Some terms for this phenomenon include functional selectivity, agonist-directed trafficking, and biased agonism. (aspetjournals.org)
Besides the heuristically interesting nature of functional selectivity, there is a clear impact on drug discovery, because this mechanism raises the possibility of selecting or designing novel ligands that differentially activate only a subset of functions of a single receptor, thereby optimizing therapeutic action. (aspetjournals.org)
Dr. Thurmond correctly points out that in light of the emerging concept of functional selectivity of GPCRs, it is mandatory not to rely on a single pharmacological tool but rather to analyze carefully and in a. (aspetjournals.org)
Thus, conclusions about functional selectivity of JNJ7777120 are restricted to such systems until now. (aspetjournals.org)
To this end, we know only very little about the factors that may have an impact on functional selectivity of H4-receptor ligands. (aspetjournals.org)
As stated by Dr. Thurmond, it is very important to watch out for potential functional selectivity of JNJ7777120 in native cells that express signalling proteins at physiologically relevant concentrations. (aspetjournals.org)
The functional selectivity and biased agonism of TCA towards TRPC4 in dependence on OR may provide a better understanding of its efficacy or side effects. (nih.gov)
In mouse V1, although previous studies have examined the excitatory/inhibitory interplay underlying orientation selectivity (OS) of simple cells, the synaptic bases for that of complex cells have remained obscure. (jneurosci.org)
In mouse V1, we report that complex cells, identified by their overlapping on/off subfields, has significantly weaker orientation selectivity (OS) than simple cells. (jneurosci.org)
Orientation selectivity (OS) of neuronal responses is considered to be fundamental for visual perception of contours. (jneurosci.org)
Empirical2
Our objective is to determine whether selectivity bias is a problem in empirical land value functions. (illinois.edu)
His main areas of research are empirical finance, particular analysing mutual funds, hedge funds, asset pricing, investment strategies, survival bias and performance evaluation. (wikipedia.org)
Racial bias2
A coalition of more than 60 Asian-American groups filed a federal discrimination complaint against Harvard University, claiming racial bias in undergraduate admissions. (bostonglobe.com)
This subjective evaluation, without defined criteria, showed a racial bias in selectivity. (bvsalud.org)
Hypothesis1
To test the hypothesis that negative interpretation bias contributes to worry and rumination, we assessed the effects of inducing more positive interpretations in re. (researchgate.net)
Receptor1
Abstract: Biased signaling represents the ability of G protein-coupled receptors to engage distinct pathways with various efficacies depending on the ligand used or on mutations in the receptor. (usherbrooke.ca)
Methods3
Within the broad vibrational spectra of C-D bonds, we discover lipid-, protein-, and DNA-specific Raman shifts and develop spectral unmixing methods to obtain C-D signals with macromolecular selectivity. (nih.gov)
Aim(s): The aim of this study was to compare two different colorimetric methods, being Folin-Ciocalteu and DMBA assays in terms of their bias and selectivity in quantification of phlorotannin in brown seaweed. (lu.se)
However, when assessing the bias between the two methods using spiked Ulva lactuca extract, the F-C and DMBA assays exhibited biases of 4.2 ± 1.0 % and -3.04 ± 1.1 %, respectively. (lu.se)
Simultaneously2
Correcting simultaneously for publication and endogeneity biases, we find that the underlying elasticity is approximately 0.15 or less. (uni-muenchen.de)
DO-SRS microscopy enables us to probe de novo lipogenesis in animals, image protein biosynthesis without tissue bias, and simultaneously visualize lipid and protein metabolism and reveal their different dynamics. (nih.gov)
Selective2
We ask if there is evidence of a politically polarized Norwegian TV audience, by exploring the relationship between partisan preferences, perceived political bias and selective exposure to TV news. (degruyter.com)
True, the press has to be selective-but what principle of selectivity is involved? (media-alliance.org)
Found2
Selectivity bias is found to be a source of bias in residential but not in non-residential land value functions. (illinois.edu)
