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  • GABA
  • Neurosteroids appear to affect sensitivity to ethanol in specific brain regions and, consequently, specific behavioral tests, possibly related to the efficacy and potency of ethanol to potentiate the release of GABA and increase neurosteroid concentrations. (frontiersin.org)
  • Thus, the GABA A receptor complex was identified as a membrane-bound target providing a pharmacological basis for shared sensitivity between neurosteroids and ethanol. (frontiersin.org)
  • Beta-adrenergic binding sites in the cerebral cortex are increased and gamma-aminobutyric acid (GABA) binding sites are decreased. (medscape.com)
  • oxidative
  • Thyroid hormones have profound effects on mitochondrial oxidative activity, synthesis and degradation of proteins, sensitivity of tissues to catecholamines, differentiation of muscle fibers, capillary growth, and levels of antioxidant enzymes and compounds. (medscape.com)
  • amino
  • Quisqualate-sensitive sites accounted for 80% of the total binding sites already at postnatal day 15, while displacement by alpha-amino-3-hydroxy-methyl-4-isoxazolepropionic and ibotenic acids attained the maximum (68%) at postnatal day 60. (muscimol.xyz)
  • In adults, the majority of glutamate binding sites were ion-independent and mainly sensitive to D,L-amino-5-phospho-valeric acid and N-methyl-D-aspartate. (muscimol.xyz)
  • steroids
  • Although direct interaction of ethanol and neuroactive steroids at common receptor binding sites has been suggested in some studies, this proposition is still controversial. (frontiersin.org)
  • Other evidence suggests that steroids bind more intracellularly in β + -α − interfaces. (asahq.org)
  • mitochondrial
  • The cognitive decline of TGM was abolished by a complex "anti-aging" dietary supplement formulated to promote membrane and mitochondrial integrity, increase insulin sensitivity, reduce reactive oxygen and nitrogen species, and ameliorate inflammation. (chiro.org)
  • propofol
  • Some evidence points to outer transmembrane β + -α − interfacial pockets, near sites that bind the anesthetics etomidate and propofol. (asahq.org)
  • channel
  • These models explicitly predicted that an aromatic residue in the CNG channel aligning with leucine 61 of CAP forms an interaction with the bound cyclic nucleotide. (aspetjournals.org)
  • The position of Y565 at the "hinge" between the C helix and another portion of the binding domain, and the consequences of Y565 mutations, strongly suggest that this portion of the binding domain is involved in channel gating processes. (aspetjournals.org)
  • Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (bioon.com.cn)
  • activity
  • This review will highlight a variety of mechanisms by which neurosteroids affect sensitivity to ethanol, including physiological states associated with activity of the hypothalamic-pituitary-adrenal (HPA) and hypothalamic-pituitary-gonadal (HPG) axes, and the effects of chronic exposure to ethanol, in addition to behavioral implications. (frontiersin.org)
  • levels of glutamate dehydrogenase and pyruvate dehydrogenase activity in the brain are reduced. (medscape.com)
  • sites
  • Autoradiographic characterization of [3H]L-glutamate binding sites in developing mouse cerebellar cortex. (muscimol.xyz)
  • Postnatal changes of [3H]L-glutamate binding sites in mouse cerebellum were studied by in vitro autoradiography. (muscimol.xyz)
  • At birth, these binding sites were diffused through the whole cerebellar mass, but became distinctly concentrated in the molecular and the internal granular layers by postnatal day 10. (muscimol.xyz)
  • These transient binding sites were sensitive to quisqualic and ibotenic acid. (muscimol.xyz)
  • The localized postnatal changes of the [3H]L-glutamate binding sites were correlated with the events occurring during growth and maturation of cerebellar structures. (muscimol.xyz)
  • higher
  • In the molecular layer the Cl-/Ca2+ effect increased during ontogeny until, in adults, the ion-dependent binding was threefold higher than the ion-independent binding. (muscimol.xyz)
  • site
  • Starting from postnatal day 15, binding site density in the molecular layer of lobules VIb and VII of the vermis was lower than in other lobules. (muscimol.xyz)