• She elucidated some alterations in metabolic pathways that led to resistance to the purine antagonists. (cuny.edu)
  • Her 1954 paper that quantified the synergistic effects of purine antagonists with pyrimidine and folic acid antagonists has become a classic in the field. (cuny.edu)
  • Additional focus will be placed on the main classes of immune inhibitor therapy utilized in transplant patients and in autoimmune disease including TNF-alpha, Calcineurin, mTOR, purine synthesis antagonists and IMPDH inhibitors. (mdpi.com)
  • Methotrexate, a folic acid analog/antimetabolite, can be curative for women with choriocarcinoma and is also useful for non-Hodgkin lymphomas and acute lymphocytic leukemias (ALLs) in children. (medquizzes.net)
  • Working in collaboration with George H. Hitchings, she synthesized a large number of purines, including 6-mercaptopurine and thioguanine, and investigated their loci of action in microbiological systems. (cuny.edu)
  • Hitchings, who would later become a member of the National Academy of Sciences, "talked about purines and pyrimidines, which I must confess I'd never even heard of up to that point, and it was really to attack a whole variety of diseases by interfering with DNA synthesis. (cuny.edu)
  • It interferes with nucleic acid synthesis by inhibiting purine metabolism and is used, usually in combination with other drugs, in the treatment of or in remission maintenance programs for leukemia. (lookformedical.com)
  • Purine bases related to hypoxanthine, an intermediate product of uric acid synthesis and a breakdown product of adenine catabolism. (lookformedical.com)
  • 65 Elion synthesized anti-metabolites of purines, and in 1950, she developed the anti-cancer drugs tioguanine and mercaptopurine. (wikipedia.org)
  • The modern drug discovery process has largely focused its attention in the so-called magic bullets, single chemical entities that exhibit high selectivity and potency for a particular target. (biomedcentral.com)
  • 6. Nelarabine: a novel purine antimetabolite antineoplastic agent. (nih.gov)
  • Nelarabine is a purine nucleoside analog and antineoplastic agent used for the treatment of with acute T-cell lymphoblastic leukemia and T-cell lymphoblastic lymphoma with inadequate clinical response to prior chemotherapeutic treatments. (drugbank.com)
  • 1. A nelarabine-resistant T-lymphoblastic leukemia CCRF-CEM variant cell line is cross-resistant to the purine nucleoside phosphorylase inhibitor forodesine. (nih.gov)
  • Nelarabine is a purine nucleoside analog converted to its corresponding arabinosylguanine nucleotide triphosphate (araGTP), resulting in the inhibition of DNA synthesis and cytotoxicity. (drugbank.com)
  • 14 Nelarabine preferentially accumulates in T-cells since T-cells have a higher expression of enzymes that convert nelarabine to the active purine analog form, making them effective against T-cells malignancies. (drugbank.com)
  • 10. Forodesine, an inhibitor of purine nucleoside phosphorylase, induces apoptosis in chronic lymphocytic leukemia cells. (nih.gov)
  • 12. Forodesine (BCX-1777, Immucillin H)--a new purine nucleoside analogue: mechanism of action and potential clinical application. (nih.gov)
  • 14. Purine nucleoside phosphorylase inhibition as a novel therapeutic approach for B-cell lymphoid malignancies. (nih.gov)
  • 15. Purine nucleoside analogs as immunosuppressive and antineoplastic agents: mechanism of action and clinical activity. (nih.gov)
  • 17. Novel purine nucleoside analogues for T-cell-lineage acute lymphoblastic leukaemia and lymphoma. (nih.gov)
  • Up- and down-regulated genes include many transcriptional regulators, stress-related proteins, transporters and several enzymes involved in purine metabolism. (biomedcentral.com)
  • The purine derivative fludarabine is part of frontline therapy for chronic lymphocytic leukaemia (CLL). (bvsalud.org)
  • The presence of the 'decoy' antimetabolites prevents the cells from carrying out vital functions and the cells are unable to grow and survive. (cancerquest.org)
  • is highly selective to cancer cells with mean selectivity indices to human (136) and murine (320) cancer cells. (bvsalud.org)
  • 9. Metabolic basis of arabinonucleoside selectivity for human leukemic T- and B-lymphoblasts. (nih.gov)
  • In the cell, antimetabolites are mistaken for the metabolites they resemble, and are processed in the cell in a manner analogous to the normal compounds. (cancerquest.org)