• Herkinorin is an opioid analgesic that is an analogue of the natural product salvinorin A. It was discovered in 2005 during structure-activity relationship studies into neoclerodane diterpenes, the family of chemical compounds of which salvinorin A is a member. (wikipedia.org)
  • Further tests are warranted to elucidate the mechanisms by which the novel salvinorin-based neoclerodane diterpene KOP receptor ligands produce both anti-addiction and adverse side effects. (salviasuppliers.com)
  • Tiasan is a semi-synthetic diterpene antibiotic. (vetplanets.com)
  • we find that the value of the natural plants' comes from 1) the rate of implementation of novel natural compounds with a broad structural diversity, such as helping as templates for semisynthetic and total synthetic modification, 2) whole ailments prevented by these compounds, continues 3) assign a value to which they are used in disease treatment. (interesjournals.org)
  • The activity has been attributed to the presence of Xylopic acid the major diterpene component of the fruit oil extract. (etsu.edu)
  • The marine sponge Dendrilla rosea was examined for the presence of new spongian diterpenes. (vuw.ac.nz)
  • Lefamulin, previously known as BC-3781, is a semisynthetic pleuromutilin antibiotic that was approved by the Food and Drug Administration for the treatment of CABP in adults. (nih.gov)
  • Valnemulin, a semisynthetic pleuromutilin derivative related to tiamulin, is broadly used to treat bacterial diseases of animals. (nih.gov)
  • Tiamulin In Poultry, (C32H51NO8S) defined as antimycoplasmal semi synthetics drugs derived from diterpene antimicrobials with a pleuromutilin chemical structure. (poultrymania.com)
  • Among abietane type semisynthetic diterpenoids, a series of quinopimaric and maleopimaric acid derivatives modified at the carboxyl and carbonyl groups, and in ring E were synthesised to obtain new compounds with antimicrobial potency against Mycobacterium tuberculosis H 37 Rv and key ESKAPE pathogens. (nih.gov)
  • Diterpenoids containing an abietane skeleton including taxodone ( 1 ) and taxodione ( 2 ), as well as the semisynthetic derivatives 12 , 14 , 15 , 17 , and 22 , were the most cytotoxic compounds for human leukemia cells. (eclatlab.com)
  • 3. Anticancer activity of andrographolide semisynthetic derivatives. (nih.gov)
  • Overexpression of the protective mitochondrial proteins Bcl-2 and Bcl-x L did not confer resistance to abietane diterpene-induced cytotoxicity. (eclatlab.com)
  • Cell death induced by these abietane diterpenes was found to be associated with the release of mitochondrial proteins, including cytochrome c , Smac/DIABLO, and AIF (apoptosis-inducing factor), accompanied by dissipation of the mitochondrial membrane potential (ΔΨ), and modulated by inhibition of extracellular signal-regulated kinases signaling and the p38 mitogen-activated protein kinase pathway. (eclatlab.com)
  • Herkinorin is an opioid analgesic that is an analogue of the natural product salvinorin A. It was discovered in 2005 during structure-activity relationship studies into neoclerodane diterpenes, the family of chemical compounds of which salvinorin A is a member. (wikipedia.org)
  • This compound selectively inhibits the nuclear enzyme DNA TOPOISOMERASES, TYPE I. Several semisynthetic analogs of camptothecin have demonstrated antitumor activity. (bvsalud.org)