Selective alpha 1. Medical search. Frequent questions

alpha(1)-Adrenoceptor agonists: the identification of novel alpha(1A )subtype selective 2'-heteroaryl-2-(phenoxymethyl)imidazolines. (nih.gov)
2-(Anilinomethyl)imidazolines as alpha1 adrenergic receptor agonists: alpha1a subtype selective 2'-heteroaryl compounds. (nih.gov)
The α1B mediates cardiac hypertrophy induced by non-selective α1-AR agonists like phenylephrine. (unc.edu)
If you combine any of these alpha 2 antagonists with caffeine or beta-agonists (aka synergists), the necessary dose decreases quite a bit. (anabolicminds.com)
This means caffeine, exercise, forskolin, and beta-agonists all work exceptionally well with alpha-2 antagonists. (anabolicminds.com)
On the basis of the results, we conclude that the combination of alpha-2 agonists and midazolam, ketamine, and glyceryl guaicol ether is an appropriate protocol for the anesthesia of tapirs in the field. (bvsalud.org)

We recently showed that an oral selective α1A agonist drug, dabuzalgron, preserves ATP content and mitochondrial function in mouse HF models. (unc.edu)
In tests carried out in vivo with rats for ascertaining alpha-2 adrenoceptor antagonism in the central nervous system--namely, accumulation of cortical dopa and antagonism of mydriasis induced by the alpha-2 agonist, clonidine--L-659,066 had, respectively, less than 1/345th and about 1/5000th of the potency of L-657,743. (aspetjournals.org)
In mice, L-659,066 had, respectively, approximately 1/29th and 1/1400th of the potency of L-657,743 as an antagonist in vivo of the predominately peripherally mediated inhibition of colonic propulsion caused by clonidine as compared with the mainly centrally mediated antinocisponsive action elicited by the alpha-2 agonist UK 14,304. (aspetjournals.org)
Beta 2 -agonist activity has been demonstrated in animals with minimal beta 1 -agonist (ISA) activity detected. (guidelinecentral.com)
Dexmedetomidine (DEX), a highly selective α2-adrenergic receptor agonist, has been demonstrated to be effective against intestinal IRI. (bvsalud.org)

As many of you may already know, alpha-2-antagonists are simply compounds that antagonize the alpha-2-adrenoreceptor. (anabolicminds.com)
And then we have the various yohimbe alkaloids like 11-OH yohimbine, that are alpha-2-antagonists (not to be confused with a broad-spectrum extract of alkaloids). (anabolicminds.com)
What works best with alpha-2-antagonists? (anabolicminds.com)
For those seeking to lose stubborn fat, alpha-2-antagonists are a great option. (anabolicminds.com)
Alpha-2 antagonists synergize with anything that potentiates catecholamine release. (anabolicminds.com)

A pharmacological profile of the methylenedioxy-substituted amphetamine derivatives indicates that MDMA and MDA exhibited highest affinity for serotonin uptake sites, 5-HT2 serotonin, alpha 2-adrenergic and M-1 muscarinic receptors. (erowid.org)
DESYREL (trazodone hydrochloride) tablets for oral administration contain trazodone hydrochloride, a selective serotonin reuptake inhibitor and 5HT2 receptor antagonist . (rxlist.com)

Alpha(1)-adrenoceptor activation: a comparison of 4-(anilinomethyl)imidazoles and 4-(phenoxymethyl)imidazoles to related 2-imidazolines. (nih.gov)
The beta-1 adrenergic receptor (β 1 adrenoceptor), also known as ADRB1, is a beta-adrenergic receptor, and also denotes the human gene encoding it. (meltingpointathens.com)
The clinical and urodynamic effects of oral alpha 1-selective adrenoceptor blockers in the treatment of symptomatic benign prostatic hyperplasia were quantified, and side effects and patient tolerance were assessed. (nih.gov)
A peripherally acting alpha-2 adrenoceptor antagonist: L-659,066. (aspetjournals.org)
L-659,066 has been characterized as a potent and selective alpha-2 adrenoceptor antagonist. (aspetjournals.org)

