Sensory and pain sensory thresholds. Medical search. Frequent questions

Weber was able to define absolute and difference threshold statistically, which led to the establishment of Weber's Law and the concept of just noticeable difference to describe threshold perception of stimuli. (wikipedia.org)
There are three common methods used to determine sensory thresholds: Method of Limits: In the first step, the subject is stimulated by strong, easily detectable stimuli that are decreased stepwise (descending sequence) until they cannot detect the stimulus. (wikipedia.org)
Intensities involve stimuli which are surely subthreshold and stimuli which are surely supra-threshold. (wikipedia.org)
Whiplash subjects showed additional widespread hypersensitivity to mechanical pressure and thermal stimuli, which was independent of state anxiety and may represent changes in central pain processing mechanisms. (lww.com)
Innocuous mechanical stimuli acting on the skin are detected by sensory neurons, known as low-threshold mechanoreceptors (LTMRs). (iasp-pain.org)
We tested the hypothesis that cryolipolysis can attenuate nociception of a range of sensory stimuli, including stimuli that evoke itch. (harvard.edu)
In this chronic pain condition there is allodynia (pain from non-noxious stimuli, in this case touch or pressure) of all or part of the outer edge of the vestibule. (bcmj.org)
Nociception refers to the neural processes of encoding and processing noxious stimuli, which results from the stimulation of sensory fibres by noxious stimuli. (hindawi.com)
As a component of the human immune and inflammatory response system, pain is experienced when sensory signals are transmitted to the nervous system to cause a motor reaction toward harmful stimuli [ 2 ]. (hindawi.com)
The responsiveness of central pain-signaling neurons of centrally sensitized OAk patients may be augmented to the input of these electrical stimuli. (biomedcentral.com)
The tooth has an unusual sensory system that converts external stimuli predominantly into pain, yet its sensory afferents in teeth demonstrate cytochemical properties of non-nociceptive neurons. (mdpi.com)
Pain is a discomforting experience that involves sensory and emotional aspects, possibly attributed to tissue damage [1] , informing the body of noxious stimuli or a problem with internal functioning. (wikibooks.org)
The latter is manifested in hypersensitivity to visual stimuli, measured with questionnaires and sensory thresholds, as well as in abnormal cortical excitability and a lack of habituation, assessed with visual evoked potentials elicited by pattern-reversal stimulation. (biomedcentral.com)
Neuropathic pain is defined as the pain resulting from a lesion or dysfunction of somatosensory system and characterized by either spontaneous pain or sensitivity exacerbated to different stimuli 22 . (bvsalud.org)

Mice lacking Kcns1 in peripheral neurons show increased basal and neuropathic pain sensitivity. (umassmed.edu)
Here, we showed that GM-CSF promotes bone cancer-associated pain by enhancing excitability of DRG neurons via the Jak2-Stat3-mediated upregulation of expression of nociceptor-specific voltage-gated sodium channels. (iasp-pain.org)
Here, we performed genetic fate mapping, showing that VGLUT3 lineage sensory neurons are divided into two groups, based on transient or persistent VGLUT3 expression. (jneurosci.org)
VGSCs play a key role in pain signaling and some TTX-sensitive VGSCs are highly expressed by adult primary sensory neurons. (mdpi.com)
During pathological pain conditions, such as neuropathic pain, upregulation of some TTX-sensitive VGSCs, including the massive re-expression of the embryonic VGSC subtype Na V 1.3 in adult primary sensory neurons, contribute to painful hypersensitization. (mdpi.com)
Sensory neurons begin frequent discharging at a lower threshold and larger magnitude through peripheral sensitization if the effects of gravity strain are beyond the safe range for body integrity. (news-medical.net)
In the past decade suggestions were already made concerning the influence of sensitization of wide dynamic range (WDR) dorsal horn neurons when explaining an increase of the mechanical pain threshold after applying a blockage of A -beta nerve fibers [ 17 ]. (biomedcentral.com)
To identify which of the dozens of chemicals that made up the tarantula's venom were specifically targeting these channels, the researchers separated the venom and applied the components one-by-one to rodent sensory neurons in a lab dish. (neurosciencenews.com)
They found two peptide molecules that specifically and powerfully activated these sensory nerves, and experiments with lab-synthesized versions of the same molecules confirmed that these chemicals could activate pain-sensing neurons on their own. (neurosciencenews.com)

