• The soluble NSF attachment proteins (SNAPs) enable N-ethyl-maleimide-sensitive fusion protein (NSF) to bind to target membranes. (antibodies-online.com)
  • Martin HG, Henley JM, Meyer G. ( 2006 ) Novel putative targets of N-ethylmaleimide sensitive fusion protein (NSF) and alpha/beta soluble NSF attachment proteins (SNAPs) include the Pak-binding nucleotide exchange factor betaPIX. (neurotree.org)
  • and the cytosolic proteins N-ethylmalemide sensitive factor (NSF), a trimeric ATPase required for membrane fusion, and the α-β-Y-SNAPs (soluble NSF attachment proteins), which function in binding NSF to the membrane [10,14] . (ommegaonline.org)
  • Vesicular Transport Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (uchicago.edu)
  • Vesicular transport proteins are distinguished from MEMBRANE TRANSPORT PROTEINS, which move molecules across membranes, by the mode in which the molecules are transported. (uchicago.edu)
  • This graph shows the total number of publications written about "Vesicular Transport Proteins" by people in this website by year, and whether "Vesicular Transport Proteins" was a major or minor topic of these publications. (uchicago.edu)
  • Below are the most recent publications written about "Vesicular Transport Proteins" by people in Profiles. (uchicago.edu)
  • Protein kinase A-mediated phosphorylation of AQP2 has been proposed to be essential in regulating AQP2-containing vesicle exocytosis. (uniba.it)
  • Evidence suggests that nerve growth factor (NGF) induces neurite outgrowth from PC12 cells by activating the receptor tyrosine kinase, TrkA. (biomedcentral.com)
  • NGF is a neurotrophic factor critical for the survival and maintenance of sympathetic and sensory neurons, and it binds to the high-affinity tyrosine kinase receptor, TrkA, leading to its phosphorylation and the subsequent activation of PI3K/Akt/GSK3β pathways. (biomedcentral.com)
  • interaction( Hh) is a bound transfer that is very proteins in modifications resulting past plasma mRNA, fibril-associated information DNA, isoform kinase and activity( characterised in Hui and Angers, 2011). (evakoch.com)
  • The second Rab3 GEF, known as GRAB, interacts with inositol hexakisphosphate kinase and Rab3A and its protein expression is primarily in brain (41). (pancreapedia.org)
  • Several patients with clinical features of chronic myeloid leukemia (CML) have fusion of the TEL (ETV6) gene on 12p13 with ABL on 9q34 and express a chimeric Tel-Abl protein that contains the same portion of the Abl tyrosine kinase fused to Tel, an Ets family transcription factor, rather than Bcr. (shengsci.com)
  • The first layer of immunity, known as pathogen-associated molecular pattern- (PAMP-) triggered immunity (PTI), is activated following recognition of the fungal pattern molecule chitin, by four lysin motif- (LysM-) containing protein (LYP) receptors, i.e., chitin elicitor binding protein (CEBiP), chitin elicitor receptor kinase (CERK1), LYP4 and LYP6 (Shimizu et al. (biomedcentral.com)
  • The AffiAB® Goat Anti-STX6 Polyclonal IgG Antibody is an antibody derived from goats that specifically targets and binds to STX6, also known as Syntaxin 6. (affigen.com)
  • It is assumed that syntaxin 2 may be involved in triggering the acrosome reaction through a ligand-receptor mediated signal transduction pathway. (ommegaonline.org)
  • In this model, the soluble N-ethylmaleimide-sensitive factor (NSF) attachment protein (SNAP) receptor (SNARE) proteins syntaxin-1, SNAP-25, and synaptobrevin form tight complexes that bring the membranes together and are crucial for membrane fusion. (elsevierpure.com)
  • NSF and SNAPs disassemble SNARE complexes and ensure that fusion occurs through an exquisitely regulated pathway that starts with Munc18-1 bound to a closed conformation of syntaxin-1. (elsevierpure.com)
  • Munc18-1 also binds to synaptobrevin, forming a template to assemble the SNARE complex when Munc13-1 opens syntaxin-1 while bridging the vesicle and plasma membranes. (elsevierpure.com)
  • These distinct Munc18-1 and Munc18c roles are related to their transient high-affinity binding with their cognate target (t-)SNAREs, Syntaxin 1A and Syntaxin 4 respectively. (ttu.edu)
  • Both the CAPS and UNC-13 docking pathways converge on syntaxin, a component of the SNARE (soluble N -ethyl-maleimide-sensitive fusion protein attachment receptor) complex. (rupress.org)
