ApoptosisAutophagyInflammationNeuronsStreptococcusStress-inducedEpithelialPainfulExtracellularMechanismsFindingsTumorGeneNauseaTreatmentsProliferationRadiation therapyPathwayBacterialInflammatoryErectileCancersCompoundsIncreasesResponsesPeripheralSpermMRNACellsClinicalCancerDamageDrugCellTherapySurgeryProvideHumanTimeNormalShowResearchGroup
Apoptosis5
- RvD1 seems to advertise alveolar epithelial restore by stimulating ATII cells wound repair, proliferation, reducing apoptosis, and inhibiting TGF-β-induced EMT. (perfect-curve.com)
- Gain of function and loss of function experiments showed that PDCD4 induced turnover (proliferation and apoptosis) of HUVECs. (plos.org)
- PDCD4 induces turnover (proliferation and apoptosis) of HUVECs. (plos.org)
- RT can directly induce cancer cell death through various mechanisms, such as apoptosis, necrosis, and autophagy. (nature.com)
- These potent effects are driven by curcumin's ability to induce G2/M cell cycle arrest, induce autophagy, activate apoptosis, disrupt molecular signaling, inhibit invasion and metastasis, and increase the efficacy of current chemotherapeutics. (hindawi.com)
Autophagy1
- Out of the seven tested recombinant human RNases, we have identified two members, RNase3 and RNase6, which were highly effective against Mycobacterium aurum extra- and intracellularly and induced an autophagy process. (frontiersin.org)
Inflammation6
- Ample evidence shows that pro-atherosclerotic disturbed flow induces sustained activation of atherogenic genes in endothelial cells to promote their oxidation, inflammation, cell cycle progression and proliferation, whereas pulsatile shear stress tends to maintain endothelial cells in a quiescent and less proliferative state with a low level of oxidation and inflammation [16] , [17] . (plos.org)
- It stimulates the immune system, helps reduce inflammation, and possesses antimicrobial properties that can help protect against bacterial and viral infections. (easytohealth.com)
- Although leukocyte count and serum C-reactive protein did not suggest inflammation, empiric antimicrobial chemotherapy with ceftriaxone, ampicillin, gentamicin, and acyclovir was started immediately. (cdc.gov)
- Together our results reveal the potential ability of gefitinib to initiate sterile inflammation via two distinct mechanisms, and identified IL-1β and HMGB1 as key determinants of gefitinib-induced inflammation that may provide insights into gefitinib-induced interstitial pneumonitis. (nature.com)
- We previously showed that genotoxic stress induced an active extracellular release of nucleophosmin (NPM) in human cardiac mesenchymal progenitor cells, and that serum deprivation provokes NPM secretion from human endothelial cells, eliciting inflammation via nuclear factor kappa B (NF-kB) transcriptional activation. (frontiersin.org)
- Another consequence of aging is the accumulation of so-called senescent cells, normal cells that stop dividing, contribute to tissue aging and secrete substances like cytokines that induce inflammation. (qualitycounts.com)
Neurons3
- The obtained data demonstrated that VBC treatment reduced the inflammatory mediators secreted by LPS-stimulated microglia, diminished their neurotoxic effects against neurons, and induced changes in phenotype profile toward M2 microglia type. (bvsalud.org)
- By using a combination of optogenetics, in vivo electrophysiology, and machine learning analysis, we find that a subset of neurons in the ACC receives S1 inputs, and activation of the S1 axon terminals increases the response to noxious stimuli in ACC neurons. (iasp-pain.org)
- Animals with pain after chronic constriction injury of the infraorbital nerve (CCI-Pain) displayed higher spontaneous and evoked activity in PB neurons, and a dramatic increase in after-discharges-responses that far outlast the stimulus-compared to controls. (iasp-pain.org)
Streptococcus1
- It may also invade and proliferate within heart and coronary artery endothelial cells, and, along with Streptococcus sanguis, it may also induce platelet aggregation associated with thrombus formation. (medscape.com)
Stress-induced3
- Immunoprecipitation revealed that pulsatile shear stress induced the coupling of ubiquitin with PDCD4 expression. (plos.org)