No association was observed between VDT and quantitative sensory testing. (clinicalpainadvisor.com)
To investigate sensory changes present in patients with chronic whiplash-associated disorders and chronic idiopathic neck pain using a variety of quantitative sensory tests to better understand the pain processing mechanisms underlying persistent symptoms. (lww.com)
The effects of cryolipolysis on sensory phenomena were evaluated by quantitative sensory testing (QST) in 11 healthy subjects over a period of 56 days. (harvard.edu)
A total of 101 diabetic patients and 17 age-matched control subjects underwent neurological evaluation, neurophysiology tests, quantitative sensory testing, and evaluation of corneal sensation and corneal nerve morphology using corneal confocal microscopy (CCM). (diabetesjournals.org)
Krumova E K, Geber C, Westermann A, Maier C. Neuropathic pain: is quantitative sensory testing helpful? (smw.ch)
Quantitative sensory testing: a comprehensive protocol for clinical trials. (smw.ch)
Quantitative sensory testing in the German Research Network on Neuropathic Pain (DFNS): Standardized protocol and reference values. (smw.ch)
Test-retest and interobserver reliability of quantitative sensory testing according to the protocol of the German Research Network on Neuropathic Pain (DFNS):A multi-centre study. (smw.ch)
Quantitative sensory tests were performed and the Neuropathic Pain Scale was assessed at 3 and 6 months. (medscape.com)

Heat pain thresholds, cold pain thresholds, and von Frey hair sensibility were measured over the cervical spine, tibialis anterior, and deltoid insertion. (lww.com)
NBD and NFL demonstrated a significant and progressive reduction with worsening heat pain thresholds ( P = 0.01). (diabetesjournals.org)

Saitoh and co-workers demonstrated in a randomized, multicenter, double-blind, crossover, sham-controlled clinical study that daily repeated 5-Hz transcranial magnetic stimulation of primary cortex provided short-term pain relief in neuropathic pain patients ( 15 , 16 ). (frontiersin.org)
Here, we showed that anterior nucleus of paraventricular thalamus (PVA) plays an essential role in the development of mechanical hyperalgesia in neuropathic and inflammatory pain models in mice. (iasp-pain.org)
Tetrodotoxin, a Potential Drug for Neuropathic and Cancer Pain Relief? (mdpi.com)
Purpose: Low intensity laser therapy (LILT) is claimed to reduce the pain of myofacial and neuropathic origin. (nova.edu)
The prediction of diabetic neuropathic foot ulceration using vibration perception thresholds. (smw.ch)
A new definition of neuropathic pain. (smw.ch)
The most common type of craniofacial neuropathic pain is trigeminal neuralgia (TN), whose prevalence is estimated in 5-30 individuals at every 100,000 43 . (bvsalud.org)

Widespread Sensory Hypersensitivity Is a Feature of Chronic. (lww.com)
The mechanisms of pain and hypersensitivity, as well as the means that the dentin-pulp complex may react to a repeated or persistent pain-producing irritation, are also discussed. (tannlegetidende.no)
Both hyperalgesia (lower pain threshold) and allodynia (pain perceived in non-sensory pathways) are involved in the development of visceral (gut) hypersensitivity. (helpforibs.com)
Interestingly, although people with IBS show this visceral hypersensitivity, their peripheral pain thresholds are normal or even elevated in comparison to healthy individuals. (helpforibs.com)
The newly discovered tarantula peptides allowed the researchers to isolate A-delta fibers in mice, and show that they also appear to play a role in touch hypersensitivity - when normally innocuous light touch causes discomfort - a type of pain common to diseases like shingles and many chronic pain syndromes. (neurosciencenews.com)
In both experiments, patients reported increased visual hypersensitivity on the Sensory Perception Quotient as compared to controls. (biomedcentral.com)

