Sequence actin related protein 2. Medical search. Frequent questions

Multi-omics analyses of these model suggest disturbed Golgi-transport, actin-cytoskeleton modifications and changed extracellular matrix composition in mutants. (europa.eu)
Keap1 is a cysteine-rich protein, known to be anchored to actin cytoskeleton [ 5 ], serving as an adaptor protein for the Cul3-dependent E3 ubiquitin ligase complex. (springer.com)
The FLNA gene provides instructions for producing the protein filamin A, which helps build cells' extensive internal network of protein filaments called the cytoskeleton. (medlineplus.gov)
The cytoskeleton is also important for certain processes inside the cells, such as the movement of proteins within the cell and the breakdown of unneeded proteins. (medlineplus.gov)
Filamin A primarily attaches (binds) to another protein called actin and helps it form the branching network of filaments that make up the cytoskeleton. (medlineplus.gov)
NCK is a major adaptor protein involved in membrane receptor signalling and modulation of actin cytoskeleton dynamics. (eu.org)
Moreover, enrichment analysis suggested that ANLN functionally affected endocytosis, regulation of actin cytoskeleton, and oxytocin signaling pathways. (biomedcentral.com)
The relative amount of ADF7 suppressed the actin cytoskeleton resistant to LatB treatment in pollen total extract whereas is increased from 2 to 3 nodes and their 45 degrees rotations are computed according to their surrounding in the brain that determines when each component participates in learning. (stpancraschurch.org)

Structure of intermediate filament Intermediate filaments (IFs) are cytoskeletal components found in the cells of vertebrate animal species,[1][2] and perhaps also in other animals, fungi, plants, and unicellular organisms. (pearltrees.com)
Initially designated 'intermediate' because their average diameter (10 nm) is between those of narrower microfilaments (actin) and wider myosin filaments found in muscle cells, the diameter of Intermediate filaments is now commonly compared to actin microfilaments (7 nm) and microtubules (25 nm). (pearltrees.com)
ERM proteins crosslink actin filaments with plasma membranes. (embl.de)
B) Images of actin filaments became fragmented in both datasets, while it provided the smallest training and inference time, compare to GraphDTA. (stpancraschurch.org)
The Arp2/3 complex generates propulsive forces by nucleating a highly branched network of actin filaments. (columbia.edu)

Isoform 1 is composed of 5304 base pairs of mRNA which form the 9 exons that make up the coding sequence. (wikipedia.org)
70 W/30E and 30 W/70E increased hypothalamic POMC mRNA 90 min post-treatment versus CTL rats suggesting a satiety-related response may have occurred in the former groups. (biomedcentral.com)
They then examined the mRNA expression pattern at a single cell level using so-called single-cell RNA sequencing analysis and found a subset of cardiac fibroblasts highly expressed genes activated by the transcription factor NF-kB and CCL2 mRNA. (kcl.ac.uk)
Reverse transcription quantitative polymerase chain reaction and immunohistochemistry were used to determine ANLN mRNA and protein expression in colorectal cancer (CRC), gastric cancer (GC), and hepatocellular carcinoma (HCC) cell lines. (biomedcentral.com)
For each patient, the team performed exome sequencing of the tumors and peripheral blood mononuclear cells, as well as mRNA sequencing of the paired tumor and adjacent normal tissues. (genomeweb.com)
Rattus norvegicus SH2B adaptor protein 2 (Sh2b2), mRNA. (genscript.com)
Dynactin is necessary for proper function of the molecular motor dynein, which is responsible for the retrograde transport of cellular cargo, including organelles, mRNA, and proteins along microtubules. (grantome.com)
Forty-four percent of cases and 78% of controls received 2 doses of either BNT162b2 or mRNA-1273 vaccine. (cdc.gov)

