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Mass SpectrometryChromatography, High Pressure LiquidTandem Mass SpectrometryChromatography, LiquidSpectrometry, Mass, Electrospray IonizationSpectrometry, Mass, Matrix-Assisted Laser Desorption-IonizationSensitivity and SpecificityGas Chromatography-Mass SpectrometryChromatography, AffinityChromatography, GasChromatography, Ion ExchangeChromatography, GelMolecular Sequence DataChromatography, Thin LayerChromatographyAmino Acid SequenceProteomicsReproducibility of ResultsProteomeSpectrometry, Mass, Secondary IonChromatography, Reverse-PhaseReference StandardsSpectrometry, Mass, Fast Atom BombardmentCalibrationMolecular WeightElectrophoresis, Polyacrylamide GelSpectrophotometry, UltravioletPeptidesIonic LiquidsLimit of DetectionElectrophoresis, Gel, Two-DimensionalMolecular StructureMagnetic Resonance SpectroscopySolid Phase ExtractionKineticsPeptide MappingIsotope LabelingPeptide FragmentsIndicators and ReagentsCarbohydrate SequenceCattleAmino AcidsTrypsinTime FactorsHydrogen-Ion ConcentrationDrug StabilityProteinsChemical FractionationBiotransformationMicrochemistryAcetonitrilesDeuterium Exchange MeasurementOligosaccharidesProtein BindingMetabolomicsIsomerismSubstrate SpecificityHydrolysisLiquid CrystalsEscherichia coliStereoisomerismSubstance Abuse DetectionRecombinant ProteinsChromatography, DEAE-CelluloseOxidation-ReductionIonsPolysaccharidesDeuteriumTemperatureLiverCarbohydrate ConformationBase SequenceBacterial ProteinsMutationGlycosylationChemistryChemistry Techniques, AnalyticalProtein Processing, Post-TranslationalCarbohydratesChromatography, AgarosePlant ExtractsChemical PhenomenaCell LineBiological MarkersBody Mass IndexMetabolomeBinding SitesAnalytic Sample Preparation MethodsSolventsElectrophoresis, CapillaryBrain ChemistryFourier AnalysisImmunoassaySpecies SpecificityMethanolRabbitsFatty AcidsBiological AssaySequence Homology, Amino AcidIsoelectric Focusing
HPLCTime-of-flight maTandemDetectionSpecificityQuadrupole massQuantitationAnalytesSupercritical Fluid ChromatoQuantify2023SelectivityAnalytical MethodsNano liquidSpectrometerSeparationPeptidesDemonstrated enhanced sensitivityPhytohormonesMetabolitesDetectorThroughputPrecisionProteomicHighRobustnessMethodsMethodInsulinProteinCharacterizationSpectrometersSolventRetentionApplicationsSoilProcedureMolecularPerformanceAnalyzerAnalysisVivoOrbitrapBiologySystemsVolatileExtractionClinical
HPLC4
  • These methods include gas chromatography (GC) combined with mass spectrometry (MS) and high-performance liquid chromatography (HPLC) combined with an ultraviolet detector (UV). (cdc.gov)
  • The main disadvantage of flight mass spectrometry (MALDI-TOF-MS) or by high- the mouse bioassay is that it requires euthanizing many ani- performance liquid chromatography (HPLC)-electrospray mals. (cdc.gov)
  • It also requires several days to determine the toxin ionization-tandem mass spectrometry (HPLC- level and type (4-6). (cdc.gov)
  • In addition to these two instruments, there are several other methods for estimating suspect PFAS concentrations, such as high-performance liquid chromatography (HPLC), ion chromatography, and inductively coupled plasma-mass spectrometry (ICP-MS). Each of these techniques has its own advantages and limitations, and the choice of method depends on the specific application and sample matrix. (chromatographytoday.com)
Time-of-flight ma3
  • We use a combination of MS techniques, namely liquid chromatography/electrospray ionization time-of-flight mass spectrometry (LC/ESI-TOF-MS) and liquid chromatography/electrospray ionization tandem mass spectrometry (LC/ESI-MS/MS) on a triple quadrupole, for the identification of the polyphenolic constituents of the soluble fraction of GADF. (unboundmedicine.com)
  • Furthermore, with the most commonly used chemometrics algorithms, it is difficult to accurately extract and discriminate the huge amounts of data generated by mass spectrometry, such as ultra-high performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UPLC-QTOF). (hindawi.com)
