• In May, Cybrexa initiated a Phase 1/2 clinical trial to evaluate CBX-12 in patients with advanced or metastatic refractory solid tumors to determine its safety and tolerability, maximum tolerated doses and dose limiting toxicities, and to establish the recommended Phase 2 dose. (globenewswire.com)
  • The Company's lead candidate, CBX-12, an alphalex™-exatecan conjugate, is expected to enter Phase I/II in 2021 in advanced solid tumors. (globenewswire.com)
  • Targeted molecular therapy against EGFR has shown promise as an adjuvant therapy in preliminary studies in several solid tumors, including head and neck cancer. (medscape.com)
  • The study enrolled both treatment-naive patients and heavily pretreated patients with a variety of advanced solid tumors including RET fusion-positive NSCLC, RET -mutant MTC, RET fusion-positive thyroid cancer, and certain other advanced solid tumors with RET alterations. (prnewswire.com)
  • However, no treatments have yet emerged as potential game changers in solid tumors due to a general lack of efficacy and high toxicity. (triumvira.com)
  • While chimeric antigen receptor (CAR) approaches have shown some success against hematological malignancies, they failed to produce good outcomes in solid tumors and are generally hampered by high toxicities. (triumvira.com)
  • Natural TCR approaches have demonstrated some clinical activity against solid tumors, but generally provide limited tumor cell recognition due to their dependency on MHC molecules, which are frequently absent or downregulated in cancer cells. (triumvira.com)
  • Effectively invades and eliminates solid tumors with low to minimal off-target toxicity. (triumvira.com)
  • A clinical trial evaluating IMA402 in patients with solid tumors is expected to start in 2023. (advfn.com)
  • HLA-A*02:01-positive patients with different solid tumors expressing PRAME will initially receive weekly infusions of IMA402. (advfn.com)
  • The selective delivery of exatecan to tumors led to extremely potent and durable anti-tumor activity in a range of xenograft models with minimal to no side effects relative to the unconjugated exatecan warhead, equimolar amounts of which are poorly tolerated. (globenewswire.com)
  • The development of such therapeutic molecules required robust preclinical investigations to determine their toxicity profiles in animals, the normal tissue-binding specificities, and to demonstrate their selective anti-tumor activity both in vitro and in vivo. (atsbio.com)
  • At the American Association for Cancer Research earlier this year, Synthekine presented data that showed STK-012 induced potent anti-tumor activity while avoiding the toxicities that have hindered the development of IL-2 therapeutics, including vascular leak syndrome (VLS). (biospace.com)
  • In vivo studies in mice demonstrated dose-dependent anti-tumor activity of IMA402. (advfn.com)
  • Preclinical studies investigating the efficacy of MMP suppression in tumor models were encouraging. (wikipedia.org)
  • It is a potent, selective and long half-life inhibitor of all three VEGF receptors and is designed to optimize VEGF blockade while minimizing off-target toxicities, potentially resulting in improved efficacy and minimal dose modifications. (businesswire.com)
  • The efficacy of every anticancer agent is usually assessed by its ability to kill tumor cells without damaging normal tissues. (researchsquare.com)
  • Currently, single chemotherapeutics or photosensitizers implemented in clinic present huge challenges in terms of unfavorable therapeutic efficacy, physiological instability and non-selective toxicity. (umn.edu)
  • In an attempt to minimise systemic toxicity and expand efficacy, we have given multiple agents intra-arterially. (bmj.com)
  • Preclinical toxicity, biodistribution, as well as efficacy research have been performed throughout these animals and Syrian rodents. (sarilumabinhibitor.com)
  • We hypothesized that the expression of COX-2 and 15-PDGH might relate to the tumor-preventive efficacy of the selective COX-2 inhibitor celecoxib," Dr Wang said when he presented the study findings at the meeting. (medscape.com)
  • This combination of chemotherapy and radiotherapy has a special role in tumor down staging and in sphincter preservation for lower rectal tumors. (wjgnet.com)
  • Based on preclinical studies, it appears that Opaxio is preferentially distributed to tumors due to their leaky blood vessels and trapped in the tumor bed, allowing significantly more of the dose of chemotherapy to localize in the tumor than with standard paclitaxel. (salesandmarketingnetwork.com)