What pathways are this gene/protein implicaed in? (cancerindex.org)
Src Homology 2 (SH2) domains are small modular domains found within a great number of proteins involved in different signalling pathways. (eu.org)
Chapter 1 provides an overview of these pathways including the key steps of DSB repair, the regulation of actin nucleation, and the proteins involved in chromatin mobility. (columbia.edu)
Cross-talk between the two divergent insulin signaling pathways is revealed by the protein kinase B (Akt)-mediated phosphorylation of adapter protein APS on serine 588. (genscript.com)
p62 is a multifunctional protein that mediates cell signaling pathways, autophagy and tumorigenesis, and participates in important regulation processes at the intersection between autophagy and cancer. (spandidos-publications.com)
Furthermore, p62 is a multifunctional adapter protein involved in selective autophagy, cellular signaling pathways, and tumorigenesis ( 19 , 20 ). (spandidos-publications.com)
Limb-girdle muscular dystrophy (LGMD) protein defects occur in several pathways involved in the biologic function of muscle and can be divided into groups based on cellular localization. (medscape.com)

Emplyoing exome sequencing, we were able to identify several novel human disease genes, such as PIH1D3, MNS1 and DNAH9, causing cilia motility defects and/or laterality defects when mutated as well as several novel genes associated with centra nervous system defects. (europa.eu)
We are using Next Generation Sequencing (NGS) technologies, mainly Exome Sequencing to unravel the underlying genetic cause of human ciliary disorders. (europa.eu)
Using exome sequencing data, they identified 56,502 nonsynonymous single-nucleotide variants and 3,598 frameshift indels. (genomeweb.com)
Background De novo mutations are emerging as an important cause of neurocognitive impairment, and whole exome sequencing of case-parent trios is a powerful way of detecting them. (bmj.com)
Methods The Deciphering Developmental Disorders study is using whole exome sequencing in family trios to investigate children with severe, sporadic, undiagnosed developmental delay. (bmj.com)

and transmembrane receptor protein tyrosine kinase signaling pathway. (nih.gov)
Orthologous to human ABL2 (ABL proto-oncogene 2, non-receptor tyrosine kinase). (nih.gov)
With respect to cadherin 1 (CDH1) and fibroblast growth factor receptor 2 (FGFR2), the mutational rates for non-neoplastic colorectal mucosa were similar to those in sporadic CRC. (iiarjournals.org)
They defined subtype 2 as representing immune response-related processes (antigen presentation, BCR/TNF/Toll-like receptor signaling, TCR signaling, and phagosome). (genomeweb.com)
Image analysis of the matched maps identified 7 proteins that were either over- or down-expressed: activated protein kinase c receptor (LACK), alpha tubulin (×2), prostaglandin f2-alpha synthase, protein disulfide isomerase, vesicular transport protein and a hypothetical protein. (who.int)

In Chapter 2, I detail our studies assessing the contribution of the Arp2/3 complex to DSB movement and clustering. (columbia.edu)
Using Xenopus laevis cell-free extracts and mammalian cells, we show that actin nucleation machinery (WASP, Arp2/3, and actin) is recruited to damaged chromatin undergoing HDR. (columbia.edu)

An Illustration of the Laminin-111 complex depicting the domain organization Laminins are high-molecular weight (~400 to ~900 kDa) proteins of the extracellular matrix. (pearltrees.com)
During the progression of colitis, genetic alterations associated with mucosal permeability [ e.g. those in extracellular matrix protein 1 ( ECM1 ), cadherin 1 ( CDH1 ), and hepatocyte nuclear factor 4 alpha ( HNF4A )] have been observed and considered to confer the risk of severe UC ( 11 , 12 ). (iiarjournals.org)
Filamin A is also involved in the organization of the extracellular matrix, which is the lattice of proteins and other molecules outside the cell. (medlineplus.gov)
Filamin A binds to proteins called integrins, which span the cell membrane and anchor cells to the extracellular matrix. (medlineplus.gov)