  • The product peptides derived from the endopeptidase injection containing a sample with more than a minimum activities of BoNTs are detected by matrix-assisted laser- lethal dose show symptoms of botulinum intoxication and desorption ionization time-of-flight mass spectrometry. (cdc.gov)
Tandem19
  • Therefore, in the present study, we performed untargeted lipid profiling of abalone tissues at different developmental stages as well as the hemolymph of mature female and male abalones using ultrahigh-performance liquid chromatography-tandem mass spectrometry. (hindawi.com)
  • Immunostained P. variotii antigens were excised and sequenced using nanoscale Ultra-Performance Liquid Chromatography Tandem Mass Spectrometry (nano scale UPLC-MS/MS). De-identified sera from 6 healthcare workers (HCW) and 2 non-atopics were used as controls. (cdc.gov)
  • Title : Two-dimensional high performance liquid chromatography separation and tandem mass spectrometry detection of atrazine and its metabolic and hydrolysis products in urine☆ Personal Author(s) : Kuklenyik, Zsuzsanna;Panuwet, Parinya;Jayatilaka, Nayana K.;Pirkle, James L.;Calafat, Antonia M. (cdc.gov)
  • Nano-flow liquid chromatography tandem mass spectrometry (nano-flow LC-MS/MS) is the mainstay in proteome research because of its excellent sensitivity but often comes at the expense of robustness. (nature.com)
  • 120,000 peptides in 16 h and sample multiplexing using tandem mass tags increases throughput to 11 proteomes in 16 h. (nature.com)
  • A team of scientists the Sports Medicine Research and Testing Laboratory at the University of Utah have developed a test that makes use of liquid chromatography-tandem mass spectrometry. (science20.com)
  • The method uses solid phase extraction (SPE) coupled with isotope dilution-ultrahigh performance liquid chromatography (UHPLC)-tandem mass spectrometry (Jayatilaka N.K., et. (cdc.gov)
  • The deconjugated target analytes in the urine extract are separated on an UHPLC system with reversed phase chromatography and quantified by isotope dilution tandem mass spectrometry. (cdc.gov)
  • Recently Romer Labs implemented an updated liquid chromatography with tandem mass spectrometry (LC-MS/MS) method. (dsm.com)
  • Benefits of prolonged gradient separation for high-performance liquid chromatography-tandem mass spectrometry quantitation of plasma total 15-series F-isoprostanes. (oregonstate.edu)
  • OxPC were extracted from BALF and specific OxPC species were identified and quantified by ultra-high performance liquid chromatography tandem mass spectrometry. (ersjournals.com)
  • Well, I guess it has been the workhorse in bioanalysis for many years prior to the ascent of LC-MS. However, in the early 2000s people started to move away from GC-MS towards triple quadrupole mass spectrometry (QqQ)‑based liquid chromatography tandem mass spectrometry (LC-MS/MS) methods that offered enhanced sensitivity for hydrophilic analytes. (chromatographyonline.com)
  • Liquid chromatography-tandem mass spectrometry (LC-MS/MS) is increasingly utilized in clinical laboratories because it has advantages in terms of specificity and sensitivity over other analytical technologies. (annlabmed.org)
  • 2021. "Resin Assisted Capture Coupled with Isobaric Tandem Mass Tag Labeling for Multiplexed Quantification of Protein Thiol Oxidation. (pnnl.gov)
  • In the mouse bioassay, when the injected matography-tandem mass spectrometry method for quan- dose is high, mice typically develop signs of botulism with- tifying active toxin, where the amount of toxin can be in 8 hours. (cdc.gov)
  • One of the most used instruments for analysing PFAS is liquid chromatography-tandem mass spectrometry (LC-MS/MS) . This technique separates and identifies individual PFAS compounds based on their chemical properties and mass-to-charge ratios. (chromatographytoday.com)
  • METHODS: Serum sex hormone-binding globulin (SHBG) was measured by immunoassay, testosterone (T), estradiol (E2), and dihydrotestosterone byliquid chromatography with tandem mass spectrometry (LC-MS/MS), calculated free T and calculated free E2 (cFE2), and homeostasis model assessment for insulin resistance (HOMA-IR) were calculated. (bvsalud.org)
