Cell AgingColorectal NeoplasmsCell Line, TumorHCT116 CellsHT29 CellsCell ProliferationGene Expression Regulation, NeoplasticColonic NeoplasmsApoptosisTumor Suppressor Protein p53Cyclin-Dependent Kinase Inhibitor p16Cyclin-Dependent Kinase Inhibitor p21TelomereSignal Transductionbeta-GalactosidaseColonoscopyAdenomaAntineoplastic AgentsTumor Cells, CulturedTelomeraseAging, PrematureRNA, Small InterferingMice, NudeAdenocarcinomaCell CycleRectal NeoplasmsReverse Transcriptase Polymerase Chain ReactionFluorouracilBlotting, WesternNeoplasm MetastasisNeoplasm InvasivenessDown-RegulationEarly Detection of CancerColorectal Neoplasms, Hereditary NonpolyposisAgingBreast NeoplasmsNeoplasm ProteinsOrganoplatinum CompoundsRNA, MessengerCell DivisionFibroblastsDNA DamageTumor Markers, BiologicalRNA InterferenceCamptothecinMutationImmunohistochemistryUp-Regulationbeta CateninNeoplasmsDrug Resistance, NeoplasmSigmoidoscopyCell SurvivalReactive Oxygen SpeciesCarcinomaCells, CulturedTransfectionTelomere ShorteningNeoplasm StagingLiver NeoplasmsPrognosisBiological ProcessesTime FactorsXenograft Model Antitumor AssaysPhenotypeColonic PolypsCaco-2 CellsDNA MethylationDose-Response Relationship, DrugDNA, NeoplasmCell Transformation, Neoplasticras ProteinsDNA-Binding ProteinsGene SilencingOccult BloodPromoter Regions, GeneticColonCarcinoembryonic AntigenLeucovorinCell MovementGenes, rasAntineoplastic Agents, PhytogenicGene Expression ProfilingFlow CytometryProto-Oncogene ProteinsAntimetabolites, AntineoplasticRetinoblastoma ProteinMicrosatellite RepeatsOxidative StressLung NeoplasmsNeoplasm TransplantationCell Growth ProcessesTransplantation, HeterologousProto-Oncogene Proteins B-rafPhosphorylationGene Knockdown TechniquesCell LineNuclear ProteinsAntineoplastic Combined Chemotherapy ProtocolsRectum