Studies have linked expression of CCDC113 in cancerous tissues to mutations present in the coding sequence. (wikipedia.org)
Missense mutations at location 86 from Arginine to Tryptophan (R86Y) and at R180C are related to adenocarcinomas of the colon. (wikipedia.org)
For example, we found that mutations in the outer dynein arm protein DNAH9 result in laterality defects associated with no or only very mild respiratory symptoms. (europa.eu)
Using cutting edge technologies such as CRISPR base editing approaches enables us to gain deeper insight into ciliary protein networks and dissect the molecular defects resulting from human patient mutations. (europa.eu)
Scope includes mutations and abnormal protein expression. (cancerindex.org)
Mutations in ras genes can cause permanent activation of ras proteins. (medscape.com)
Mutations identified in many SH2 domain-containing proteins as well as the SH2 domain itself are associated with human diseases ranging from cancers, diabetes, to immunodeficiencies. (eu.org)
In this study, by targeted next-generation sequencing of 414 known deafness genes, we identified compound heterozygous mutations p.R34X/p.M413T in TMC1 and p.S3417del/p.R1407T in MYO15A in two recessive Chinese Han deaf families. (hindawi.com)
Intrafamilial cosegregation of the mutations with the hearing phenotype was confirmed in both families by the Sanger sequencing. (hindawi.com)
MYO15A mutations are responsible for congenital deafness DFNB3 in human and cochleovestibular dysfunction in shaker 2 mice which shows abnormally short stereocilia bundles and diminished staircase [ 20 , 21 ]. (hindawi.com)
It is one of the most common causes of ADNSHL in Mideast countries due to prevalent consanguineous marriage [ 22 , 23 ], with majority associated with prelingual severe-to-profound hearing loss and mutations in exon 2 leading to a milder auditory phenotype [ 23 ]. (hindawi.com)
Using targeted next-generation sequencing of 414 known deafness genes, we identified compound heterozygous mutations in TMC1 and MYO15A as the genetic causes of the hearing loss in those families. (hindawi.com)
Results Protein-altering de novo mutations in PURA were identified in four subjects. (bmj.com)
These diseases are discussed here in part because mutations in 2 genes can present with either an LGMD or a myofibrillar myopathy phenotype. (medscape.com)

There are several obstacles to this process including damage from endogenous or exogenous sources, nucleotide depletion, and hard-to-replicate sequences in the DNA. (hhs.gov)
The goal of this project is to compare a nucleotide and or protein sequence from one species with the corresponding genes/proteins in other species. (homeworkdoyen.com)

The interaction between the adaptor protein APS and Enigma is involved in actin organisation. (genscript.com)

In this study, we combined transcript profiling and proteomic analysis to better understand which genes and proteins are altered by opaque2 in the W64A inbred line. (biomedcentral.com)

The S. cerevisiae Reference Genome sequence is derived from laboratory strain S288C . (yeastgenome.org)
Whole-genome sequencing of patients with rare diseases in a national health system. (ox.ac.uk)
Here we used whole-genome sequencing (WGS) in a national health system to streamline diagnosis and to discover unknown aetiological variants in the coding and non-coding regions of the genome. (ox.ac.uk)
The resected DNA strands are poor substrates for NHEJ and instead search for homology in the genome to resynthesize the sequence surrounding the break site. (columbia.edu)
Recent studies have proposed roles for cytoskeletal proteins in genome organization and chromosomal dynamics. (columbia.edu)
Whole genome sequencing technology and complementation analysis were used to determine that the stl83 phenotype is the result of a missense mutation in the gene actin-related protein 10 (actr10), which encodes a critical component of the dynactin complex. (grantome.com)
We retrieved OC-related RNA sequence, copy number variation, somatic mutation, and clinicopathological information from The Cancer Genome Atlas database and mitophagy-related gene sets from the Reactome database. (biomedcentral.com)

3] They are composed of a family of related proteins sharing common structural and sequence features. (pearltrees.com)
[ 2 ] Ras -GTPase is part of a family of related proteins that are universally expressed in cells and are involved in cellular signal transduction. (medscape.com)