  • The aim of this study is to establish an operational analysis platform of effective and noninvasive diagnostic tool with a high sensitivity to explore protein expression profiles by shotgun proteomics using nano-liquid chromatography coupled tandem mass spectrometry (nanoLC-MS/MS) and stable isotope dimethyl labeling. (longdom.org)
  • The most optimal cutoff values for serum cortisol as measured by immunoassay and for salivary cortisol and salivary cortisone as measured by liquid chromatography-tandem mass spectrometry (LC-MS/MS) were 376, 8.6, and 33.5 nmol/L, respectively, for post-LDSST peak values, and 170, 1.7, and 12.5 nmol/L, respectively, for basal values. (medscape.com)
Detection14
  • Also, we sought to improve the sensitivity of obesogen detection/validation methods to establish a framework for post-toxicological chemical assessment. (nist.gov)
  • The MS instrument allows unambiguous identification/quantification of e.g. peptides, by first recording the molecular mass of a compound (single MS) and then creating a "molecular fingerprint" by fragmenting the compound to smaller parts (MS/MS). Separating compounds in a mixture (e.g. plasma) prior to MS detection further strengthens identification and sensitivity. (nature.com)
  • Their ionization efficiencies for mass spectrometry (MS) detection are rather poor, whereas their retention and separation on reverse phase liquid chromatography (RPLC) are often unsatisfying. (unboundmedicine.com)
  • Lastly I apply mass spectrometry to enable tracking of steroid metabolism, using stable-isotope tracers and also advanced methods of MS detection e.g. imaging. (ed.ac.uk)
  • The updated Romer Labs PLUS method has been utilized on samples that have arrived at the lab for analysis since August 1, 2023, and features enhanced sensitivities as indicated by lower limits of detection (LOD) as outlined in Table 1. (dsm.com)
  • As ICP-OES is a technique for scientists that look for simultaneous multi-element detection plus sensitivity and throughput, ANTISEL offers instruments and support assuring superior flexibility, ruggedness and the lowest possible detection limits. (antisel.gr)
  • The PerkinElmer product family offers a variety in products and accessories to lead you to remarkable results when it comes to high-sensitivity simultaneous detection of elements. (antisel.gr)
  • Improved detection, versatility, and sensitivity for protein complex subunit analysis and biopharmaceutical characterization with an extended optional mass range up to m/z 16,000. (thermofisher.com)
  • 2021. "Mass spectrometry-based direct detection of multiple types of protein thiol modifications in pancreatic beta cells under endoplasmic reticulum stress. (pnnl.gov)
  • Developments in ionization techniques, mass analyzers and detection systems, along with the ability to hyphenate to other tools, have meant that MS has been able to keep pace with evolving analytes and demands, earning it a place in many labs. (technologynetworks.com)
  • MS-based detection offers a low limit of detection and excellent sensitivity in monitoring the issue. (technologynetworks.com)
  • Due to the significant detection interference caused by the complex food matrix, false negative results caused by trace amounts of harmful substances, and the failure of targeted detection caused by endless adulteration, the specificity, and sensitivity of spectrum analysis need to be further improved. (hindawi.com)
  • Mixtures of neutralizing anti- detection of the unique peptide products by mass spec- bodies are given to mice in conjunction with the sample. (cdc.gov)
  • In Japan, although PAC and ARC are measured by radioimmunoassay and immunoradiometric assay, respectively, non-radioisotopic methods with better detection sensitivity, measurement accuracy, and technical simplicity are needed. (jsce-ip.com)
Specificity3
  • Results: Serum-free conditions greatly enhanced sensitivity without reducing specificity in ligand binding assays. (nist.gov)