  • The main barrier to utilizing almost all common chemotherapy agents is their toxicity. (researchsquare.com)
  • The major issue in cancer chemotherapy is obtaining significant concentrations of drug at the site of tumor required to kill cancer cells, while at the same time having low levels of drug at non-cancerous sites in order to reduce off-target toxicities. (shu.edu)
  • Chemotherapy and radiotherapy are associated with side effects which reduce tolerance to treatment and likelihood of tumour response. (cambridge.org)
  • Most interestingly, the combination therapy including photodynamic therapy and chemotherapy exhibited a synergistic effect against tumor cells in both in vivo and ex vivo experiments. (umn.edu)
  • Aims To report outcomes with selective intra-arterial chemotherapy (SIAC) using simultaneous carboplatin, topotecan, and melphalan for advanced intraocular retinoblastoma. (bmj.com)
  • Selective intra-arterial chemotherapy (SIAC), sometimes termed 'chemosurgery', is an accepted technique for treating intraocular retinoblastoma. (bmj.com)
  • Overexpression of p62 is likely related to tumorigenesis and has been observed in many types of tumors ( 13 , 21 - 23 ), such as chemotherapy-resistant epithelial cell carcinoma ( 24 ). (spandidos-publications.com)
  • Nevertheless, the composition of the immunologic tumor microenvironment undergoes changes upon radiotherapy, chemotherapy, or even after anti-angiogenic therapy ( 6 ). (frontiersin.org)
  • Recent studies have shown that MMPs may even have paradoxical roles in tumor progression. (wikipedia.org)
  • Further compounding this conundrum is the difficulty in accurately assessing response, as an increase in contrast enhancement on standard post-contrast MRI can be seen in treatment-related changes and true tumor progression. (abta.org)
  • Promising results were found in mice and canines with a 25-fold decrease of concentration in the bloodstream with significant reduction of tumor progression in the pancreas and breast. (shu.edu)
  • GBM stem-like cells (GSCs) represent a subpopulation of the tumor which is responsible for tumor initiation, progression, and re-growth after chemoradiation [ 5 , 6 ], as well as supporting tumor vessel growth and function [ 7 ]. (oncotarget.com)
  • These findings indicate that, the continuous low-dose administration of GEM and GEM+CDDP can promote tumorigenesis and tumor progression in vivo by inhibiting apoptosis, mobilizing BMDCs, and promoting angiogenesis in certain dose ranges. (researchsquare.com)
  • This study observes a previously neglected pharmacological phenomenon and investigates its mechanism of that the continuous low-dose administration of some antineoplastic agents in certain dose ranges can promote tumorigenesis and tumor progression in vitro and in vivo , through stimulation of tumor cell functions directly as well as enhancement of tumor angiogenesis by BMDCs recruitment indirectly. (researchsquare.com)
  • Although the EGFR tyrosine kinase inhibitor (TKI) osimertinib is the current standard of care in this first-line setting, "resistance and disease progression are nearly inevitable," and secondary EGFR and MET mutations may account for up to 50% of tumor resistance, Cho noted. (medscape.com)
  • In-vitro, the nanoparticles manifested best and sustained release in moderately acidic (pH 4.5) milieu enabling passive tumor targeting potential. (ac.ir)
  • The anti-inflammatory nanoparticles manifested tumor specific release potential exhibiting selective cytotoxicity at cancerous milieu with slightly acidic environment and activated inflammatory pathways. (ac.ir)
  • A fundamental reason to choose silibinin in developing targeted anticancer nanoparticles is its low toxicity in humans. (researchsquare.com)
  • A key and successful strategy to enhance anticancer drugs solubility and their tumour targeting properties are to use polymer nanoparticles (nanocarriers) capable of carrying a wide range of anticancer drugs (20-24). (researchsquare.com)
  • The temperature elevation and thermal toxicity of nanoparticles were studied. (dovepress.com)
  • Integrating porphyrins with nanoparticles represents a promising avenue, offering improved selectivity, reduced toxicity, and heightened biocompatibility. (bvsalud.org)
  • This task can be accomplished by replacing tumor suppressor genes that have been lost or mutated, selectively inserting genes that produce cytotoxic substances, or modifying the immune system to destroy the tumor cells. (medscape.com)
