• CD62P antibody LS-B3656 is an unconjugated mouse monoclonal antibody to human CD62P (SELP / P-Selectin). (lsbio.com)
  • CD62P is a 140 kD type I transmembrane glycoprotein also known as P-selectin, platelet activation-dependent granule membrane protein (PADGEM), and GMP-140. (biolegend.com)
  • Recognizes the CD62P cell surface antigen, a 140kD glycoprotein also known as P-selectin. (lsbio.com)
  • The ligand for P-selectin, P-selectin glycoprotein ligand-1 (PSGL-1), is expressed on subsets of activated effector T cells and is believed to become essential for the movement of CD4- good T cells into inflamed tissues [11]. (bet-bromodomain.com)
  • Platelet function was assessed with remote measurement of surface expression of P-selectin (CD62P) using commercial kits sensitive to aspirin or clopidogrel. (bmj.com)
  • Conclusions Remote measurement of platelet function assessed using the platelet surface expression of P-selectin is feasible. (bmj.com)
  • Surface platelet expression of P-selectin (CD62P) correlates with other platelet function measures and can be tested remotely from the patient, 10 in contrast to other techniques that cannot be used remotely. (bmj.com)
  • Thrombin-activated human peripheral blood platelets were stained with CD62P (P-Selectin) (clone AK4) Brilliant Violet 650™ (filled histogram) or mouse IgG1, κ Brilliant Violet 650™ isotype control (open histogram). (biolegend.com)
  • CD62P is primarily stored in secretory α-granules in platelets and Weibel-Palade bodies in endothelial cells, and is rapidly relocated to the plasma membrane upon activation. (biolegend.com)
  • Additional reported applications (for the relevant formats) include: immunohistochemical staining of acetone-fixed frozen tissue sections 4 and in vitro blocking of adhesion of platelets 1 . (biolegend.com)
  • CD62P is expressed by activated platelets and endothelial cells, and plays an important role in adhesive processes between leucocytes and endothelial cells. (lsbio.com)
  • We also found that large numbers of platelets accumulated in Rip1-Tag2 mouse insulinomas via a P-selectin-dependent mechanism [ 3 ]. (ijbs.com)
  • These granules, unique to the platelets, are a subtype of lysosome-related organelles (LROs), a group that also includes melanosomes, lamellar bodies of the type II alveolar cells, and lytic granules of cytotoxic T cells. (cloudfront.net)
  • Fibrinogen receptors, CD62p (P-selectin) and CD63 are neoepitopes that seem only around the surface of activated platelets. (bet-bromodomain.com)
  • P-selectins mediate interaction amongst endothelium, platelets and leucocytes by phosphorylation of histidine residues on the molecule [6]. (bet-bromodomain.com)
  • Additional reported applications (for the relevant formats of this clone) include: activation of LFA-1 and MAC-1 1,2 . (biolegend.com)
  • Molecules known to be important for thymus entry include P-selectin (CD62P) and the chemokine receptors CCR7 and CCR9. (wikipedia.org)
  • They contain mainly proteins, both membrane-associated receptors (for example, αIIbβ3 and P-selectin) and soluble cargo (for example, platelet factor 4 [PF4] and fibrinogen). (cloudfront.net)
  • 2012). APPL1 is recruited by Rab5 to endosomes involved in traffic of transmembrane receptors including integrins (Miaczynska et al. (bio2009.org)
  • α-Granule exocytosis is evaluated primarily by plasma membrane expression of P-selectin (CD62P) by flow cytometry or estimation of the release of PF4, VWF, or other granule cargos. (cloudfront.net)
  • P-selectin, soluble endothelial protein C receptor, soluble thrombomodulin, plasminogen activator inhibitor 1, ADAMTS-13, von Willebrand factor, tissue factor, soluble intercellular adhesion molecule 1, and vascular cell adhesion molecule 1 were more elevated in LF patients than in controls. (cdc.gov)
  • Recent studies have shown that P-selectin deletion inhibits tumor growth in Rip1-Tag2 mice by suppressing platelet accumulation in tumor tissues. (ijbs.com)
  • These results indicate that P-selectin deletion significantly decreases tumor stiffness in Rip1-Tag2 mice by inhibiting LOX expression. (ijbs.com)
  • Furthermore, our previous study demonstrated that P-selectin deletion inhibited melanoma metastasis by suppressing platelet adhesion and that P-selectin-mediated platelet adhesion promoted intestinal tumor growth in Apc Min/+ mice [ 1 , 2 ]. (ijbs.com)
  • Nonetheless, it was surprisingly located that mice with targeted deletion with the P-selectin gene (PsKO mice) created unpolarized sort 1type two cytokine reactions and vigorously enhanced liver pathology following infection together with the kind 2-promoting S. mansoni [10]. (bet-bromodomain.com)
