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Sendai virusParainfluenza Virus 1, HumanRespirovirusRespirovirus InfectionsParamyxoviridae InfectionsVirus ReplicationRNA VirusesViral ProteinsViral Fusion ProteinsHN ProteinVaccinia virusDefective VirusesReceptors, VirusVirus CultivationRNA, ViralVirus DiseasesHemadsorptionCell LineVirus AssemblyMeasles virusHemagglutination, ViralVirus SheddingCell FusionNucleocapsid ProteinsSindbis VirusAntigens, ViralSimian virus 40Genes, ViralHemagglutinins, ViralPlant VirusesVesicular stomatitis Indiana virusParainfluenza Virus 3, HumanDNA VirusesNucleoproteinsVirionParamyxoviridaeChick EmbryoViral InterferenceVirus ActivationInfluenza A Virus, H1N1 SubtypeRespiratory Syncytial VirusesMumps virusCytopathogenic Effect, ViralRabies virusInfluenza A Virus, H5N1 SubtypeViral Core ProteinsMolecular Sequence DataNeuraminidaseInterferon-betaCercopithecus aethiopsVero CellsOrthomyxoviridaeVirus InactivationInfluenza A Virus, H3N2 SubtypeHemagglutinin Glycoproteins, Influenza VirusHepatitis B virusNucleocapsidWest Nile virusViral Plaque AssayGenetic VectorsInterferon Regulatory Factor-3Membrane FusionInterferonsHemolysisCricetinaeAmino Acid SequenceGlycoproteinsHeLa CellsAntiviral AgentsHaplorhiniAntibodies, ViralVirus LatencyCapsidOrthomyxoviridae InfectionsCells, CulturedNeutralization TestsNewcastle disease virusGene Expression Regulation, ViralCulture TechniquesOncogenic VirusesDNA, ViralSimian immunodeficiency virusViral Matrix ProteinsL Cells (Cell Line)Microscopy, ElectronPneumonia, ViralMosaic VirusesHemagglutination TestsRodent DiseasesRNA, MessengerCentrifugation, Density GradientTranscription, GeneticTemperatureHepatitis A virusSemliki forest virusHemagglutination Inhibition TestsDNA-Directed RNA PolymerasesAvian Sarcoma VirusesVirus AttachmentBK Virus
PeptideInfectionReplicationLymphoblastoid cellsInfluenza virusParainfluenzaStrainsCellsGeneCharacterizationGenomicVirologyPneumoniaDifferentiationProteinNewcastleInterferonHumanHiPSCViral vectorsMicePandemicStrainMammalianVaccinesZoonoticRespiratoryTypeClonesAirborneTransmissibilityJapanDiseasePhenotypicIsolationCellGenesIdentificationAfricaHumansProteinsHost
Peptide1
  • The FAPGNYPAL peptide is from Sendai virus nucleoprotein (324-332). (biolegend.com)
Infection5
  • The high efficiency of Sendai virus infection resulted in high rates of on-target mutagenesis in cell lines (75-98% at various endogenous and transgenic loci) and primary human monocytes (88% at the ccr5 locus) in the absence of any selection. (geg-tech.com)
  • Respiratory epithelium appears to be the major site of virus binding and subsequent infection. (medscape.com)
  • Vaccine-induced antibody and T cell responses correlated with protection against lethal influenza virus infection. (researchsquare.com)
  • Moreover, antibody responses induced by influenza virus vaccines are usually short-lived and less cross-reactive against antigenically drifted virus variants than those induced by a natural influenza virus infection 1 . (researchsquare.com)
  • The findings suggest that viral infections and chronic rejection play a synergistic role in the development of bronchiolitis obliterans after human heart-lung and lung transplantation: the virus infection may stimulate chronic rejection and rejection may hamper the local defense against the virus. (rug.nl)
Replication3
  • The rule of six, a basic feature for efficient replication of Sendai virus defective interfering RNA. (microbiologyresearch.org)
  • Defective genomes arise when the viral polymerases lose processivity during virus replication at high titers. (plos.org)
  • To cause pandemics, zoonotic respiratory viruses need to adapt to replication in and spread between humans, either via (indirect or direct) contact or through the air via droplets and aerosols. (bvsalud.org)
Lymphoblastoid cells2