Defining and measuring sensory thresholds requires setting the sensitivity limit such that the perception observations lead to the absolute threshold. (wikipedia.org)
The level of sensitivity is usually assumed to be constant in determining the threshold limit. (wikipedia.org)
Higher habitual dietary caffeine consumption is related to lower experimental pain sensitivity in a community-based sample. (umassmed.edu)
It also explains the increased sensitivity to pain. (eorthopod.com)
Cryolipolysis produced a marked decrease in mechanical and thermal pain sensitivity. (harvard.edu)
Not only subjective measures improved, but also mechanical pain sensitivity differed significantly between the two groups, suggesting that cupping has an influence on functional pain processing. (biomedcentral.com)
The end result is heightened pain sensitivity and abnormal gut motility, in the form of irregular or increased GI muscle contractions. (helpforibs.com)
Other research by the Pain Management Unit has looked at the relationship between gender differences in anxiety sensitivity and pain. (sciencedaily.com)
Anxiety sensitivity is the tendency to be fearful of anxiety-related sensations (e.g., rapidly beating heat), and seems to be important in the experience of pain sensations. (sciencedaily.com)
Here, the goal was to determine whether factors such as age and/or disease severity may exert a modulatory influence on sensory sensitivity, cortical excitability, and habituation. (biomedcentral.com)
Sensory sensitivity was assessed with the Sensory Perception Quotient and group comparisons were carried out. (biomedcentral.com)
One of the questionnaires used to assess sensory sensitivity is the Sensory Perception Quotient (SPQ), which evaluates a variety of visual parameters and has been used in both healthy and clinical populations [ 16 ]. (biomedcentral.com)

GM-CSF is also involved in bone cancer pain development by regulating tumor-nerve interactions, remodeling of peripheral nerves and sensitization of damage-sensing (nociceptive) nerves. (iasp-pain.org)
Prediction of peripheral nerve stimulation thresholds of MRI gradient coils using coupled electromagnetic and neurodynamic simulations [tech./dosim. (emf-portal.org)
Predicting Magnetostimulation Thresholds in the Peripheral Nervous System using Realistic Body Models [tech./dosim. (emf-portal.org)
Environmental Health Perspectives Vol. 44, pp. 23-30, 1982 Structure and Function of the Somatosensory System: A Neurotoxicological Perspective by Joseph C. Arezzo*, Herbert H. Schaumburg* and Peter S. Spencer* The somatosensory system comprises those elements of the peripheral nervous system (PNS) and the central nervous system (CNS) subserving the modalities of touch, vibration, tempera- ture, pain and kinesthesia. (cdc.gov)

At the circuitry level, PVA received innervation from central nucleus of amygdala, a known pain-associated locus. (iasp-pain.org)
Sensory innervation of the periodontal ligaments provides proprioceptive information about pressure on the teeth and oral stereognosis (perceiving the form of an object) as well as jaw opening and salivation reflexes. (medscape.com)

The second stage is characterized by burning pain, allodynia, hyperalgesia, coolness of the skin, hair loss, changes in skin such as paleness, and brittle or cracked nails. (eorthopod.com)
Allodynia is when pain is felt from stimulation which is not usually painful, such as light touch or a breeze. (eorthopod.com)

Both chronic whiplash-associated disorders and idiopathic neck pain groups were characterized by mechanical hyperalgesia over the cervical spine. (lww.com)
Conversely, inhibition of PVA neuronal activity using DREADDs (designer receptors exclusively activated by designer drugs) or inactivation of PVA extracellular signal-regulated kinase at the critical time window blunted mechanical hyperalgesia in chronic pain models. (iasp-pain.org)
Hyperalgesia is an increased, prolonged pain response. (eorthopod.com)
The pathophysiology of this visceral hyperalgesia (lower pain threshold in the gut) is incompletely understood and appears to be stem from multiple factors. (helpforibs.com)