  • Menin is a putative tumor suppressor associated with multiple endocrine tumor type 1 (MEN-1 syndrome). (cancer-research-network.com)
  • We identified that repression of the tumour suppressor TRIM16 diminished WFA cytotoxicity, suggesting that TRIM16 was in part responsible for the cytotoxic effects of WFA in melanoma cells. (edu.au)
  • COX-2 promotes PGE2 expression, and 15-PGDH is a tumor suppressor that degrades PGE2. (medscape.com)
  • Our preliminary and published studies uncovered a remarkably better response to standard care in female glioblastoma patients than in male patients as well as sex-specific differences in signaling networks and interactions in the tumor microenvironment. (abta.org)
  • Some of the new approaches depend on tumor biology and aim specifically to inhibit tumor growth and metastasis by targeting the tumor microenvironment or vasculature (leaving normal cells unaffected) or focusing on specific protein or signal transduction pathways. (medscape.com)
  • Thus, addressing the presence of immunosuppressive myeloid cell populations in the periphery and tumor microenvironment of patients with cancer is likely to be required for effective NK cell-based immunotherapy. (elifesciences.org)
  • We have determined that different nanoparticle systems induce toxicity in a cell-specific and microenvironment-dependent manner. (boisestate.edu)
  • While GB tumors are frequently infiltrated by natural killer (NK) cells, these are actively suppressed by the GB cells and the GB tumor microenvironment. (frontiersin.org)
  • Here, we discuss effects of the GB tumor microenvironment on NK-cell functionality, summarize early treatment attempts with ex vivo activated NK cells, and describe relevant CAR target antigens validated with CAR-T cells. (frontiersin.org)
  • Malignant gliomas remain aggressive and lethal primary brain tumors in adults. (oncotarget.com)
  • In contrast to other cancers such as adenocarcinomas of the lung or melanoma, primary brain tumors like GB and low grade gliomas (LGG) are known as rather immunologically "cold" tumors, typically with low numbers of tumor-infiltrating lymphocytes (TILs) ( 4 ), and the mere amount of TILs is not associated with patient survival ( 5 ). (frontiersin.org)
  • Acquisition of these mutations by normal cells can lead to microscopic abnormalities starting years before detectable tumors appear. (abta.org)
  • Brain tumors in general are derived mostly from glial cells, astrocytes and oligodendrocytes, but not neurons. (abta.org)
  • The study found that CBX-12 displays pH selectivity, stability in plasma and selective delivery of exatecan to tumor cells versus healthy tissue. (globenewswire.com)
  • Dependence on antigens is a major barrier to the development of effective cancer therapeutics, and this study supports Cybrexa's approach to delivering exatecan selectively to tumor cells in an antigen-independent manner," said Vishwas Paralkar, Ph.D., Chief Scientific Officer of Cybrexa. (globenewswire.com)
  • Various techniques have been developed for targeting cancer cells: gene therapy, monoclonal antibodies (MAbs), antibody toxin conjugates, small-molecule inhibitors, antisense molecules, and tumor vaccines. (medscape.com)
  • The goal of gene therapy is to introduce new genetic material into cancer cells that selectively kills them without causing toxicity to the surrounding cells. (medscape.com)
  • Therapeutic approaches that target the metabolism of tumor cells have been a popular research topic in recent years. (spandidos-publications.com)
  • However, the mitochondrial oxidative phosphorylation (OXPHOS) pathway in tumor cells has also been implicated in lung cancer metabolism. (spandidos-publications.com)
  • Certain metabolic alterations, also referred to as metabolic reprogramming, are commonly observed in tumor cells and are proposed to be hallmarks of cancer ( 8 ). (spandidos-publications.com)
  • Given the vast differences in metabolism between healthy and tumor cells, there is hope that selective targeting of tumor metabolism may be achieved while limiting toxicity to healthy tissue. (spandidos-publications.com)
  • Treatment of syngeneic tumors resulted in CD8 and PD-L1-dependent tumor rejection or growth inhibition and a reduction in myeloid cells endogenously expressing high levels of PD-L1. (elifesciences.org)
