Selectins ligands that integrins. Medical search. Frequent questions

In molecular biology, CD18 (Integrin beta chain-2) is an integrin beta chain protein that is encoded by the ITGB2 gene in humans. (wikipedia.org)
CD18 also exists in soluble, ligand binding forms. (wikipedia.org)
Leukocyte adhesion deficiency type I (LAD I) is a failure to express CD18, which composes the common ß 2 subunit of LFA1 family (ß2 integrins). (medscape.com)
Variants of leukocyte adhesion deficiency have also been reported, including fully expressed but nonfunctional CD18 and an E selectin that is expressed but rapidly cleaved from the cell surface (only present in soluble form). (medscape.com)
Type 1 results from mutations in the integrin beta-2 gene ( ITGB2 ), encoding CD18 beta-2 integrins. (msdmanuals.com)
Flow cytometry is used to assess the presence of the β2 integrins CD11a/CD18 (LFA-1 or aL/b2) on leukocytes, CD11b/CD18 (Mac-1 or aM/b2) on myeloid cells, and CD11c/CD18 (p150,95 or aX/b2) on myeloid cells. (medscape.com)
Because gallium relies on the presence of phagocytic cells, gallium scan findings are most likely to be informative when patients with leukocyte adhesion deficiency have residual expression of integrins or when granulocytes are transfused to patients with severe leukocyte adhesion deficiency (absence of CD18 expression). (medscape.com)
Neutrophils were freshly isolated from blood of 10 male healthy volunteers, stimulated the same way as endothelial cells and analyzed for surface expression of L-selectin, CD11b and CD18. (biomedcentral.com)
CD18, also known as integrin β2 subunit, LFA-1 β subunit, and β2 integrin, is a 90 - 95 kD type I glycoprotein. (biolegend.com)
Li R, Nortamo P, Valmu L , Tolvanen M, Huuskonen J, Kantor C and Gahmberg C G (1993) A peptide from ICAM-2 binds to the Leu-kocyte Integrin CD11a/CD18 and inhibits endot-helial cell adhesion. (leenavalmu.fi)
Valmu L and Gahmberg C G (1995) Treatment with okadaic acid reveals strong threonine phosphorylation of CD18 after activation of CD11/CD18 leukocyte integrins with phorbol esters or CD3 antibodies. (leenavalmu.fi)
Valmu L , Hilden T J, van Willigen G and Gahmberg C G (1999) Characterization of b2 (CD18) integrin phosphorylation in phorbol ester activated T lymphocytes. (leenavalmu.fi)
Valmu L , Fagerholm S, Suila H and Gahmberg C G (1999) The cytoskeletal association of CD11/CD18 leukocyte integrins in phorbol ester activated cells correlates with CD18 phosphorylation. (leenavalmu.fi)

These interactions involve several families of adhesion molecules including integrins and immunoglobulin superfamily members and selectins and carbohydrate-bearing ligands. (biomedcentral.com)

Klapproth S, Sperandio M, Pinheiro EM, Prünster M, Soehnlein O, Gertler FB, Fässler R, Moser M. Loss of the Rap1 effector RIAM results in leukocyte adhesion deficiency due to impaired β2 integrin function in mice. (phagocytes.eu)

There are specific receptor proteins like integrin on the external surface of focal attachments. (omicsonline.org)
This includes pattern recognition receptors, the role of posttranslational glycosylation on selectin ligand, chemokine-receptor function and integrin activation. (phagocytes.eu)
Integrins are not constitutively active but rather exist in multiple activation states wherein ligand binding stability is related to the activation status of the receptor. (thno.org)
Moreover, this work identifies a specific subset of ligand-receptor interactions that may yield new therapeutic and diagnostic targets for brain metastasis. (ox.ac.uk)
The 41 integrin and the chemokine receptor CXCR4 are key molecules for MM, ALL, and CLL cell trafficking into and out of the BM. (globaltechbiz.com)
Ligand binding by chemokine receptors involves the receptor N-terminal domain and three extracellular loops, whereas the intracellular loops and the C-terminal region are coupled to receptor internalization and to heterotrimeric G proteins, respectively (35). (globaltechbiz.com)
The most common example of this type of fusion protein combines the hinge and Fc regions of an immunoglobulin (Ig) with domains of a cell-surface receptor that recognizes a specific ligand (Box 1). (coek.info)
In PC12 cells, we recently showed that the engagement of integrin a3b1 to a binding sequence within the human laminin a2 chain was sufficient to recruit PKCa and PKCd to the integrin receptor [6]. (mirnamimic.com)
Taking advantage of the diverse γδ TCR repertoire or other ligand-receptor interactions, γδ T cells can recognize a broad spectrum of tumor-associated antigens (TAAs) in a major histocompatibility complex (MHC)-independent manner, thereby activating downstream pleiotropic effects. (explorationpub.com)