Rolke R, Campbell KA, Magerl W, Treede RD. Deep pain thresholds in the distal limbs of healthy human subjects. (smw.ch)
The present report highlights these features and, furthermore, suggests that analysis of these regions is invaluable in studying the three most common varieties of toxic neuropathy: toxic distal axonopathy, toxic myelinopathy and toxic sensory neuronopathy. (cdc.gov)

Effects of subthalamic deep brain stimulation with duloxetine on mechanical and thermal thresholds in 6OHDA lesioned rats. (umassmed.edu)
Mechanical and thermal pain thresholds were measured on treated and contralateral untreated (control) flanks. (harvard.edu)
Details] Human exposure to a specific pulsed magnetic field: effects on thermal sensory and pain thresholds [med. (emf-portal.org)
The expression of temperature-sensitive ion channels has been extensively investigated because thermal stimulation often evokes tooth pain. (mdpi.com)

CRPS is felt to occur as the result of stimulation of sensory nerve fibers. (eorthopod.com)
The result is inflammation or swelling leading to more stimulation of the sensory nerve fibers. (eorthopod.com)
Our data suggest that controlled skin cooling to specifically target cutaneous nerve fibers has the potential to be useful for prolonged relief of cutaneous pain and might have a use as a research tool to isolate and study cutaneous itch-sensing nerves in human skin. (harvard.edu)
In order to do this, you would need to find a way to control the cohort of nerve fibers that transmit the specific type of pain you would like to block. (neurosciencenews.com)
This spider's massive fangs deliver a poison that causes excruciating pain in part by triggering a specific kind of sodium channel within A-delta nerve fibers, according to the new research. (neurosciencenews.com)

Researchers conducted a study to determine whether there is an association between vibration detection thresholds and sensory responses in patients with type 1 and type 2 diabetes. (clinicalpainadvisor.com)
Patients with type 1 diabetes (T1D) may be more hypoalgesic to bone pressure pain detection thresholds (pPDT) and pressure pain tolerance thresholds (pPTT), regardless of lower vibration detection thresholds (VDT), according to results of a study recently published in Frontiers in Pain Research . (clinicalpainadvisor.com)
Pain in the upper extremities is a common symptom in workers with Hand-Arm Vibration Syndrome (HAVS). (cdc.gov)
In addition, the mechanical-detection thresholds (MDT), vibration-detection thresholds (VDT), and pressure-pain thresholds (PPT) were determined at pain-related and control areas. (biomedcentral.com)
Instead, measuring the vibration perception threshold (VPT) by 64 Hz graduated Rydel-Seiffer tuning fork has become standard clinical practice to screen for neuropathy and ulcer proneness. (smw.ch)
Does instantaneous blood glucose affect vibration perception threshold measurement using biothesiometer? (smw.ch)

Low back pain (LBP) is a musculoskeletal complaint that can be defined as pain or discomfort referred to the lower part of the spine, between the last thoracic vertebra and the first sacral vertebra, above the upper gluteal line, and which may or may not radiate to the lower limbs. (researchgate.net)
Maximal voluntary isometric contraction and evoked torque, muscle architecture, sensory discomfort (visual analog scale), and electromyographic activity were evaluated before and after the 6-week period. (humankinetics.com)
If someone is hypersensitive, they may experience significant discomfort or 'overload' from sensory input and be sensation avoidant, whereas if they are hyposensitive, they may not be receiving sufficient sensory input and be sensation seeking. (nursinginpractice.com)

Tiling and somatotopic alignment of mammalian low-threshold mechanoreceptors. (iasp-pain.org)
VGLUT3-expressing unmyelinated low-threshold mechanoreceptors (C-LTMRs) are proposed to mediate pleasant touch and/or pain, but the molecular programs controlling C-LTMR development are unknown. (jneurosci.org)

Established diabetic neuropathy leads to pain and foot ulceration. (diabetesjournals.org)