  • T cell-based immunotherapy, such as immune checkpoint blockade or adoptive T cell transfer, is limited by the ability of T cells to detect major histocompatibility complex (MHC)-presented antigen by tumor cells. (elifesciences.org)
  • Advances in research techniques since then have shown the mitochondria in cancer cells to be functional across a range of tumour types. (researchgate.net)
  • The scientific relevance of macroautophagy -herein known as autophagy for simpleness- is due to its potential to safeguard cells against a number of intracellular and extracellular tension signals and favour tumor advancement (Mathew et al. (immune-source.com)
  • Right here we have evaluated the interplay between autophagy and apoptosis in the framework of tumor cell-selective eradication Paeoniflorin of melanoma cells. (immune-source.com)
  • GBM stem-like cells (GSCs) present in tumors are felt to be highly tumorigenic and responsible for tumor recurrence. (oncotarget.com)
  • Tumor and endothelial cell functions, apoptosis, cell cycle analysis, as well as bone marrow derived cells (BMDCs) mobilization, were evaluated with transwell, MTT or flow cytometry analysis in vitro , respectively. (researchsquare.com)
  • Additionally, GEM or GEM+CDDP at low concentrations dramatically facilitated the proliferation, migration, and invasion of tumor cells in vitro . (researchsquare.com)
  • Cell-cycle arrest, activation of associated apoptotic proteins, and inhibition of apoptosis were also observed in tumor cells. (researchsquare.com)
  • Moreover, any tumor cells that do manage to evade the initial antitumor immune response are mopped up after a second-line virus-based immunotherapy comprising a different set of antigens. (genengnews.com)
  • The team's previous work had already shown that killing normal cells in situ using the adjuvant hsp70 generated T cell responses to antigens that mediated rejection of tumors of the same histological type. (genengnews.com)
  • Autophagy contributes to the prolonged survival of tumor cells, whereas defects in autophagy play a critical role in tumorigenesis ( 15 , 16 ). (spandidos-publications.com)
  • A recent study showed that the hypoxic environment produced by PDT can induce autophagy in tumor cells ( 17 ). (spandidos-publications.com)
  • This suggests that autophagy is a form of adaptation of the nutritional environment of rapidly growing tumor cells in response to hypoxia. (spandidos-publications.com)
  • NK cells contribute to cancer immune surveillance not only by their direct natural cytotoxicity which is triggered rapidly upon stimulation through germline-encoded cell surface receptors, but also by modulating T-cell mediated antitumor immune responses through maintaining the quality of dendritic cells and enhancing the presentation of tumor antigens. (frontiersin.org)
  • WFA showed selective toxicity to melanoma cells compared to non-malignant cells. (edu.au)
  • Recent studies revealed that nano-sized TiO2 can cause inflammatory response in airways of rats and mice, fibrosis or lung tumors in rats and DNA damage in Chinese hamster ovary (CHO) cells, Syrian hamster embryo fibroblasts and human lymphoblastoid cells. (cdc.gov)
  • It has also been reported that unprocessed NGF precursor, proNGF, binds p75NTR preferentially over trkA, and this selective binding of proNGF to p75NTR leads to apoptotic death of cells. (cdc.gov)
  • To evaluate the mechanism of TiO2 mediated toxicity, the bronchial epithelial cells were exposed to TiO2 (10 microg/mL) and the apoptosis and necrosis were measured. (cdc.gov)
  • The major cytokines released from antigen-presenting cells and T cells after activation by SAgs are tumor necrosis factor alpha (TNF-α), tumor necrosis factor beta (TNF-β), interleukin (IL)-1, and IL-2 ( 11 - 14 ). (cdc.gov)
  • It is worth mentioning that many of the electron-affinic radiosensitizers of hypoxic cells also have the property of preferential or selective toxicity directed against hypoxic cells even in the absence of radiation [1,2]. (who.int)
  • The Cybrexa alphalex™ technology platform - which consists of a pHLIP ® peptide, linker, and small molecule anti-cancer agent (payload) - enables antigen-independent targeting of tumors and intracellular delivery of highly potent anticancer therapies, creating therapeutics that can revolutionize the standard of care. (globenewswire.com)
  • Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity. (lclabs.com)