This disease is a defect in fucose metabolism (lack of fucosylation of the carbohydrate selectin ligands) that results in failure to express the ligand for E and P selectin, sialyl Lewis-X (CD15s) expressed on leukocytes and endothelial cells. (medscape.com)
In the first phase of the extravasation process, selectins such as L-selectin on leukocytes and E- and P-selectin on endothelial cells lead to a loose connection that permits tethering and rolling of leukocytes on the endothelium under hydrodynamic shear [ 10 ]. (biomedcentral.com)
Selectins are a family of 3 C-type lectins expressed exclusively by bone marrow-derived cells and endothelial cells. (goconqr.com)
We've determined a system because of this improvement also, discovering that L-NAME-treated neutrophils generate L-selectin- and PSGL-1-expressing microparticles and these coat the top of artificial migration chambers or endothelial cells to aid improved migration of consequently added neutrophils. (woofahs.com)
Bombeli,T., Schwartz,B.R., and Harlan,J.M. (1998): Adhesion of Activated Platelets to Endothelial Cells: Evidence for a GPIIb/IIIa-dependent Bridging Mechanism and Novel Roles for Endothelial Intercellular Adhesion Molecule 1 (ICAM-1), α V β 3 -Integrin and GPIbα. (9dok.net)
Selectins are a family of C-type lectin receptors divided according to their expression in leukocytes (L-selectin), platelets (P-selectin), or endothelial cells (E- and P-selectins) (39, 40). (globaltechbiz.com)

They can be activated by either chemokine engagement or selectin engagement. (goconqr.com)

TRAIL = Tumour necrosis-factor Related Apoptosis-Inducing Ligand. (goconqr.com)

Endothelial members of the immunoglobulin superfamily including ICAM-l and VCAM-l / INCAM-IIO bind to leukocyte cell-surface integrins. (sagepub.com)
CAMs have been classified into: cadherins, the immunoglobulin superfamily, integrins and selectins. (bvsalud.org)

Lymphocytes are recruited to tissues from blood via binding to vessels in the target tissue mediated by interactions between specific receptors on the lymphocyte surface and ligands on the endothelium. (biomedcentral.com)
Integrin-mediated interactions with the extracellular matrix (ECM) are required for the attachment, cytoskeletal organization, mechanosensing, migration, proliferation, differentiation and survival of cells in the context of a multitude of biological processes including fertilization, implantation and embryonic development, immune response, bone resorption and platelet aggregation. (thno.org)
Key factors that collectively determine the homing of leukocytes and their interaction with resident endothelial, epithelial, stromal and immune cells are interactions between integrins or selectins with their tissue adhesion molecules as well as chemokine receptors and their ligands. (ox.ac.uk)
Integrins are heterodimers of and subunits that mediate cell-cell and cell-ECM interactions, and connect the ECM with the actin cytoskeleton (23, 24). (globaltechbiz.com)

For example, lymphoid cells may fine tune the presence and concentration of adhesion molecules belonging to the IgSF, Selectin and Integrin class that interact with a number of vascular markers of inflammation. (reactome.org)
Integrins also function in pathological processes such as inflammation, wound healing, angiogenesis, and tumor metastasis. (thno.org)
Chen,M. and Geng,J.G. (2006): P-Selectin mediates adhesion of leukocytes, platelets and cancer cells in inflammation, thrombosis, cancer growth and metastasis. (9dok.net)

Pretreatment of BI-1356 microparticles with antibodies to L-selectin (DREG-200) or PSGL-1 (PL-1) significantly ( 0.001) inhibited this effect. (woofahs.com)
Hallikas O K, Aaltonen J M, von Koskull H, Lindberg L A, Valmu L , Kalkkinen N, Wahlström T, Kataoka H, Andersson L, Lindholm D and Schröder J (2006) Identification of antibodies against HAI-1 and integrin α6β4 as immunohistochemical markers of human villous cytotrophoblast. (leenavalmu.fi)

The selectins, two of which are found on endothelium and one on leukocytes, support adhesion through the recognition of carbohydrates. (sagepub.com)

We discover how the broad-spectrum NOS inhibitor NG-nitro-l-arginine methyl ester (L-NAME) enhances neutrophil migration in response towards the chemokine interleukin (IL)-8 with a mechanism that's reliant on adhesion between L-selectin and P-selectin glycoprotein ligand-1 (PSGL-1). (woofahs.com)

Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain, and are crucial for cells to be able to efficiently bind to the extracellular matrix. (wikipedia.org)
Many proteins in adhesion plaque such as integrin, cytoskeleton proteins, proteases, protein kinases, phosphatases take part in signal transferring by co-localizing with vinculin and talin [ 3 ]. (omicsonline.org)
The integrin tails have no intrinsic kinase activity but rather serve as a site for the docking of various kinases and related adaptor proteins that comprise focal adhesions. (thno.org)
Integrins are membrane-bound proteins that are key inflammatory proteins. (goconqr.com)

For instance, studies in mice have demonstrated that CD4+ T cells activated in cutaneous lymph nodes upregulate trafficking determinants specific for the skin, such as P-selectin ligand, while T cells responding to antigen in intestinal lymph nodes express high levels the gut-associated adhesion molecule integrin α4β7 and acquire responsiveness to the intestinal CC-chemokine ligand CCL25 [ 2 ]. (biomedcentral.com)
Binds to VLA1 (Very Late Antigen-1) and α4β1 integrins. (goconqr.com)
discuss the role of integrins in T cell- mediated immunity, with a focus on how these receptors participate in lymphocyte recirculation and T cell activation, how antigen stimulation regulates integrin activity, and how integrins define functionally unique subsets of T cells and APCs. (scielo.br)

At the same time, the natural ligands to these adhesion molecules were highly expressed on the metastatic tumor cells both in vitro and in vivo. (ox.ac.uk)
Selectins have also been implicated in the initial adhesion steps of the trafficking of hematologic tumor cells. (globaltechbiz.com)

After two, four and 24 hours, fluorescence activated cell sorter (FACS) analysis for vascular cell adhesion molecule-1, intercellular adhesion molecule-1 and E-selectin was performed. (biomedcentral.com)

The beta 2 integrins have also been found in a soluble form, meaning they are not anchored into the plasma membrane of the cell, but rather exist outside of the cell in the plasma, and are capable of ligand binding. (wikipedia.org)
The soluble beta 2 integrins are ligand binding and plasma levels are inversely associated with disease activity in the autoimmune disease spondyloarthritis. (wikipedia.org)

Integrins are heterodimeric, transmembrane receptors that function as mechanosensors, adhesion molecules and signal transduction platforms in a multitude of biological processes. (thno.org)

Purified and phycoerythrin-conjugated anti-human L-selectin (DREG-200) and isotype control (MOPC-21) had been bought from Becton Dickinson (Oxford, UK). (woofahs.com)

The biodirectional nature of integrin mediated signaling allows both extra- and intracellular cues to regulate activation [ 4 ] (Fig. 1 ). (thno.org)
Intracellular signaling events that converge on the cytoplasmic domain of integrin tails are also capable of activating the high affinity state. (thno.org)
Intracellular signals that result in integrin activation are referred to as 'inside-out' signaling events. (thno.org)
Integrin ligation via cell-to-cell and cell-to-matrix contacts transduces intracellular signaling events in a process called 'outside-in' signaling (Fig. 2 ). (thno.org)
Additionally, integrin-dependent cell adhesion triggers intracellular signaling that contributes to the control of cell growth and survival (23, 25). (globaltechbiz.com)
Integrins adopt different conformations, which determine their state of activation linked to their ability to bind ligands with high-affinity and to induce subsequent intracellular signaling (26C29). (globaltechbiz.com)

The role of selectin-selectin-ligand interaction in in the malignancy of colon carcinoma. (tau.ac.il)
Recent efforts resulted in the identification, characterization, and c loning of multiple endothelial cell-surface glycoproteins that support adhesion through an interaction with specific ligands (or counter-receptors) on leukocytes. (sagepub.com)

Biological activities of laminin are mediated through binding to a subset of integrin family of cell adhesion receptors, a3b1, a6b1, a6b4, and a7b1 [2]. (mirnamimic.com)

Of these, the [blank_start]__________[blank_end] is the only one with HIGH affinity for ligand. (goconqr.com)

We show here that emperipolesis is a dynamic process mediated actively by both lineages, in part through the β2-integrin/ICAM-1/ezrin pathway. (elifesciences.org)
Oncogenic activity of major protein in the integrin signaling pathway. (tau.ac.il)
Chung KJ, Mitroulis I, Wiessner JR, Zheng YY, Siegert G, Sperandio M, Chavakis T. A novel pathway of rapid TLR-triggered activation of integrin-dependent leukocyte adhesion that requires Rap1 GTPase. (phagocytes.eu)

Integrin-dependent tyrosine phosphorylation and growth regulation by VAV. (tau.ac.il)
Hilden T J, Valmu L , Kärkkäinen S and Gahmberg C G (2003) Threonine phosphorylation sites in the beta2 and beta7 leukocyte integrin polypeptides. (leenavalmu.fi)