  • Pathologic changes seen on autopsy lack major cell and tissue injury but include signs of pleural effusion, pulmonary edema, ascites, and gastrointestinal mucosa bleeding ( 5 , 6 ), all indications of systemic vascular leakage. (cdc.gov)
  • To explore the role of P-selectin in tissue stiffness, we demonstrated that tumor progression in Rip1-Tag2 mice was correlated with tissue stiffness using immunofluorescence and histological staining. (ijbs.com)
  • Furthermore, we showed that P-selectin deficiency significantly decreased tissue stiffness by inhibiting lysyl oxidase (LOX) expression. (ijbs.com)
  • Further study demonstrated that P-selectin-mediated platelet accumulation increases tissue stiffness mainly by increasing LOX expression and thus promotes tumor growth. (ijbs.com)
  • Importantly, we found that P-selectin deficiency inhibited insulinoma progression using Rip1-Tag2 transgenic mice and Rip1-Tag2;P-sel -/- mice [ 3 ]. (ijbs.com)
  • With the three identified E, L and P-selectins, P-selectins had been discovered to have a essential role within the progression of CLD brought on by schistosome parasites. (bet-bromodomain.com)
  • Notch signaling dictates cell fate decisions in mammalian cells including megakaryocytes. (elifesciences.org)
  • A primary function of CD62P is cell adhesion during neutrophil rolling, and platelet-neutrophil and platelet-monocyte interactions. (biolegend.com)
  • P-selectin, a cell adhesion molecule, is an important member of the selectin family. (ijbs.com)
  • See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more. (lsbio.com)
  • therefore, we recommend that special precautions be taken (such as wrapping vials, tubes, or racks in aluminum foil) to prevent exposure of conjugated reagents, including cells stained with those reagents, to room illumination. (bdbiosciences.com)
  • Proteins associated with FAs include the nonreceptor tyrosine kinases FAK and Src. (bio2009.org)
  • 2012). However, FAs also function as signaling platforms, affecting several signaling pathways including Akt (Erez et al. (bio2009.org)
  • Therefore, P-selectin may be an effective therapeutic targeting for treating human insulinomas. (ijbs.com)
  • Ischemia-reperfusion injury, which involves complex inflammatory pathways, is a significant cause of liver damage and an important factor in a variety of diseases, injuries, and procedures that include (but not limited to) transplant and trauma. (ectrx.org)
  • In this discussion of antioxidant molecules, it is also important to include melatonin, which exerts multiple protective effects in hepatic ischemia and reperfusion (33-36). (ectrx.org)
  • This study aimed to evaluate whether and how P-selectin affects tumor stiffness in Rip1-Tag2 mice. (ijbs.com)
  • Methods: Adult patients enrolled in an observational, multinational registry, the International Severe Acute Respiratory and Emerging Infections COVID-19 study, between January 1, 2020, and September 15, 2021, met inclusion criteria, including admission to a hospital for laboratory-confirmed, acute COVID-19 and data on complications and survival. (bvsalud.org)
  • Results: The study population included 495,682 patients from 52 countries, with 63% from LMICs and 85% in the basic treatment cohort. (bvsalud.org)
  • we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented. (thermofisher.com)
  • Liver ischemia and reperfusion - which cause liver damage that is significant in a variety of diseases, injuries, and procedures (including but not limited to trauma and transplant) - have been the focus of many investigations in recent years. (ectrx.org)
  • Many studies have reported that P-selectin has significant effects on the growth and metastasis of many cancers including melanoma, lung cancer, and colorectal carcinoma. (ijbs.com)
  • Other free-radical scavengers that produce beneficial effects have been studied, including edaravone (MCI-186) (22-26), 2-mercaptoethane sulfonate (27,28), nitronyl nitroxide-amino acid conjugates (29), a-lipoic acid (30), ascorbic acid and mannitol (31), and metalloporphyrins (32). (ectrx.org)
  • [ 5 ] C1q is a member of the collectin family, which also includes surfactant A, surfactant D, and mannose-binding lectin (MBL). (medscape.com)
  • Natural and synthetic glucocorticoids bind to GR, producing major conformational changes that result in nuclear translocation or transrepression of transcription factors, including nuclear factor κB. (ashpublications.org)