- Atherosclerosis plaques preferentially develop at arterial branches and curvatures under low and oscillatory or even static shear stress induced by disturbed blood flow as opposed to in straight parts, featuring protective unidirectional pulsatile shear stress [14] , [15] . (plos.org)
- The importance of these pathways in cancer prevention is illustrated by the fact that individuals who inherit mutations in any one of the many genes that participate in these stress-induced signal transduction pathways have a very high incidence of cancer. (the-scientist.com)
Epithelial2
- The aim of this study was to investigate whether or not RvD1 exerts protective results on alveolar epithelial cell perform/differentiation and protects towards fibroproliferative stimuli. (perfect-curve.com)
- Initial works revealed that activation of the EMT program in epithelial cells induces the acquisition of stem cell properties, which in the context of cancer may contribute to the appearance of tumor initiating cells (TIC). (mdpi.com)
Painful2
- Pau d'arco is noted clinically for its ability to reduce sensitivity to painful stimuli and swelling, according to BMC Pharmacology . (naturalnews.com)
- One of the most painful side effects of Chemotherapy is peripheral neuropathy pain, which comes in different forms including tingling, burning sensation, and pain in hands and feet. (carolinapainscrambler.com)
Extracellular1
- Both the innate stimuli, such as lipopolysaccharides and Poly inositol-cytosine and adaptive stimuli, that is, cytokine mix, were able to induce the extracellular release of NPM in immortalized keratinocytes and human skin fibroblasts in the absence of cytotoxicity. (frontiersin.org)
Mechanisms5
- Findings from the Cusack Laboratory have shown that conventional anti-cancer therapies, such as radiation and chemotherapy, induce resistance mechanisms under the control of the gene transcription factor NF-kappaB. (massgeneral.org)
- 3 Such cellular-suicide mechanisms can eliminate cells that could present problems for the whole organism because of alterations in the DNA or difficulties in dealing with stressful stimuli. (the-scientist.com)
- Although these cellular-suicide mechanisms may protect the organism in some physiologic settings, such as by preventing cancer, the double-edged sword is that these same DNA-damage response pathways that help prevent cancer can also contribute to debilitating disease processes. (the-scientist.com)
- Inquest of the regulation of the prominence return traditionally led to a richer reconsider sensitivity of gene regulatory mechanisms, and bourgeoning has been made in this attentiveness in T. Shi SR, Key ME, Kalra KL (1991) Antigen retrieval in formalin-fixed, paraffin-embedded pile: an enhancement method for immuno- histochemical staining based on microwave oven heating of tissue sections. (wgc2010.sk)
- However, clinical trials testing the impact of exercise interventions on chemotherapy-induced cognitive decline in patients with cancer are lacking, and the mechanisms through which exercise could improve cognitive function are unclear. (researchprotocols.org)
Findings1
- If positive, our findings will establish the pilot efficacy of HIIT on chemotherapy-induced cognitive function in patients with breast cancer, providing the foundation for future larger phase-II and phase-III trials to confirm the findings and potentially establish HIIT as a standard of care for women undergoing chemotherapy for breast cancer. (researchprotocols.org)
Tumor1
- Moreover, NPM is crucial for inflammatory gene expression induced by tumor necrosis factor alpha (TNF-α) and lipopolysaccharides (LPS) in fibroblasts and macrophages ( 6 ). (frontiersin.org)
Gene1
- The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of organic hydroperoxides and hydrogen peroxide (H2O2) by glutathione, and thereby protect cells against oxidative damage. (nih.gov)
Nausea1
- It is often recommended for relieving chemotherapy, pregnancy, or motion sickness-related nausea. (easytohealth.com)
Treatments3
- The emergence of immunotherapy has recently disrupted the paradigm of traditional cancer treatment (including the three traditional treatments RT, chemotherapy, and surgery), and immunotherapy functions by activating the body's immune system to fight cancer. (nature.com)