Integrins are heterodimeric cell surface receptors found in nearly all metazoan cell types, composed of non-covalently linked α and β subunits. (thno.org)
The ability of L-NAME-induced microparticles to enhance migration was found to be dependent on the number of microparticles produced and not an increase in microparticle surface L-selectin or PSGL-1 expression. (woofahs.com)
Cytokines are also able to act in a manner independent of secretion and can act as cell surface ligands. (encyclopedia.pub)
The roles of these cell surface receptors and their glycosylated ligands have been BACE1-IN-1 extensively explored in leukocyte recruitment, granular secretion, and placental development (40, 41). (globaltechbiz.com)
Surface ligands that mediate cell-to-cell adhesion and function in the assembly and interconnection of the vertebrate nervous system. (bvsalud.org)

This in turn triggers the activation of integrins leading to firm arrest followed by transmigration into tissue. (phagocytes.eu)

Several molecules are involved in the process of cell adhesion to bone grafts, highlighting the role of integrins, the focal adhesion mechanism, the influence of the collagen matrix, and the activity of alkaline phosphatase in bone matrix formation. (bvsalud.org)

It is a defect in the expression of ligands for selectins due to lack of enzymes required for expression of selectin ligands. (medscape.com)
associated with skin-homing) as well as the expression of integrin α4β7 and CCR9 (associated with gut-homing) was analyzed on CD4+ memory T cells in CSF from individuals with non-inflammatory neurological diseases using flow cytometry. (biomedcentral.com)
Some progress has been made in defining trafficking determinants for inflamed CNS microvessels: CD8+ T cells activated in cervical lymph nodes draining intracerebral tumors in the mouse acquire a phenotype characterized by high expression of the two integrins α4 and α1 as well as a modest increase in the expression of P-selectin ligand [ 12 ]. (biomedcentral.com)
RESULTS: Endothelial expression of E-selectin, VCAM-1, ALCAM, ICAM-1, VLA-4, and β4 integrin was markedly increased early in tumor seeding. (ox.ac.uk)
Two of these ligands showed particularly high tumor cell expression (ALCAM and VLA-4), and consequently their functional role in tumor seeding was determined. (ox.ac.uk)

Integrin activation is a dynamic process that can be achieved by several stimuli from outside (outside-in) or inside (inside-out) the cell, a property that highlights the integrin role as main BACE1-IN-1 connectors between the BACE1-IN-1 cancer cells and their environment (24). (globaltechbiz.com)

In experiments probing for a role of PKCa in human laminin-2-integrin-mediated cell adhesion and spreading of PC12 cells, we observed unexpected enhancements of adhesion, spreading and stress fiber formation to 1 mM Go¨6976 with concomitant increase in membrane translocation of PKCd and autophosphorylation of focal adhesion kinase (FAK). (mirnamimic.com)

Lymphoid cells are able to regulate their location and movement in accordance to their state of activation, and home in on tissues expressing the appropriate complementary ligands. (reactome.org)
Extracellular factors that influence integrin activation are ligand binding, divalent cation concentration, chemokine signaling and mechanical stress. (thno.org)

From this pool, 24 distinct heterodimer combinations have been observed in vivo that confer cell-to-cell and cell-to-ligand specificity relevant to the host cell and the environment in which it functions [ 2 ]. (thno.org)

Integrin mediated signal transduction events in malignancy, and their relevance to tumor progression. (tau.ac.il)

It's a member of the [blank_start]__________[blank_end] ligand family. (goconqr.com)
PKC family of serine-threonine kinases plays key roles in many of the signaling pathways that control cellular function, including those mediated through integrin signaling. (mirnamimic.com)

Integrin mediated signal transduction events in normal and human melanoma cells. (tau.ac.il)
In addition, integrin binding has been identified as a means of viral entry into cells [ 3 ]. (thno.org)
CSF contained similar proportions of CD4+ memory T cells expressing CLA, CCR4, integrin α4β7 and CCR9 as paired blood samples. (biomedcentral.com)
Integrins are the main adhesion receptors facilitating the trafficking of neoplastic cells. (globaltechbiz.com)

Anatomy14

Organisms4

Diseases4

Chemicals and Drugs60

Analytical, Diagnostic and Therapeutic Techniques and Equipment4

Phenomena and Processes16

Information Science3

CD1813

Carbohydrate-bearing1

Leukocyte adhesion d1

Receptor9

Endothelial cells6

Activated by either ch1

Apoptosis-Inducing Ligand1

Immunoglobulin2

Interactions4

Inflammation3

Antibodies2

Endothelium1

Glycoprotein1

Proteins4

Antigen3

Tumor Cells2

Adhesion molecule1

Soluble2

Transmembrane1

Isotype1

Intracellular6

Interaction2

Subset1

High affinity1

Pathway3

Phosphorylation2

Surface5

Triggers1

Molecules1

Expression5

Cancer1

Focal1

Activation2

Vivo1

Progression1

Family2

Cells4