Sequence alignments protein sequences protein residues. Medical search. Frequent questions

The primase pUL70 contains several conserved motifs or regions, including a region (residues 881-920) that corresponds to a putative zinc-finger pattern shown to play essential role in HSV-1 ( Biswas and Weller, 1999 ). (frontiersin.org)
The TPR motif consists of 3-16 tandem-repeats of 34 amino acids residues, although individual TPR motifs can be dispersed in the protein sequence. (embl.de)
The tetratricopeptide repeat (TPR) is a degenerate 34 amino acid sequence identified in a wide variety of proteins, present in tandem arrays of 3-16 motifs, which form scaffolds to mediate protein-protein interactions and often the assembly of multiprotein complexes. (embl.de)
However, a number of well known and experimentally documented secretory/erythrocyte membrane associated proteins lack these motifs, thus emphasizing the existence of multiple pathways that operate in parallel [ 9 ]. (biomedcentral.com)
Automatic extraction of motifs from biological sequences is an important research problem in study of molecular biology. (biomedcentral.com)
For proteins, it is desired to discover sequence motifs containing a large number of wildcard symbols, as the residues associated with functional sites are usually largely separated in sequences. (biomedcentral.com)
We previously proposed a new constraint model to handle large wildcard regions for discovering functional motifs of proteins. (biomedcentral.com)
Considering large gaps reflects the fact that functional residues are not always from a single region of protein sequences, and restricting motif symbols into clusters corresponds to the observation that short motifs are frequently present within protein families. (biomedcentral.com)
The resultant motifs are then employed in predicting protein function and functional sites when given a novel sequence (pattern matching). (biomedcentral.com)
The conserved residues appear to define two putative signature motifs, namely GXEX3G and GGL/IGPX3D. (calpaininhibitor.com)
Multiple sequence alignment revealed that AIBCA contains the two sequence motifs, CXDXR and HXXC, typical for β-CAs. (biomedcentral.com)
The seven conserved helicase motifs, the point mutations of BLM protein as well as the insertion and deletions are displayed above the sequences, the ATP-binding (Ã Â ) and DNA-binding residues (Ã Â¤) of PcrA helicase are shown (24-26). (lu.se)

Examples of this kind of meta data are secondary structures (RNA and protein), protein hydrophobicity assignments, or other alternative alphabets for polypeptides, sequence quality data and nucleotide alignments with translations. (metacpan.org)
The source of information for the prediction can be the homology of nucleotide sequences, gene expression profiles or phylogenetic and phenotypic profiles. (custom-essay.org)
HuCaT uses an algorithm based on number of matching queries, k-mers are used to calculate the actual matching nucleic acid k-mers (short substrings of DNA [n 9 nt in number of nucleotide sequence matches for type assignment using the HuCaT]) to build alignments between query and reference sequences. (cdc.gov)

The RNA-binding protein NANOS3 poses as an interesting candidate gene for POI since members of the Nanos family have an evolutionarily conserved function in germ cell development and maintenance by repressing apoptosis. (hindawi.com)
The ProQ/FinO family of RNA binding proteins mediate sRNA-directed gene regulation throughout gram-negative bacteria. (nature.com)
The recently discovered TPR gene family encodes a diverse group of proteins that function in mitosis, transcription, splicing, protein import and neurogenesis. (embl.de)
Based on an established filtering strategy and data analyses, along with confirmation by Sanger sequencing and co‑segregation, a novel frameshift mutation c.1317delA (p.Ala440LeufsTer14) in exon 10 of the APC gene was identified. (spandidos-publications.com)
Eine Southern-Blot Analyse mit genomischer DNA aus L. esculentum wurde zur Abschätzung der Kopienzahl der zum Protein der MeJA-Esterase korresporendierenden Gene durchgeführt. (uni-wuerzburg.de)
Each local alignment is then refined by a more careful alignment comparison to the germline gene segments from species specified in the detection settings. (labkey.org)
If, after the variable and constant regions have been detected, there remains an N-terminal portion of the query sequence that is unmatched, the N-terminal portion is aligned to germline leaders from the specified germline gene sets and also to user-specified SeqPart sequences which have been provided to the detector. (labkey.org)
This hypothesis could be tested by purifying the gau gene product and determining its sequence. (biomedcentral.com)
The number of mitochondrial protein genes is believed to vary from 3 to 67, while the tRNA gene content varies from 0 to 27 [ 2 ]. (biomedcentral.com)
Programmable DNA binding proteins have emerged as an exciting platform for engineering synthetic transcription factors for modulating endogenous gene expression 5 - 11 . (cdc.gov)
There were two different mismatches in the probe target sites of the HA gene sequences of all isolates ( n = 23) with additional mismatches only at position 7 (template binding site) identified for all eight negative real-time RT-PCR isolates. (who.int)
The full HA and NA genes of 16 H1N1-positive samples obtained in our study and 21 published HA sequences and 20 published NA sequences from Jordanian viruses that were available on online gene databases were analysed. (who.int)

