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  • regulation
  • This overall topic is too large for a single lecture, so will focus on our understanding of the regulation of the cell cycle. (edu.au)
  • neurons
  • This study aimed at evaluating whether apoptosis of interstitial cells of Cajal (ICC), smooth muscle cells (SMC), and enteric neurons was involved in a guinea pig model of intestinal ischemia and reperfusion injury. (biomedsearch.com)
  • In the SGZ, new granule neurons are generated by NSCs over the lifetime of an animal, but contrary to the VZ-NSCs, these cells have no replenishment function [ 1 ]. (iospress.com)
  • regulate
  • We have discovered unique sets of microRNAs that regulate these processes and show targets are important for maintaining quiescence of promotion cell cycle entry. (stanford.edu)
  • transcription
  • β-Catenin then translocates to the nucleus and induces target gene expression together with transcription factors of the T cell factor/lymphoid enhancer factor (TCF/LEF) family. (biologists.org)
  • Signal Transducer and Activator of Transcription 3 (STAT3) is a transcription factor with many important functions in the biology of normal and transformed cells. (springer.com)
  • epithelial
  • Mammary epithelial cells form a network of branching ducts composed of a luminal and a basal myoepithelial layer. (rupress.org)
  • Epithelial cells stained strongly, with trophoblasts having the greatest staining. (diva-portal.org)
  • Moreover, bulge stem cells can give rise to different epithelial cell types of hair follicles and participate in the formation of hair follicles, epidermis and sebaceous glands. (medsci.org)
  • molecular
  • First, we are using microarray and next-generation high throughput sequencing to derive molecular signatures of young and old stem cells and the transcriptional and epigenetic levels. (stanford.edu)
  • Recently, this cellular heterogeneity could also be demonstrated on the molecular level using single cell transcriptomics [ 10 ]. (iospress.com)
  • We have employed single-cell mass cytometry and RNA-sequencing to provide a refined set of molecular definitions to the muscle stem and progenitor cell functional hierarchy and discovered dysfunctional MuSC subpopulations that are increasing observed in advanced aging. (buffalo.edu)
  • hematopoietic
  • Ihor will be remembered for his great sense of humor and his pioneering work on embryonic and hematopoietic stem cells. (utahcordbank.com)
  • Hematopoietic and CD45 − /VEGFR2 + cells (known as endothelial progenitor cells or circulating angiogenic cells) have been reported to contribute to angiogenesis through the paracrine secretion of proangiogenic factors, as well as incorporate into new vessels, although luminal incorporation appears to be a relatively rare event ( 48 , 55 ). (physiology.org)
  • functional
  • The main goal was to retard the atrophy and replace diseased muscle with new healthy and functional muscle fibers by using myogenic stem cells ( Brunelli and Rovere-Querini, 2008 ). (frontiersin.org)
  • In this review, the distribution of telocytes in different stem cell niches will be explored, highlighting the intimate relationship between the two types of cells and their possible functional relationship. (springer.com)
  • mechanisms
  • These results indicate that Wnt5a is a cell-extrinsic factor that supports SSC self-renewal through β-catenin-independent mechanisms. (biologists.org)
  • Second, we have pioneered the use of heterochronic parabiosis to study potential mechanisms of rejuvenation whereby an aged stem cell is reprogrammed to become a young stem cell. (stanford.edu)