  • Cloning, expression and biological activity of a new variant of human interferon alpha identified in virus induced lymphoblastoid cells. (nih.gov)
  • Mixture of natural human a -interferons derived from lymphoblastoid cells exposed to Sendai virus. (drugfuture.com)
Influenza virus4
  • Preliminary experiments showed that similar effector cells can be recovered from the lungs of mice 5 days after intranasal inoculation of infectious influenza virus, so they may contribute to the host control of the disease. (edu.hk)
  • Despite several vaccine candidates available on the market, influenza virus is responsible for severe illness in humans, with a substantial global death toll every year (https://gis.cdc.gov/grasp/fluview/flu_by_age_virus.html). (researchsquare.com)
  • Protective anti-influenza immunity often correlates with antibody responses to influenza surface glycoproteins, particularly hemagglutinin (HA), the main antigenic determinant on the surface of both influenza virus and infected cells. (researchsquare.com)
  • During influenza virus entry, the hemagglutinin (HA) protein binds receptors and causes membrane fusion after endosomal acid activation. (bvsalud.org)
Parainfluenza7
  • Parainfluenza viruses (PIVs) are paramyxoviruses of the order Mononegavirales, the family Paramyxoviridae, and the subfamily Paramyxovirinae. (medscape.com)
  • Parainfluenza virus, type 1. (prosci-inc.com)
  • Parainfluenza Virus antibody is purified from ascites fluid or culture medium by protein A chromoatography or sequential differential precipitations. (prosci-inc.com)
  • Parainfluenza Virus antibody is in a phosphate saline buffer (0.01M, pH 7.2) containing 0.1% sodium azide preservative. (prosci-inc.com)
  • Parainfluenza Virus antibody can be stored at -20°C, stable for one year. (prosci-inc.com)
  • The studies utilized the Ao/PR/8/34-influenza and Sendai-parainfluenza virus strains incubated with Rhesus-monkey kidney and human Chang conjunctival cell lines. (cdc.gov)
  • The remaining 16 rats in each group were infected with Sendai virus (parainfluenza type 1) intratracheally. (rug.nl)
Strains4
  • However, due to antigenic drift in influenza viruses, vaccines need to be updated every year to protect against the circulating strains of the virus. (researchsquare.com)
  • Because seasonal influenza viruses are constantly changing, vaccine strains should be updated to ensure the closest possible match with circulating strains. (who.int)
  • 3 Many viruses isolated in the Region have been recommended as vaccine strains by WHO. (who.int)
  • For seawater, 10 L was filtered, viruses were sapovirus (SaV), norovirus (NoV), rabbit hemorrhagic dis- absorbed to a filter (type HA negatively charged mem- ease virus, and feline calicivirus strains, respectively. (cdc.gov)
Cells6
  • In conjunction with extensive former work on Sendai virus as a promising gene therapy vector that can infect a wide range of cell types including hematopoietic stem cells, this proof-of-concept study opens the door to using Sendai virus as well as other RNA viral vectors as versatile and efficient tools for gene editing. (geg-tech.com)
  • Cytotoxic activity of cba mouse spleen cells against sendai virus infected l cells. (jax.org)
  • Injection of infectious but not of non‐infections influenza A virus or of infectious or non‐infectious Sendai virus intraperitoneally into mice induces the generation of plastic‐adherent cells that arc able to effect release of 51 Cr from labelled virus‐infected target cells but not from labelled, uninfcctcd cells. (edu.hk)
  • Although the effector cells are cross‐reactive in that cells activated by an influenza A strain virus lyse target cells infected with the same or other A strain viruses or with Sendai virus, there is preferential lysis of cells infected with the homologous virus. (edu.hk)
  • The viruses attach to the host cells through hemagglutinin, which specifically combines with neuraminic acid receptors in the host cells. (medscape.com)