Stress has been found to alter pain thresholds and contribute to central sensitization by affecting the circuitry in the top-down modulation of pain from brain to dorsal horn cells. (bcmj.org)
There is increasing evidence that provoked vestibulodynia is associated with central sensitization of the pain circuits within the brain and spinal cord, and that small-group psychoeducation programs can help women with this distressing condition. (bcmj.org)
It is believed that, as a result of central sensitization, a sensory memory response is created, which exaggerates and prolongs subsequent stimulation. (helpforibs.com)
Acute pain can become chronic over time through central sensitization. (news-medical.net)
So far, the presence of central sensitization has not been considered as a confounding factor in studies assessing the pain inhibitory effect of tens on osteoarthritis of the knee. (biomedcentral.com)
The purpose of this study is to explore the pain inhibitory effect of burst tens in OAk patients and to explore the prognostic value of central sensitization on the pain inhibitory effect of tens in OAk patients. (biomedcentral.com)
Central sensitization embodies modified sensory processing in the brain and malfunctioning of descending pain-inhibitory mechanisms [ 15 ]. (biomedcentral.com)

We therefore set up a diagnostic case-control study to compare the VPT, the cutaneous pressure pain perception threshold (CPPPT) and the deep pressure pain perception threshold (DPPPT) at the foot sole in diabetic patients with and without past or present painless plantar ulcer. (smw.ch)
Changes in sensory quantification (electrical perception threshold) of up to five levels below the site of spinal injury were observed," reported Gulliem Cuatrecasas, MD, PhD, an endocrinologist from Hospital Quiron-Teknon, Barcelona, Spain, who presented the work here at the European Congress of Endocrinology (ECE) 2017 . (medscape.com)

PEMF devices can affect the levels of calcium and nitric oxide in tissues, which can influence extensive and complex pathways involved in metabolism, inflammation, pain transduction, tissue growth and repair, and many other biological activities. (veterinarypracticenews.com)
The Togo starburst tarantula's venom struck them as being particularly interesting because it appeared to activate a particular type of sodium channel within sensory nerves that was not a part of known pain pathways. (neurosciencenews.com)

In psychophysics, sensory threshold is the weakest stimulus that an organism can sense. (wikipedia.org)
Absolute threshold: the lowest level at which a stimulus can be detected. (wikipedia.org)
Recognition threshold: the level at which a stimulus can not only be detected but also recognized. (wikipedia.org)
Differential threshold: the level at which an increase in a detected stimulus can be perceived. (wikipedia.org)
Terminal threshold: the level beyond which any increase to a stimulus no longer changes the perceived intensity. (wikipedia.org)
The strength of the stimulus, perceived in more than half of the presentations, will be taken as the threshold. (wikipedia.org)
These conclusions are based on several studies into the pain response of volunteers exposed to a pain stimulus, such as a cold water bath, as well as field studies in clinics and hospitals. (sciencedaily.com)

Additionally, "the protocol revealed differences in responses to bone pain between [patients with] T1D [vs those with] T2D," which may be of interest in future research. (clinicalpainadvisor.com)
There were also significant differences in the SF-36 subscales for bodily pain (Δ13.8, p = 0.006) and vitality (Δ10.2, p = 0.006). (biomedcentral.com)
PET scans show pronounced differences in the activation of certain parts of the brain relating to perception and pain in IBS patients versus normal individuals. (helpforibs.com)
Scientists investigating gender differences in pain have found that not only do women report more pain throughout the course of their lifetime, they also experience it in more bodily areas, more often and for longer duration when compared to men. (sciencedaily.com)
There also seem to be differences in how men and women think and feel about their pain. (sciencedaily.com)
Unfortunately all too often the differences between males and females are not considered in pain research or practice, and instead are either ignored or statistically averaged. (sciencedaily.com)
There remains much discussion in the scientific community about why these gender differences in pain exist. (sciencedaily.com)
Ribeirão Preto, PAHO/WHO Collaborating Centre for Nursing in pressure pain threshold, with significant differences in Research Development, Ribeirão Preto, SP, Brazil. (bvsalud.org)
The sensory test was specially designed to detect subclinical intraindividual differences, said Dr Cuatrecasas. (medscape.com)