  • 2009) Transforming Growth Factor beta can stimulate Smad1 phosphorylation independently of Bone Morphogenic Protein receptors. (columbiabiosciences.com)
  • Conserved salt-bridge competition triggered by phosphorylation regulates the protein interactome. (uchicago.edu)
  • This close juxtapositioning of the two membranes allows the interaction between SNARE's (soluble NSF (N-ethylmaleimide sensitive Factor) attachment protein receptor) on both compartments. (wikipedia.org)
  • NSF and SNAPs appear to be general components of the intracellular membrane fusion apparatus, and their action at specific sites of fusion must be controlled by SNAP receptors particular to the membranes being fused. (antibodies-online.com)
  • There is no known specific Rab3 GDI, but rather a common family of Rab GDI isoforms which bind prenylated Rabs in the cytoplasm and participates in insertion and removal from membranes (75). (pancreapedia.org)
  • The details of how proteins are concentrated or localized to the exit site is unclear but the actual process of budding a vesicle containing these proteins starts with a protein called Sec12. (wikipedia.org)
  • TRAPP I binds these ER derived vesicles and brings the vesicle closer to the acceptor membrane. (wikipedia.org)
  • The controversy would be solved if binding to closed syntaxin1 were shown to be stimulatory for vesicle fusion and/or additional essential interactions were identified between Munc18-1 and the fusion machinery. (jneurosci.org)
  • A mutation that diminished Munc18 binding to syntaxin1 in vitro attenuated the vesicle-docking step but rescued vesicle priming in excess of docking. (jneurosci.org)
  • Conversely, expressing the Munc18-2 isoform, which also displays binding to closed syntaxin1, rescued vesicle docking identical with Munc18-1 but impaired more downstream vesicle priming steps. (jneurosci.org)
  • In conclusion, binding of Munc18-1 to closed syntaxin1 stimulates vesicle docking and a distinct interaction mode regulates the consecutive priming step. (jneurosci.org)
  • However, the use of mutant expression in the presence of endogenous protein left it unclear how the observed effects were related to the defect of vesicle docking in (M)unc18-1 knock-outs. (jneurosci.org)
  • The results show that vesicle docking correlates with the ability of Munc18-1 to bind to closed syntaxin1. (jneurosci.org)
  • 2012 ) SNARE protein recycling by αSNAP and βSNAP supports synaptic vesicle priming Neuron . (neurotree.org)
  • 2010 ) SNARE protein recycling by αSNAP and βSNAP supports synaptic vesicle priming. (neurotree.org)
  • STX6 is a member of the SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) protein family and is involved in intracellular membrane trafficking and vesicle fusion events. (affigen.com)
  • It interacts with other SNARE proteins and vesicle-associated membrane proteins (VAMPs) to mediate membrane fusion events during intracellular transport processes. (affigen.com)
  • This antibody provides a valuable tool for investigating intracellular membrane trafficking, vesicle fusion, and the role of STX6 in cellular processes such as protein sorting, secretion, and endocytosis. (affigen.com)
  • 750 kDa), conserved macromolecular machines that are essential for soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE)-mediated membrane fusion in all eukaryotes.MTCs are thought to organizemembrane trafficking by mediating the initial long-range interaction between a vesicle and its target membrane and promoting the formation of membrane-bridging SNARE complexes. (princeton.edu)
  • This structure suggests how theDsl1 complex might tether a vesicle to its target membrane by binding at one end to the COPI coat and at the other to ER-associated SNAREs. (princeton.edu)
  • Key interacting proteins of the plasma membrane, the cytosol and the vesicle membrane which function in the membrane fusion pathway, have been identified in a variety of cell types and characterized at the molecular level [10-14] . (ommegaonline.org)
  • More than 90% of extracellular miRNAs are vesicle-free, but form a complex with proteins such as Agonaute2 (AGO2) ( 22 , 23 ). (frontiersin.org)
  • Data for functional involvement of the SNARE vesicle-associated membrane protein 2 in AQP2 targeting has recently been provided. (uniba.it)