Design of potent selective zinc-mediated serine protease inhibitors. (expasy.org)
In radioligand binding assays, RG 12915 is a potent and selective displacer of binding of 5-hydroxytryptamine (5-HT)3 binding sites (IC50 value = 0.16 nM), whereas failing to displace binding of ligands for the alpha-1, alpha-2 and beta adrenergic, 5-HT1 or 5-HT2 or cholinergic-muscarinic sites with IC50 values less than 1 microM. (aspetjournals.org)

Other behavioral, cardiovascular, and toxic effects of MDMA and related derivatives may be mediated by actions at other central and/or peripheral recognition sites, including muscarinic cholinergic receptors and alpha 2-adrenergic receptors, for which these compounds exhibit relatively high affinity. (erowid.org)
These studies demonstrate that beta(1)-adrenergic receptors play a dominant role in the murine vascular system to mediate vasodilation. (meltingpointathens.com)
Pharmacological characterization of rat alpha 2-adrenergic receptors. (aspetjournals.org)

The beta 1 receptor is vital for the normal physiological function of the sympathetic nervous system. (meltingpointathens.com)
Through various cellular signaling mechanisms, hormones and medications activate the beta-1 receptor. (meltingpointathens.com)
Targeted activation of the beta-1 receptor increases heart rate, renin release, and lipolysis. (meltingpointathens.com)
What does the alpha 1 receptor do? (meltingpointathens.com)
What is beta 1 adrenergic receptor? (meltingpointathens.com)
How does beta-1-adrenergic dysfunction affect the G-protein receptor? (meltingpointathens.com)
RAPAFLO, an alpha-1 adrenergic receptor antagonist, is indicated for the treatment of the signs and symptoms of benign prostatic hyperplasia (BPH). (globalrph.com)
Magnesium - decreased catech-olamine release, decreases sensit-ivity of the alpha receptor to NE/Epi and is a direct vasodi-lator. (cheatography.com)
Yohimbine possess extreme affinity for the alpha-2-adrenoreceptor, but due to receptor homology with various 5-HT receptors, yohimbine HCl is highly anxiogenic and is clinically used to model panic disorder. (anabolicminds.com)
The alpha-2 receptor is an autoreceptor, meaning it is located NOT on the postsynaptic neuron chiefly, but on the pre-synaptic neuron. (anabolicminds.com)
Scholars@Duke publication: Fetal terbutaline exposure causes selective postnatal increases in cerebellar alpha-adrenergic receptor binding. (duke.edu)
Despite the absence of body or brain growth impairment, selective increases were seen postnatally in cerebellar alpha 1- and alpha 2-receptor subtypes, whereas the same receptor populations were decreased by small amounts in cerebral cortex and midbrain + brainstem. (duke.edu)
TORONTO and HOUSTON, March 30, 2023 (GLOBE NEWSWIRE) -- Medicenna Therapeutics Corp. ("Medicenna" or "the Company") (NASDAQ: MDNA TSX: MDNA), a clinical stage immunotherapy company, today announced updated data from its Phase 1/2 ABILITY study of MDNA11, a next-generation IL-2 with superior CD122 (IL-2 receptor beta) binding without CD25 (IL-2 receptor alpha) affinity thereby preferentially stimulating cancer killing effector T cells and NK cells. (tmcnet.com)
The estrogen component is estetrol, a synthetic trihydroxy analogue of a native estrogen ( FIGURE 1 ) present during pregnancy, which is selective for nuclear estrogen receptor (ER)-alpha and ER-beta. (uspharmacist.com)
Labetalol hydrochloride tablets, USP are adrenergic receptor blocking agents that have both selective alpha 1 -adrenergic and nonselective beta-adrenergic receptor blocking actions in a single substance. (guidelinecentral.com)
Labetalol HCl's beta 1 -receptor blockade in man was demonstrated by a small decrease in the resting heart rate, attenuation of tachycardia produced by isoproterenol or exercise, and by attenuation of the reflex tachycardia to the hypotension produced by amyl nitrite. (guidelinecentral.com)
Due to the alpha 1 -receptor blocking activity of labetalol HCl, blood pressure is lowered more in the standing than in the supine position, and symptoms of postural hypotension (2%), including rare instances of syncope, can occur. (guidelinecentral.com)