- Calmare "Pain Scrambler" Therapy can ease the pain caused by chemotherapy and other cancer treatments. (carolinapainscrambler.com)
- It's worth noting that reduced pain caused by chemotherapy can even help patients endure their consistent chemotherapy treatments over time. (carolinapainscrambler.com)
Proliferation1
- Moreover RvD1 inhibited human lung fibroblast proliferation, collagen production, and myofibroblast differentiation induced by both TGF-β and bronchoalveolar lavage fluid from acute respiratory distress syndrome (ARDS) patients. (perfect-curve.com)
Radiation therapy2
- It is also common to combine radiation therapy with surgery, chemotherapy, hormone therapy, Immuno-therapy or some mixture of the four. (medicalmarijuana.com)
- The use of radiation therapy in non-malignant conditions is limited partly by worries about the risk of radiation-induced cancers. (medicalmarijuana.com)
Pathway1
- Pulsatile shear stress induces ubiquitin-proteasome-mediated degradation of PDCD4 via a PI3K/Akt pathway in HUVECs. (plos.org)
Bacterial2
- Because the bacterial biofilm is responsible for an aggressive surgical approach and prolonged antibiotic treatment, the nanoparticles have been functionalized with a functional coating able to both disaggregate the biofilm, hamper premature antibiotic release and protect the intact bone. (ucm.es)
- The pathophysiology of erythema multiforme (EM) is still not completely understood, but it is probably immunologically mediated and appears to involve a hypersensitivity reaction that can be triggered by a variety of stimuli, particularly bacterial, viral, or chemical products. (medscape.com)
Inflammatory1
- These activate both arousability and the testicular artery, a branch (which form the intrinsic back sacral spinous processes with patients as renal transplant vasculitits 190 penile surgery arteriovenous malformations vascular arterial compromise veno-occlusive dysfunction metabolic abnormalities, which can such as playing or graphic movies and magazines contributes to the pelvis and urinary continence and preoperative introduction chemotherapy followed by an inflammatory reaction. (ben.edu)
Erectile1
- This is usually performed between to have drug-induced erectile dysfunc- 18. (ben.edu)
Cancers1
- As one of the four major means of cancer treatment including surgery, radiotherapy (RT), chemotherapy, immunotherapy, RT can be applied to various cancers as both a radical cancer treatment and an adjuvant treatment before or after surgery. (nature.com)
Compounds2
- Metallothionein biosynthesis can also be induced by certain hormones, pharmaceuticals, alcohols, and other compounds. (wikipedia.org)
- Both compounds induced up-regulation of proapoptotic BH3-only proteins Bim and Puma, and subsequent cell death. (ashpublications.org)
Increases1
- Over time, as chemotherapy increases, these side effects also tend to increase. (carolinapainscrambler.com)
Responses1
- It also stimulates brain responses to sexual stimuli and may improve libido and overall sexual health. (easytohealth.com)
Peripheral2
- Patients who use the Pain Scrambler to combat side effects of chemotherapy have found relief, especially from the pain of peripheral neuropathy pain. (carolinapainscrambler.com)
- Continued treatment helps reduce overall pain for chemotherapy patients, and there is no other treatment as effective or safe for peripheral neuropathy pain. (carolinapainscrambler.com)
Sperm1
- It also helps protect sperm from oxidative stress, a leading cause of male infertility. (easytohealth.com)
MRNA1
- After ovariectomy, expression of OPG mRNA was suppressed however that of RANKL was induced. (perfect-curve.com)
Cells3
- When associated with dacarbazine, bixin restored the sensitivity of A2058 cells to chemotherapy, enhancing its antiproliferative, anti-migratory and pro-apoptotic effects. (perfect-curve.com)
- En face co-immunostaining of the mouse aortic arch revealed a low level of PDCD4 in endothelial cells undergoing pulsatile shear stress. (plos.org)
- RT-induced damage to cancer cells leads to different outcomes, such as survival, senescence, or death. (nature.com)
Clinical1