  • Vesicle-associated membrane proteins 721 and 722 (VAMP721/722) are secretory vesicle-localized arginine-conserved soluble N -ethylmaleimide-sensitive factor attachment protein receptors (R-SNAREs) to drive exocytosis in plants. (molcells.org)
  • We have found that the calcium-activated protein for secretion (CAPS) protein is required for dense core vesicle docking but not synaptic vesicle docking. (rupress.org)
  • In contrast, we see that UNC-13, a docking factor for synaptic vesicles, is not essential for dense core vesicle docking. (rupress.org)
  • CAPS function in dense core vesicle docking parallels UNC-13 in synaptic vesicle docking, which suggests that these related proteins act similarly to promote docking of independent vesicle populations. (rupress.org)
  • A molecular understanding of membrane traffic has broad implications for our understanding of growth control in cancer, receptor trafficking errors in heart disease, regulation of insulin secretion in diabetes and synaptic vesicle biogenesis and transport in neurological disorders. (stanford.edu)
  • Membrane mix inside endomembrane technique comes after a detailed purchase associated with events: membrane tethering, mediated by Rabs and also tethers, assemblage regarding disolveable N-ethylmaleimide-sensitive factor (NSF) attachment health proteins receptor (SNARE) buildings, and also lipid bilayer combining. (notes.io)
  • Another distinction that has been drawn contrasts the constitutive and the regulated pathways to distinguish the ongoing transport of protein and lipid to the cell surface from the ability to secrete hormones and transmitters in response to specific stimuli. (sdbonline.org)
  • Higher cells of download Hanging Sam: A Military and mental Canadian initiation in the 5'-end novo depends the lipid protein directly than NALP1-mediated deafness to the chain. (evakoch.com)
  • D: In the download Hanging Sam: A Military Biography of General Samuel T. Williams: From Pancho Villa phase of the module, the pattern-recognition: GTP plays the form, widely containing the region out of the A chaperone to spiral Loss and binds the Convention lipid: GDP. (evakoch.com)
  • By combining lipidomics and molecular dynamic simulations the authors show that oxidatively truncated (ox-tr) triacylglycerides accumulate in large lipid droplets of tumour-associated mouse DCs, and that these highly electrophilic species are predicted to preferentially occupy the droplet surface where they can directly access cytosolic proteins. (biomedcentral.com)
  • These ox-tr lipids contain reactive functional groups that were capable of mediating a covalent attachment to HSP70, and lipid droplets of DCs exposed to tumour extracts but not of controls strongly accumulated HSP70. (biomedcentral.com)
  • Exocytosis of secretory or synaptic vesicles is executed by a mechanism including the SNARE (soluble N -ethylmaleimide-sensitive factor attachment protein receptor) proteins. (jneurosci.org)
  • This binding mode prompted the "negative regulator" hypothesis according to which Munc18-1 sequesters syntaxin1 and inhibits exocytosis. (jneurosci.org)
  • Syntaxins are membrane integrated Q-SNARE proteins known to participate in exocytosis. (ommegaonline.org)
  • Biphasic glucose-stimulated insulin secretion (GSIS) from pancreatic β-cells involves soluble N-ethylmaleimide-sensitive fusion protein-attachment protein receptor (SNARE) proteinregulated exocytosis. (ttu.edu)
  • Two important pathways were examined in the current study: (1) a basic pathway of exocytosis that brings new proteins to the cell surface and permits the cell to grow, and (2) synaptic transmission, a specialized form of exocytosis, regulated by Ca 2+ entry, in which vesicles already present at synapses fuse with the membrane and recycle locally (Murthy, 2003). (sdbonline.org)
  • Soluble N-ethylmaleimide sensitive fusion factor attachment protein receptors ( SNARE) and actin cytoskeleton organization regulated by small GTPase of the Rho family were also proved to be essential for AQP2 trafficking. (uniba.it)
  • Chemotaxis of neutrophils involves movement of pseudopodia and polymerization of cytoskeletal proteins or actin. (medscape.com)
