Clostridium tertium was initially isolated from war wounds by Captain Herbert Henry (RAMC) in 1917, but it was not until the first human cases of C. tertium bacteremia were reported in 1963 that it was recognized as a human pathogen. (wikipedia.org)
Three major factors have been associated with C. tertium bacteremia: intestinal mucosal injury, neutropenia, and history of exposure to β-lactam antibiotics (particularly third generation cephalosporins). (wikipedia.org)
Almost all reported cases of C. tertium bacteremia have been in neutropenic patients without any obvious source of infection. (wikipedia.org)
Clostridium tertium bacteremia can cause fever, and directed antibiotic therapy is indicated. (wikipedia.org)
Mortality related to C. tertium bacteremia treated appropriately appears to be quite low. (wikipedia.org)
After 24 h, the has been with septicemia in patients tam antibiotics predisposing to C. ter- patient's left leg and thigh turned gan- with neutropenia and hematologic tium bacteremia (3). (cdc.gov)
38.6°C) and an elevated leukocyte tors for C. tertium bacteremia include fasciitis and gangrene has not been count of 14,000/mm3 (70% neu- intestinal mucosal injury, neutropenia, reported. (cdc.gov)
Traditionally1
Clostridium tertium has traditionally been considered nonpathogenic, but increasingly it is being reported as a human pathogen. (wikipedia.org)
Spores2
Also, C. tertium only forms spores anaerobically, as opposed to Bacillus spp. (wikipedia.org)
Both isolates of C. tertium isolated by Henry from war wounds in spores. (cdc.gov)
Organism1
C. tertium is easily decolorized in Gram-stained smears and can be mistaken for a Gram-negative organism. (wikipedia.org)
Anaerobic3
Clostridium tertium is an anaerobic, motile, gram-positive bacterium. (wikipedia.org)
Clostridium tertium is a Gram-positive, spore forming, anaerobic bacillus found in the soil and the gut of many animal species, including humans. (wikipedia.org)
the genus Clostridium are anaerobic neutrophils, 11% lymphocytes, and Anaerobic culture directly from spec- or aerotolerant, gram-positive, 9% monocytes. (cdc.gov)
Antibiotics1
The selection effect of antibiotics on C. tertium may occur in cases where patients have had prior exposure to β-lactam antibiotics. (wikipedia.org)
Humans1
C. tertium has also been implicated with osteomyelitis, and miscellaneous soft tissue infections in humans. (wikipedia.org)
Cephalosporins1
Microscopy cephalosporins), cytotoxic chemo- caused by C. tertium . (cdc.gov)
Fever1
C. tertium as the grenous, and a high-grade fever malignancies (3,4). (cdc.gov)
Patients1
C. tertium has been isolated in neutropenic and nonneutropenic patients, and in cases of necrotizing fasciitis and gangrene. (wikipedia.org)
Bacteremia in neutropenic1
Significance of Clostridium tertium bacteremia in neutropenic and nonneutropenic patients: review of 32 cases. (nih.gov)
Perfringens1
Most Clostridium perfringens are susceptible, but other species, e.g. (nih.gov)
Neutropenic4
Clostridium tertium Bacteremia in a Non-neutropenic Patient with Liver Cirrhosis. (nih.gov)
C. tertium has been isolated in neutropenic and nonneutropenic patients, and in cases of necrotizing fasciitis and gangrene. (wikipedia.org)
Almost all reported cases of C. tertium bacteremia have been in neutropenic patients without any obvious source of infection. (wikipedia.org)
Polymicrobial septic arthritis due to Clostridium species: case report and review. (nih.gov)
Clostridium tertium is a Gram-positive, spore forming, anaerobic bacillus found in the soil and the gut of many animal species, including humans. (wikipedia.org)
C. tertium distinguishes itself from other clostridia as a non-toxin producing, aerotolerant, non-histotoxic and non-lipolytic species. (wikipedia.org)
Clostridium species: case report and egories reported in this study included patient had neutropenia when they review. (cdc.gov)
Neutropenia3
Three major factors have been associated with C. tertium bacteremia: intestinal mucosal injury, neutropenia, and history of exposure to β-lactam antibiotics (particularly third generation cephalosporins). (wikipedia.org)
After 24 h, the has been with septicemia in patients tam antibiotics predisposing to C. ter- patient's left leg and thigh turned gan- with neutropenia and hematologic tium bacteremia (3). (cdc.gov)
38.6°C) and an elevated leukocyte tors for C. tertium bacteremia include fasciitis and gangrene has not been count of 14,000/mm3 (70% neu- intestinal mucosal injury, neutropenia, reported. (cdc.gov)
Reported in 19631
Clostridium tertium was initially isolated from war wounds by Captain Herbert Henry (RAMC) in 1917, but it was not until the first human cases of C. tertium bacteremia were reported in 1963 that it was recognized as a human pathogen. (wikipedia.org)
Anaerobic3
Anaerobic organisms, bacteremia and septicemia]. (nih.gov)
Clostridium tertium is an anaerobic, motile, gram-positive bacterium. (wikipedia.org)
the genus Clostridium are anaerobic neutrophils, 11% lymphocytes, and Anaerobic culture directly from spec- or aerotolerant, gram-positive, 9% monocytes. (cdc.gov)
Cytotoxic1
Microscopy cephalosporins), cytotoxic chemo- caused by C. tertium . (cdc.gov)
Resistant2
Clostridia are more resistant than most anaerobes to clindamycin. (nih.gov)
Clostridium tertium are frequently resistant to clindamycin. (nih.gov)
Patients2
The selection effect of antibiotics on C. tertium may occur in cases where patients have had prior exposure to β-lactam antibiotics. (wikipedia.org)
J, McCullough D. Aerotolerant Clostridium children 5-9 years of age had the isolates were susceptible to these tertium brain abscess following a lawn dart largest proportion of cases, whereas in three antibiotics in vitro. (cdc.gov)
Antibiotic1
Clostridium tertium bacteremia can cause fever, and directed antibiotic therapy is indicated. (wikipedia.org)
Infections1
C. tertium has also been implicated with osteomyelitis, and miscellaneous soft tissue infections in humans. (wikipedia.org)
Penicillin1
Aerobic blood culture was were susceptible in vitro to penicillin, 1917 (1), C. tertium was recognized sterile. (cdc.gov)
Shock1
After seven days of ECMO support, septicemia with shock ensued. (bvsalud.org)
Diarrhea1
Clostridium difficile associated diarrhea (CDAD) has been reported with use of nearly all antibacterial agents, including clindamycin and may range in severity from mild diarrhea to fatal colitis. (nih.gov)