  • The company is focused on developing and commercializing its lead candidate tivozanib, a potent, selective, long half-life inhibitor of vascular endothelial growth factor 1, 2 and 3 receptors, in North America as a treatment for renal cell carcinoma and other cancers. (businesswire.com)
  • today announced that the U.S. Food and Drug Administration (FDA) has granted priority review of the New Drug Application (NDA) for fruquintinib, a highly selective and potent inhibitor of vascular endothelial growth factor receptors (VEGFR) -1, -2 and -3 for the treatment of adult patients with previously treated metastatic colorectal cancer (CRC). (takeda.com)
  • Unlike standard radiosensitizing agents, Opaxio appears tumor selective and does not appear to enhance radiation toxicity to normal tissues. (salesandmarketingnetwork.com)
  • Renal and neuropathic toxicities of cisplatin are due to interaction of activated cisplatin with critical renal and nervous system tissues. (shu.edu)
  • If the concentration of cisplatin were to be higher in the tumor than in normal tissues (bone marrow, for example), the therapeutic ratio of cisplatin would be significantly increased. (shu.edu)
  • Histological methods were employed to assess angiogenesis in tumor tissues. (researchsquare.com)
  • The results showed that tumor formation and growth were both significantly promoted by GEM or GEM+CDDP at as low as half of the metronomic dosages, which were accompanied by enhancements of angiogenesis in tumor tissues and the release of proangiogenic BMDCs in the circulating blood. (researchsquare.com)
  • While this approach led to a broad repertoire of individually weak T cell responses against multiple TAAs that cumulatively resulted in strong selective pressure against immune escape, the need to inject the vectors into normal tissues often results in toxicity, they admit. (genengnews.com)
  • Early tumour bearing tissues. (cdc.gov)
  • in xenograft tumor models in vivo . (researchsquare.com)
  • Active compounds are selective for 17β-HSD3 over 17β-HSD1 and 17β-HSD2, non-androgenic with low toxicity, and efficacious in both an in vitro proof of concept model and in an in vivo tumour model. (bath.ac.uk)
  • Effective cancer immuno- and virotherapies are hindered by a lack of identified tumor-associated antigens (TAAs), poor coverage of the antigenic repertoire expressed by tumors, and difficulties associated with targeting vectors to tumors in vivo , explains Dr. Vile, together with co-lead author Alan Melcher, at the U.K. Leeds Institute of Molecular Medicine and Cancer Research U.K. Clinical Center, and colleagues. (genengnews.com)
  • Nevertheless, building on the positive aspects of this approach, the researchers postulated that it may be possible to provide a broad antigenic repertoire for in vivo immune selection of relevant tumor-associated antigens by expressing a cDNA library of a normal tissue using a systemically delivered, immunogenic vector. (genengnews.com)
  • The discovery is potentially applicable to other types of tumors harboring specific DNA repair defects, a line of inquiry the researchers are pursuing. (yale.edu)
  • Bindra is also scientific director of the Chênevert Family Brain Tumor Center at Smilow Cancer Hospital. (yale.edu)
  • Blood vessels in tumor tissue, unlike blood vessels in normal tissue, are porous to macromolecules such as Opaxio. (salesandmarketingnetwork.com)
  • The long-circulating and higher tumor accumulation of E/PCF-NPs resulted in complete ablation of breast tumor tissue through the enhanced photothermal effect by NIR laser irradiation-mediated cell apoptosis. (dovepress.com)
  • A poignant reminder here was the disastrous peripheral nerve damage experienced by women with breast cancer treated with a ricin A chain-based immunotoxin which unexpectedly also targeted nervous tissue.4 The most sensitive in vitro method for determining the selective cytotoxic potency of saporin-based immunotoxins is by measuring their ability to selectively inhibit protein synthesis in antigen-expressing cell lines in a dose-dependent manner. (atsbio.com)
  • While many agents that generate interstrand cross-links are used in the clinic for patients with cancer, most cannot discriminate between healthy tissue and tumors, leading to significant, dose-limiting toxicity. (yale.edu)
  • The newly developed compounds selectively generate this DNA damage in tumors but not in healthy tissue. (yale.edu)
  • Researchers have developed a virus-based vaccine expressing a broad spectrum of undefined antigens from normal human prostate tissue that they claim completely eradicates established mouse prostate tumors in experimental animals. (genengnews.com)