  • Different immunoglobulin G (IgG) subclasses produced by class-switched B cells help in opsonization and virus neutralization and hence, facilitate viral clearance from the host. (researchsquare.com)
Gene2
  • Analysis of the Sendai virus M gene and protein. (microbiologyresearch.org)
  • In this study, the scientists repurpose Sendai virus, an RNA virus with no viral DNA phase as a delivery system for efficient Cas9-mediated gene editing. (geg-tech.com)
Characterization4
  • Molecular cloning and characterization of a Sendai virus internal deletion defective RNA. (microbiologyresearch.org)
  • Stang A , Korn K . Characterization of virus isolates by particle-associated nucleic acid PCR. (cdc.gov)
  • Detection, quantitation, and characterization of the major internal virion antigen of the bovine leukemia virus by radioimmunoassay. (nih.gov)
  • Isolation and characterization of an antigen of the bovine C-type virus. (nih.gov)
Genomic1
  • 7529 /organism="Norovirus GII/Hu/JP/2007/GII.P7_GII.14/Sendai/YG99" /mol_type="genomic RNA" /isolate="Sendai/YG99" /host="Homo sapiens" /db_xref="taxon:1529921" /country="Japan" /collection_date="2007" /note="genotype: GII.P7_GII.14" CDS 5. (cdc.gov)
Virology1
  • In 2016, 2018, and 2020, we organized international virology conferences, held in Basel, Switzerland (2016) and Barcelona, Spain (2018 and 2020), and we are currently planning the Viruses 2022 conference, to be held virtually. (mdpi.com)
Pneumonia1
  • HPIV-3 is second only to respiratory syncytial virus (RSV) as a cause of pneumonia and bronchiolitis in infants and young children. (medscape.com)
Differentiation2
  • Intramembrane structural differentiation in Sendai virus maturation. (microbiologyresearch.org)
  • Schulze M , Nitsche A , Schweiger B , Biere B . Diagnostic approach for the differentiation of the pandemic influenza A(H1N1)v virus from recent human influenza viruses by real-time PCR. (cdc.gov)
Protein4
  • Substitution of Val 113 in Sendai virus (SeV) M protein generates non-functional polypeptides, characterized by their exclusion from virus particles and by their ability to interfere with virus particle production. (microbiologyresearch.org)
  • Sendai virus M protein is found in two distinct isoforms defined by monoclonal antibodies. (microbiologyresearch.org)
  • We have detected a leucine zipper-like motif in the ectodomain of Sendal virus fusion protein (a. a. 269-307) which is extremely conserved in the family of Sendal viruses. (tau.ac.il)
  • The data suggest a possible rote of this putative leucine zipper motif in the assembly of the Sendal virus fusion protein in solution and membrane. (tau.ac.il)
Newcastle3
  • Newcastle disease virus is a rubulavirus that infects poultry, penguins, and other birds and has been responsible for conjunctivitis in bird handlers and laboratory workers. (medscape.com)
  • Glicoproteína del virus de Sendai, el virus paragripal, el virus de la enfermedad de Newcastle y otros virus, que interviene en la unión del virus a los receptores de la superficie celular. (bvsalud.org)
  • Glycoprotein from Sendai, para-influenza, Newcastle Disease, and other viruses that participates in binding the virus to cell-surface receptors. (bvsalud.org)
Interferon2
  • Identification of nine interferon-alpha subtypes produced by Sendai virus-induced human peripheral blood leucocytes. (nih.gov)
  • The authors conclude that the effects of BaP metabolites on virus mediated interferon induction extends the existing assay methods for identifying biologically reactive mutagenic carcinogens. (cdc.gov)
Human5
  • Here, we describe the StemCellFactory, an automated, modular platform covering the entire process of hiPSC production, ranging from adult human fibroblast expansion, Sendai virus-based reprogramming to automated isolation, and parallel expansion of hiPSC clones. (frontiersin.org)