What happens when beta 1 receptors are stimulated? (meltingpointathens.com)
When beta-1 receptors are stimulated they increase the heart rate and increase the heart's strength of contraction or contractility. (meltingpointathens.com)
Do beta-1 receptors cause vasoconstriction? (meltingpointathens.com)
Norepinephrine can then go on to bind three main receptors: alpha1 (alpha-1), alpha-2, and beta receptors. (meltingpointathens.com)
It's thought that stubborn fat is particularly rich in these alpha-2-receptors, hence why fat loss is always inhibited in these regions. (anabolicminds.com)

The selective sodium-glucose cotransporter-2 (SGLT2) inhibitors empagliflozin and dapagliflozin are indicated to reduce the risk of cardiovascular death and hospitalization in patients with heart failure. (medscape.com)
Concomitant use of PDE5 inhibitors with alpha-blockers including Rapaflo can potentially cause symptomatic hypotension. (globalrph.com)
It was hypothesized that there would be a difference in inhibition of FIH-1 from the other HIF-1 regulating enzyme, the prolyl hydroxylase domain-2 (PHD2), when testing a series of ten small molecule inhibitors. (umass.edu)

These 3 categories of alpha-2-antagonist each possess a unique goal-specific attribute, but before we delve into specifics, let's look at how effective these compounds are for fat loss. (anabolicminds.com)
Furthermore, because alpha-2 antagonism can increase insulin release, these compounds are best taken fasted. (anabolicminds.com)

Factors that may contribute to the antihypertensive action include: (1) decreased cardiac output, (2) inhibition of renin release by the kidneys, and (3) diminution of tonic sympathetic nerve outflow from vasomotor centers in the brain. (nih.gov)
Cardiac alpha (α)1-ARs have received less attention, however data from cell and animal studies indicate that they protect against the development of HF. (unc.edu)

1998. Cypermethrin increases apo A-1 and apo B mRNA but not hyperlipidemia in rats. (cdc.gov)

Prazosin and doxazosin: (alpha 1 compet-itive antago-nist) short acting and causes less tachyc-ardia. (cheatography.com)

From what I can gather this is all some publicity stunt to raise awareness for Alpha-1 Antitrypsin Deficiency, a rare lung disease. (adland.tv)
Bromley D, Anderson PC, Daggett V. Structural consequences of mutations to the alpha-tocopherol transfer protein associated with the neurodegenerative disease ataxia with vitamin E deficiency. (medlineplus.gov)
Pang J, Kiyosawa M, Seko Y, Yokota T, Harino S, Suzuki J. Clinicopathological report of retinitis pigmentosa with vitamin E deficiency caused by mutation of the alpha-tocopherol transfer protein gene. (medlineplus.gov)
1. AIDS: Acquired immune deficiency syndrome Acquired immunodeficiency syndrome 2. (cdc.gov)

The results of the study demonstrated that silodosin binds with high affinity to the alpha-1A subtype. (globalrph.com)

Collagen I Alpha 1 antibody LS-C343921 is an unconjugated rabbit polyclonal antibody to Collagen I Alpha 1 (COL1A1) (aa1192-1207) from mouse. (lsbio.com)
shaded) or with the FITC Mouse Anti-Human MIP-1β antibody (Cat. (bdbiosciences.com)
Right Panel: Both unstimulated (shaded) and stimulated PBMC (unshaded) were harvested, fixed, permeabilized with BD Cytofix/CytoPerm Plus Kit (with GolgiStop), and stained with the FITC Mouse Anti-Human MIP-1β antibody. (bdbiosciences.com)

Synthetic peptide within Human Alpha-synuclein (phospho Y125). (abcam.com)