  • A high concentration of gemcitabine in close proximity to the tumor can increase the selectivity, which was shown from results in mice with pancreatic tumors. (shu.edu)
  • The pancreatic tumors reduced significantly within a week of treatment. (shu.edu)
  • Due to the high frequency of RAS mutations in PDAC, we hypothesized that pelareorep would promote selective reovirus replication in pancreatic tumors and enhance the anticancer activity of gemcitabine. (nih.gov)
  • Tivozanib has been investigated in several tumors types, including renal cell, colorectal and breast cancers. (businesswire.com)
  • PDT is considered as a complementary therapy aimed at preventing tumor recurrence after surgical resection of colorectal cancer ( 3 ), making it a suitable approach for continuous removal of small fractions of tumors ( 4 ). (spandidos-publications.com)
  • In addition, recurrent tumors expressed genes associated with an epithelial-to-mesenchymal-type transition, and had lost, or at least reduced, expression of mouse homologs of the human RNAs encoding prostate-specific antigens in the ASEL. (genengnews.com)
  • Breast cancers are most often epithelial tumors involving the ducts or lobules. (msdmanuals.com)
  • General references Breast cancers are most often epithelial tumors involving the ducts or lobules. (msdmanuals.com)
  • The formulation displayed impressive oral bioavailability, sustained release, negligible cytotoxicity against THLE-2 normal human hepatocytes, low toxicity (high LD 50 ) and wide therapeutic window. (ac.ir)
  • The highly selective binding properties of ANAVEX 2-73 has led to beneficial effects at very low doses, which may ultimately lead to a favorable tolerability profile and offer a wide therapeutic index. (pharmanews.eu)
  • Selective compounds have been developed that target either the extracellular ligand-binding region of the EGFR (including a number of monoclonal antibodies [MAbs], immunotoxins, and ligand-binding cytotoxic agents) or the intracellular tyrosine kinase region (including various small-molecule inhibitors). (medscape.com)
  • TY - JOUR AB - Although selective BRAF inhibitors and novel immunotherapies have improved short-term treatment responses in metastatic melanoma patients, acquired resistance to these therapeutics still represent a major challenge in clinical practice. (edu.au)
  • Data show that chemoprevention with selective cyclooxygenase-2 (COX-2) inhibitors, particularly celecoxib ( Celebrex , GD Searle), can reduce the incidence of these lesions. (medscape.com)
  • Three intravenous ASEL injections typically induced initial tumor regression, but with subsequent aggressive tumor recurrence. (genengnews.com)
  • To address the problem of tumor recurrence, the researchers evaluated combinations of vaccination with differ-ent libraries. (genengnews.com)
  • SIAC has been accomplished with acceptable systemic toxicity and tolerable local ophthalmic toxicity. (bmj.com)
  • In our hands, systemic toxicity in treated children with advanced intraocular retinoblastoma was most frequently asymptomatic Grade III neutropenia and was related to the total dose of melphalan given. (bmj.com)
  • However, single-agent SIAC is not successful in all patients, and systemic toxicity limits the dose that can be applied to an eye, especially in patients with bilateral retinoblastoma. (bmj.com)
  • These initial results encouraged us to undertake preclinical investigations with immunotoxins directed against the B-cell restricted CD19 antigen for B-lymphoid tumors and against the CD38 molecule for multiple myeloma. (atsbio.com)
  • Late intervention with anti-BRAF(V600E) therapy induces tumor regression in an orthotopic mouse model of human anaplastic thyroid cancer. (lclabs.com)
  • Irradiated Ce6 produced singlet oxygen which rapidly induces tumor cell death. (spandidos-publications.com)
  • PDT has been reported to be effective for treating aggressive colon cancer showing a high level of the vascular endothelial growth factor, which promotes tumor growth through angiogenesis ( 5 ). (spandidos-publications.com)
  • Upon binding to an antigen, the TCR catalyzes a highly complex and broad signaling cascade that leads to T cell activation, proliferation, and tumor cell killing. (triumvira.com)
  • PD analysis revealed reovirus replication within pancreatic tumor and associated apoptosis. (nih.gov)