In salivaricin D-producing strain Streptococcus salivarius 5M6c, self-immunity against the intrinsically trypsin-resistant salivaricin is mediated via ABC transporter proteins SlvF, SlvE and SlvG, while in Lactococcus lactis, self-immunity against nisin is mediated by the ABC transporter NisFEG. (nih.gov)
Intrinsically disordered regions (IDRs) lacking a fixed three-dimensional protein structure are widespread and play a central role in cell regulation. (iucr.org)
Protein-protein interactions involving intrinsically disordered proteins are important for cellular function and common in all organisms. (elifesciences.org)
Experiments together with molecular modeling using NMR chemical shifts suggest that new interactions involving intrinsically disordered proteins may evolve via a low-affinity complex which is optimized by modulating direct interactions as well as dynamics, while tolerating several potentially disruptive mutations. (elifesciences.org)
However, a group of proteins called 'intrinsically disordered proteins' are flexible in their shape and lack a stable three-dimensional structure. (elifesciences.org)
analyzed the amino acid sequences of two specific intrinsically disordered proteins from different organisms to reconstruct the versions of the proteins that were likely found in their common ancestors 450-600 million years ago. (elifesciences.org)

By using sequence alignment of herpesviruses homologs, we identified conserved amino acids in the putative pUL105 ATP binding site and in the putative pUL70 zinc finger pattern. (frontiersin.org)

doi:10.1371/journal.pone.0065595.gMutagenesis Guided by Multiple Sequence Alignment and Structural Analysis Reveals the Identity of Catalytic ResiduesA multiple sequence alignment using a collection of 361 bacterial, 36 archaeal, and 34 eukaryotic completely sequenced genomes, annotated in The SEED database [23], revealed that the COG1058 domain is highly conserved (Figure S2). (calpaininhibitor.com)

We performed phylogenetic reconstruction, resurrection and biophysical characterization of two interacting disordered protein domains, CID and NCBD. (elifesciences.org)
Outputs include alignments and phylogenetic trees of the 12 top matching reference sequences for each query. (cdc.gov)
Noroviruses are associated with an compared to an established set of reference sequences to determine estimated 70,000-200,000 deaths annually [2,3 ] while sapoviruses genotypes and polymerase types based on phylogenetic clustering, or by primarily cause sporadic AGE in young children although outbreaks in employing NCBI BLAST web service. (cdc.gov)

To get an insight into the possible functions of the conserved residues, we performed a structural homology search by using as the query the ?available high-resolution (2 A) crystal structure of the Thermoplasma acidophilum COG1058 protein (PDB ID: 3KBQ), as determined atthe Midwest Center for Structural Title Loaded From File Genomics (http://www.mcsg. (calpaininhibitor.com)

The first, ubiquitous, enzyme of the pathway, MtnA (methylthioribose-1-phosphate isomerase), belongs to a family of proteins related to eukaryotic intiation factor 2B alpha. (biomedcentral.com)
Though TargetP is successful for eukaryotic protein but fails to predict known P. falicparum secretory proteins like PfEMP1. (biomedcentral.com)
The top-level topology of the species tree, i.e. the bacterial, archaeal and Title Loaded From File eukaryotic proteins form distinct clusters. (calpaininhibitor.com)
The analysis of the tree also shows that the proteins in the aproteobacterial group are evolutionarily closer to the eukaryotic and archaeal proteins than to their bacterial counterparts. (calpaininhibitor.com)
In addition, the d-proteobacterial group of enzymes is present in the eukaryotic branch, suggesting that it likely represents the ancestor group of the eukaryotic proteins. (calpaininhibitor.com)
As to the domain composition, the two-domain bacterial proteins cluster into a homogenous group, well separated from all other forms, i.e. the bacterial, archaeal and eukaryotic single-domain enzymes and the eukaryotic two-domain enzymes. (calpaininhibitor.com)
The superimposition of the 3KBQ three-dimensional structure and domain III of E. coli MoeA (PDB ID: 1G8L) is shown.The top-level topology of the species tree, i.e. the bacterial, archaeal and eukaryotic proteins form distinct clusters. (calpaininhibitor.com)

