Cell AgingCyclin-Dependent Kinase Inhibitor p16TelomereFibroblastsTumor Suppressor Protein p53Aging, PrematureCyclin-Dependent Kinase Inhibitor p21TelomeraseAgingTelomere Shorteningbeta-GalactosidaseDNA DamageCells, CulturedCell ProliferationRetinoblastoma ProteinCell CycleCell Cycle CheckpointsCell Line, TumorOxidative StressCell Transformation, NeoplasticSignal TransductionTumor Suppressor Protein p14ARFPlant LeavesTumor Suppressor ProteinsCell LineSirtuin 1LongevityReactive Oxygen SpeciesProgeriaTelomeric Repeat Binding Protein 2PhenotypeNeoplasmsNuclear ProteinsRNA, Small InterferingDiploidyApoptosisGenes, p16Gene Expression RegulationRNA InterferenceDown-RegulationModels, BiologicalCell DivisionDNA-Binding ProteinsHydrogen PeroxideHeterochromatinras ProteinsGene Knockdown TechniquesWerner SyndromeRepressor ProteinsTranscription FactorsUp-RegulationMutationOncogenesForeskinCell Cycle ProteinsOxidantsBlotting, WesternGenes, rasMice, KnockoutHCT116 CellsCyclin-Dependent Kinase Inhibitor p15TOR Serine-Threonine KinasesGene SilencingCell Line, TransformedNevus, PigmentedHistonesGene Expression Regulation, PlantChlorophyllEthylenesPolycomb Repressive Complex 1Proto-Oncogene Proteins c-mycReverse Transcriptase Polymerase Chain ReactionGene Expression Regulation, NeoplasticGenes, p53Protein-Serine-Threonine KinasesTelomere HomeostasisRNA, MessengerInhibitor of Differentiation Protein 1Endothelial CellsTime FactorsSirtuinsMicroRNAsCell ShapeCyclin-Dependent Kinase Inhibitor p27Promoter Regions, GeneticMice, Inbred C57BLGenomic InstabilityEmbryo, MammalianArabidopsisCyclin-Dependent Kinase 6Jumonji Domain-Containing Histone DemethylasesIsopropyl ThiogalactosideEpithelial CellsRadiationTranscription, GeneticMolecular Sequence DataTransfectionMelanocytesAutophagyBiological Markers