  • 2017). The method relies on an enzymatic hydrolysis of urinary conjugates, automated off-line SPE to pre-concentrate the target compounds while minimizing urine matrix potential interferences to increase the overall sensitivity and specificity. (cdc.gov)
  • LC-MS, the gold standard in clinical testing, is a powerful analytical tool that delivers high accuracy, sensitivity, and specificity. (thermofisher.com)
Quadrupole mass6
  • The platform, which includes the new Thermo Scientific Quantiva triple-stage quadrupole mass spectrometer and the new Thermo Scientific Endura triple-stage quadrupole mass spectrometer , made its debut at the ASMS Conference on Mass Spectrometry and Allied Topics. (labmate-online.com)
  • The TSQ Quantiva triple quadrupole mass spectrometer employs Active Ion Management (AIM) to optimise ion creation and transmission from the source to the detector, resulting in extreme sensitivity. (labmate-online.com)
  • The TSQ Endura triple quadrupole mass spectrometer shares much of the advanced technology of the TSQ Quantiva MS, but was designed to deliver higher uptime than any competitive triple quadrupole instrument. (labmate-online.com)
  • Choose Thermo Scientific TSQ Altis MD triple-stage quadrupole mass spectrometers for routine quantitative analyses. (thermofisher.com)
  • Thermo Scientific TSQ Altis MD triple-stage quadrupole mass spectrometers deliver speed, robustness and the ability to improve selectivity with H-SRM. (thermofisher.com)
  • The 6475 triple quadrupole mass spectrometer monitors its own vitals, giving you a real-time overview of the system's health. (agilent.com)
Quantitation4
  • Thermo Fisher Scientific have introduced a new-generation triple quadrupole liquid chromatography-mass spectrometry (LC-MS) platform designed to transform quantitation experiments with extreme sensitivity, productivity, precision and usability. (labmate-online.com)
  • This enhanced level of sensitivity greatly improves results in applications such as peptide quantitation, metabolomics and biopharmaceutical QA/QC compared to previous Thermo Fisher triple quads. (labmate-online.com)
  • The new trend of Untargeted Analysis is covered by the Triple TOF line that combines the high mass accuracy - high resolution with the reliable quantitation and the high throughput. (antisel.gr)
  • A specific liquid chromatography-mass spectrometry/mass spectrometry spectrometric procedure for the quantitation of amprenavir drug in biological matrices was developed and validated. (japsonline.com)
Analytes1
Supercritical Fluid Chromato4
  • Supercritical Fluid Chromatography (SFC): A Powerful. (chromatographytoday.com)
  • The high separation power and short analysis time obtained demonstrate for the first time that supercritical fluid chromatography is a fast and reliable technique for the analysis of lignin-derived phenols in complex environmental samples. (lu.se)
  • Alkaline cupric oxide (CuO) oxidation is one of the mostly performance supercritical fluid chromatography (UHPSFC) adopted methods for analyzing lignin in various complex using columns with sub-2 m packing can further improve environmental matrices such as soils and sediments [9]. (lu.se)
  • UHPSFC , ultra- pacted by other parameters, such as the addition of the mod- high performance supercritical fluid chromatography ifier and the change of the mobile phase density [20]. (lu.se)
Quantify2
  • Quantify proteins, contaminants, pesticides or screen for drug metabolites with a high level of sensitivity. (selectscience.net)
  • Wei-Jun Qian is a bioanalytical chemist whose research centers primarily on the development and applications of mass spectrometry-based approaches to better quantify the dynamic changes in protein abundances and protein post-translational modifications in biological and clinical applications. (pnnl.gov)
20232
  • Although we're anticipating 2023 to be a high mycotoxin pressure crop year, it's likely that at least a portion of these shifts in occurrence are an artifact of the enhanced sensitivities of the updated Romer Labs PLUS method. (dsm.com)