  • If approved, fruquintinib will be the first and only highly selective inhibitor of all three VEGF receptors approved in the U.S. for previously treated metastatic CRC. (takeda.com)
  • Early clinical data suggest that combining amivantamab with the highly selective third-generation EGFR TKI lazertinib leads to clinical activity and durable responses. (medscape.com)
  • Our proposal is an unprecedented opportunity specifically tailored to patients with BM in which we will obtain detailed tumor blood vessel changes and the genomic basis for such changes during treatment. (abta.org)
  • Up to 50 percent of patients with RET fusion-positive NSCLCs can have tumors that metastasize to the brain. (prnewswire.com)
  • The factors responsible for response to tamoxifen in 5% to 10% of patients with ERa-negative tumors are not clear. (lu.se)
  • ExperimentalDesign: We investigated ERh by immunohistochemistry in 353 stage II primary breast tumors from patients treated with 2 years adjuvant tamoxifen, and generated gene expres- sion profiles for a representative subset of 88 tumors. (lu.se)
  • Patients with tumors lacking ERa in general do not charges. (lu.se)
  • Requests for reprints: Sofia K. Gruvberger-Saal, Institute for Cancer Genetics, tumors in the adjuvant or metastatic setting. (lu.se)
  • Reporting in Nature Medicine , the team in the U.S. and U.K. that developed the approach says the vaccine can be delivered systemically without the need for tumor targeting, appears to have no side effects, and doesn't induce autoimmunity. (genengnews.com)
  • Toxicity data were found for five of these compounds (thallium sulfate, thallium oxide, thallium nitrate, thallium acetate, and thallium carbonate). (cdc.gov)
  • In addition to renal disease, cardiovascular effects, and reproductive toxicity, lead may cause irreversible neurologic damage. (cdc.gov)
  • Making anticancer drugs target-oriented about tumour which results in a selective concentration of these drugs in tumour sites. (researchsquare.com)
  • However, in recent years, there has been increasing evidence that metformin exerts its anticancer effects through the inhibition of oxidative phosphorylation (OXPHOS) of tumor cell mitochondria, and metabolic pathways based on metformin targeting have only recently become the focus of intensive research. (spandidos-publications.com)
  • Furthermore, p62 is a multifunctional adapter protein involved in selective autophagy, cellular signaling pathways, and tumorigenesis ( 19 , 20 ). (spandidos-publications.com)
  • In B-Raf(V600E)-dependent tumor xenograft models, PLX4720 caused significant tumor growth delays without evidence of toxicity. (lclabs.com)
  • ATSDR has invited a cross-section of scientific experts in the fields of toxicology, epidemiology, pulmonology/pathology, and medicine to participate in 12 days of discussions on a variety of topics, including depositional patterns of fibers in the lung and mechanisms of toxic action, the relationship of fiber size to toxicity, irritant effects of fibers, relationships between measured fiber levels and observed adverse health outcomes, and recommendations for future research. (cdc.gov)
  • The Tasmanian devil faces extinction due to devil facial tumour disease (DFTD), a highly transmittable clonal form of cancer without available treatment. (nature.com)
  • The Tasmanian devil is an endangered Australian species, restricted to the island state of Tasmania 1 , and threatened with extinction due to a contagious and transmissible "parasitic" form of cancer known as devil facial tumour disease (DFTD) 2 , which has killed ~80% of the devil population since emerging in 1996 1 . (nature.com)
  • Cybrexa is a privately-held biotechnology company dedicated to developing next-generation tumor-targeted cancer therapies using its alphalex™ platform. (globenewswire.com)
  • PLX4720 induced significant tumor regression and reversal of cachexia in an orthotopic mouse model of human anaplastic thyroid cancer that harbored the BRAF(V600E) mutation. (lclabs.com)
  • The aim of this research was to achieve cancer debulking and proliferation prevention by limiting 'cancer-sustaining' tumor niche inflammation through non-conventional oral approach employing anti-inflammatory agents and avoiding conventional cytotoxic agents. (ac.ir)
  • They have the ability to eliminate tumors by using their T cell receptor (TCR) to identify cell surface markers known as cancer antigens, or tumor-associated antigens. (triumvira.com)