  • This inhibition reflects the binding of Munc18-1 to a closed conformation of the target-SNARE syntaxin1. (jneurosci.org)
  • Furthermore, many of us noticed which Vps16, Vps18, as well as the Sec1/Munc18 proteins Vps33, which part of the HOPS complex, hole towards the Q-SNARE complicated. (notes.io)
  • Because Doc2b binds to Munc18-1 and Munc18c via its distinct C2A and C2B domains respectively, we hypothesized that Doc2b may provide a plasma membranelocalized scaffold/platform for transient docking of theseMunc18 isoforms during GSIS. (ttu.edu)
  • Competitionbased GST-Doc2b interaction assays revealed that Doc2b could simultaneously bind both Munc18-1 and Munc18c. (ttu.edu)
  • In plants, three groups of regulatory proteins such as Sec1/Munc18 (SM), small GTPase and synaptotagmin (SYT) have been studied for modulating the trafficking functionality of SNAREs. (molcells.org)
  • In contrast, chemokine secretion and trafficking of plasma membrane proteins, transported via the constitutive secretory pathway, are unaffected by the lack of WASp. (aai.org)
  • Because of its localization and homology to the yeast protein Sec4, it was believed to play a role in the terminal steps of secretion. (pancreapedia.org)
  • New insights into protein secretion: TANGO1 runs rings around the COPII coat. (uchicago.edu)
  • The tether that functions to tether ER derived vesicles to the VTC (or Golgi apparatus in case of lower eukaryotes), the next compartment in the transport pathway, is the Transport Protein Particle (TRAPP). (wikipedia.org)
  • These receptors trigger inflammation through the NFkB-dependent and interferon regulatory factor-dependent signaling pathway. (medscape.com)
  • Opsonins are often antibodies or components of the complement pathway that bind to the surface of target organisms to facilitate this phagocytosis. (medscape.com)
  • The combination of growth factors and RTKs can activate the PI3K/AKT signaling pathway and negatively regulate TSC1/2, promoting Rheb to become GTP loaded, which can activate mTORC1. (biomedcentral.com)
  • In this study, we demonstrate that the Wiskott-Aldrich syndrome protein (WASp) is an essential component of the cytokine secretory pathway in CD4 + T cells. (aai.org)
  • 2008) Highly specific inhibition of C1q globular-head binding to human IgG: a novel approach to control and regulate the classical complement pathway using an engineered single chain antibody variable fragment. (columbiabiosciences.com)
  • The download Hanging Sam: A Military Biography of General of Insulin like Growth Factor Binding Proteins( IGFBPs) phase 50 response pathway good research with reviewed N cell and C formation enzymes binding for conjugating Insulin like Growth Factors I and II( IGF I and IGF II). (evakoch.com)
  • Bioactive peptides are small protein fragments that promote metabolic health by exerting a positive influence on biological responses within the body. (psyclopeptide.com)
  • These bacteria or yeast secrete their proteolytic enzymes in due course to release peptides from the proteins. (psyclopeptide.com)
  • Affibody molecules are small (58 amino acids) engineered scaffold proteins that can be selected to bind to a large variety of proteins with a high affinity. (mdpi.com)
  • Plasma levels of renalase, an anti-inflammatory secretory protein, dramatically decrease in a murine acute pancreatitis model. (bvsalud.org)
  • The survival factor renalase (RNLS) is a recently discovered secretory protein with potent prosurvival and anti-inflammatory effects. (bvsalud.org)
  • The exocyst complex, a set of eight proteins first identified from secretory mutants in yeast, is an attractive candidate for mediating directed traffic. (sdbonline.org)
  • Although the members of Q-SNARE proteins are characterized in somatic cells, it is not known whether related proteins function in the sperm acrosome reaction. (ommegaonline.org)
  • Characterization of DNA binding, transcriptional activation, and regulated nuclear association of recombinant human NFATp. (colorado.edu)
  • His-Ubiquitin recombinant protein probed with Mouse anti Histidine Tag ( MCA1396 ). (bio-rad-antibodies.com)
  • 2004 ) Regulation of synaptic strength and AMPA receptor subunit composition by PICK1. (neurotree.org)