  • The NJ Mass Spectrometry Discussion Group is pleased to announce the return of our Fall 2023 Annual Vendor Show and Symposium, after our pandemic hiatus. (njacs.org)
Selectivity1
  • LC-MS/MS can provide high sensitivity and selectivity, making it an ideal choice for detecting low levels of PFAS in environmental samples. (chromatographytoday.com)
Analytical Methods1
Nano liquid1
  • We describe a robust nano liquid chromatography-mass spectrometry (nanoLC-MS) platform for measuring the total amount of OT in human plasma/serum. (nature.com)
Spectrometer3
  • Finally, most of the identities were unequivocally confirmed by accurate mass measurements on the TOF spectrometer. (unboundmedicine.com)
  • Molecular measurements using capillary electrophoresis time-of-flight or orbitrap mass spectrometer platforms revealed proteomic and metabolomic differences between the X. laevis cells that correlated with phenotype. (njacs.org)
  • With new capabilities for multiplexed quantitative proteomics and native protein characterization, the Thermo Scientific Orbitrap Ascend Tribrid mass spectrometer delivers ultimate experimental throughput, versatility, and ease-of-use. (thermofisher.com)
Separation3
  • To overcome these limitations, a novel approach utilizing nanoflow separation and trapped ion mobility spectrometry (TIMS) was implemented to increase sensitivity. (premierbiosoft.com)
  • GC-MS was an ideal choice because it allowed the separation of all closely related intermediates of the pathway, as well as gathering characteristic mass spectra, which is obviously very useful for substance identification. (chromatographyonline.com)
  • LC-MS (liquid chromatography-mass spectrometry) systems and equipment are used for separation and quantitative analysis of complex mixtures, combining liquid chromatography and mass spectrometry. (selectscience.net)
Peptides3
  • Peptides are typically separated using liquid chromatography (LC). (nature.com)
  • Also for so-called data-independent acquisition (DIA) 16 methods that aim to catalog the peptides present in a sample systematically, the field is increasingly adopting 300 µm ID columns as a compromise between sensitivity and robustness 17 , 18 . (nature.com)
  • Mice receiving the appropriate anti-BoNT serotype anti- a unique cleavage site on a unique peptide, the mass-spe- body are asymptomatic and survive, while mice treated cific product peptides detected by mass spectrometry dif- with the other serotype antibodies show symptoms of botu- ferentiate active BoNT serotypes. (cdc.gov)
Demonstrated enhanced sensitivity1
  • The developed method demonstrated enhanced sensitivity, as the CKs and their glycoconjugates could be analysed with LODs within the range of 0.62-25.9 pg/mL. (unboundmedicine.com)
Phytohormones1
  • Chemical isotope labelling LC-MS analysis methods have been developed for most other phytohormones, enhancing their LC separations and quantitative sensitivity. (unboundmedicine.com)
Metabolites2
  • In total, 791 annotated endogenous metabolites were measured by ultra-performance liquid. (lu.se)
  • Similar metabolites and pathways were also related to insulin sensitivity (Matsuda index) in a separate study (POEM, n=501). (lu.se)
Detector2
  • The high sensitivity and resolution of the TOF detector over the triple quadrupole facilitate the preliminary characterization of the fractions. (unboundmedicine.com)
  • ANTISEL offers GC, GC/MS and GC MSMS-TOF systems by PerkinElmer , combining the chromatography with sample handling, detector choices, data management, service and reliable access to accessories and consumables. (antisel.gr)
Throughput2
  • It covers all demands and needs in terms of sensitivity, accuracy, sample throughput etc. for a wide range of applications. (antisel.gr)
  • Flexible options to meet sensitivity and throughput needs. (thermofisher.com)
Precision1
  • No comparisons can be made between methods since no data were given regarding sensitivity, recovery, or precision. (cdc.gov)
Proteomic2
