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  • K562
  • In these studies, we have examined the effects of combining lovastatin and paclitaxel (Taxol), a microtubule-stabilizing agent, in the human leukemia K562 and HL-60 cell lines. (aacrjournals.org)
  • In this study, we evaluated the effects of combining lovastatin and paclitaxel in two human leukemia cell lines (K562 and HL-60) and investigated the mechanisms underlying the observed synergistic interaction. (aacrjournals.org)
  • Doses
  • Doses of N-methyl-N-nitrosourea (MNU) that produced 20-50% survival of colony-forming units increased poly (ADP-R) in both lymphoma lines by only 25% compared with 377% in L1210 cells when synthesis was measured immediately after a 30-min exposure of MNU. (openrepository.com)
  • Uptake
  • Concentrations of 3-aminobenzamide (3AB) above 2.5 mM inhibited colony-forming ability of lymphoma cells and equally inhibited uptake of [14C]formate into protein, RNA and DNA indicating that 3AB behaves as a general metabolic poison. (openrepository.com)
  • synthesis
  • This thesis is concerned with the use of plant cell cultures in combination with organic synthesis to provide efficient routes for the synthesis of novel diterpene analogs of triptolide (Tl) and tripdiolide (Td), the two most active principles of the Chinese medicinal plant Tripterygium wilfordii. (ubc.ca)
  • protein
  • Ispinesib (SB-715992) is a potent, specific and reversible inhibitor of kinesin spindle protein (KSP) with K i app of 1.7 nM in a cell-free assay, no inhibition to CENP-E, RabK6, MCAK, MKLP1, KHC or Kif1A. (selleckchem.com)
  • BACKGROUND: Etanercept is a tumor necrosis factor-alpha binding fusion protein that demonstrates efficacy in the treatment of psoriasis, which is accompanied by decreased plaque infiltration of T cells and myeloid dendritic cells. (biomedsearch.com)
  • resistance
  • The dGuo-R cell line showed an increased level of resistance to 2-fluoro-2'-deoxyadenosine and 2-fluoroadenine arabinoside (11-14-fold), but essentially no increase in resistance to deoxyadenosine or adenine arabinoside. (ecu.edu)
  • Moreover, a growing body of evidence implies that a variety of miRNAs suppress malignant phenotypes of pancreatic cancer cells including drug resistance through the down-regulation of RUNX2. (beds.ac.uk)
  • however, clinical resistance is common, with mechanisms including a reduction in topo I levels and/or activity and increased DNA repair. (aacrjournals.org)
  • toxicity
  • The problems of drug access to the tumor cells, efflux, inactivation, toxicity, etc., are being addressed by advances in pharmacogenetics, delivery routes, development of new generation platinum compounds, and modifiers of metabolism and damage repair. (springer.com)
  • mouse
  • In the mouse, the NK1.1 Ag, which is a homologue of NKRP1 ( 15 ), is expressed on all NK cells in appropriate strains ( 16 ), is encoded by genes in the NK complex ( 4 ), and may be involved in recognition as judged by the ability of Ab to NK1.1 to induce or enhance killing by NK cells ( 17 ). (jimmunol.org)
  • Recent studies have indicated that the 10A7 Ab, which reacts with most but not all mouse NK cells ( 18 ), binds to one or more members of the mouse NKRP1 family (J. C. Ryan and W. E. Seaman, personal communication) and may therefore delineate a subpopulation of NK cells with distinct recognition capabilities. (jimmunol.org)
  • Higher activity of oxidative drug demethylation in the liver microsomes from dystrophic mouse. (jax.org)
  • Isoenzyme transitions of creatine phosphokinase, aldolase and phosphoglycerate mutase in differentiating mouse cells. (jax.org)
  • Selection in the mouse thymus of pha- and con a-responsive cells. (jax.org)
  • Regeneration and dose-response characteristics of irradiated mouse dorsal epidermal cells. (jax.org)
  • Lovastatin-induced G 2 -M arrest has also been reported in several cell lines including the T24 human bladder carcinoma cell line ( 12 ) and the L1210 mouse leukemia cell line ( 13 ). (aacrjournals.org)
  • 5 nmol/L). PARP-1 −/− mouse embryonic fibroblasts were 3-fold more sensitive to topotecan than PARP-1 +/+ mouse embryonic fibroblasts (GI 50 , 21 and 65 nmol/L, respectively). (aacrjournals.org)
  • Poly (ADP-ribose) metabolism in alkylated mouse L5178Y cells. (openrepository.com)
  • Basal activities in both lymphoma lines were 3-4-fold greater than in mouse L1210 leukaemia cells. (openrepository.com)
  • line