CSNK2A2 the casein kinase 2, alpha prime polypeptide contains a protein kinase domain and a catalytic domain. (wikipedia.org)
and protein tyrosine kinase activity. (nih.gov)
The Src Homology 2 (SH2) domain is a major protein interaction module that is central to tyrosine kinase signaling. (eu.org)
APS was identified as a novel substrate for protein kinase B/Akt. (genscript.com)
L'analyse d'image des cartes appariées a permis d'identifier sept protéines qui étaient soit surexprimées, soit sous-exprimées : le récepteur de la protéine kinase C activée, la tubuline alpha (×2), la prostaglandine F2-alpha synthase, la protéine disulfide isomérase, une protéine du transport vésiculaire et une protéine hypothétique. (who.int)

The N-terminal domain is highly conserved, and is also found in merlin, band 4.1 proteins and members of the band 4.1 superfamily. (embl.de)
PURA encodes Pur-α, a highly conserved multifunctional protein that has an important role in normal postnatal brain development in animal models. (bmj.com)

Download DNA or protein sequence, view genomic context and coordinates. (yeastgenome.org)
Our preliminary data indicates that the DNA damage response protein SMARCAL1 (SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin, subfamily A-like1) acts as a component of this general pathway to promote genomic stability at telomeres. (hhs.gov)
Regulation of actin dynamics and analysis of genomic influences on actin function. (upstate.edu)

The following Sh2b2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). (genscript.com)

Oxidative stress generated during such stressful conditions may damage DNA and proteins, and as a consequence the cellular processes are disturbed. (springer.com)
encoded by Nfe2l2 gene) is a transcription factor responsible for the regulation of cellular redox balance and protective antioxidant and phase II detoxification responses in mammals [ 1 , 2 ]. (springer.com)
In the active state it binds to a diversity of effector proteins to regulate cellular responses. (prospecbio.com)

The Abl-related gene (Arg) requires its F-actin-microtubule cross-linking activity to regulate lamellipodial dynamics during fibroblast adhesion. (nih.gov)
Elucidate the structure, dynamics and functions of intrinsically disordered proteins and protein regions (IDPs/IDRs) and their biological regulation by Post-translational modifications. (upstate.edu)
Actin Cytoskeletal Dynamics in the leukocyte inflammatory phenotype. (upstate.edu)

Serous carcinoma of the ovaries has been related to a missense mutation S6F. (wikipedia.org)

CCDC113 is located on chromosome 16q21 and encodes two distinct isoforms with isoform 2 containing one less alternate in-frame exon compared to the full length protein, isoform 1. (wikipedia.org)
NDRG4 a member of the N-myc downregulated gene family belonging to the alpha/beta hydrolase superfamily which encodes a cytoplasmic protein responsible for cell cycle progression and survival in primary astrocytes and may be involved in regulation of mitogenic signaling in vascular smooth muscle cells. (wikipedia.org)
The TMC1 gene is located on chromosome 9q21 and contains 24 exons that encodes a 760 amino acid membrane protein TMC1 with six transmembrane domains [ 12 , 13 ]. (hindawi.com)
The MYO15A gene is located at chromosome 17p11.2 and contains 66 coding exons, which encodes an unconventional myosin protein Myosin XVA [ 19 ]. (hindawi.com)

The Tir protein of EPEC binds NCK1/NCK2 SH2 domains through a high affinity pYDEV motif ( Frese,2006 ). (eu.org)

To investigate this essential function of SMARCAL1, I propose two aims: (1) to fully characterize the extent of this novel SMARCAL1 function at telomeres and (2) to identify the mechanism of Smarcal1 localization to telomeres. (hhs.gov)

Biotin labeled cRNA transcript was synthesized using cDNA, fragmented and hybridized to HuGeneFL GeneChip probe arrays representing more than 6800 human genes and expressed sequence tags. (cdc.gov)

In addition, we were able to establish a number of phenotype genotype correlation for motile ciliopathies/laterality disorders, inherited renal and skeletal phenotypes and neuro-developmental disorders By creating several of dynein-2- and IFT-mutant cell lines harboring human disease alleles using CRISPR base editing technologies, the project achieved generation of unique in-vitro ciliary condrodysplasia disease models. (europa.eu)
however, the phenotype of individuals with NF1 is widely variable, even among genetically related family members. (medscape.com)
Our study expanded the mutation spectrums of TMC1 and MYO15A and illustrated that genotype-phenotype correlation in combination with next-generation sequencing may improve the accuracy for genetic diagnosis of deafness. (hindawi.com)