Low oxygen tension or von Hippel-Lindau (Vhl) tumor suppressor loss is known to stabilize hypoxia-inducible factors alpha (Hif-1α and Hif-2α) to mediate adaptive responses, but it remains unknown if peroxisome homeostasis and metabolism are interconnected with Hif-α signaling. (uzh.ch)
Hif-2α activation augments peroxisome turnover by selective autophagy (pexophagy) and thereby changes lipid composition reminiscent of peroxisomal disorders. (uzh.ch)

The following descriptions of NMEs approved in 2021 detail the basic clinical and pharmacologic profile for each new drug, as well as key precautions and warnings ( TABLE 1 ). (uspharmacist.com)

When the subjects used the active lozenges, they demonstrated marked increases in the alpha wave activities that are associated with relaxation. (lifeextension.com)

RAPAFLO is the brand name for silodosin, a selective antagonist of alpha-1 adrenoreceptors. (globalrph.com)
Silodosin is a selective antagonist of post-synaptic alpha-1 adrenoreceptors, which are located in the human prostate, bladder base, bladder neck, prostatic capsule, and prostatic urethra. (globalrph.com)
Blockade of these alpha-1 adrenoreceptors can cause smooth muscle in these tissues to relax, resulting in an improvement in urine flow and a reduction in BPH symptoms. (globalrph.com)
An in vitro study examining binding affinity of silodosin to the three subtypes of the alpha-1 adrenoreceptors (alpha-1A, alpha-1B, and alpha-1D) was conducted. (globalrph.com)
Furthermore, it's partially adrenolytic, as it is less selective than yohimbine on the adrenergic system, partially antagonizing alpha-1- adrenoreceptors. (anabolicminds.com)

What are beta-1 selective beta blockers? (meltingpointathens.com)
Beta-1 selective blockers are a subclass of beta blockers that are commonly used to treat high blood pressure. (meltingpointathens.com)
Is beta-1 a vasodilator? (meltingpointathens.com)
Esmolo-l:(Beta 1 selective) good for Epi secreting pheo's. (cheatography.com)
Liegel N, Schneider D, Wascher E, Arnau S: Task prioritization modulates alpha, theta and beta EEG dynamics reflecting proactive cognitive control. (ifado.de)
Selective activity and cellular pharmacology of (1R-1 alpha,2 beta,3 alpha)-9-[2,3-bis(hydroxymethyl)cyclobutyl]guanine in herpesvirus-infected cells. (aspetjournals.org)
Labetalol HCl combines both selective, competitive, alpha 1 -adrenergic blocking and nonselective, competitive, beta-adrenergic blocking activity in a single substance. (guidelinecentral.com)
In man, the ratios of alpha- to beta-blockade have been estimated to be approximately 1:3 and 1:7 following oral and intravenous (IV) administration, respectively. (guidelinecentral.com)
In animals, at doses greater than those required for alpha- or beta-adrenergic blockade, a membrane stabilizing effect has been demonstrated. (guidelinecentral.com)
Both the alpha- and beta-blocking actions of orally administered labetalol HCl contribute to a decrease in blood pressure in hypertensive patients. (guidelinecentral.com)
Labetalol HCl produces dose-related falls in blood pressure without reflex tachycardia and without significant reduction in heart rate, presumably through a mixture of its alpha- and beta-blocking effects. (guidelinecentral.com)
The beta particle is not stopped in matter as quickly as an alpha particle. (cdc.gov)
Alpha, Beta, Gamma and Delta variants. (who.int)

alpha-Blockers were beneficial in the treatment of benign prostatic hyperplasia. (nih.gov)

At 1, 3, 9 or 14 days post-injury, TA muscles were harvested for histology, immunohistochemistry or gene expression evaluation by quantitative real time RT-PCR. (cdc.gov)
Clodronate treatment also significantly attenuates inflammatory (TNF-alpha, Mac-1 and MCP-1), growth (IGF-BP) factor and antioxidant (thioredoxin) gene expression in injured TA muscle compared to injured non-treated TA muscle. (cdc.gov)

Genome: 1-7 [Epub ahead of print]. (sdbonline.org)