  • Altogether, our results demonstrate that βγ subunit of heterotrimeric G proteins play a critical role in neurite outgrowth and differentiation by interacting with MTs and modulating MT rearrangement. (biomedcentral.com)
  • The majority of adaptor proteins exist as multi-subunit complexes, however monomeric varieties have also been found. (jefferson.edu)
  • Major recent advances and previous data have led to a plausible model of how key proteins mediate neurotransmitter release. (elsevierpure.com)
  • 5) Lysosomes can also fuse with the plasma membrane to mediate membrane repair or discharge contents outside the cell, such as cathepsins or immune factors. (biomedcentral.com)
  • This gene encodes soluble NSF attachment protein gamma. (antibodies-online.com)
  • 60% of human protein-coding genes, mostly by binding to the 3′- untranslated region (3′UTR) of the target mRNAs ( 5 ) and, therefore, miRNAs affect gene expression networks of a variety of biological processes including development, apoptosis, proliferation, and metabolism ( 1 , 2 ). (frontiersin.org)
  • Each of our Cisplatin datasheet data hence assistance a model associated with HOPS-controlled membrane combination through recognizing distinct aspects of the particular Pitfall intricate.Inches"Multiple epigenetic signifies have been offered to contribute to the actual regulating antigen receptor gene set up through /(Deborah)M recombination. (notes.io)
  • The mature miRNAs are loaded onto ARGONAUTE (AGO) proteins, forming a miRNA-induced gene silencing complex (miRISC). (biomedcentral.com)
  • Then, the miRISC binds to target sites with sequences complementary to the miRNAs, leading to either cleavage or translational inhibition of the target mRNAs, or methylation of the target sequences, resulting in post-transcriptional and transcriptional gene silencing, respectively. (biomedcentral.com)
  • Previously, we reported the structure of the yeast Dsl1 complex, the simplest known MTC, which is essential for coat protein I (COPI) mediated transport fromthe Golgi to the endoplasmic reticulum(ER). (princeton.edu)
  • Protein is hydrolyzed by culturing bacteria or yeast on the protein substrates. (psyclopeptide.com)
  • These diverse functions performed by the acrosomal segment during fertilization reveal the importance of identifying the specific signaling events and protein constituents which initiate and regulate the membrane fusion process of the acrosome reaction and prepare spermatozoa to fuse with the egg. (ommegaonline.org)
  • Synaptotagmin-1 and complexin bind to partially assembled SNARE complexes, likely stabilizing them and preventing fusion until Ca2+ binding to synaptotagmin-1 causes dissociation from the SNARE complex and induces interactions with phospholipids that help trigger release. (elsevierpure.com)
  • We show homotypic fusion and necessary protein sorting (HOPS) binds Vam7 by means of it's subunits Vps16 as well as Vps18. (notes.io)
  • Neurons generate their polarity by directing membrane traffic to growing neurites and growth cones, and by sorting proteins differentially between the axon and dendrites. (sdbonline.org)
  • A total of 257 differentially expressed proteins (DEPs) were identified by iTRAQ, which provided a comprehensive overview on the functional protein profile changes of tuber development regulated by JA. (biomedcentral.com)
  • Some cell wall polysaccharide synthesis and cytoskeleton formation-related proteins were up-regulated by JA to promote tuber cell expansion. (biomedcentral.com)
  • The ER provides an environment that helps nascent polypeptides fold into and become functional or partially functional proteins. (wikipedia.org)
  • Therefore, identifying the factors and mechanisms that regulate the functional status and spatial distribution of lysosomes and elucidating the relationship between lysosomes and the development and progression of cancer can provide important information for cancer diagnosis and prognosis prediction and may yield new therapeutic targets. (biomedcentral.com)
  • EphA2 is a functional receptor for the growth factor progranulin. (jefferson.edu)
  • [ 1 ] Neutrophils move to the site of invasion by means of chemotaxis, which occurs in response to microbial products, activated complement proteins, and cytokines. (medscape.com)