These sequences represent the protein coding region of the Sh2b2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. (genscript.com)

Cross-reactivity occurs when amino acid sequence homology exists between a pathogen and self-tissue proteins ( 1 ). (frontiersin.org)

Confocal immunofluorescent analysis of COS-7 cells using β-Actin (13E5) Rabbit mAb (Alexa Fluor ® 647 Conjugate) (blue pseudocolor). (cellsignal.com)
Flow cytometric analysis of Hela cells using β-Actin (13E5) Rabbit mAb (Alexa Fluor ® 647 Conjugate) (solid line) compared to concentration-matched Rabbit (DA1E) mAb IgG XP ® Isotype Control (Alexa Fluor ® 647 Conjugate) #2985 (dashed line). (cellsignal.com)

The 3'/5' cRNA transcript ratios for both GAPDH and a-actin were found to be consistent between control and treatment groups over a period of 12 h exposure. (cdc.gov)

We also did selective epitope mapping using BLAST and showed similarities and homology between spike, nucleoprotein, and many other SARS-CoV-2 proteins with the human tissue antigens mitochondria M2, F-actin and TPO. (frontiersin.org)

Overexpression of p62 is likely related to tumorigenesis and has been observed in many types of tumors ( 13 , 21 - 23 ), such as chemotherapy-resistant epithelial cell carcinoma ( 24 ). (spandidos-publications.com)
25 independent samples (14 tumors, 2 generally reflected in related patterns of fluorescein. (lu.se)

The CCDC113 protein is composed of 377 amino acids which form a secondary structure composed primarily of alpha-helices. (wikipedia.org)
Nrf2 consists of six functional Neh domains (Neh1-Neh6), from which, the amino-terminal Neh2 domain controls binding Keap1-the inhibitor protein Kelch-like ECH-associated protein 1, that is responsible for the cytosolic sequestration of Nrf2 under physiological conditions (Fig. 2 a). (springer.com)
A cadherin repeat is an independently folding sequence of approximately 110 amino acids that contains motifs with the conserved sequences DRE, DXNDNAPXF, and DXD. (embl.de)
Maize protein is deficient in the essential amino acids lysine and tryptophan, which limits its value for monogastric animals. (biomedcentral.com)
The underlying mechanism for rebalancing amino acid content for both o2 and RNAi is unclear, although it depends on reduced synthesis of the zein storage proteins and a compensatory increase in non-zein protein content [ 17 ]. (biomedcentral.com)

Myosin XVA is a large actin-based motor protein. (hindawi.com)

However, in the mid 1990s, other proteins were also found to accumulate in the abnormal muscle fibers, and molecular genetic studies revealed several chromosomal loci. (medscape.com)

Although previous studies have shown that ANLN is related to carcinogenesis, no pan-cancer analyses of ANLN have been reported. (biomedcentral.com)
These analyses showed that the accumulation of some lysine-rich proteins, such as sorbitol dehydrogenase and glyceraldehyde3-phosphate dehydrogenase, was increased in mature kernels and may contribute substantially to the lysine content of opaque2 endosperm. (biomedcentral.com)

Structural basis for phosphotyrosine recognition by the Src homology-2 domains of the adapter proteins SH2-B and APS. (genscript.com)

Other than water, the mesoglea is composed of several substances including fibrous proteins like collagen and heparan sulphate proteoglycans. (pearltrees.com)
In response to tissue injury or stress, the resident cardiac fibroblasts undergo a transition to activated myofibroblasts, a highly synthetic cell type that induces the genes encoding smooth muscle α actin (ACTA2) and collagen. (kcl.ac.uk)

TREATCilia aimed to uncover underlying molecular pathophysiology in dynein based ciliopathies from gene to mechanism and we hope to identify future pharmacological entry points to ameliorate ciliary dynein-related phenotypes. (europa.eu)