  • In this presentation, we will discuss the development of in situ/vivo approaches by cellular and subcellular mass spectrometry that enabled our lab to determine the proteomic and metabolomic profile of identified cells in live Xenopus laevis frog embryos developing to tadpoles and neurons in mouse brain tissues. (njacs.org)
  • To aid these efforts, we developed a workflow using data acquired from discovery proteomic experiments, retention time prediction, and standard-flow chromatography to rapidly develop targeted proteomic assays. (dtu.dk)
High6
  • Sensitivity and high starting amounts are the major limitations of this method. (premierbiosoft.com)
  • This method has incredibly high sensitivity (down to 1 ng/ml) and increases the power with which officials can search for both testosterone and epitestosterone within a sample. (science20.com)
  • A wide range of high quality optimized liquid scintillation cocktails and vials complement the LSA solution and ensure optimum counting results. (antisel.gr)
  • Multiple fragmentation techniques - CID and HCD with optional UVPD, ETD, PCTR - are available at any stage of MS, with subsequent mass analysis in either the ion trap or ultra-high resolution Orbitrap mass analyzer. (thermofisher.com)
  • In This Edition Modern & Practocal Applications - Accelerating ADC Development with Mass Spectrometry - Implementing High-Resolution Ion Mobility into Peptide Mapping Workflows Chromatogr. (chromatographytoday.com)
  • The new ultra-high performance super- critical fluid chromatography method was also applied for the qualitative and quantitative analysis of lignin-derived phenolic compounds obtained upon alkaline cupric oxide oxida- tion of a commercial humic acid. (lu.se)
Robustness1
Methods4
  • Q. You and your team have developed a lot of interesting methods using gas chromatography‑mass spectrometry (GC-MS) in bioanalysis. (chromatographyonline.com)
  • Is GC-MS an underrated technique in bioanalysis, and what benefits can it offer over liquid chromatography‑mass spectrometry (LC-MS) methods? (chromatographyonline.com)
  • Current methods for detecting BoNT include a mouse cause human botulism (A, B, E, and F). We developed a bioassay (2-4) and an enzyme-linked immunosorbent assay rapid, mass spectrometry-based method (Endopep-MS) to (ELISA) (5,6). (cdc.gov)
  • We describe a novel method to measure petroleum distillates in BAL fluid using gas chromatography-mass spectrometry (GC/MS). METHODS: n-Hexane, n-heptane, n-octane, methylcyclopentane, and cyclohexane were measured in BAL fluid specimens by headspace solid-phase microextraction/gas chromatography/mass spectrometry. (cdc.gov)
Method4
  • Liquid chromatography (LC) coupled with mass spectrometry (MS) is an established method for lipidomics workflow. (premierbiosoft.com)
  • The content knowledge of LC-MS/MS users is quite broad and deep and spans multiple scientific fields, including biology, clinical chemistry, chromatography, engineering, and MS. However, there are no formal academic programs or specific literature to train laboratory staff on the fundamentals of LC-MS/MS beyond the reports on method development. (annlabmed.org)
  • A commutability confirmation test for the blood aldosterone measurement was performed on liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS) as a designated comparison method (DCM) and four chemiluminescent enzyme immunoassay (CLEIA) measurement procedures based on metrological traceability. (jsce-ip.com)
  • The first liquid-chromatography (LC)-based method was presented in 1977. (medscape.com)
Insulin2
  • Fasting insulin decreased by ∼ 84% (23.3 ± 3.8 vs. 3.8 ± 0.5 mU/ml), and insulin sensitivity, as determined by minimal model, increased by ∼360% (1.2 ± 0.3 vs. 4.1 ± 0.5 min −1 · [μ U/kg −1 ]) indicating enhanced insulin action. (diabetesjournals.org)
  • In healthy adult men, physiological changes in sex steroid exposure clearly correlate with changes in adiposity but not so with lean mass, insulin resistance, or grip strength. (bvsalud.org)
Protein2
  • Specific activity is equal to the rate of reaction multiplied by the volume of reaction divided by the mass of total protein. (wikipedia.org)