  • These include four regions participating in guanine nucleotide binding, and effector region corresponding to the effector region in Ras, and a CXC prenylation motif at the C-terminal (45). (pancreapedia.org)
  • Similar to other small G proteins, the guanine binding state of Rab3 proteins is regulated by guanine nucleotide exchange proteins or factors (GEPs or GEFs) and GTPase activating proteins (GAPs). (pancreapedia.org)
  • much 75 cytosol of pairing substrates are in 1500 220 KDa proteins with IGFBP3 and ALS. (evakoch.com)
  • Here we define the precise Rab29 binding region of the LRRK2 Armadillo domain between residues 360-450 and show that this domain, termed 'Site #1', can also bind additional LRRK2 substrates, Rab8A and Rab10. (stanford.edu)
  • The protein complexes form a mesh at the ER exit site and through mechanical curvature form a little "blob" that pinches off from the ER with proteins inside. (wikipedia.org)
  • Tethers come in two "flavors": long protein(s) with domains called "coiled-coil," or complexes of many subunits which are for the most part globular. (wikipedia.org)
  • New technologies for purifying membrane-bound protein complexes in combination with cryo-electron microscopy (EM) have recently allowed the exploration of such complexes under near-native conditions. (researchgate.net)
  • Binding of complement to a foreign substance, or antigen, amplifies and augments the body's innate immune system by means of its role as an opsonin (a factor that enhances phagocytosis of unwanted particles) and as a chemoattractant (a factor that recruits cells to areas of inflammation). (medscape.com)
  • After a complex process of education and maturation, a circulating lymphocyte can bind to an antigen. (medscape.com)
  • Proteins that are destined for the plasma membrane or export to the extracellular environment in eukaryotic cells are translated on ribosomes that sit on the rough endoplasmic reticulum (RER). (wikipedia.org)
  • Numerous exported proteins form disulfide bonds-covalent bonds that stabilize the protein structure in harsh extracellular environments. (wikipedia.org)
  • This 37 kD protein can regulate cell signaling as an extracellular molecule and probably also at intracellular sites. (bvsalud.org)
  • The long term goal of our research is to elucidate the molecular mechanisms by which proteins are targeted to specific and distinct compartments. (stanford.edu)
  • Although 271 genes linked to hereditary retinal diseases have already been identified, these genes encode diverse functions, including phototransduction, retinol metabolism, and intracellular protein transport. (oist.jp)
  • A subfamily of MARVEL domain-containing proteins that are found in SYNAPTIC VESICLES, where they may play a role in modulating neuronal signaling. (ouhsc.edu)
  • This in turn leads to the recruitment of a protein complex, the Sec23/Sec24 and the Sec13/Sec31 complex (also known as the COPII coat). (wikipedia.org)
  • The observed binding modes appear to anchor the Dsl1 complex to the ER target membrane while simultaneously ensuring that both SNAREs are in open conformations, with their SNARE motifs available for assembly. (princeton.edu)
  • The generation of receptors specific for antigens is a unique and complex process that generates 10 12 specific receptors for each cell type of the adaptive immune system, including T and B cells. (medscape.com)
  • 2011) The Dsl1 Tethering Complex Actively Participates in Soluble NSF (N-Ethylmaleimide-sensitive Factor) Attachment Protein Receptor (SNARE) Complex Assembly at the Endoplasmic Reticulum in Saccharomyces cerevisiae. (columbiabiosciences.com)
  • The function of the SEDL protein is not known although it is speculated that it may participate in the ER-to-Golgi transport as part of a novel highly conserved multiprotein TRAPP complex. (nature.com)
  • strongly suggests that at least one regulatory protein should control the SNARE complex formation of VAMP721/722 with a specific Qa-SNARE in a particular biological process in plants. (molcells.org)
  • However, support for the third model is missing at the physiological level, and it is unclear which role the two suggested binding modes play in the exocytotic cascade. (jneurosci.org)
  • The expression of Insulin and Pancreatic and duodenal homeobox-1 mRNA was significantly reduced in MIPβ1KO islets, along with reductions in insulin exocytotic proteins. (oncotarget.com)
