Annotation Process On Jun 2, 2016 this sequence version replaced XM_508537.3. (genscript.com)
  • Every single our BAC clones have analyzed their terminal end sequences to map on the genome. (riken.jp)
  • c-maf is a transcription factor for IL-10 gene expression in LPS-activated macrophages. (thermofisher.com)
  • 2005. Diminished expression of transcription factors nuclear factor kappaB and CCAAT/enhancer binding protein underlies a novel tumor evasion mechanism affecting macrophages of mammary tumor-bearing mice. . (cornell.edu)
  • Is leucine zipper a domain? (neighborshateus.com)
  • Where is the ZIP domain of the leucine zipper located? (neighborshateus.com)
  • All six members of this family exhibit a high sequence similarity in their C-terminal DNA binding domain and a more diverge regulatory N-terminus [ 1 , 2 ]. (biomedcentral.com)
  • The leucine-zipper domain is involved in the interaction with LRPICD. (thermofisher.com)
  • Despite the availability of six completely sequenced legume genomes, a comprehensive investigation of bZIP family members in legumes has yet to be presented. (datadryad.org)
  • So far, the genomes of quinoa and 3 other Amaranthaceae crops ( Spinacia oleracea , Beta vulgaris , and Amaranthus hypochondriacus ) have been fully sequenced. (biomedcentral.com)
  • Many additional serpins are likely to be identified as more sequenced genomes become available in the era of rapid and desktop based next-generation DNA sequencing methods. (jgenomics.com)
  • Molecular mechanisms of the initiation of transcription from TATA box have been well known as the most essential nuclear events in mammalian cells. (intechopen.com)
  • Using a 22-nucleotide-long duplex random library, nanomolar binding, specific 22-mer thiophosphate backbone substitution sequences (at dA positions only) were selected. (utmb.edu)
  • Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories. (lookformedical.com)
  • It is also called nucleotide sequence. (lookformedical.com)
  • Pan troglodytes basic leucine zipper ATF-like transcription factor 2 (BATF2), transcript variant X1, mRNA. (genscript.com)
  • The clone could differ from the NCBI mRNA reference sequence. (riken.jp)
  • Exposure of isolated human adipocytes to tumor necrosis factor-α (TNF-α) produced a marked and specific decrease in the mRNA encoding the SREBP1c isoform and completely blocked the insulin-induced cleavage of SREBP1 protein. (diabetesjournals.org)
  • 2012 ). The plasma membrane-associated NAC transcription factor OsNTL3 regulates the expression of OsbZIP74 by binding to its promoter under heat stress, and in turn, OsbZIP74 also regulates the expression of OsNTL3 . (biomedcentral.com)
  • These show a different consensus sequence than normal phosphate backbone CCAAT/enhancer binding protein recognition sites for NF-IL6. (utmb.edu)
  • CCAAT/enhancer-binding protein α ( CEBPA ) is a member of the family of basic leucine zipper (bZIP) transcription factors. (e-crt.org)
  • Synthetic lethal interactions suggest a role for the Saccharomyces cerevisiae Rtf1 protein in transcription elongation. (embl-heidelberg.de)
  • Strong evidence indicates that transcription elongation by RNA polymerase II (pol II) is a highly regulated process. (embl-heidelberg.de)
  • Here we present genetic results that indicate a role for the Saccharomyces cerevisiae Rtf1 protein in transcription elongation. (embl-heidelberg.de)
  • First, the general TFs (GTFs), including preinitiation complex components TFIIA, TFIIB, TFIID, TFIIE, TFIIF, and THIIH, are the primary protein factors that are required for the initiation of transcription from the TATA box (or TATA element), then elongation is executed by RNA polymerase II (RNA pol II) [ 1 ]. (intechopen.com)
  • Transcription regulation of taxol biosynthesis. (frontiersin.org)
  • Differential regulation of interleukin (IL)-12 p35 and p40 gene expression and interferon (IFN)-gamma-primed IL-12 production by IFN regulatory factor 1. (cornell.edu)