  • Demonstration of m/z 16,000 mass range on purified GroEL 800 kDa protein on a single Orbitrap scan at 7500 resolution at m/z 200. (thermofisher.com)
Characterization1
  • Recent improvements in the speed and sensitivity of liquid chromatography-mass spectrometry systems have driven significant progress toward system-wide characterization of the proteome of many species. (dtu.dk)
Spectrometers1
  • And as the sensitivity of mass spectrometers has improved, researchers have realized that they can finally achieve single-cell proteomics. (acs.org)
Solvent2
  • Liquid-liquid extraction was carried out for drug and internal standard isolation with an ethyl acetate solvent. (japsonline.com)
  • Factors like solvent concentration, solid-liquid ratio, temperature and time affect extraction efficiency. (zmuni.com)
Retention1
  • The literature on amprenavir unveiled that there are few analytical procedures available for the estimation of drug in API and dosage forms on liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS) with more retention times. (japsonline.com)
Applications1
  • The Column spoke to Martin Giera of Leiden University Medical Center in the Netherlands, about the importance of gas chromatography‑mass spectrometry (GC-MS) in bioanalysis applications and the latest advances he has made with this technique. (chromatographyonline.com)
Soil1
  • 1989). For soil and solid waste samples, sensitivity was in the ppm (µg/L) range using GC/MS and GC/ECD. (cdc.gov)
Procedure1
Molecular1
Performance1
  • Tweaking and fine-tuning your liquid chromatography/mass spectrometry system to optimize analytical performance is challenging and time consuming. (agilent.com)
Analyzer1
  • LC-MS/MS instruments equipped with a qTOF or triple quadrupole analyzer give greater sensitivity and resolving power to your analysis. (selectscience.net)
Analysis2
  • Mass spectrometry coupled to liquid chromatography is a powerful tool for the analysis of complex plant derivatives such as GADF. (unboundmedicine.com)
  • Environmental analysis Their sensitivity makes MS-based techniques an excellent fit for many forensics studies. (technologynetworks.com)
Vivo1
  • She specialises in understanding regulation of glucocorticoid action in metabolic and inflammatory diseases and has developed innovative tools to study steroid metabolism and flux in vivo, most recently by mass spectrometry imaging. (ed.ac.uk)
Orbitrap1
  • LC-MS systems and equipment include reverse phase, normal phase and specialized columns integrated with various MS detectors such as time-of-flight (TOF), quadrupole, orbitrap or ion trap mass analyzers. (selectscience.net)
Biology1
  • The limitation has been a lack of sufficiently sensitive mass spectrometry technologies that can measure these biomolecules with compatibility for live development, a prerequisite for functional biology. (njacs.org)
Systems3
  • Application of advanced mass spectrometry to visualise and track steroid hormones in biological systems. (ed.ac.uk)
  • Experience versatility and accuracy from our LC-MS systems for in vitro diagnostic (IVD) tests and Laboratory Developed Tests (LDTs), which offers clinical diagnostic laboratories a unique choice to address sensitivity needs. (thermofisher.com)
  • Software is at the heart of the use and accessibility of our mass spectrometry systems. (thermofisher.com)
Volatile1
  • Another technique that is frequently employed in estimating PFAS concentrations is gas chromatography-mass spectrometry (GC-MS). GC-MS is particularly useful for analysing volatile PFAS, such as perfluoro carboxylic acids (PFCAs) and perfluoroalkyl sulfonates (PFASs), which can be challenging to detect using other techniques. (chromatographytoday.com)
Extraction1
  • penetration depth of the microwave is limited (in the same order of magnitude as its wavelength), and its mass transfer function is not significant in the enhanced extraction process. (zmuni.com)
Clinical1
  • Senior Clinical Research Nurse, Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School. (silverchair.com)