Therefore, the aim of the present study was to identify a regulatory signaling pathway in cardiac inflammation based on the hypothesis that a distinct subset of inflammation-related activated fibroblasts plays crucial roles in the recruitment of inflammatory cells, especially monocytes/macrophages, and in the pathology of heart failure. (kcl.ac.uk)
the mechanisms involved were activation of the LPS-TLR4 signalling pathway in the intestine and hippocampus, reduced BDNF-CREB signaling pathway in hippocampus, increased abundance of depression-related bacteria, and decreased abundance of beneficial bacteria. (biomedcentral.com)

The NF1 gene product is a cytoplasmic protein called neurofibromin 1, which appears to have diverse functions in many different tissues. (medscape.com)

First, does cross-reactivity play a role in the multi-system disorders associated with SARS-CoV-2 infection? (frontiersin.org)
Data table showing topics related to specific cancers and associated disorders. (cancerindex.org)
This condition is a member of a group of related conditions called otopalatodigital spectrum disorders, which also includes otopalatodigital syndrome type 1 , otopalatodigital syndrome type 2 , frontometaphyseal dysplasia , and Melnick-Needles syndrome (described below). (medlineplus.gov)
Different variants in the FLNA gene appear to produce specific changes in the protein, resulting in particular signs and symptoms that are classified as individual FLNA -related disorders. (medlineplus.gov)
Neurofibromatosis type 1 (NF1) and type 2 (NF2) are neurocutaneous disorders inherited as autosomal dominant genetic syndromes. (medscape.com)
Case 4 was a phenotypically isolated case recruited into an undiagnosed rare disorders sequencing study. (bmj.com)

Researchers suspect that the variants involved in frontometaphyseal dysplasia may change the way the filamin A protein helps regulate processes involved in skeletal development, but it is not known how changes in the protein relate to the specific signs and symptoms of the condition. (medlineplus.gov)

The multifunctional regulator nuclear factor erythroid 2-related factor (Nrf2) is considered not only as a cytoprotective factor regulating the expression of genes coding for anti-oxidant, anti-inflammatory and detoxifying proteins, but it is also a powerful modulator of species longevity. (springer.com)

Click "Sequence Details" to view all sequence information for this locus, including that for other strains. (yeastgenome.org)
Click "Protein Details" for further information about the protein such as half-life, abundance, domains, domains shared with other proteins, protein sequence retrieval for various strains, physico-chemical properties, protein modification sites, and external identifiers for the protein. (yeastgenome.org)
ABSTRACT In order to define the protein expressional changes related to the process of meglumine antimoniate resistance in anthroponotic cutaneous leishmaniasis (CL), we performed a comparative proteomics analysis on sensitive and resistant strains of Leishmania tropica isolated from Iranian CL patients. (who.int)
Our preliminary study using 2D isolates were recovered from liq- new cases throughout the world cu- gel electrophoresis in drug sensitive/ uid nitrogen, and sub-cultured in taneous leishmaniasis (CL) remains resistant strains of L. tropica showed RPMI1640 medium (Gibco/BRL) a serious public health problem in that some proteins were differentially supplemented with 10% fetal bovine numerous countries [1,2]. (who.int)

Subtype 3 uniquely represented metabolism-related processes (oxidative phosphorylation, fatty acid b-oxidation, and citrate cycle). (genomeweb.com)

These annotations have been derived from physical molecular interaction evidence extracted from the literature and cross-referenced in the entry, or by curator inference from information on homologs in closely related species or by inference from scientific background. (yeastgenome.org)
Cadherins are evolutionary related to the desmogleins which are component of intercellular desmosome junctions involved in the interaction of plaque proteins. (embl.de)

an effect which may be explained by an increased expression of adipose tissue lipolysis-related gene expression patterns following chronic supplementation [ 12 ], an increase in protein-induced thermogenesis (reviewed in [ 15 ]), and/or a consistent reduction in food intake given its satiety-stimulatory effects as discussed above. (biomedcentral.com)
Concurrently, p62 gene expression is increased by oxidative stress through activation of the transcription factor NF-E2-related factor 2 ( 18 ). (spandidos-publications.com)
Altered gene expression pattems were observed in 194 RNA transcripts with at least a 2 fold change. (cdc.gov)

