• However, if an affected baby is detected the patient would be faced with a difficult decision of whether to terminate the pregnancy (which may not be an option for some couples) or to continue the pregnancy and deliver a baby that is affected by a specific genetic disease. (thefertilityexperts.com)
  • Beyond these three great pioneers of 20th century biology, S. Kauffman added a molecular dimension to network-thinking with an early, if necessarily rather abstract, exploration of the generic structural properties of regulatory genetic networks ( 10 ). (pnas.org)
  • Indeed, the study of molecular and genetic networks is central to the new field of systems biology ( 4 ). (pnas.org)
  • It was, however, only the confluence, more than two decades later, of advances in genetics and molecular techniques in the 1990s with the then-new graph theory analyses of various networks ( 1 , 2 ) that launched the current wave of interest amongst biologists, in networks generally and, more specifically, in genetic networks (reviewed in ref. 13 ). (pnas.org)
  • He has made groundbreaking contributions in developing the zebrafish as a molecular genetic model and in understanding the evolution of new gene functions in vertebrates. (genetics.org)
  • The Metabolic and Molecular Bases of Inherited Disease , chapter Color vision and its genetic defects, 5955-76, McGraw-Hill, 2001. (aimsciences.org)
  • The differences between methods for detecting selection all lie in the information they use to find such alleles (since for the moment, we don't have good data on historical allele frequencies). (genomesunzipped.org)
  • Because selection is often sex-dependent, alleles can have positive effects on fitness in one sex and negative effects in the other, resulting in intralocus sexual conflict. (uzh.ch)
  • When a population is expanding geographically, genetic hitchhiking can be intensified at the invasive species front, where adaptive alleles get a double advantage: they are adaptive, and they also arrive first in new territories. (wikipedia.org)
  • These findings highlight the need for inferences from genetic studies of prostate cancer risk to carefully consider the influence of control selection criteria. (aacrjournals.org)
  • Our findings and the scarce evidence from other studies suggest that the intersexual genetic correlation for lifetime fitness may be very low in nature. (diva-portal.org)
  • A genetic bottleneck has been routinely observed in both horizontal and vertical transmission, although findings on characteristics of these transmitted viruses are conflicting and may depend on the mode of transmission or subtype of the infecting virus. (asm.org)
  • These theoretical and empirical findings about the complexity of selection signatures have prompted the development of methods that are sensitive to both hard and soft sweeps and capable of distinguishing between the two. (biomedcentral.com)
  • The findings have implications for future population genetic studies on vaccine candidates, showing that the biological context must also be considered as a framework for analysis. (biomedcentral.com)
  • Medical Xpress)-A team of researchers with member affiliations to institutions in the U.S. and Hong Kong, has found that researchers going after drug targets that have supporting genetic evidence could double the success rate of new drugs making it through clinical trials. (medicalxpress.com)
  • However, there is little guidance about how much weight should be given to genetic evidence in making these key decisions. (medicalxpress.com)
  • To answer this question, we investigated how well the current archive of genetic evidence predicts drug mechanisms. (medicalxpress.com)
  • In addition, evidence of selection near a homologous locus of FAR1 concurred with sorghum phenotypic diversity for sensitivity to photoperiod. (www.gov.uk)
  • Schrider and Kern [ 1 ] recently applied a novel machine learning approach to systematically evaluate the evidence for positive selection in humans. (biomedcentral.com)
  • However, there was a strong contrast between domain I, which showed strong evidence for positive balancing selection, and domain II which was neutral. (biomedcentral.com)
  • Most importantly, however, the structure of genetic networks (in particular, one class of genetic networks, those underlying the biochemistry of mammalian coat colors) was central to the work of S. Wright ( 8 , 9 ). (pnas.org)
  • We demonstrate how these conditions can be applied to justifying the strategies and their stabilities for a special class of genetic selection games including some in the study of genetic disorders. (aimsciences.org)
  • The epidemiology of X-linked recessive diseases, a class of genetic disorders, is modeled with a discrete-time, structured, non linear mathematical system. (aimsciences.org)
  • M. Stierschneider, S. Gaubitzer, J. Schmidt, O. Weichselbaum, D. Kopecky, A. Kremer, S. Fluch, E. M. Sehr (2016) The Evoltree Repository Centre - A central access point for reference material and data of forest genetic resources. (ait.ac.at)