Selective and time dependent modulation of the innate immune system may provide optimal resolution of skeletal muscle injury. (cdc.gov)

Microsomal reduction of 3-amino-1,2,4-benzotriazine 1,4-dioxide to a free radical. (aspetjournals.org)

MDNA11 continued to exhibit prolonged, selective, and dose-dependent effects on anti-cancer immunity. (tmcnet.com)
Two alpha-ketoglutarate dependent non-heme iron dioxygenases are responsible for the regulation of HIF-1 through hydroxylation of residues on the HIF-1a subunit. (umass.edu)

These data demonstrate that changes in alpha activity are specific to listening conditions. (frontiersin.org)
At a p.o. dose (1 mg/kg) in which RG 12915 is highly protective against cisplatin-induced emesis in the dog, RG 12915 has no significant gastroprokinetic activity in the same species. (aspetjournals.org)

NE (alpha) - systolic & diastolic HTN with reflex bradyc-ardia. (cheatography.com)

Recombinant full length protein corresponding to Human Alpha-synuclein. (abcam.com)

1987. Biochemical responses to induced intoxication with insecticides: 1. (cdc.gov)

The aim of this study was to measure cortical alpha during attentive listening in a commonly used SiN task (digits-in-noise, DiN) to better understand the neural processes associated with "top-down" cognitive processing in adverse listening environments. (frontiersin.org)

Both in vitro and in vivo, L-659,066 exhibited specificity (comparable to rauwolscine) for alpha-2 over alpha-1 adrenoceptors. (aspetjournals.org)

Previous work has shown that brain oscillations, particularly alpha rhythms (8-12 Hz) play important roles in sensory processes involving working memory and attention. (frontiersin.org)
Functionally distinct alpha oscillations form the basis of attention. (ifado.de)

If they're doing this stunt to inform these people that they might have alpha-1 instead, they might get better results by targeting them directly, no? (adland.tv)
A total of 29 original reports of placebo controlled clinical trials of alpha-blockers in which results were adequately presented was identified and reviewed, along with additional pertinent literature. (nih.gov)

Similar relative potencies were obtained in vivo in pithed rats with regard to blocking peripherally located postjunctional and prejunctional alpha-2 adrenoceptors (L-659,066 = one-seventh and one-fourth of L-657,743, respectively). (aspetjournals.org)

Alpha particle ( ionizing radiation ) - two neutrons and two protons bound as a single particle (a helium nucleus) that is emitted from the nucleus of certain radioactive isotopes in the process of disintegration. (cdc.gov)

However, variants with specific mutations that affect the way the virus behaves are now considered either Variants of Interest (VOI) or Variants of Concern (VOC) with respect to public health implications (1). (who.int)

Coop's Corner #4: Alpha-2 Antagonism? (anabolicminds.com)

To report SUSPECTED ADVERSE REACTIONS, contact Watson Pharmaceuticals, Inc. at 1-800-272-5525 or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch. (globalrph.com)

Peak plasma concentrations occur about 1 to 4 hours after an oral dose. (nih.gov)
Dose may be titrated at 1 to 2 week intervals, up to 8 mg once daily. (nih.gov)

Anatomy24

Organisms13

Diseases1

Chemicals and Drugs150

Analytical, Diagnostic and Therapeutic Techniques and Equipment20

Psychiatry and Psychology1

Phenomena and Processes47

Disciplines and Occupations1

Information Science4

Agonists6

Agonist5

Antagonists5

Serotonin2

Adrenoceptor5

Potent2

Adrenergic receptors3

Receptor17

Receptors5

Inhibitors3

Compounds2

Cardiac2

19981

Doxazosin1

Deficiency4

Subtype1

Antibody3

Peptide1

Peroxisome2

20211

Increases1

Adrenoreceptors5

Beta13

Benign Prostatic H1

Gene2

Epub1

Modulation1

Amino1

Dependent2

Activity2

Diastolic1

Protein1

19871

Cortical1

Specificity1

Oscillations2

Results2

Rats1

Bound1

Variants1

Antagonism1

ADVERSE REACTIONS1

Dose2