  • Cessation of the stimulus is followed by endocytosis of the AQP2 proteins exposed on the plasma membrane and their recycling to the original stores, in which they are retained. (uniba.it)
  • We found that distal regions of each leg bind N-terminal Habc domains of the ER SNAREs Sec20 (a Qb-SNARE) and Use1 (a Qc-SNARE). (princeton.edu)
  • 2007 ) GISP: a novel brain-specific protein that promotes surface expression and function of GABA(B) receptors. (neurotree.org)
  • The cytoHubba plug-in were used to identify hub genes from the protein-protein interaction network. (biomedcentral.com)
  • The structure of the Rabs changes upon binding GTP and mutant Rab3 species have been described similar to Ras that are locked into active and inactive configurations (6). (pancreapedia.org)
  • Antibody:?Mouse anti-6x Histidine IgG Clone: AD1.1.10 Reactivity:?Polyhisitidine tagged proteins (N- or. (columbiabiosciences.com)
  • Most proteins are co-translationally transported into the ER (i.e., while the ribosome is translating the mRNA code into a polypeptide, the polypeptide is simultaneously inserted via the translocon pore into the ER). (wikipedia.org)
  • Intercellular adhesion molecule 5, which binds to and activates integrins, may be a direct target of perisynaptic MMP proteolysis during LTP. (nature.com)
  • Because we have shown earlier that prenylation and subsequent methylation/demethylation of γ subunits are required for the Gβγ-MTs interaction in vitro , small-molecule inhibitors (L-28 and L-23) targeting prenylated methylated protein methyl esterase (PMPMEase) were tested in the current study. (biomedcentral.com)
  • More precisely, recent data support the hypothesis that, in vivo external calcium, through activation of calcium-sensing receptors, modulates the expression/trafficking of AQP2. (uniba.it)
  • In the renal glomeruli, VEGFA is mainly expressed in and secreted from podocytes and tubular epithelial cells, which induces renal injury through binding to the receptor VEGFR, mainly VEGFR2, which is expressed on the surface of endothelial cells [ 8 ]. (biomedcentral.com)
  • Although the members of these protein families are widely distributed among various types of somatic cells [10,11] , it is not known whether related proteins function in the acrosome reaction. (ommegaonline.org)
  • AQP2 is redistributed to the apical membrane of collecting duct cells through activation of a cAMP signaling cascade initiated by the binding of vasopressin to its V2-receptor. (uniba.it)
  • Various cell types can process and present these antigens to T cells, or antigens may be soluble and bound to B-cell receptors. (medscape.com)
  • Over the years, pheochromocytoma (PC12) cells have been used as a model to study neuronal differentiation because they respond to nerve growth factor (NGF) and exhibit a typical phenotype of neuronal cells sending out neurites [ 4 ]. (biomedcentral.com)
  • Such processes require membrane traffic to particular domains of the cell surface, in order to insert proteins at restricted regions of the membrane, to enlarge particular regions of the cell membrane, or to signal asymmetrically to neighboring cells. (sdbonline.org)
  • 2001) Characterization of self-T-cell response and antigenic determinant of U1A protein with bone marrow-derived dendritic cells in NZB x NZW F1 mice. (columbiabiosciences.com)
  • 2007) Identification of CLEC12B, an inhibitory receptor on myeloid cells. (columbiabiosciences.com)
  • Recent studies have shown that soluble factors elaborated by human T lymphocytes enhance erythroid burst formation by human peripheral blood null cells. (shengsci.com)
  • 2010) Periplasmic expression of soluble single chain T cell receptors is rescued by the chaperone FkpA. (columbiabiosciences.com)
  • In the axon, MTs are bundled by the microtubule-associated protein (MAP) tau, with their plus ends oriented toward the nerve terminal. (biomedcentral.com)
  • G protein-coupled receptors (GPCRs) as well as heterotrimeric G proteins are also involved in regulating neurite outgrowth. (biomedcentral.com)
  • Upon induction of LTP, but not other forms of short- or long-lasting plasticity, pro-MMPs are rapidly (within ∼ 15 min) converted to proteolytically active MMPs through an NMDA receptor-dependent mechanism. (nature.com)