Deciphering protein–protein interactions. (crossref.org)
The eponymous FinO protein was discovered as a regulator of F plasmid conjugation nearly 50 years ago, and acts to bind a single partner sRNA called FinP to stabilize FinP and facilitate its interactions with its antisense partner, the mRNA encoding the major F plasmid transcription factor, TraJ 5 . (nature.com)
The structure of the tetratricopeptide repeats of protein phosphatase 5: implications for TPR-mediated protein-protein interactions. (embl.de)
Biochemical analysis of BacC mutants with potential disruptions in non-covalent interactions along this path revealed that residues that form nodes in pathways of non-covalent interactions influence catalytic activity more than others in a similar chemical environment. (rcsb.org)
Protein conformation is critically linked to function and often controlled by interactions with regulatory factors. (cipsm.de)
At multiple time points during evolution, new or modified proteins - and consequently new potential interactions between proteins - have emerged. (elifesciences.org)
The findings shed light on fundamental principles of how new protein-protein interactions emerge and evolve on a molecular level. (elifesciences.org)
A next step for the future will be to investigate how other protein-protein interactions have evolved and to identify general underlying patterns. (elifesciences.org)
A deeper knowledge of how this molecular evolution happened will broaden our understanding of present day protein-protein interactions and might aid the design of drugs that can mimick proteins. (elifesciences.org)
Replacements that favored (Q44R) or impaired (Q44D) the polar interactions predicted between residues Q44 and D32 did not abolish dimer formation of transiently expressed 3A, indicating that these interactions are not critical for 3A dimerization. (asm.org)

A total of eight residues (highlighted in magenta in Figure 8) were 23148522 conserved among over 95 of the COG1058 proteins in all sequenced genomes, suggesting their likely role in protein's function or stability. (calpaininhibitor.com)

One of the most critical tasks of modern bioinformatics is to predict and foretell the structure and, consequently, the functions of bacterial proteins. (custom-essay.org)
Traditionally, prediction of the functions of bacterial proteins is carried out for poorly studied molecules or hypothetical proteins predicted based on these genome sequences. (custom-essay.org)
This essay on Predicting Bacterial Proteins' Structure and Function was written by a student just like you. (custom-essay.org)

These proteins are highly conserved across all kingdoms of life and thus likely share a common transport mechanism. (nature.com)

This subfamily includes lantibiotic ABC transporter permease subunits EpiE, MutE, SlvE and NisE, which are highly hydrophobic, integral membrane proteins, and part of the bacitracin ABC transport system that confers resistance to the Gram-positive bacteria in which this system operates, specifically to the lantibiotics mutacin, epidermin, nisin and salivaricin, respectively. (nih.gov)
A molecular model of the FMDV 3A protein, derived from the nuclear magnetic resonance (NMR) structure of the poliovirus 3A protein, predicted a hydrophobic interface spanning residues 25 to 44 as the main determinant for 3A dimerization. (asm.org)
Replacements L38E and L41E, involving charge acquisition at residues predicted to contribute to the hydrophobic interface, reduced the dimerization signal in the protein ligation assay and prevented the detection of dimer/multimer species in both transiently expressed 3A proteins and in synthetic peptides reproducing the N terminus of 3A. (asm.org)
These replacements also led to production of infective viruses that replaced the acidic residues introduced (E) by nonpolar amino acids, indicating that preservation of the hydrophobic interface is essential for virus replication. (asm.org)

DNA methylation, particularly 5-methylcytosine (5mC) at CpG sequences, is widely conserved in eukaryotes. (elifesciences.org)
It has been shown in past that secretory proteins of eukaryotes have signal sequence at N-terminus, which can be used to predict its secretory nature. (biomedcentral.com)
Thus it is not possible to use subcellular localization methods developed either for eukaryotes [ 4 ] or prokaryote [ 5 ] for localization of P. falciparum proteins. (biomedcentral.com)