  • Seasonal Influenza A virus (IAV) and influenza B virus (IBV) co-circulate in the human population and keep evolving with time. (researchsquare.com)
  • Mixture of natural, human a -interferons produced by human leukocytes exposed to Sendai virus. (drugfuture.com)
  • 1 In addition to seasonal influenza epidemics, antigenically distinct viruses originating from animal species tend to emerge in the human population every 10 to 40 years. (who.int)
  • Since most the human population does not have immunity to such viruses, global epidemics with significant impact, i.e. influenza pandemics, have occurred in the past. (who.int)
HiPSC1
  • Our HiPSC are generated with the RNA-based Sendai virus to deliver reprogramming factors to donor skin fibroblasts. (cellapplications.com)
Viral vectors1
  • Since its founding, the DDL has become one of the world's leading vaccine research and development labs, evolving their design of viral vectors based on the vesicular stomatitis virus (VSV) to develop HIV vaccine candidates. (iavi.org)
Mice1
  • Working with Sendai and influenza viruses in mice, Carolina López and colleagues show that defective viral genomes accumulate during acute viral respiratory infections. (plos.org)
Pandemic6
  • SOLNA, SWEDEN-The use of air cleaners has become more frequent during the pandemic, but how effective are they at fighting viruses? (greenlodgingnews.com)
  • During the COVID-19 pandemic, the question of whether airborne viruses can be eliminated from indoor air was raised. (greenlodgingnews.com)
  • The proclivity of the current A(H5N1) 2.3.4.4b virus lineage to reassort and target the central nervous system warrants concerted planning to combat the spread and evolution of the virus within the continent and to mitigate the impact of a potential influenza pandemic that could originate from similar A(H5N1) reassortants. (bvsalud.org)
  • To improve vaccine efficiency and pandemic risk assessment for currently-dominant H3N2 influenza viruses, we investigated HA stability of 6 vaccine reference viruses and 42 circulating viruses. (bvsalud.org)
  • 4 Therefore, influenza surveillance in the Region is critical in monitoring antigenic changes of seasonal influenza and detecting viruses with pandemic potential. (who.int)
  • 7 If this virus acquires transmissibility among humans and becomes a pandemic virus, it may have devastating health and social impacts. (who.int)
Strain1
Mammalian2
  • He B , Li Z , Yang F , Zheng J , Feng Y , Guo H , Virome profiling of bats from Myanmar by metagenomic analysis of tissue samples reveals more novel mammalian viruses. (cdc.gov)
  • They also highlight questions about the interactions between bat viruses and their flying mammalian hosts. (plos.org)
Vaccines3
  • Most vaccines are made with killed or weakened viruses. (healthline.com)
  • Live vector vaccines use non-HIV viruses to carry HIV genes into the body to trigger an immune response. (healthline.com)
  • The DDL is also expanding on the VSV technology to design vaccines against viruses responsible for emerging infectious diseases such as Lassa fever, Marburg virus disease, COVID-19, and most recently Sudan Ebola virus. (iavi.org)
Zoonotic1
  • In their Pearl, James Wynne and Lin-Fa Wang focus on bat viruses that have caused zoonotic disease outbreaks in humans and domestic animals. (plos.org)
Respiratory2
  • Chimpanzees, macaques, squirrels, owls, and rhesus monkeys have been asymptomatically infected with HPIV-3 or HPIV-4, and only marmosets have developed symptomatic upper respiratory tract infections (URTIs) with HPIV-3 and Sendai virus. (medscape.com)
  • We here summarize available data from (animal) studies on the impact of HA acid stability on airborne transmission and hypothesize that the transmissibility of other respiratory viruses may also be impacted by an acidic environment in the airways. (bvsalud.org)