Ras-like protein belongs to the Rac subfamily of the Rho family of GTPases. (prospecbio.com)

We sought to determine whether immune reactivity occurs between anti-SARS-CoV-2 protein antibodies and human tissue antigens, and whether molecular mimicry between COVID-19 viral proteins and human tissues could be the cause. (frontiersin.org)
We found that SARS-CoV-2 antibodies had reactions with 28 out of 55 tissue antigens, representing a diversity of tissue groups that included barrier proteins, gastrointestinal, thyroid and neural tissues, and more. (frontiersin.org)
We believe the answer is probable, since some of the systemic disease clinical manifestations of COVID-19 cannot be explained solely by the binding of SARS-CoV-2 spike proteins with cell membranes of tissues that exhibit angiotensin-converting enzyme 2 (ACE2). (frontiersin.org)

Consistent with the lack of actin tail formation, vΔF12L produced a very small plaque. (ox.ac.uk)

This extensive immune cross-reactivity between SARS-CoV-2 antibodies and different antigen groups may play a role in the multi-system disease process of COVID-19, influence the severity of the disease, precipitate the onset of autoimmunity in susceptible subgroups, and potentially exacerbate autoimmunity in subjects that have pre-existing autoimmune diseases. (frontiersin.org)
The macrophage produces inflammatory cytokines, which is a small protein that influences the immune systems and damages to the heart. (kcl.ac.uk)
Early studies reported that hyperactive T helper (Th) type 1 and Th17 immune responses were related to the development of BD [ 4 , 5 ]. (oncotarget.com)

Cadherins are a group of transmembrane proteins that serve as the major adhesion molecules located within adherens junctions. (embl.de)

ABSTRACT Vaccinia virus gene F12L is shown to encode a 65-kDa protein that is synthesized early and late during infection and that is not modified by glycosylation. (ox.ac.uk)

This entry represents the extracellular repeated domains found in cadherins and related proteins. (embl.de)
In comparing their own GC subtypes to GC subgroups in TCGA data, the researchers found that subtype 2- and 4-like TCGA subgroups showed the best and worst survivals, respectively. (genomeweb.com)

Lactobacillus rhamnosus is an anaerobic facultative heterofermentative rod-shaped bacterium that can live in different parts of the human body, including the gastrointestinal tract (GIT) 2 . (nature.com)

J Cell Biol, 2019 Dec 2. (nih.gov)
Loss of the F12L protein reduced the formation of IMV 2-fold, but there was a dramatic (99.5%) reduction in actin tail formation, and the levels of cell-associated enveloped virus and extracellular enveloped virus were reduced 8- to 11-fold and 7-fold, respectively. (ox.ac.uk)
Cadherins form protein complexes with cytoplasmic proteins (catenins) that convert the specific, homophilic-binding capacity of the extracellular domain into stable cell adhesion. (embl.de)
Filamin A can also bind to many other proteins in the cell to carry out various functions, including the attachment of cells to one another (cell adhesion), cell movement (migration), determination of cell shape, the relay of signals within cells, and cell survival. (medlineplus.gov)
A cascade effect occurs when ras -GTPase is "switched on" by incoming signals, leading to activation of other proteins, which, in turn, activate genes responsible for cell growth and differentiation. (medscape.com)
Anillin (ANLN) is an actin-binding protein that is essential for cell division and contributes to cell growth and migration. (biomedcentral.com)
They also further defined subtype 1 as representing cell proliferation-related processes (cell cycle and DNA replication RNA processing, translation, and protein degradation). (genomeweb.com)
Cells overexpressing p62 showed a higher cell death rate than cells not expressing this protein. (spandidos-publications.com)
Cell proteins were analysed with 2-dimensional electrophoresis and differentially expressed proteins were identified by matrix-assisted laser desorption/ ionization time-of-flight mass spectrometry. (who.int)
protein patterns of subjects with leish- Cell culture maniasis [17]. (who.int)