The trimeric Sec61/SecY complex is a protein-conducting channel (PCC) for secretory and membrane proteins. (cipsm.de)
Thus identification of these secretory proteins is important for developing vaccine/drug against malaria. (biomedcentral.com)
The existing motif-based methods have got limited success due to lack of universal motif in all secretory proteins of malaria parasite. (biomedcentral.com)
In this study a systematic attempt has been made to develop a general method for predicting secretory proteins of malaria parasite. (biomedcentral.com)
All models were trained and tested on a non-redundant dataset of 252 secretory and 252 non-secretory proteins. (biomedcentral.com)
In this study, for the first time PSSM profiles obtained from PSI-BLAST, have been used for predicting secretory proteins. (biomedcentral.com)
This study demonstrates that secretory proteins have different residue composition than non-secretory proteins. (biomedcentral.com)
Thus, it is possible to predict secretory proteins from its residue composition-using machine learning technique. (biomedcentral.com)
A web server PSEApred has been developed for predicting secretory proteins of malaria parasites,the URL can be found in the Availability and requirements section. (biomedcentral.com)
The identification of secretory proteins of Plasmodium falciparum has got limited success, since experimental identification of these proteins is rather difficult due to complex nature of parasite. (biomedcentral.com)
With the completion of Plasmodium genome sequence, the challenge is to combine experimental and bioinformatics tools in order to develop algorithm with high predictive value for secretory proteins of malaria parasite. (biomedcentral.com)
When expressed as a recombinant protein in transfected cells, PV 3A cofractionates with endoplasmic reticulum markers ( 66 ), and its single transient expression can disrupt the secretory apparatus ( 23 ) and decrease major histocompatibility complex (MHC) class I expression ( 22 ). (asm.org)

Fragment libraries play a key role in fragment-assembly based protein structure prediction, where protein fragments are assembled to form a complete three-dimensional structure. (biomedcentral.com)
To better leverage the valuable structural information for protein structure prediction, we extracted seven types of structural information from fragment libraries. (biomedcentral.com)
We broadened the usage of such structural information by transforming fragment libraries into protein-specific potentials for gradient-descent based protein folding and encoding fragment libraries as structural features for protein property prediction. (biomedcentral.com)
Our work implies that the rich structural information extracted from fragment libraries can complement sequence-derived features to help protein structure prediction. (biomedcentral.com)
Although fragment libraries are extensively utilized in fragment assembly, the rich structural information has not yet been systematically analyzed and leveraged by other protein structure prediction approaches. (biomedcentral.com)
Protein prediction is an incredibly important goal since it allows to simplify biotechnological research in the process of designing new drugs or enzymes. (custom-essay.org)
Taking into account multi-variant protein functions, the task of accurate and analytical prediction is one of the most important directions of modern bioinformatics. (custom-essay.org)
Prediction of protein structure and functions is a complex task for two reasons. (custom-essay.org)
To efficiently discover W-patterns for large-scale sequence annotation and function prediction, this paper first formally introduces the problem to solve and proposes an algorithm named WildSpan (sequential pattern mining across large wildcard regions) that incorporates several pruning strategies to largely reduce the mining cost. (biomedcentral.com)

Multiple-TPR motif proteins would fold into a right-handed super-helical structure with a continuous helical groove suitable for the recognition of target proteins, hence defining a novel mechanism for protein recognition. (embl.de)
These methods dramatically increase the likelihood of producing proteins that cannot fold or assemble appropriately. (cipsm.de)
Notably, a DALI search revealed high structural similarity (Z score .10 ) with the fold of proteins from the E. coli MoCo biosynthetic pathway (MogA, the domain III of MoeA, and MobA), as well as with domains of mammalian gephyrin and plant Cnx1, which are also involved in MoCo biosynthesis [30,31,32]. (calpaininhibitor.com)

Proteins containing TPRs are involved in a variety of biological processes, such as cell cycle regulation, transcriptional control, mitochondrial and peroxisomal protein transport, neurogenesis and protein folding. (embl.de)
TPR-containing proteins include the anaphase promoting complex (APC) subunits cdc16, cdc23 and cdc27, the NADPH oxidase subunit p67 phox, hsp90-binding immunophilins, transcription factors, the PKR protein kinase inhibitor, and peroxisomal and mitochondrial import proteins. (embl.de)
The co-chaperone Hep1 is required to prevent the aggregation of mitochondrial Hsp70 proteins. (cipsm.de)
Immunohistochemical analyses using an anti-Gau monoclonal antibody revealed strict co-localization of Gau proteins and a mitochondrial marker. (biomedcentral.com)