  • Notable human health toxicity effects identified from human and/or animal studies include respiratory cancer, non-cancer toxicity effects following inhalation, dermatitis, and reproductive effects. (mdpi.com)
  • 17β-HSD Type 3 (17β-HSD3) has been seen to be over-expressed in prostate cancer, and catalyses the reduction of androstenedione (Adione) to testosterone (T), which stimulates prostate tumour growth. (bath.ac.uk)
  • A systematic review of acute and late toxicity of concomitant chemoradiation for cervical cancer. (medscape.org)
  • Whilst there have been anti-tumor responses with ricin-based immunotoxins, particularly in hematological malignancies,2 their toxicity profile has limited their clinical usefulness and interest in their utility has consequently dropped away. (atsbio.com)
  • The primary objective was Clinical Benefit Rate (complete response (CR) + partial response (PR) + stable disease (SD) ≥ 12 weeks) and secondary objectives include overall survival (OS), toxicity, and pharmacodynamics (PD) analysis. (nih.gov)
  • Nine intravenous injections of ASEL were sufficient to cure over 80% of mice with the prostate tumors, with no detectable autoim-mune prostatitis. (genengnews.com)
  • Here, we leverage two novel, complementary approaches - perfusion MRI and circulating tumor DNA from blood and CSF - to understand the longitudinal changes within the tumor environment as a result of ICI. (abta.org)
  • Besides, in vitro endocytosis experiment performed with confocal laser scanning microscopy and flow cytometry testified the LA-mediated accurate tumor-specific targeting ability of synthesized nanocarriers. (umn.edu)
  • It is the most common type of malignant brain tumor among adults. (yale.edu)
  • Glioblastoma (GB) is the most frequent malignant primary brain tumor in adults, without any curative treatment options available at present. (frontiersin.org)
  • The risk is increased 1000-fold for squamous cell carcinoma, basal cell carcinoma, malignant melanoma, and fibrosarcoma and is increased 10-fold to 20-fold for other tumors. (medscape.com)
  • The HER (erbB) family of transmembrane receptor tyrosine kinases is one of the cytostatic targets in tumor cell growth and survival. (medscape.com)
  • Also, the lack of sufficient concentrations of drug in the tumor reduces potential effectiveness, therefore, suboptimal survival rates are observed. (shu.edu)
  • Both these therapies help in suppressing tumor growth. (kron4.com)
  • Tumors harboring exon 20 insertions are largely insensitive to targeted therapies and immune checkpoint, explained Girard, from Curie-Montsouris Thorax Institute, Institut Curie, Paris, France. (medscape.com)
  • Intravenous injection generated a prostate-specific T H 17 response and led to the CD4+ T cell-mediated cure of established tumors, without generating an IFN-γ response. (genengnews.com)
  • For treatment of neuroendocrine cancers (i.e., carcinoid tumors and pancreatic endocrine tumors) involving the liver. (aetna.com)
  • They first tried a second vaccination comprising virally expressed immune-escape epitope libraries (IEELs) constructed using cDNA from the recurrent tumors of ASEL-treated mice. (genengnews.com)
  • The implications of this finding overshadowed the importance of mitochondria for tumor growth for a long time. (spandidos-publications.com)
  • Treatment of xenograft tumors resulted in PD-L1-dependent tumor growth inhibition. (elifesciences.org)
  • There are indications that certain antineoplastic agents at low dosages may exhibit abnormal pharmacological actions, such as promoting tumor growth. (researchsquare.com)
  • The recurrent tumors demonstrated substantial histological differences from the parental tumors, and extensive interstitial lymphocyte infiltrates. (genengnews.com)
  • Experimental Design: VCN-01 copying and also strength ended up considered within a solar panel involving tumour cellular collections. (sarilumabinhibitor.com)
  • They then went on to test the virus-expressed human cDNA library in mice with established prostate tumors. (genengnews.com)
  • Synergistic anti-inflammatory agents, i.e. celecoxib as selective COX-2 inhibitor and montelukast as cysteinyl leukotriene receptor antagonist, were selected. (ac.ir)
  • Glioblastoma (GB) is the most common and aggressive primary brain tumor in adults and currently incurable. (frontiersin.org)
  • Because highly efficacious doses can be administered with minimal toxicity, this also provides the basis to explore novel combinations, such as with immunotherapies. (globenewswire.com)