  • Flow cytometry-based efflux assays were performed to examine KB-V1 cells incubated with either calcein AM (1 uM, red line) or calcein AM plus BEZ235, BI 2536, IKK 16, ispinesib, or bryostatin-1 (5 uM, blue line). (selleckchem.com)
  • The present study is also devoted to providing a better understanding with regard to the biosynthesis of related diterpenes in the plant cell culture line of T. wilfordii designated as TRP4a. (ubc.ca)
  • Twenty nine compounds (28 diterpenes) were isolated, of which 26 (including 14 new natural products) were isolated for the first time from this cell culture line. (ubc.ca)
  • Epithelial Cells
  • In the FT, interactions between mucosal epithelial cells and gonococci are pivotal events in the pathogen's infection cycle and the inflammatory response. (biomedsearch.com)
  • induce
  • Given that both lovastatin and paclitaxel are used in the clinic and are capable of inducing cell cycle-specific effects, it is of great interest to determine whether combinations of these agents induce additive or supra-additive effects that may be harnessed for novel therapeutic applications. (aacrjournals.org)
  • Biological Activity
  • In particular, proteins of the RAS superfamily, including Ras, RhoB, and Rap1A, are highly dependent upon farnesylation and geranylgeranylation for membrane localization and biological activity. (aacrjournals.org)
  • malignant
  • Cytochalasin B is a cytokinesis inhibitor that preferentially enlarges and multinucleates malignant cells, making them much more sensitive to ultrasonic irradiation. (jove.com)
  • human
  • Cell surface antigens coded for by the human chromosome 7. (jax.org)
  • Different cells and tissues show differential expression of GSLs, and changes in structures of GSL glycan moieties occur during development of numerous types of human cancer. (frontiersin.org)
  • membrane
  • As 2 O 3 treatment for 24 h induced low (HPB-ALL), intermediate (Jurkat) and high (EL-4, BW5147) levels of B220 membrane expression, membrane-bound HSP70 and cell death, but inhibited NF-κB p50 nuclear translocation. (biomedcentral.com)
  • IC50
  • The IC50 values for araC and araG were increased, but only 10-12-fold in the dGuo- R cells when compared with the wild-type cells. (ecu.edu)
  • L1210 cells (which contain GM1a ganglioside) are sensitive to the inhibiting activity of CT (IC50 in the clonogenic assay = 10(-9) M) but no cAMP accumulation was observed after the treatment. (unimi.it)
  • childhood leukemia
  • The ability of combination chemotherapy to cure acute childhood leukemia and advanced Hodgkin's disease in the 1960s and early 1970s overcame the prevailing pessimism about the ability of drugs to cure advanced cancers, facilitated the study of adjuvant chemotherapy, and helped foster the national cancer program. (aacrjournals.org)
  • Maternal smoking and childhood leukemia and lymphoma risk among 1,440,542 Swedish children. (openrepository.com)
  • cytosine arabinoside
  • when cytosine arabinoside or deoxyguanosine was used as the substrate, the kinase activity in the extracts from the dGuo-R cells was only 10% of the enzyme activity in the extracts from the wild-type cells. (ecu.edu)
  • the Km values for deoxycytidine and cytosine arabinoside were increased in the extracts from the dGuo-R cells. (ecu.edu)
  • There was the specific loss of kinase activity toward cytosine arabinoside and deoxyguanosine as substrates. (ecu.edu)
  • pathway
  • Although the existence of NK cells has been known for more than 20 years, many of the basic issues concerning these cells, such as their developmental pathway, their mechanisms of recognition, and their physiologic function, are still poorly understood. (jimmunol.org)
  • kinase
  • These data indicate that the dGuo-R cells have decreased levels of a specific deoxyribonucleoside kinase activity. (ecu.edu)
  • Cancer
  • A steadily increasing number of subsequent studies described aberrant expression and function of GSLs and related enzymes in cancer cells and tissues. (frontiersin.org)
  • He was also the first person to document the effectiveness of animal models to screen a series of chemicals for their potential activity against diseases, an accomplishment that had major ramifications for cancer drug development. (aacrjournals.org)
  • The major limitations of drug discovery were two-fold: first, the development of models that could effectively be used to reduce the vast repertoire of chemicals to those few that might have activity against cancer in humans, and second, the access to clinical facilities to test such agents. (aacrjournals.org)