Enzyme InhibitorsCyclooxygenase 2 InhibitorsCyclooxygenase InhibitorsCyclooxygenase 2SulfonamidesProstaglandin-Endoperoxide SynthasesIsoenzymesCyclic Nucleotide Phosphodiesterases, Type 4RolipramPyrazolesSulfonesPhosphodiesterase InhibitorsCyclooxygenase 13',5'-Cyclic-AMP PhosphodiesterasesNitrobenzenesDose-Response Relationship, DrugAnti-Inflammatory Agents, Non-SteroidalDrug DesignMolecular StructureIndazolesAmidinesProtein Kinase InhibitorsInhibitory Concentration 50IndolesCells, CulturedHeterocyclic Compounds, 2-RingStructure-Activity RelationshipLactonesPyridinesPhosphorylationEnzyme ActivationSignal TransductionLipoxygenase InhibitorsNitric Oxide SynthasePhospholipase A2 InhibitorsRats, Sprague-DawleyKineticsCyclic Nucleotide Phosphodiesterases, Type 1Rats, WistarDinoprostonePyrrolidinonesModels, MolecularPyrimidinesOxadiazolesProtein Kinase CImidazolesBenzamidesGuanidinesPhosphodiesterase 4 InhibitorsNitric Oxide Synthase Type IICell Line, TumorCell LineProtease InhibitorsDiclofenacSubstrate SpecificityPiperazinesNitric OxideCyclic Nucleotide Phosphodiesterases, Type 3IsothiuroniumAdamantaneMembrane ProteinsAntineoplastic AgentsThioureaStereoisomerismIsoxazolesMitogen-Activated Protein KinasesMaleimidesCatalytic DomainDrug Evaluation, PreclinicalMicrosomes, LiverNitric Oxide Synthase Type ICyclic GMPApoptosisCytochrome P-450 Enzyme SystemCarbazolesQuinoxalinesSmall Molecule LibrariesIndomethacinPhosphodiesterase 3 InhibitorsMatrix Metalloproteinase InhibitorsRecombinant ProteinsCrystallography, X-RayThiazolesMonoamine Oxidase InhibitorsPhenyl EthersArachidonic AcidSodium-Glucose Transporter 2AlkaloidsAmidesBenzylaminesCell Proliferationp38 Mitogen-Activated Protein KinasesBlotting, WesternBenzimidazolesProtein BindingFlavonoidsNaproxenBinding SitesAniline CompoundsPurines