• The frequency and relative percent of convulsive and nonconvulsive spontaneous seizures were monitored for a period of 21 days, and the brains were then harvested for immunohistochemical analysis. (ovid.com)
  • Electrophysiological recordings, before overt cell death, showed normal excitatory transmission, but revealed spontaneous epileptiform activity consistent with seizures in the mutants. (strath.ac.uk)
  • Inflammatory processes, febrile seizures, and subsequent epileptogenesis. (semanticscholar.org)
  • Further, our data indicate a natural temperature-dependent shift in sodium current deactivation (exacerbated by mutation) may contribute to febrile seizures in GEFS+ and perhaps normal individuals. (pubmedcentralcanada.ca)
  • More conservative missense mutations generally confer more benign conditions, including over 40 that result in GEFS+, which is characterized by febrile seizures that persist in individuals past 6 years of age ( Scheffer and Berkovic, 1997 ) ( http://www.molgen.vib-ua.be/SCN1AMutations/Mutations/Default.cfm ). (pubmedcentralcanada.ca)
  • Blood-derived BCAAs can readily enter the brain, where they contribute to glutamate biosynthesis and may either suppress or trigger acute seizures. (ovid.com)
  • Pretreatment with antagonists of the NMDA subtype of glutamate receptor selectively and markedly decreased seizure-induced c- fos mRNA expression in the dentate granule cells, despite increasing the number of granule cell population action potentials. (jneurosci.org)
  • In the substantia nigra, where neuronal populations have previously been demonstrated to exhibit synchronous firing during kindled seizures, no induction of c-fos mRNA was detected in either pars compacta or pars reticulata. (jneurosci.org)
  • Transition to seizure is haracterized by a rapid expansion and fusion of the neuronal populations responsible for HFA, associated with a progressive slowing of HFA, leading to a single, massive, hypersynchronous cluster generating the high-amplitude low-frequency activity of the seizure. (bham.ac.uk)
  • Electrophysiological recordings from flight muscles in the giant fiber pathway of adult eas flies reveal that induction of paralysis with electrical stimulation results in a brief seizure, followed by a failure of the muscles to respond to giant fiber stimulation. (nih.gov)
  • Challenges in single-neuron ensemble recordings during human seizures and in the statistical assessment of synchrony have posed difficult obstacles to determining the degree of neuronal spike synchrony and its role in seizures. (jneurosci.org)
  • Preictal EEG changes occur in both human patients and animal models, but their underlying mechanisms and relationship with seizure initiation remain unknown. (bham.ac.uk)
  • Topics include patterning of the nervous system, generation of neuronal diversity, axonal guidance, synapse formation, the control of behavior by specific neural circuits and neurodegenerative diseases. (brown.edu)
  • Autoantibodies to neuronal antigens in children with new-onset seizures classified according to the revised ILAE organization of seizures and epilepsies. (ox.ac.uk)
  • Overall, these studies show a fine correlation between miRNA regulation/dysregulation and inflammation, seizure-induced neuronal death and other relevant biological pathways. (frontiersin.org)
  • However, the underlying changes in sodium channel function were different in these SCN1A mutants and neither channel function nor neuronal excitability were explored at high temperature. (pubmedcentralcanada.ca)
  • The consequent depolarization of the neuronal GABA reversal potential (EGABA) selectively impairs cortical inhibitory networks. (sigmaaldrich.com)
  • The second case is a 64-year-old man suffering from partial complex seizures secondary to unilateral perisylvian syndrome, a type of polymicrogyria presenting as cortical dysplasia along the left lateral sulcus ( Figure 2 ). (omicsonline.org)
  • Electrophysiological studies of GABAergic interneurons in the brains of adult GEFS+ flies reveal a novel cellular mechanism underlying heat-induced seizures: the deactivation threshold for persistent sodium currents reversibly shifts to a more negative voltage when the temperature is elevated. (pubmedcentralcanada.ca)
  • Anticonvulsant medication is the mainstay of treatment for seizures, although the choice of anticonvulsant drug varies with different seizure types and epileptic syndromes. (medscape.com)
  • The first case is a nineteen-year-old female patient suffering from partial complex seizures , secondary to sub ependymal grey matter heteropia ( Figure 1 ) along the left ventricle. (omicsonline.org)
  • Felbamate is approved by the FDA for medically refractory partial seizures and Lennox-Gastaut syndrome. (medscape.com)
  • This agent is approved for generalized, primary generalized, tonic-clonic, and partial-onset seizures. (medscape.com)
  • Expression of the immediate-early gene c-fos has been advanced as a marker of neuronal activity in the adult nervous system. (jneurosci.org)
  • The development of the central nervous system is a complex process, organized in the following steps: primary neurulation (3-4 weeks), prosencephalic development (2-3 months), neuronal proliferation (3-4 months), neuronal migration (3-5 months), organization (5 months of gestation to after birth), and myelination (after birth) . (omicsonline.org)
  • Fine temporal synchrony can also induce changes in synaptic efficacy (effective network connectivity) via neuronal spike timing-dependent plasticity ( Dan and Poo, 2006 ). (jneurosci.org)
  • Created to engage in education and medical research toward diagnosis, treatment and/or cure of Juvenile neuronal ceroid lipofuscinosis (Batten disease) and to assist persons with the disease. (dmoztools.net)
  • Immediately before seizure onset, CA1 is in a state of high sensitivity in which weak depolarizing or synchronizing perturbations can trigger seizures. (bham.ac.uk)
  • MicroRNA-34a upregulation during seizure-induced neuronal death. (rcsi.ie)
  • Thus, prolonged seizures cause subfield-specific, temporally restricted upregulation of miR-34a, which may be p53 dependent, but miR-34a is probably not important for seizure-induced neuronal death in this model. (rcsi.ie)
  • Estrone is the major estrogen after menopause, and this hormone may be very influential in seizure control of the catamenial woman if she is severely overweight or obese. (wikipedia.org)
  • The Drosophila easily shocked gene: a mutation in a phospholipid synthetic pathway causes seizure, neuronal failure, and paralysis. (nih.gov)
  • Here we report knock-in of a GEFS+ SCN1A mutation (K1270T) into the Drosophila sodium channel gene, para , causes a semi-dominant temperature-induced seizure phenotype. (pubmedcentralcanada.ca)
  • This seizure exacerbation has a statistically significant positive correlation to serum estradiol/estrogen levels and ratios. (wikipedia.org)
  • Thus, it is unclear whether the stimulus inducing c‐fos expression after generalized brain trauma is direct neuronal injury or associated, secondary effects of injury. (deepdyve.com)
  • In addition, transient fine synchrony occurred primarily during the initial ∼20 ms period of the SWC spike phase and varied across subjects and seizures. (jneurosci.org)
  • Our findings indicate that fine neuronal ensemble synchrony occurs mostly during SWC, not gamma-band, seizures, and primarily during the initial phase of SWC spikes. (jneurosci.org)
  • In addition, there are reports of miRNAs involved in cell proliferation, fate specification, and neuronal maturation and these processes are tightly linked to the pathogenesis of MCD. (frontiersin.org)
  • Seizures are a combination of electrical and behavioral events that are able to induce chemical, molecular, and anatomic alterations. (dovepress.com)
  • Sporadic coherence events between neuronal population spike counts and LFPs were observed during SWC seizures in high (∼80 Hz) gamma-band and during high-frequency oscillations (∼130 Hz). (jneurosci.org)