  • D. Bick , Engineering in genomics-genetic disease diagnosis: Challenges and opportunities, IEEE Engineering in Medicine and Biology Magazine , 14 (1995), 226-228. (aimsciences.org)
  • Moreover, genome-wide data can be used to search for signals of recent positive selection, thereby providing new insights into the genetic adaptations that occurred as modern humans spread out of Africa and around the world. (blogspot.com)
  • Here, we report at genome-wide level the diversity and signature of positive selection in these two breeds. (datadryad.org)
  • With availability of genome-wide resequencing data from 40 silkworms, here we have the opportunity to make numerous comparisons and to investigate the phylogeny of silkworm mitochondria, in order to study whether the silkworm mt population has experienced any expansion or contraction, and to detect the selection effect shaping on the mt genome. (biomedcentral.com)
  • Genetic diversity analysis of rice genotypes withRAPD marker system and phenotypic screening for blast resistance revealed that White Ponni (susceptible) and Moroberekan(resistant) were one among the genetically distant and contrasting parents for leaf blast resistance. (oalib.com)
  • The genetic diversity of Sugarcane yellow leaf virus (SCYLV) was investigated in a sugarcane selection plot in Guadeloupe to determine the incidence of the different known virus genotypes (BRA-PER, CUB and REU) in a breeding progeny. (cirad.fr)
  • Eighty-two percent of the tested leaves were infected by SCYLV and all known virus genotypes occurred in the selection plot. (cirad.fr)
  • Such adjustments may occur through genetic and/or non-genetic mechanisms that increase their fitness. (elifesciences.org)
  • We found that, among well-studied indications, the proportion of drug mechanisms with direct genetic support increases significantly across the drug development pipeline, from 2.0% at the preclinical stage to 8.2% among mechanisms for approved drugs, and varies dramatically among disease areas. (medicalxpress.com)
  • Although there were no obvious phenotypic correlations among gut microbiota, significant genetic correlations were observed. (nih.gov)
  • Parametric methods were unable to predict phenotypic values when the underlying genetic architecture was based entirely on epistasis. (g3journal.org)
  • This study characterized the degree of change in growth rates and meat yield that was due to genetic selection, and opened a lively conversation in the media. (ualberta.ca)
  • In order to promote the research and cultivation of sacha inchi in the Brazilian territory, this study aimed to analyze, in the central Amazon region, different accessions of this oilseed for characteristics of production and quality of fruits and seeds, as well as to estimate genetic parameters, through mixed models, with identification of superior accessions, for breeding purposes. (scielo.br)
  • Partial NIb/CP sequences of 28 Brugmansia CDV isolates from this study were compared with all 16 CDV isolates in GenBank and found to share high levels of nucleotide and amino acid identity, with negative selection estimated to be occurring. (apsnet.org)
  • Many breeders study pedigrees and swear that they can use them to make accurate selection decisions, and they do help, especially if there is line breeding or close relationships in the pedigree. (quechuabenefit.org)
  • The objective of this study was, by means of simulation, to quantify the effect of ignoring individual heterogeneity in Weibull sire frailty models on parameter estimates and to address the consequences for genetic inferences. (pubfacts.com)
  • Only one year after this project's completion, Canadian Dairy Network (CDN) is able to move the research to the field in the form of genetic evaluations for Hoof Health - an index that promotes increased resistance to eight key foot lesions. (cdn.ca)
  • Genetic selection for increased resistance to Digital Dermatitis has been possible since December 2017. (cdn.ca)
  • Selection for Hoof Health will lead to improved resistance to the eight key lesions. (cdn.ca)
  • If this was the case, genetic change would be expected at loci underlying beetle resistance. (frontiersin.org)
  • Genetic selection for Johne's disease resistance by certification and surveillance is too slow for practical purpose, but that selection on the sire level is able to contribute to the control of Johne's disease in the long run. (wur.nl)
  • Thus, while a strong genetic bottleneck was detected during MCTC, with viruses of shorter and fewer glycosylation sites in env present in IP transmission, our data do not support this bottleneck being driven by selective resistance to antibodies. (asm.org)
  • Man, W.Y.N. , Nicholls, N. , Woolhouse, M.E.J. , Lewis, R.M. and Villanueva, B. (2009) Evaluating different PrP genotype selection strategies for expected severity of scrapie outbreaks and genetic progress in performance in commercial sheep. (gla.ac.uk)