However, a combination of light traps and drift nets would reduce the biases associated with size and species selectivity found for individual gears, and this approach would be preferable for sampling small tropical streams. (bioone.org)
Media3
Accuracy in Media uses investigative journalism and citizen activism to expose media bias, corruption and public policy failings. (aim.org)
We are told by media people that some news bias is unavoidable. (media-alliance.org)
Reveal2
In previous studies, features were extracted from responses to a set of stimuli designed to reveal the main spatial and temporal receptive field properties, as well as specific properties such as direction selectivity (DS). (frontiersin.org)
It goes on to show that a telling selectivity in popular outrage and the application of the majesty of the law reveal a troubling majoritarian bias in society and the law. (epw.in)
Control3
Understanding the structural features of Rieske oxygenases responsible for control over selectivity is essential to enable the development of this class of enzymes for biocatalytic applications. (nature.com)
This study tested whether entirely internet-delivered interpretation training [cognitive bias modification (CBM)] versus control promotes positive interpretations and reduces worry and anxiety in individua. (researchgate.net)
Individuals with high levels of worry are more likely than others to attend to possible threats, although the extent of top-down attentional control processes on this bias is unknown. (researchgate.net)
Show1
After correcting for selectivity bias stemming from both observed and unobserved factors, we show that the TE scores of Internet users and nonusers are 0.571 and 0.537, respectively. (repec.org)
Impact1
This paper fills the gap by analyzing the impact of Internet use on the TE of banana production in China, using an innovative approach that combines a propensity score matching technique with Greene's (2010) selectivity-corrected stochastic frontier model to address selectivity bias. (repec.org)
Cells1
This can be primarily attributed to the differential tuning selectivity of inhibitory synaptic input: inhibition in complex cells is more narrowly tuned than excitation, whereas in simple cells inhibition is more broadly tuned than excitation. (jneurosci.org)
Potential1
Structural studies on enzymes with divergent selectivities have the potential to illuminate critical features that are responsible for selectivity and provide valuable insight on how reactivity can be controlled in biocatalytic reactions. (nature.com)
Research1
Prior research is inconclusive because work effects have been biased by selectivity and obscured by the interaction of age and employment. (ojp.gov)
Negative4
At a sufficiently high frequency, insulated electrodes in an RF system acquire a negative bias. (pcc.edu)
e.g., worry and rumination) is common across emotional disorders, as is the tendency to generate negative interpretations (interpretation bias). (researchgate.net)
Ameliorating negative interpretations via cognitive bias modification of interpretations (CBM-I) reduces worry/rumination, and improves mood in people diagnos. (researchgate.net)
Recently, cognitive bias modification (CBM) procedures have shown that such negative biases are causally related to emotional vulnerability. (researchgate.net)
Publication1
Ashenfelter, O., C. Harmon, & H. Oosterbeek (1999): "A review of estimates of the school- ing/earnings relationship, with tests for publication bias. (uni-muenchen.de)
Technique1
A sample of 1,654 healthy thrifts and 621 failed or soon-to-fail thrifts for which consistent official estimates of the cost of liquidation were available from the FSLIC is analyzed using a variation of the technique suggested by Heckman (1979) to correct for sample-selectivity bias. (ssrn.com)
Public1
We find that many Norwegians believe that both the public broadcaster and the leading commercial broadcasters are politically biased. (degruyter.com)
Models1
Testing for selectivity bias in panel data models. (wikipedia.org)
Specific1
Based on these structures, substrate-bound structures, and mutagenesis experiments, we implicate specific residues in substrate positioning and the divergent reaction selectivity observed in these two enzymes. (nature.com)
Political1
Why perceived political bias on TV does not inevitably lead to a polarized audience. (degruyter.com)
Good1
In addition, there is a good correlation between inhibitory tuning selectivity and the spatial organization of inhibitory inputs. (jneurosci.org)