Fragment libraires improved the accuracy of protein folding and outperformed state-of-the-art algorithms with respect to predicted properties, such as torsion angles and inter-residue distances. (biomedcentral.com)
Motif finding algorithms have been widely used in this field for finding sequence signatures when given a set of related sequences (pattern mining). (biomedcentral.com)
The CoreAb Java library (developed at Just - Evotec Biologics) contains algorithms for the classification and alignment of antibodies and antibody-like sequences. (labkey.org)

Based on primary sequence comparisons, β subunits are predicted to be modular structures composed of five domains (A-E) that are related to the large family of membrane-associated guanylate kinase proteins. (jneurosci.org)
Sigma factors are a class of proteins constituting essential dissociable subunits that confer sequence-specific DNA binding properties to RNA polymerase (RNAP). (hindawi.com)
Typical triploblastic animal mtDNAs contain genes that encode the large and small subunit ribosomal RNAs, 22 transfer RNAs (tRNAs), and 13 proteins that are all components of the oxidative phosphorylation process: ATPase subunits 6 and 8 (ATP6 and 8), cytochrome b (Cyt b), cytochrome c oxidase subunits 1-3 (Cox1-3) and NADH dehydrogenase subunits 1-6 and 4L (ND1-6 and 4L). (biomedcentral.com)

In higher plants and microalgae, there are four major groups of DGATs: (1) the membrane bound form of DGAT1, (2) the membrane bound form of DGAT2 sharing low sequence similarity with DGAT1, (3) the soluble type of DGAT3, which is localized in the cytosol, and (4) the dual function of WS/DGAT, which possesses both wax ester and TAG biosynthesis activities [12-18]. (researchsquare.com)
Some proteins are transported to lysosomes, other internalized proteins are delivered to the trans-Golgi network or back to the plasma membrane by recycling endosomes. (biomedcentral.com)
in poliovirus (PV), the interaction between the RNA replication complex and intracellular membranes appears to be accomplished by proteins 3A and 2C, which have membrane-binding properties ( 11 , 60 ). (asm.org)

In addition, some recent works such as [ 19 , 20 ] adopted structural information in other bioinformatics fields and the considerable performance gains indicate the huge potential of protein structural information. (biomedcentral.com)
The field of protein-analysis is a major research area for bioinformatics. (uni-goettingen.de)
In this study, we identified an A. lumbricoides β-CA (AIBCA) protein from protein sequence data using bioinformatics tools. (biomedcentral.com)

Furthermore, we note that nodes in the non-covalent interaction networks are co-localized with compensatory mutation sites identified by multiple sequence alignment of proteins with low sequence similarity to BacC. (rcsb.org)

Likewise, the ProQ/FinO domain-containing protein RocC of Legionella pneumophila interacts with only one trans -acting sRNA (RocR) to repress post-transcriptionally multiple mRNA targets 6 . (nature.com)
If you need more, use multiple copies of the sequence object. (metacpan.org)
Prefix named_ in method names allows the used to attach multiple meta strings to one sequence by explicitly naming them. (metacpan.org)
Traditional methods for phylogeny reconstruction are based on multiple sequence alignments and character-based methods. (uni-goettingen.de)
The multiple sequence alignment provides more information than sequence itself. (biomedcentral.com)
The discovered W-patterns are used to characterize the protein sequence and the results are compared with the conserved positions identified by multiple sequence alignment (MSA). (biomedcentral.com)
Multiple sequence alignment of selected COG1058 proteins. (calpaininhibitor.com)
Multiple alignment of representative members of the COG1058 family (full version is available in Figure 2). (calpaininhibitor.com)
A multiple alignment of the domain in the most divergent sequences, including the AtCOG1058 and the SoCOG1058/PncC proteins characterized in this work, is depicted in Figure 8. (calpaininhibitor.com)

This phenotype co-segregates with either of two frameshift mutations, 1988delAGAG and 2469delGTCA, in ESPN , which encodes a calcium-insensitive actin-bundling protein called espin. (bmj.com)
The viral particle is composed of a protein capsid that contains a positive-sense RNA molecule of about 8,500 nucleotides that is infectious and encodes a single polyprotein, which is processed in infected cells by cis - and trans -acting viral proteases ( 55 ) to yield different polypeptide precursors and the mature viral proteins ( 9 , 62 ). (asm.org)
The viral genome encodes four structural capsid proteins (VP1 to VP4) and seven nonstructural (NS) proteins, the leader Lb/ab protease, and proteins encoded in the P2 (2B and 2C) and P3 (3A, 3B, 3C, and 3D) regions ( 9 ). (asm.org)

