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  • drugs
  • The results demonstrate that the Na + channel selectivity filter is involved in interactions with the hydrophilic part of the drugs, and it normally limits extracellular access to and escape from their binding site just within the selectivity filter. (pnas.org)
  • These possible relationships between local anesthetics and the selectivity filter prompted us to investigate the roles of the selectivity filter in binding and access of the drugs by using mutagenesis of the adult rat skeletal muscle Na + channel (μ1). (pnas.org)
  • NSAIDs Selectivity - Drug Class Review: Nonsteroidal Antiinflammatory Drugs (NSA. (nih.gov)
  • For one anti-inflammatory example, we show how such selectivity is achieved through differential expression of the drugs' targets in cell types associated with therapeutic, but not toxic, effects and validate its therapeutic relevance in a rat model of asthma. (nih.gov)
  • residues
  • We hypothesized that the charged amino group of the drug may interact with charged residues in the channel's selectivity filter. (pnas.org)
  • Mutation of the other selectivity residues, D400A (domain I), E755A (domain II), and A1529D (domain IV) allowed block by externally applied quaternary membrane-impermeant derivatives of lidocaine (QX314 and QX222) and accelerated recovery from block by internal QX314. (pnas.org)
  • equivalent
  • 0 {\displaystyle \sigma _{u}>0} , the coefficient on λ {\displaystyle \lambda } can only be zero if ρ = 0 {\displaystyle \rho =0} , so testing the null that the coefficient on λ {\displaystyle \lambda } is zero is equivalent to testing for sample selectivity. (wikipedia.org)
  • context
  • The context specificity of synergistic combinations creates many opportunities for therapeutically relevant selectivity and enables improved control of complex biological systems. (nih.gov)
  • novel
  • The resulting novel phases are explored for their improved chromatographic performance, selectivity and value in method development for a range of analytes and separations. (rsc.org)
  • rational
  • There are two types of selectivity that are critical for the rational design of highly specific oligonucleotides probes. (scirp.org)
  • provide
  • The relative rigidity of the bonded phase is also believed to provide enhanced shape selectivity of analytes differing in size and spatial attributes. (sigmaaldrich.com)
  • review
  • In this seminar, we review the importance of chromatographic selectivity from a theoretical and practical perspective and how this relates to analyte resolution for method development. (rsc.org)