Patellofemoral pain (PFP) may contribute to less activation of the quadriceps muscle, favoring joint overload and pain. (researchgate.net)
Sensory overload can lead to sensory meltdowns. (understood.org)

Pain in the upper extremities that arises proximal to the hand is thought to be due mainly to musculoskeletal factors. (cdc.gov)

As the measurements come closer to the absolute threshold, the variability of the noise increases, causing the threshold to be obscured. (wikipedia.org)
A universal absolute threshold is difficult to define a standard because of the variability of the measurements. (wikipedia.org)
It might also, indirectly, help to reduce the number of animals needed for experimental purposes: uncontrolled pain or distress can increase variability in experimental data and so require the use of more animals in a study for it to achieve statistical significance. (nationalacademies.org)
Details] Perception of ELF electromagnetic fields: excitation thresholds and inter-individual variability [med. (emf-portal.org)

The special surface of the Sensory Ball increases sensations and aims to stimulate nerve endings for enhanced relaxation. (backcountry.com)
Whilst women tend to focus on the emotional aspects of pain they experience, men tend to focus on the sensory aspects, for example concentrating on the physical sensations they experience. (sciencedaily.com)
Researchers believe that it is the fear of anxiety-related sensations and an increased tendency to negatively interpret such sensations, both of which are more predominant in women than men that influences women's experiences of pain. (sciencedaily.com)
What if there were a drug that could specifically block pain, but leave the rest of your sensations alone? (neurosciencenews.com)

Relieve tension in your muscles with the PTP Sensory Ball. (backcountry.com)
Pain remains a major cause of morbidity and mortality worldwide and the current drugs used to treat pain cannot fully relieve pain due to inadequate effectiveness, especially in chronic pain [ 6 ]. (hindawi.com)
The use of tens to relieve knee pain in osteoarthritis of the knee (OAk) is recommended in various clinical guidelines as a conservative treatment to relieve knee pain [ 10 - 12 ]. (biomedcentral.com)
Applying creams and lotions containing capsaicin, the active chemical in capsicum, can temporarily relieve chronic pain from several conditions. (medlineplus.gov)

Chapters 2 - 4 focus on what is known about pain, stress, and distress in humans and animals. (nationalacademies.org)
Scepticism argues for the suspension of judgment , hence, despite the uncertain nature of an objective reality, the subjective experience of pain in humans is real and represents the truth of pain. (wikibooks.org)

Amount of stimulation required before the sensation of pain is experienced. (nih.gov)
When your dentist injects lidocaine into your gums, the drug blocks the pain of the oncoming drill, but it also blocks all other sensation - leaving your mouth feeling numb and swollen. (neurosciencenews.com)
QUESTION UNDER STUDY: Repetitive skin trauma and reduced pressure pain sensation are necessary components of plantar ulcer risk in patients with diabetic neuropathy. (smw.ch)

We also collaborate with Pruitt's group in Mechanical Engineering (http://microsystems.stanford.edu) to develop and fabricate novel devices for the study of sensory transduction. (stanford.edu)

Tens influences pain through the electrical stimulation of low-threshold A-beta cutaneous fibers. (biomedcentral.com)

Sleep quality and acute pain response in a chronic pain population. (umassmed.edu)
Surprisingly, both acute and chronic mechanical pain was largely unaffected in these Runx1 mutants. (jneurosci.org)
Acute pain can result at each point along this crane due to excess tension between the gravity-bound load and the support scaffold. (news-medical.net)
Trigeminal neuralgia is def ined by the International Association for the Study of Pain (IASP) as a "sudden, usually unilateral, severe and brief pain episodes occurring in one the distribution of one or more branches of the trigeminal nerve" 32,46 and characterized by severe, acute, electric shock-like piercing pain, followed by refractory period 3,24 . (bvsalud.org)