Type1
  • We found that the wild type SV-269 specifically binds Sendal virus, whereas MuSV-269 cannot. (tau.ac.il)
Clones1
Airborne3
  • The result shows that the QleanAir FS 30 air cleaner can remove over 95 percent of airborne virus particles in only 10 minutes. (greenlodgingnews.com)
  • The recent vaccine reference viruses with destabilized HA proteins had reduced infectivity, had no airborne transmissibility unless reversion to HA1-P194L occurred, and had skewed antigenicity away from the studied viruses and circulating H3N2 viruses. (bvsalud.org)
  • Understanding how animal influenza A viruses (IAVs) acquire airborne transmissibility in humans and ferrets is needed to prepare for and respond to pandemics. (bvsalud.org)
Transmissibility1
  • Other vaccine reference viruses with stabilized HAs retained infectivity, transmissibility, and antigenicity. (bvsalud.org)
Japan2
  • A joint study by the Virus Research Centre at Sendai Medical Center and QleanAir Japan center has succeeded in measuring this. (greenlodgingnews.com)
  • Public Health and Environment, Sendai, Japan wastewater). (cdc.gov)
Disease2
  • The immune system, which fights disease, doesn't respond to the HIV virus. (healthline.com)
  • These reassortant A(H5N1) viruses are genotypically and phenotypically diverse, with many causing severe disease with dramatic neurologic involvement in mammals. (bvsalud.org)
Phenotypic1
  • To render influenza A viruses transmissible via air, three phenotypic viral properties must change, of which receptor-binding specificity and polymerase activity have been well studied. (bvsalud.org)
Isolation1
  • Baker KS , Leggett RM , Bexfield NH , Alston M , Daly G , Todd S , Metagenomic study of the viruses of African straw-colored fruit bats: detection of a chiropteran poxvirus and isolation of a novel adenovirus. (cdc.gov)
Cell4
  • We have developed a feeder-free, Sendai virus-mediated reprogramming protocol suitable for cell culture processing via a robotic liquid handling unit that delivers footprint-free hiPSCs within 3 weeks with state-of-the-art efficiencies. (frontiersin.org)
  • Since the virus does not go through a DNA phase, its genetic material and transgenes do not integrate into the host cell genome. (cellapplications.com)
  • Virus growth in cell culture was independent of HA stability. (bvsalud.org)
  • Sendai virus clearance, cell authentication (STR), pluripotency and undifferentiated state confirmation, molecular karyotype, g-banding and iPS growth pattern and morphology analysis. (lu.se)
Genes1
  • Here we show that the western movement of clade 2.3.4.4b was quickly followed by reassortment with viruses circulating in wild birds in North America, resulting in the acquisition of different combinations of ribonucleoprotein genes. (bvsalud.org)
Identification1
  • Clem AL , Sims J , Telang S , Eaton JW , Chesney J . Virus detection and identification using random multiplex (RT)-PCR with 3′-locked random primers. (cdc.gov)
Africa1
  • Highly pathogenic avian influenza A(H5N1) viruses of clade 2.3.4.4b underwent an explosive geographic expansion in 2021 among wild birds and domestic poultry across Asia, Europe, and Africa. (bvsalud.org)
Humans1
  • This virus is highly pathogenic in chickens, but it also causes very severe infections in humans. (who.int)
Proteins1
  • Recent vaccine reference viruses had destabilized HA proteins due to egg-adaptive mutation HA1-L194P. (bvsalud.org)
Host2
  • Microscopy of internal structures of Sendai virus associated with the cytoplasmic surface of host membranes. (microbiologyresearch.org)
  • Recent studies show that there may be a correlation between HA acid stability and virus survival in the air, suggesting that a premature conformational change of HA, triggered by low pH in the airways or droplets, may render viruses noninfectious before they can reach a new host. (bvsalud.org)