- Dr. Cusack wrote the first clinical trial of combination chemotherapy with the drug bortezomib for solid organ malignancies, reported in the journal Cancer . (massgeneral.org)
Cancer6
- Optimiser les soins des patients atteints du cancer de la prostate résistant à la castration en utilisant une stratégie de triple traceur en imagerie moléculaire et en radiothérapie ciblée. (usherbrooke.ca)
- Currently, it's challenging to predict what method of HIF inhibition mixed with chemotherapy will make improvements to the cancer therapy. (hdacassay.com)
- Women diagnosed with breast cancer who receive intravenous chemotherapy treatment at a quaternary referral metropolitan cancer centre in Melbourne, Australia, will be recruited. (biomedcentral.com)
- More than 75% of patients with breast cancer treated with chemotherapy experience cognitive impairments (eg, memory and attention problems), commonly known as chemo-brain . (researchprotocols.org)
- The objective of the Improving Cognitive Function Through High-Intensity Interval Training in Breast Cancer Patients Undergoing Chemotherapy trial is to examine the effects of HIIT on cognitive function in patients with breast cancer undergoing chemotherapy. (researchprotocols.org)
- This 2-arm, single-center, pilot randomized controlled trial will randomize 50 patients with breast cancer undergoing chemotherapy to HIIT or attention control. (researchprotocols.org)
Damage2
- It aids recovery and promotes faster healing of exercise-induced muscle damage. (easytohealth.com)
- Drug-induced damage to these structures of the auditory and balance system can result in hearing loss, tinnitus , and dysequilibrium or dizziness . (medscape.com)
Drug3
- PSDDS wherein the drug release is controlled primarily by the delivery system, stimuli induced PSDDS in which release is controlled by the stimuli, such as the pH present in the intestinal tract. (scialert.net)
- The pH range of fluids in various segments of the gastrointestinal tract may provide environmental stimuli for responsive drug release. (scialert.net)
- Polymer drug conjugates, nano-based drug delivery systems can be utilized to protect normal body tissues from the adverse side effects of anticancer drugs and also to overcome drug resistance. (mdpi.com)
Cell1
- It is used, in contrast to necrosis, to describe the situation in which a cell actively pursues a course toward death upon receiving certain stimuli [ 7 ]. (biomedcentral.com)
Therapy1
- Cate that attempts to escape the dead- my me fuck takes boyfriend viagra and and friends his body appeared to depend to a complete or moderate impotence in adolescents with dsd is complex and obviously i don t necessarily protect them from the cluster working with lesbian, gay, and bisexual clients (pink therapy vol. (ben.edu)
Surgery1
- Dr. Cusack organized the Mass General Peritoneal Surface Malignancy Program in 2011 and treated his first patient with cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) in October 2011. (massgeneral.org)
Provide1
- In summary, our results provide novel experimental evidence that spared nerve injury-induced neuropathic pain reshapes gut microbial diversity, and alters the stability and key microbes in the gut. (biomedcentral.com)
Human1
- Intranasal trigeminal sensations are important in everyday life of human beings, as they play a governing role in protecting the airways from harm. (crnacs.com)
Time1
- We collected 66 fecal samples over 2 weeks (three mice and 11 time points in spared nerve injury-induced neuropathic pain and Sham groups). (biomedcentral.com)
Normal1
- We found that NPM was induced in 6 skin biopsies compared to 6 normal skin biopsies and was markedly increased in lesional (LS) vs. non-lesional skin (NLS) biopsies. (frontiersin.org)
Show1
- Here we show that spared nerve injury-induced neuropathic pain alters gut microbial diversity in mice. (biomedcentral.com)
Research1
- Research suggests ginger can improve fasting blood sugar levels and enhance insulin sensitivity. (easytohealth.com)
Group1
- Oscillospira , which was classified as a low-abundance and core microbe, was identified as the key microbe in the Sham group, whereas Staphylococcus , classified as a rare and non-core microbe, was identified as the key microbe in the spared nerve injury-induced neuropathic pain group. (biomedcentral.com)