Our research has shown that whilst the sensory-focused strategies used by men helped increase their pain threshold and tolerance of pain, it was unlikely to have any benefit for women," said Dr Keogh. (sciencedaily.com)
The cold pressor tank allows researchers to monitor the pain threshold (the point at which volunteers first notice the pain) and pain tolerance (the point at which volunteers can no longer stand the pain). (sciencedaily.com)
They may also be undersensitive to pain and have an unusually high tolerance for it. (understood.org)

Patients had significant higher spatial discrimination thresholds at CRPS-affected extremities compared to both unaffected sides and control subjects. (nih.gov)
Two other senses, body awareness (proprioception) and spatial orientation (the vestibular sense) , can also affect kids with sensory issues. (understood.org)

Most of the nerves are motor, but some are sensory. (eorthopod.com)

Methods have been developed to measure thresholds in any of the senses. (wikipedia.org)
Sensory processing issues are difficulties with organizing and responding to information that comes in through the senses. (understood.org)

Our findings describe a novel bone cancer pain mechanism and provide a new insight into the physiological and pathological functions of GM-CSF.It has been reported that GM-CSF plays a key role in bone cancer pain, yet the underlying mechanisms involved in GM-CSF-mediated signaling pathway in nociceptors is not fully understood. (iasp-pain.org)

Even though provoked vestibulodynia can be confirmed through physical examination and the sexual and pain symptoms are characteristic, diagnosis is typically delayed unduly. (bcmj.org)

The focus of our research is understanding, measuring, and treating people with pain associated with osteoarthritis of the knee. (nottingham.ac.uk)

Recently, several functional imaging studies have shown that sensorimotor cortical representations may be changed in complex regional pain syndromes (CRPS). (nih.gov)
In this preliminary trial we investigated the effects of dry cupping, an ancient method for treating pain syndromes, on patients with chronic non-specific neck pain. (biomedcentral.com)
Women with provoked vestibulodynia have lower pain thresholds in nongenital sites when compared with control subjects, and comorbidity with other chronic pain syndromes is common. (bcmj.org)

The causes of chronic neck pain are manifold and can include inflammatory diseases, degenerative processes, trauma, space-occupying lesions, or systemic conditions. (biomedcentral.com)
Such behavioral processes can be short-term and adaptive or, as in cases of chronic pain and other potential sources of distress, can continue to the point where they become maladaptive. (nationalacademies.org)
Biology takes a positivist approach to pain, arguing that the only way of knowing is through biological processes that offer an objective representation of reality and therefore hold the data from sensory encoding as empirical data. (wikibooks.org)
Previous studies exploring whether sensory processing is altered in migraine have focused on different processes. (biomedcentral.com)

Measurement of magnetostimulation thresholds in the porcine heart [med. (emf-portal.org)

Small-group programs providing psychoeducation and cognitive behavioral therapy or mindfulness-based cognitive therapy have been found to ameliorate the pain and suffering from provoked vestibulodynia. (bcmj.org)

The first systematic studies to determine sensory thresholds were conducted by Ernst Heinrich Weber, a physiologist and pioneer of experimental psychology at the Leipzig University. (wikipedia.org)
9,10 However, systematic reviews of studies evaluating PEMF for pain associated with osteoarthritis (OA) of the knee are mixed, with some showing no effect, 11 some inconclusive, 12-15 and others suggesting some benefit. (veterinarypracticenews.com)

Pressure pain thresholds were measured over the articular pillars of C2-C3, C5-C6, the median, radial, and ulnar nerve trunks in the arm and over a remote site, the muscle belly of tibialis anterior. (lww.com)

In some patients a constant background pain may persist, additionally to pain attacks, which can make difficult to differentiate the trigeminal neuralgia from other orofacial pain types. (bvsalud.org)

Displacement of the dome by as little as 5 ,um can result in a supra-threshold generator potential within the Merkel cell-axon ter- minal complex. (cdc.gov)

As OA is a dynamic process that involves phases of inflammation with possible increase of pain during these phases, tens may then be indicated as a facilitator for exercise. (biomedcentral.com)