Thus performance of method based on PSSM profile is more accurate than method based on sequence composition. (biomedcentral.com)
A Position-Specific Sequence Matrix (PSSM) has been pre-built for each type and is used as a low threshold first pass filter for region detection using the Smith-Waterman algorithm to find local alignments. (labkey.org)
To generate an alignment for variable regions, the PSSM-matched sub-sequence is aligned to both germline V-segments and J-segments and these results are combined to synthesize an alignment for the entire variable region. (labkey.org)
Use a PSSM for the region type to find local alignments in the query ii. (labkey.org)
Generate a refined region alignment for the PSSM alignment i. (labkey.org)

Here, we investigate the structural basis for RNA recognition by ProQ/FinO proteins, through the crystal structure of the ProQ/FinO domain of the Legionella pneumophila DNA uptake regulator, RocC, bound to the transcriptional terminator of its primary partner, the sRNA RocR. (nature.com)
The BdCBF proteins possess transcriptional activation activity and bind directly to the promoters of the target genes. (biomedcentral.com)

The substituted amino acid is located within the second C2HC motif in the conserved zinc finger domain of NANOS3 and in silico molecular modelling suggests destabilization of protein-RNA interaction. (hindawi.com)
This interaction network, in turn, enabled an analysis of non-covalently connected paths that span the protein structure. (rcsb.org)
In addition, knowledge of protein structure may prompt potential partners for protein interaction and thus encourage researchers to develop or improve new enzymes or antibodies, or, for example, to explain the phenotype of the mutations performed or to help determine the location of the mutations in order to change specific phenotypes. (custom-essay.org)

Proteins experimentally characterized in this work are marked by red stars. (calpaininhibitor.com)

This class defines an abstract interface for basic residue-based meta information. (metacpan.org)

More recently, the application of RNA-seq technologies has enabled the elucidation of the biological partners and targets of several ProQ/FinO family proteins. (nature.com)
Cell biological experiments are needed to determine the physiological role of this protein. (biomedcentral.com)

Its crystal structure reveals a previously unknown outward-facing state of the protein family. (nature.com)
It is necessary to carry out pairwise alignment, which allows revealing conservative residues in the whole family or separate subfamilies of proteins. (custom-essay.org)
Modelling by template has a vast practical potential because if the structure of at least one protein from which functional family is known, then it is possible to try to build models for almost every protein in this family. (custom-essay.org)
We conducted experiments with two mining strategies, protein-based and family-based mining, to evaluate the usefulness of W-patterns and performance of WildSpan. (biomedcentral.com)
The family-based mining mode of WildSpan is developed for extracting sequence signatures for a group of related proteins (e.g. a protein family) for protein function classification. (biomedcentral.com)
Positions of residues conserved in all members of the family are highlighted at the top of the alignment in magenta. (calpaininhibitor.com)

Sequence alignment of the helicase domains of the RecQ DNA helicases and the PcrA and Rep DNA helicases. (lu.se)

The heterochromatin-enriched HP1 proteins play a critical role in regulation of transcription. (cipsm.de)
Among the established custom DNA binding domains, Cas9 is most easily scaled to facilitate genome-scale perturbations 3 , 4 due to its simplicity of programming relative to zinc finger proteins and transcription activator-like effectors (TALEs). (cdc.gov)
Cas9 nuclease can be converted into an RNA-guided DNA binding protein (dCas9) via inactivation of its two catalytic domains 12 , 13 and then fused to transcription activation domains. (cdc.gov)

Anti-PnMas1 and anti-PnMas2 antibodies co-labelled two high-molecular-weight (~400 kDa) protein complexes in native gels but anti-PnMas3 antibodies labelled a 65 kDa protein complex. (springer.com)

This group contains uncharacterized proteins including Drosophila melanogaster GM13116p and Caenorhabditis elegans hypothetical protein R11G1.4, both of which contain C2 (a calcium-binding domain) and C1 domains. (nih.gov)

Structure-guided mutagenesis reveals key RNA contact residues that are critical for RocC/RocR to repress the uptake of environmental DNA in L. pneumophila . (nature.com)
Sequence alignment of the TPR domains reveals a consensus sequence defined by a pattern of small and large amino acids. (embl.de)