Provide a list of 4-5 species (other than those named in your response to Prompt 1 and Prompt 2) that are present in the distance tree. (homeworkdoyen.com)

E7 from human papil omavirus type 16 cooperate to cancer: the European prospective investigation into doi:10.1093/carcin/bgp321 PMID:20047954 target the PDZ protein Na/H exchange regulatory cancer and nutrition study. (who.int)

Analysis of liver by in situ hybridization presumed since its initial description in 1959 because with viral probes and immunohistochemical testing of the causative agent passed through 100-nm membranes, serum demonstrated viral nucleic acid and protein in livers was acid stable, was not affected by antimicrobial drugs, of diseased poults. (cdc.gov)
Individuals enrolled in the analysis were randomized to get panitumumab 6 mg/kg every 14 days plus FOLFIRI (Arm 1) versus FOLFIRI only (Arm 2). (smartrailexpo-europe.com)
Therefore, analysis of oncogene expression may facilitate the identification of cancer and cancer-related mechanisms and to determine patient prognosis. (biomedcentral.com)
Pearson's correlation analysis was used to distinguish mitophagy-related lncRNAs. (biomedcentral.com)

Colorectal carcinogenesis is considered to develop through multistep genetic or epigenetic alteration along with the pathological change called the adenoma-carcinoma sequence ( 1 - 5 ). (iiarjournals.org)
Colorectal cancer is the third most commonly diagnosed cancer and fourth leading cause of cancer-related deaths ( 1 ). (spandidos-publications.com)
To treat patients with colorectal cancer, an approach that selectively targets cancer cells without damaging normal cells and which minimizes the risk of perforating the intestinal barrier is needed ( 2 ). (spandidos-publications.com)

It is known that C-C motif chemokine ligand 2 (CCL2) is a chemokine which facilitates monocyte movement and positioning. (kcl.ac.uk)

These changes in protein accumulation result in an endosperm that has nearly twice the lysine and tryptophan content of wild-type maize [ 3 ], which substantially improves its value for monogastric animals [ 9 ]. (biomedcentral.com)
Oxidative stress has been shown to correlate with increasing protein toxicity, linking loss of protein, accumulation of ROS, and protein aggregate formation. (spandidos-publications.com)

The encoded protein is secreted and has chemokinetic and inflammatory functions. (cancerindex.org)

We applied both human monoclonal anti-SARS-Cov-2 antibodies (spike protein, nucleoprotein) and rabbit polyclonal anti-SARS-Cov-2 antibodies (envelope protein, membrane protein) to 55 different tissue antigens. (frontiersin.org)

Chapter 1 provides context for the rest of the thesis in which I explore the contribution of nuclear actin polymerization to DSB repair. (columbia.edu)

Anatomy27

Organisms16

Chemicals and Drugs114

Analytical, Diagnostic and Therapeutic Techniques and Equipment28

Phenomena and Processes63

Disciplines and Occupations3

Technology, Industry, Agriculture3

Information Science8

Cytoskeleton8

Filaments5

MRNA8

Pathways7

Exome5

Receptor5

Arp22

Extracellular matrix4

Mutations14

Nucleotide2

Adaptor protein1

Genes and proteins1

Genome7

Family of related proteins2

Kinase5

Highly conserved2

Genomic3

RefSeq1

Cellular3

Dynamics3

Missense mutation1

Encodes4

Binds1

Localization1

Human genes1

Phenotype3

CDNA1

Pathogen1

Alexa Fluor2

Transcript1

Mitochondria1

Tumors2

Amino5

Myosin1

Chromosomal1

Analyses2

Homology1

Collagen2

Phenotypes1

Signaling pathway2

Cytoplasmic protein1

Disorders6

Regulate1

Multifunctional1

Strains4

Phosphorylation1

Interaction2

Gene expression3

Subfamily1

Tissues3

Consistent1

Immune3

Molecules1

Abstract1

Found2

Gastrointestinal1

Cell10

Species1

PMID1

Analysis4

Colorectal3

Motif chemokine1

Accumulation2

Inflammatory1

Membrane protein1

Nuclear1