This review summarizes the recent knowledge underlying this paradoxical nociception, with a focus on the ion channels involved in tooth pain. (mdpi.com)

The normal correlation between subjective pain intensity and activation of the anterior cingulate and insula cortices parts of the brain is lost in IBS. (helpforibs.com)
While pain and suffering in another being is, strictly speaking, unknowable, yet for practical purposes there are a number of lines of evidence of their presence and intensity which deserve attention. (nationalacademies.org)
Transcutaneous spinal stimulation in people with and without spinal cord injury: Effect of electrode placement and trains of stimulation on threshold intensity [med. (emf-portal.org)

Identifying brain regions involved in persistent neuronal changes will provide new insights for developing efficient chronic pain treatment. (iasp-pain.org)
Conclusion: According to the new classification of the International Headache Society, classic trigeminal neuralgia is divided in purely paroxysmal and with concomitant persistent facial pain. (bvsalud.org)
According to the new classification of the International Headache Society (IHS) 18 , classic trigeminal neuralgia is caused by neurovascular compression more frequently through the superior cerebellar artery and is divided into classical trigeminal neuralgia purely paroxysmal and classical trigeminal neuralgia with concomitant facial persistent facial pain. (bvsalud.org)

Prediction of experimental cardiac magnetostimulation thresholds using pig-specific body models [tech./dosim. (emf-portal.org)

The authors believe that in most experimental and husbandry situations laboratory animals need not experience substantial pain or stress and that prevention and alleviation of pain and stress in laboratory animals is an ethical imperative. (nationalacademies.org)

Although TN presents a low prevalence in general population (i.e. 5-30 new patients per 100,000), trigeminal neuralgia is an important clinical concern both by pain severity and difficulty of its satisfactory control. (bvsalud.org)

Brain Cortical Stimulation Thresholds to Different Magnetic Field Sources Exposures at Intermediate Frequencies [tech./dosim. (emf-portal.org)

Migraine is a cyclic, neurosensory disorder characterized by recurrent headaches and altered sensory processing. (biomedcentral.com)
Migraine is often characterized as a cyclic, neurosensory disorder due to reports of altered sensory processing in both ictal (migraine attack) and interictal (attack-free) phases [ 1 , 2 ]. (biomedcentral.com)

Thanks for visiting Clinical Pain Advisor . (clinicalpainadvisor.com)
Don't miss out on today's top content on Clinical Pain Advisor . (clinicalpainadvisor.com)
Thought you might appreciate this item(s) I saw in The Clinical Journal of Pain. (lww.com)
Pain is often the main symptom in the clinical diagnosis of various human and animal diseases [ 1 ]. (hindawi.com)
Graziela Valle da Silva1 pain undergoing mindfulness-based interventions, by demonstrating brain, hormonal, and clinical changes. (bvsalud.org)

Diseases19

Chemicals and Drugs2

Analytical, Diagnostic and Therapeutic Techniques and Equipment3

Psychiatry and Psychology10

Phenomena and Processes9

Health Care3

Stimuli14

Neurons9

Quantitative9

Heat pain thresholds2

Neuropathic7

Hypersensitivity6

Sensitivity12

Peripheral4

Innervation2

Allodynia2

Hyperalgesia4

Distal2

Thermal4

Nerve fibers5

Vibration6

Discomfort3

Mechanoreceptors2

Foot ulceration1

Central sensitization7

Perception Threshold2

Pathways2

Stimulus7

Differences9

Overload2

Proximal1

Variability4

Sensations4

Relieve4

Humans2

Sensation3

Transduction1

Cutaneous1

Acute4

Tolerance3

Spatial2

Nerves1

Senses2

Pathological1

Symptoms1

Osteoarthritis of the knee1

Syndromes3

Processes4

Measurement1

Cognitive1

Systematic2

Pressure pain1

Orofacial Pain1

Supra-threshold1

Inflammation1

Nociception1

Intensity3

Persistent3

Prediction1

Experimental1

Severity1

Cortical1

Neurosensory2

Clinical5