Most of the mutations causing FAP are nonsense or frameshift mutations, and can result in premature stop codons thus produce truncated APC proteins ( 7 ). (spandidos-publications.com)

In this paper, we describe the development and evaluation of an forces that drive norovirus evolution [ 9 , 10 ] and most frequently occur alternative web-based tool, Human Calicivirus Typing (HuCaT) tool for at the junction of the RdRp (polymerase) and VP1 (capsid) encoding typing of human norovirus and sapovirus sequences. (cdc.gov)

Sequencing was conducted on 23 influenza (H1N1)pdm09 isolates that were recovered from positive samples. (who.int)

The identification of an inactivating missense mutation in NANOS3 suggests a mechanism for POI involving increased primordial germ cells (PGCs) apoptosis during embryonic cell migration and highlights the importance of NANOS proteins in human ovarian biology. (hindawi.com)
Mutants of residues in the transition-metal ion-binding site severely affect transport, whereas a mutation of a conserved histidine located near this site results in metal ion transport that appears uncoupled to proton transport. (nature.com)

New drugs targeting essential viral proteins other than pUL54 are therefore urgently needed. (frontiersin.org)
NS proteins are involved in crucial aspects of the viral cycle and pathogenesis, such as rearrangements of intracellular membranes required for endomembrane recruitment and the lysis of host cells ( 1 , 12 , 14 , 18 , 73 ). (asm.org)
However, it is difficult to capture the complexity of transcript isoform variance using these libraries, and large cDNA sequences are often difficult to clone into size-limited viral expression vectors. (cdc.gov)

Similarly, a minimal ProQ/FinO domain protein, NMB1681, has been shown to bind a range of structured RNAs in Neisseria meningitidis 15 . (nature.com)
Insight into how these proteins recognize their cognate RNAs initiated with FinO. (nature.com)

In the current study, genes encoding two related proteins, PnMas1 and PnMas3, were identified in the genome of P. parasitica . (springer.com)

Here we report the selection of camelid-derived single-domain antibodies (nanobodies) that modulate the conformation and spectral properties of the green fluorescent protein (GFP). (cipsm.de)
This topic describes the methodology developed by Just-Evotec Biologics, Inc for the structural alignment and classification of full sequences from antibodies and antibody-like structures using the Antibody Structural Numbering system (ASN). (labkey.org)

Plastid-specific ribosomal proteins (PSRPs) have been proposed to play roles in the light-dependent regulation of chloroplast translation. (cipsm.de)
Yet, these proteins play important roles in many processes that require the protein to interact with a number of other proteins. (elifesciences.org)
Foot-and-mouth disease virus (FMDV) nonstructural protein 3A plays important roles in virus replication, virulence, and host range. (asm.org)

Peu de renseignements sont disponibles sur les mutations des virus saisonniers de la grippe A(H1N1)pdm09 et H3N2 en Jordanie. (who.int)
Les mutations individuelles sont décrites en détail. (who.int)

The classification process generates a series of ASN-aligned regions which can be used to uniquely describe residue locations in common across different molecules. (labkey.org)

Anatomy5

Organisms17

Diseases1

Chemicals and Drugs56

Analytical, Diagnostic and Therapeutic Techniques and Equipment50

Psychiatry and Psychology1

Phenomena and Processes96

Disciplines and Occupations4

Anthropology, Education, Sociology and Social Phenomena1

Technology, Industry, Agriculture4

Information Science37

Health Care17

Motifs12

Nucleotide3

Gene12

Intrinsically6

Identified conserved1

Completely sequenced1

Phylogenetic3

Homology1

Eukaryotic7

Interactions10

Genomes1

Bacterial Proteins3

Highly conserved1

Hydrophobic4

Eukaryotes3

Secretory12

Prediction9

Fold3

Mitochondrial4

Algorithms3

Subunits3

Membrane3

Bioinformatics3

Similarity1

Multiple9

Encodes3

PSSM5

Transcriptional2

Interaction3

Experimentally1

Abstract1

Biological2

Family6

Helicase1

Transcription3

Complexes1

Hypothetical1

Reveals2

Stop codons1

Capsid1

Influenza1

Mutation2

Viral3

RNAs2

Genes1

Antibodies2

Roles3

Mutations2

Molecules1